nach oben

Medical Oncology

Erschienen in:

01.09.2011 | Original paper

Natural products and their role in cancer therapy

verfasst von: David Siu

Erschienen in: Medical Oncology | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Abstract

This paper documented several natural products that have antineoplastic activities. Detailed descriptions of the mechanism of action of these products are given. Side effects of these natural products are also described. Based on these side effect profiles and their benefits, these natural products could be used as adjuvant cancer therapies. Traditional anticancer agents usually have debilitating side effects. These natural products would be of great benefit due to their anticancer activities. Additionally, some of these natural products can work proactively in preventing cancer formation with their chemopreventive properties. Incorporation into diet can be recommended after discussion with physician and other health care professionals.

Stiborova M, Breuer A, Aimova D, Stiborova-Rupertova M, Wiessler M, Frei E. DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling. Int J Cancer. 2003;107:885–90.PubMedCrossRef

Siu D. Activity-dependent hepatocyte growth factor expression and its role in organogenesis and cancer growth suppression. Med Hypotheses. 2004;63:62–70.PubMedCrossRef

Iizuka N, Miyamoto K, Okita K, Tangoku A, Hayashi H, Yosino S, Abe T, Morioka T, Hazama S, Oka M. Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines. Cancer Lett. 2000;148:19–25.PubMedCrossRef

Mitani N, Murakami K, Yamaura T, Ikeda T, Saiki I. Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. Cancer Lett. 2001;165:35–42.PubMedCrossRef

Kim YJ, Kang SA, Hong MS, Park HJ, Kim MJ, Park HJ, Kim HK. Coptidis rhizoma induces apoptosis in human colorectal cancer cells SNU-C4. Am J Chin Med. 2004;32:873–82.PubMedCrossRef

Chen JK, Chen TT. Chinese medical herbology and pharmacology. 2nd ed. California: Art of Medicine Press; 2004.

Park CS, Lee YC, Kim JD, Kim HM, Kim CH. Inhibitory effects of Polygonum cuspidatum water extract (PCWE) and its component resveratrol [correction of rasveratrol] on acyl-coenzyme A-cholesterol acyltransferase activity for cholesteryl ester synthesis in HepG2 cells. Vascul Pharmacol. 2004;40:279–84.PubMedCrossRef

Fuggetta MP, D’Atri S, Lanzilli G, Tricarico M, Cannavo E, Zambruno G, Falchetti R, Ravagnan G. In vitro antitumour activity of resveratrol in human melanoma cells sensitive or resistant to temozolomide. Melanoma Res. 2004;14:189–96.PubMedCrossRef

10.

Kimura Y, Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr. 2001;131:1844–9.PubMed

11.

Feng L, Zhang LF, Yan T, Jin J, Tao WY. Studies on active substance of anticancer effect in Polygonum cuspidatum. Zhong Yao Cai. 2006;29:689–91.PubMed

12.

Giridharan P, Somasundaram ST, Perumal K, Vishwakarma RA, Karthikeyan NP, Velmurugan R, Balakrishnan A. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. Br J Cancer. 2002;87:98–105.PubMedCrossRef

13.

Huang ST, Yang RC, Chen MY, Pang JH. Phyllanthus urinaria induces the Fas receptor/ligand expression and ceramide-mediated apoptosis in HL-60 cells. Life Sci. 2004;75:339–51.PubMedCrossRef

14.

Huang ST, Yang RC, Yang LJ, Lee PN, Pang JH. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci. 2003;72:1705–16.PubMedCrossRef

15.

Kiefer D, Pantuso T. Panax ginseng. Am Fam Physician. 2003;68:1539–42.PubMed

16.

Chang YS, Seo EK, Gyllenhaal C, Block KI. Panax ginseng: a role in cancer therapy? Integr Cancer Ther. 2003;2:13–33.PubMedCrossRef

17.

Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res. 1998;89:733–40.PubMed

18.

Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol. 2006;13:14–26.PubMed

19.

Cheng YL, Chang WL, Lee SC, Liu YG, Lin HC, Chen CJ, Yen CY, Yu DS, Lin SZ, Harn HJ. Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci. 2003;73:2383–94.PubMedCrossRef

20.

Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ. Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Lett. 2005;222:183–93.PubMedCrossRef

21.

Hsia SM, Yeh CL, Kuo YH, Wang PS, Chiang W. Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro. Exp Biol Med (Maywood). 2007;232:1181–94.CrossRef

22.

Chang HC, Huang YC, Hung WC. Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo. J Agric Food Chem. 2003;51:3656–60.PubMedCrossRef

23.

Hung WC, Chang HC. Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. J Agric Food Chem. 2003;51:7333–7.PubMedCrossRef

24.

Wu J, Wu Y, Yang BB. Anticancer activity of Hemsleya amabilis extract. Life Sci. 2002;71:2161–70.PubMedCrossRef

25.

Garbett NC, Graves DE. Extending nature’s leads: the anticancer agent ellipticine. Curr Med Chem Anti-Canc Agents. 2004;4:149–72.CrossRef

26.

Stiborova M, Rupertova M, Schmeiser HH, Frei E. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006;150:13–23.PubMed

27.

Stiborova M, Stiborova-Rupertova M, Borek-Dohalska L, Wiessler M, Frei E. Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans. Chem Res Toxicol. 2003;16:38–47.PubMedCrossRef

28.

Faddeeva MD, Beliaeva TN. Sanguinarine and ellipticine cytotoxic alkaloids isolated from well-known antitumor plants. Intracellular targets of their action]. Tsitologiia. 1997;39:181–208.PubMed

29.

Frei E, Bieler CA, Arlt VM, Wiessler M, Stiborova M. Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes. Biochem Pharmacol. 2002;64:289–95.PubMedCrossRef

30.

Chitra M, Sukumar E, Suja V, Devi CS. Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy. 1994;40:109–13.PubMedCrossRef

31.

Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47:2430–40.PubMedCrossRef

32.

Mori T, Doi R, Kida A, Nagai K, Kami K, Ito D, Toyoda E, Kawaguchi Y, Uemoto S. Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. J Surg Res. 2007;142:281–6.PubMedCrossRef

33.

Scott DW, Loo G. Curcumin-induced GADD153 gene upregulation in human colon cancer cells. Carcinogenesis. 2004;25:2155–64.PubMedCrossRef

34.

Radhakrishna Pillai G, Srivastava AS, Hassanein TI, Chauhan DP, Carrier E. Induction of apoptosis in human lung cancer cells by curcumin. Cancer Lett. 2004;208:163–70.PubMedCrossRef

35.

Blasiak J, Trzeciak A, Kowalik J. Curcumin damages DNA in human gastric mucosa cells and lymphocytes. J Environ Pathol Toxicol Oncol. 1999;18:271–6.PubMed

36.

Chauhan DP. Chemotherapeutic potential of curcumin for colorectal cancer. Curr Pharm Des. 2002;8:1695–706.PubMedCrossRef

37.

Collett GP, Campbell FC. Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis. 2004;25:2183–9.PubMedCrossRef

38.

Thangapazham RL, Sharma A, Maheshwari RK. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J. 2006;8:E443–9.PubMedCrossRef

39.

Kakar SS, Roy D. Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin. Cancer Lett. 1994;87:85.PubMedCrossRef

40.

Koo JY, Kim HJ, Jung KO, Park KY. Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil. J Med Food. 2004;7:117–21.PubMedCrossRef

41.

Van’t Land B, Blijlevens NM, Marteijn J, Timal S, Donnelly JP, de Witte TJ, M’Rabet L. Role of curcumin and the inhibition of NF-kappaB in the onset of chemotherapy-induced mucosal barrier injury. Leukemia. 2004;18:276–84.CrossRef

Titel: Natural products and their role in cancer therapy
verfasst von: David Siu
Publikationsdatum: 01.09.2011
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 3/2011
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-010-9528-x

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Natural products and their role in cancer therapy

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2011

Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer

Determination of clonal status of pulmonary sclerosing hemangioma with X-chromosome inactivation mosaicism and polymorphism of phosphoglycerate kinase and androgen receptor genes

Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies

Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC)

P53 gene polymorphisms and breast cancer risk in Arab women

Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie