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Naunyn-Schmiedeberg's Archives of Pharmacology

Ausgabe 11/2025

Inhalt (102 Artikel)

The role of TLR4/NF-kB signaling axis in pneumonia: from molecular mechanisms to regulation by phytochemicals

  • Review

Jun Yin, Jianxiang Huang, Ping Zhou, Linwei Li, Qin Zheng, Hong Fu

Cellular toxicity of organotellurans: a systematic review of pre-clinical studies

  • Review

Maria Luisa Lima Barreto do Nascimento, Isabela Ribeiro de Sá Guimarães Nolêto, Francisco Leonardo Torres-Leal, Felipe Cavalcanti Carneiro da Silva, João Marcelo de Castro e Sousa

Factor XI/XIa inhibitors versus direct oral anticoagulants in atrial fibrillation with stroke risk: a GRADE-assessed meta-analysis of randomized controlled trials

  • Review

Ahmed Emara, Ahmed Farid Gadelmawla, Mohamed Emara, Mohamed R. Murad, Mohamed S. Elgendy, Mohamed Ellebedy, Lina Hemmeda, Mohamed A. Aldemerdash, Ahmed Abduljalil Mohammed, Basel Abdelazeem

Advancing fungal keratitis treatment: transitioning from conventional amphotericin B therapy to nanocarrier-based delivery systems

  • Review

Gourav Kumar, Aians H. Kalita, Jabin Ahmed, Shubhi Saxena, Subhi Sharma, Astha Mehta, Amit Sharma, Balak Das Kurmi, Ghanshyam Das Gupta, Shubham Thakur

Bridging diabetes and cancer: harnessing biomarkers as dual sentinels for diagnosis, prognosis, and therapeutic advancements

  • Review

Iman Mohammad Said Jallod, Ammar Khalo Abbas, Faheemah Ismael Yaqoob, Abdul-Aziz Ahmed Aziz

Nanomaterials for delivery of drugs and genes to disrupt notch signaling pathway in breast cancer

  • Review

Ramakrishna Gummadi, Lakshmi Prasanthi Nori, Sai Kiran S. S. Pindiprolu, Nagasen Dasari, Zubair Ahmad, Muhasina KM

The SOX gene superfamily in oncogenesis: unraveling links to ncRNAs, key pathways, chemoresistance, and gene editing approaches

  • Review

Ammar Yasir Ahmed, Subasini Uthirapathy, Enwa Felix Oghenemaro, Rekha M. M., Rohit Kumawat, Yasser Fakri Mustafa, Muthena Kariem, Abed J. Kadhim, Shilpa Sharma, M. Ravi Kumar

LincRNA-miR interactions in hepatocellular carcinoma: comprehensive review and in silico analysis: a step toward ncRNA precision

  • Open Access
  • Review

Nadia M. Hamdy, Al-Aliaa M. Sallam, Ola Elazazy, Ahmed M. Kabel, Rania M. Salama, Shaimaa A. Gouhar, Sherien M. El-Daly, Samar F. Darwish

Antidiabetic potentials of gypenosides: A review on the preclinical effects in glucose and insulin modulation as well as diabetes-related complications

  • Review

Yu Zhao Lee, Audrey Siew Foong Kow, Qi Long Lee, Luis Wei Cheng Lim, Rohana Yusof, Chau Ling Tham, Yu-Cheng Ho, Ming Tatt Lee

Tumor immune evasion and the Let-7 family: insights into mechanisms and therapies

  • Review

Omer Qutaiba B. Allela, Ali Fawzi Al-Hussainy, Gaurav Sanghvi, R. Roopashree, Aditya Kashyap, D. Alex Anand, Rajashree Panigrahi, Lilia Maratovna Garifulina, Sada Ghalib Taher, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq

Anti-metastatic potential of flavonoids for the treatment of cancers: focus on epithelial-mesenchymal transition (EMT) process

  • Review

Suleiman Ibrahim Mohammad, Asokan Vasudevan, Sumaya Nadhim Mohammed, Subasini Uthirapathy, Rekha M. M., Mayank Kundlas, G. V. Siva Prasad, Mukesh Kumari, Yasser Fakri Mustafa, Zainab Ali Hussein

Innovative approaches for the treatment of stroke: a recent update

  • Review

Priya Bindal, Dhruvika Kumar, Sara Dhamnaskar, Ginpreet Kaur

lncRNA H19 as a molecular rheostat in autoimmunity: orchestrating miRNA-mediated gene regulation and immune cell reprogramming

  • Review

Thikra Majid Muhammed, Mahmood Yaseen Mukhlif, Ahmed Hossein, Renuka Jyothi. S, Vishal Thakur, Swati Mishra, Ashish Singh Chauhan, Mahmood Hasen Shuhata, Mohammed Jawad Alnajar, Hayder Abdulhasan Hammoodi

Unraveling the therapeutic landscape of miRNAs in pancreatic cancer

  • Review

Zeinab A. El-Moaty, Maria Wagdy Wasef, Yara A. Elsayed, Amina Sayed Shafiq, Mai A. Elnagar, Hadeer Rashad Mohamed, Ahmed E. Elesawyf, Sherif S. Abdel Mageedg, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Rabab S. Hamad, Raydaa Abdullah S. Alshomrani, Ahmed S. Doghish

The effect of flavonoids on the doxorubicin efficacy in cancer treatment

  • Review

Solmaz Asnaashari, Elham Amjad, Babak Sokouti

A comprehensive review of immunotherapy in gastrointestinal tumors with a focus on the role of combination therapy with PARP inhibitors

  • Review

Saade Abdalkareem Jasim, Jitendra Gupta, Subasini Uthirapathy, Roopashree R., Syeda Wajida Kazmi, Jasur Alimdjanovich Rizaev, Mamdouh Eldesoqui, Maythum Ali Shallan, Yasser Fakri Mustafa, Beneen Hosseen

Unlocking the therapeutic potential of protocatechualdehyde: pharmacological applications and mechanism insights

  • Review

Ibrahim Mssillou, Youness El Abdali, Fatima Ez-Zahra Amrati, Adrian Lim, Asaad Khalid, Hafiz A. Makeen, Mohammed Albratty, Youssra Lefrioui, Boutaina Louafi, Dalila Bousta

Exploring NMDAR pathways in ischemic stroke: implications for neurotoxic and neuroprotective mechanisms and therapeutic strategies

  • Review

Sara Khan, Mohd Muazzam Khan, Badruddeen, Usama Ahmad, Wasim Akhtar, Anas Islam

Overcoming resistance mechanisms in cancer immunotherapy—novel approaches and combinations

  • Review

Rahaman Shaik, Billa Yashaswi, Meravath Anjali, Sana Syeda, Huda Khan

A comprehensive review on schizophrenia: epidemiology, pathogenesis, diagnosis, conventional treatments, and proposed natural compounds used for management

  • Open Access
  • Review

Alaa Anwar, Aya M. Mustafa, Kareem Abdou, Mostafa A. Rabie, Riham A. El-Shiekh, Ahmed M. El-Dessouki

Progress and challenges in obesity pharmacotherapy: semaglutide as a milestone

  • Review

Francesco Ferrara, Denise Bazzani, Barbara Crivelli, Elisa Danieli, Pietro Gazzola, Greta Guarnieri, Giulia Handschin, Claudia Lauria, Carlotta Marchetti, Emanuele Sbraga, Carmen Zero, Andrea Zovi, Roberto Langella, Chiara Parati

QbD assisted development of hyaluronic acid and TPGS incorporated DOX liposome(s): in vitro assessment of cytotoxicity, uptake, ROS, and NF-κB potential on MDA-MB-231 cells

  • Research

Lakshmi Kumari, Rajveer Singh, Preeti Patel, Amrinder Singh, Dilpreet Singh, Nitin Sharma, Ghanshyam Das Gupta, Balak Das Kurmi

Pentadecanoic acid attenuates thioacetamide-induced liver fibrosis by modulating oxidative stress, inflammation, and ferroptosis pathways in rat

  • Research

Mohammad Aabis, Priyanka Tiwari, Vinod Kumar, Gurpreet Singh, Archana Panghal, Gopabandhu Jena

Octreotide attenuates intestinal ischemia/reperfusion mischief in rats through modulation of Nrf2/PRX2/ASK1/JNK signaling pathway

  • Open Access
  • Research

Nermein F. El Sayed, Diaa Ragab, Walied Abdo, Mai El-Sayed Ghoneim

Molecular docking and antitumor evaluation of liposomal nanoformulations containing citrinin

  • Research

Ag-Anne Pereira Melo de Menezes, Michely Laiany Vieira Moura, José Williams Gomes de Oliveira Filho, Maria Luisa Lima Barreto do Nascimento, Juan Carlos Ramos Gonçalves, Marianna Vieira Sobral, Karinne Kelly Gadelha Marques, Felipe Cavalcanti Carneiro da Silva, Guilherme Barroso L. De Freitas, Vladimir Costa Silva, Shamya Gabriella Corrêa Coêlho, Marjorie Pereira Gualter, Helber Alves Negreiros, João Pedro Alves Damaceno do Lago, Igor Gabriel Barbosa de Sousa, Hercília Maria Lins Rolim, João Marcelo de Castro e Sousa

Chemopreventive effects of chitosan nanogel with thiocolchicoside and lauric acid in chemically induced oral carcinogenesis, in a rodent model

  • Research

Ameena Mustafa, Meignana ArumughamIndiran, Elumalai Perumal, Anandakumar Ponnala, Dinsha Abdul Rasheed, Karthikeyan Ramalingam, Rajeshkumar Shanmugham, Mohmed Isaqali Karobari

Assessment of protective effect of the losartan against cisplatin-induced nephrotoxicity in mice

  • Open Access
  • Research

Selçuk Teke, Gülsen Bayrak, Erdem Ak, Ali Can Korkmaz, Şakir Necat Yilmaz, Ali Delibaş

Monitoring of antibacterial capabilities of biosynthesized gold nanoparticles facilitated cyanobacterium, Spirulina subsalsa, against MDR pathogenic bacteria

  • Research

Shuvasree Bej, Surendra Swain, Ajit Kumar Bishoyi, Chita Ranjan Sahoo, Bigyan Ranjan Jali, Rabindra Nath Padhy

Tubeimoside I inhibits the growth of triple-negative breast cancer via the NR3 C2/PI3 K/AKT signaling pathway

  • Research

Qinxiang Zhang, Wenjin Cheng, Ye Li, Yubao Zhang, Yang Yu, Shijie Wei, Ying Yang, Wenfeng Zhang, Cun Liu, Qibiao Wu, Changgang Sun

L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1

  • Research

Xuanxuan Huang, Xinglong Lu, Yi Wu, Zhenghua Wu, Mingrui Li, Yuping Miao, Zhongwen Xie, Zipeng Gong, Yin Cao

Ivermectin repurposing for COVID-19: pharmacological and bibliometric analysis

  • Open Access
  • Research

Maresa Dulle, Roland Seifert

Unveiling the pharmacological mechanisms of Spirulina platensis in rheumatoid arthritis rats through the integration of serum metabolomics, pathways analysis, and experimental validation

  • Open Access
  • Research

Dina S. Ghallab, Eman Shawky, Asmaa A. Khalifa, Samar S. Elblehi, Mohamed M. Mohyeldin, Reham S. Ibrahim

New drugs and their performance 10 years after approval: a systematic analysis

  • Open Access
  • Research

Bores Manfouo, Roland Seifert

Screening of key active ingredients of Fuyuan Shenghua granules for the treatment of medical abortion using ingredient-target interaction and pharmacokinetics

  • Research

Qi-qiang Zhang, Mei-xiang Yu, Xue-mei Di, Xiang Cao, Ai-jia Zhao, Yong-hong Nie, Wen Shuai, Qin-hua Zhang, Hai Zhang

NDUFA8 promotes cell viability and inhibits ferroptosis and cisplatin sensitivity by stabilizing Fe-S clusters in cervical cancer

  • Research

Huaguo Xiang, Junfang Sun, Lingyue Kong, Yingzhen Wang, Xiaorou Qiu, Jinting Zeng, Guo Li, Jiehong He

Nanogel-based delivery of dequalinium chloride: A novel approach for antimicrobial and controlled drug release

  • Research

Ammara Sayyeda, Zulcaif Ahmad, Syeda Momna Ishtiaq, Asma Irshad, Saniia Shchinar, Muhammad Farhan Sohail

Repurposing of modafinil as an anti-inflammatory drug: a systematic review of experimental studies

  • Research

Mohammad Javad Amini, Niloofar Seighali, Razman Arabazadeh Bahri, Moein Ala, Razieh Mohammad Jafari, Ahmad Reza Dehpour

Cannabichromene, a key non-psychotropic phytocannabinoid in treatment of major depressive disorder: in silico and in vivo explorations

  • Research

Abhishek Sharma, Rahul Singh, Tarun Virmani, Neeraj Kumar Chouhan, Garima Kapoor, Girish Kumar, Rubina Bhutani, Neha Rana, Shivkant Sharma

Protective effects and mechanisms of Saikosaponin A against myocardial ischemia based on network pharmacology, molecular docking, and experimental validation

  • Research

Hongyu Wu, Wei Wang, Lintong Wen, Jie Cheng, Yurun Xue, Man Liao, Haoying Li, Xia Li, Jingyi Zhang, Shijiang Sun, Shengjiang Guan

Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in type II collagen–induced arthritis rat model

  • Open Access
  • Research

Sara M. El-Sayed, Hanaa H. Ahmed, Hadeer A. Aglan, Mohamed M. Naguib, Mohamed R. Mohamed

Toxicological and anti-inflammatory activities of doxorubicin loaded onto pH-sensitive poly(β-amino ester) modified mesoporous silica nanoparticles in mice

  • Research

Alejandro Ávila-Ortega, Fabiola Elizabeth Villa-de la Torre, Cristian Carrera-Figueiras, Abril Bernardette Martínez-Rizo, William Alejandro Talavera-Pech, Julio César Torres-Romero, Emanuel Ceballos-Góngora, Valeria García-Martínez, Valeria Guadalupe Pintor-Romero, Claribel Huchin-Chan, Alfredo Rafael Vilchis-Nestor, Víctor Ermilo Arana-Argáez

“Exosomal therapy: a promising approach to alleviate renal dysfunction induced by hypoxia in neonatal seizures”

  • Research

Khojasteh Hoseinynejad, Samireh Ghafouri, Ali Asadirad, Shokouh Shayanpour, Parisa Arvin

The m6 A modification of CDKN2 A inhibites ferroptosis and affects the resistance of cervical squamous cell carcinoma to cisplatin

  • Research

Xiang Yong, Xifeng Xu, Xiaoping Zhang, Rui Song, Huaiyuan Hu, Zhen Li, Yanzi Qin

Therapeutic effect of bismuth subsalicylate in a propionic acid–induced autism model

  • Open Access
  • Research

Kubilay Doğan Kılıç, Burak Çakar, Yiğit Uyanıkgil, Lora Koenhemsi, Berzah Güneş, Ebru Eroğlu, Oytun Erbaş

Sinomenine alleviates gouty inflammation by inhibiting macrophage M1 polarization and neutrophil extracellular trap formation

  • Research

Shan Zhang, Haibo Tan, Zhihao Zhang, Ziyu Wang, Chenyang Zhang, Jianyong Zhang, Ertao Jia

Proanthocyanidin and mitoglitazone suppress lipogenesis by targeting ferroptosis in metabolic dysfunction-associated steatohepatitis

  • Open Access
  • Research

Sohair M. Abd El-Naby, Naglaa F. Khedr, Nahla E. El-Ashmawy, Amera O. Ibrahim

Dapagliflozin mitigates cognitive deficits in a rat model of chronic restrained stress by addressing insulin resistance and mitochondrial dysfunction

  • Open Access
  • Research

Nourhan M. Gamal, Wesam El Bakly, Sherin S. T. Saad, Dalia A. A. El Waseef, Amal S. El-Shal, Wessam Ezzat, Yosra M. Magdy

Anti-osteoporotic effect of sitagliptin in an osteoporosis model of ovariectomized rats: role of RUNX2 and RANKL/OPG ratio

  • Open Access
  • Research

Salma Ahmed El-Marasy, Rehab F. Abdel-Rahman, Reham M. Abd-Elsalam, Hanan A. Ogaly, Rasha M. Allam

Investigation of the effects of monosodium glutamate and tannic acid on the glutathione and thioredoxin systems in the liver of rats

  • Open Access
  • Research

Mohammad A. A. Abushikha, Medine Sibel Karagac, Esra Nur Yesilkent, Hamid Ceylan

Investigation of the protective effect of beta caryophyllene against indomethacin-induced gastric ulcer in rats: in vivo and in vitro study

  • Open Access
  • Research

Merve Bolat, Fikret Çelebi, Emin Şengül, İrfan Çınar, Serkan Yıldırım, İsmail Bolat

The effects of melatonin on oxidative stress, inflammation, apoptosis and Nrf2/HO-1 in acrylamide-induced lung injury in rats

  • Open Access
  • Research

Aslıhan Atasever, Samet Tekin, İsmail Bolat, Merve Bolat, Yusuf Dağ, Burak ÇınaR, Emin Şengül, Serkan Yıldırım, Mohamad Warda, Fikret Çelebi

Paroxetine attenuated liver fibrosis in liver of bile duct ligated rats: role of P2X4 purinoreceptor

  • Research

Alireza Karimollah, Golnaz Nasiri, Nasim Dabaghi, Maryam Sadat Nabavinia, Ali Moradi, Azam Hasanpour, Ameneh Khodarahmi

Pharmacokinetics, bioequivalence, and food effect assessment of enteric-coated aspirin tablets: a randomized, single-dose, four-period crossover study in Chinese healthy subjects

  • Research

Minwan Hu, Shuyu Zhang, Peng Xu, Jiangfan Li, Hongxian Pang, Man Yang, Fangyu Chen, Baoqing Gao, Xuhong Wang

Montelukast alleviates thioacetamide-induced hepatic encephalopathy in rats

  • Research

Rehab S. Abdelrahman, Rania R. Abdelaziz, Marwa E. Abdelmageed

Hepatoprotective effect of diosmetin against thioacetamide-induced liver injury via modulating Bax/NF-κB/caspase-3/Nrf-2/PPARϒ signaling pathway in rats

  • Research

Radha Goel, Rosaline Mishra, Nitin Kumar, Nungsangtula Imsong, Neelam Singh, Praveen Gaur, Mohd Nazam Ansari, Hassan A. Madkhali

Bi-functional carbonaceous hybrid nanocomposites with anticancer and antibacterial potential: synthesis, characterization, and cytotoxicity assessment

  • Research

Juhi Saxena, Tarun Kumar Upadhyay, Anupam Jyoti, Unnati Joshi, Anand Joshi, Mahendra Singh Rathore, Sanketsinh Thakor, Jaivik Pathak, Sumit Das Lala, Payel Deb

ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen

  • Research

Jie Yuan, Wenjun Huang, Minxia Lin, Shishen Sun, Fei Zhong, Lei Ye, Hao Yin, Xiaowei Ou, Zhiqiang Zeng

Investigation of the mechanism of Dan Zhi Qing’e Formula for treating menopausal hot flashes using UHPLC-Q-TOF MS and network pharmacology

  • Research

Xinyu Li, Xinyu Liu, Minghui Cai, Shuang Wei, Rui Wang, Nanjian Xu, Jingtian Qu, Yuming Wang

Therapeutic efficacy of canagliflozin against hepatocarcinogenesis induced by CDD/DEN/TAA in a rat model: regulation of AMPK/HIF-1α/YAP-1/TAZ signaling pathways

  • Open Access
  • Research

Hany M. Fayed, Gihan F. Asaad, Marawan A. Elbaset, Ola A. Sharaf, Sawsan S. Mahmoud, Mohamed M. Amin, Zeinab A. El-Gendy, Fatma A. Ibrahim, Sherein S. Abdelgayed, Rehab F. Abdel-Rahman

Contractile effects of dexmedetomidine in the human heart

  • Open Access
  • Research

Joachim Neumann, Uwe Kirchhefer, Britt Hofmann, Ulrich Gergs

Oleuropein modulates anti-inflammatory activity of celecoxib and ketoprofen through cyclooxygenase pathway: in vivo, in silico and pharmacokinetics approaches

  • Research

Nishat Jahan, Manoj Mandal, Imam Hossen Rakib, Md. Sakib Al Hasan, Emon Mia, Noshin Tasnim Yana, Mohammed Alfaifi, Faisal H. Altemani, Rakib Hossan, Umme Habiba Sumaya, Ali Mohamod Wasaf Hasan, Md. Abu Sayeed, Moushumi Afroza Mou, Muhammad Torequl Islam, Md. Shimul Bhuia

Temperature alters the inotropic and chronotropic effect of D1-dopamine receptor stimulation in the mammalian atrium

  • Open Access
  • Research

Peter Grundig, Thanh Hoai Pham, Britt Hofmann, Joachim Neumann, Ulrich Gergs

Association between novel agents targeting proprotein convertase subtilisin/kexin type 9 and cancer incidence

  • Research

Hsueh-Ju Lu, Shiow-Ing Wang, Wei-Shiou Huang, Frank Sheng Fan, James Cheng-Chung Wei

Germany in pharmacology publishing: 192 articles with 1367 citations in Naunyn–Schmiedeberg’s Archives vs. 16,775 articles with 274,225 citations elsewhere

  • Brief Report

Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M. Moshi, Saeed Alshahrani, Waseem Hassan

From Germany to the world: analysis of 25,931 documents (from 1873 to 2025) published in Naunyn–Schmiedeberg’s Archives of Pharmacology

  • Brief Report

Waseem Hassan, Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M. Moshi, Saeed Alshahrani

Exploring the presence of DFG-funded publications in Naunyn-Schmiedeberg’s Archives of Pharmacology

  • Brief Report

Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M. Moshi, Saeed Alshahrani, Waseem Hassan

Authorship analysis of publications in Naunyn–Schmiedeberg’s Archives of Pharmacology (1969–2024)

  • Brief Report

Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M. Moshi, Saeed Alshahrani, Waseem Hassan

International symposium “The Different Facets of Guanine Nucleotide Signaling”

  • Open Access
  • Meeting Report

Maximilian Lucas Haas, Timo Hinnenthal, Tassula Proikas-Cezanne, Robert Feil, Bernd Nürnberg

Retraction Note: A double-edged sword effect of silver nanoparticles on angiogenesis in 4T1 breast cancer-bearing mice

  • Retraction Note

Hemen Moradi-Sardareh, Fataneh Esmaeili, Sara Momtahan, Sadra Samavarchi Tehrani, Maliheh Paknejad