Ausgabe 3/2025
Inhalt (68 Artikel)
A critical review on phytochemicals as antiviral medications for SARS-CoV-2 virus infection
- Review
Manoja Das, Namita Panigrahy
A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside—a phenylethanoid glycoside
- Review
Ritika Baidya, Biswatrish Sarkar
An updated landscape on nanopharmaceutical delivery for mitigation of colon cancer
- Review
Maria Shahzad, Huma Hameed, Ayesha Amjad, Mahtab Ahmad Khan, Inaba Shujaat Qureshi, Anam Hameed, Asad Saeed, Rabia Munir
Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape
- Review
Meghana N. Patel, Archita J. Patel, Manish N. Nandpal, Manan A. Raval, Ravish J. Patel, Amit A. Patel, Keshav Raj Paudel, Philip M. Hansbro, Sachin Kumar Singh, Gaurav Gupta, Kamal Dua, Samir G. Patel
Exploring chitosan nanoparticles for enhanced therapy in neurological disorders: a comprehensive review
- Review
Safa A Vahab, Anjali K I, Sabitha M, Vrinda S Kumar
Exploring miRNA therapies and gut microbiome–enhanced CAR-T cells: advancing frontiers in glioblastoma stem cell targeting
- Review
K. Sandhanam, T. Tamilanban, Bedanta Bhattacharjee, K. Manasa
Fritillaria steroidal alkaloids and their multi-target therapeutic mechanisms: insights from network pharmacology
- Review
Pankaj Kumar, Vinay Kumar, Shagun Sharma, Rohit Sharma, Ashish R. Warghat
A comprehensive review of natural compounds and their structure–activity relationship in Parkinson’s disease: exploring potential mechanisms
- Open Access
- Review
Rana M. Merghany, Salma A. El-Sawi, Asmaa F. Aboul Naser, Shahira M. Ezzat, Sherifa F. A. Moustafa, Meselhy R. Meselhy
From resistance to remedy: the role of clustered regularly interspaced short palindromic repeats system in combating antimicrobial resistance—a review
- Review
Ali Raza, Pakiza Fatima, Bushra Yasmeen, Zulqarnain Amjad Rana, Doha El-Sayed Ellakwa
Deciphering the mechanisms underlying the neuroprotective potential of kaempferol: a comprehensive investigation
- Review
Satyam Chaubey, Lovedeep Singh
Preclinical studies of natural flavonoids in inflammatory bowel disease based on macrophages: a systematic review with meta-analysis and network pharmacology
- Review
Shasha Shi, Hao Jiang, Wenke Ma, Zitong Guan, Mengxue Han, Shuai Man, Zhuzhu Wu, Shan He
Glycogen synthase kinase 3 (GSK3) inhibition: a potential therapeutic strategy for Alzheimer’s disease
- Review
Dipanjan Karati, Shreyasi Meur, Souvik Roy, Swarupananda Mukherjee, Biplab Debnath, Sajal Kumar Jha, Biresh Kumar Sarkar, Saheli Naskar, Priya Ghosh
Total flavonoids from Rosa rugosa Thunb.: A comprehensive review of its extraction and purification process, chemical composition, biological effect and applications
- Review
Guangfeng Dong, Lina Lv, Gang Ding, Fengying Li, Pan Zhao, Jiangting Liu, Hongyan Liu
A new opportunity for N-acetylcysteine. An outline of its classic antioxidant effects and its pharmacological potential as an epigenetic modulator in liver diseases treatment
- Review
Marina Galicia-Moreno, Hugo Christian Monroy-Ramirez, Fernando Caloca-Camarena, Scarlet Arceo-Orozco, Pablo Muriel, Ana Sandoval-Rodriguez, Jesús García-Bañuelos, Alejandro García-González, José Navarro-Partida, Juan Armendariz-Borunda
Navigating the therapeutic landscape for breast cancer: targeting breast cancer stem cells
- Review
Soudeep Dey, Yirivinti Hayagreeva Dinakar, Soundarya R, Vikas Jain, Rupshee Jain
Beneficial effects of resveratrol on diabetes mellitus and its complications: focus on mechanisms of action
- Review
Amir Mahmoud Ahmadzadeh, Mehraneh Movahedi Aliabadi, Seyed Behzad Mirheidari, Mahdie Hamedi-Asil, Setareh Garousi, Mehran Mottahedi, Amirhossein Sahebkar
Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics
- Open Access
- Review
Gihan F. Asaad, Ahmed S. Doghish, Ahmed A. Rashad, Walaa A. El-Dakroury
Polyphenols in wound healing: unlocking prospects with clinical applications
- Review
Biswajit Kumar Utpal, Baishakhi Sutradhar, Mehrukh Zehravi, Sherouk Hussein Sweilam, Uttam Prasad Panigrahy, Deepadarshan Urs, Ayesha Farhath Fatima, P. Kumar Nallasivan, Gurmeet Singh Chhabra, Mohammed Sayeed, Mohammed Ali Alshehri, Safia Obaidur Rab, Sharuk L. Khan, Talha Bin Emran
Emerging insights into the role of natural products and miRNAs in psoriasis: from pathophysiology to precision medicine
- Review
Osama A. Mohammed, Mushabab Alghamdi, Emad Bahashwan, AbdulElah Al Jarallah AlQahtani, Adel Alfaifi, Rania H. Hassan, Jaber Alfaifi, Mohannad Mohammad S. Alamri, Abdullah Hassan Alhalafi, Masoud I. E. Adam, Waad Fuad BinAfif, Mustafa Ahmed Abdel-Reheim, Sherif S. Abdel Mageed, Ahmed S. Doghish
Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins
- Review
Zahra Shamsipour Nehzomi, Kobra Shirani
Nitric oxide: Potential therapeutic target in Heat Stress–induced Multiple Organ Dysfunction
- Review
Priya Jaswal, Seema Bansal, Rishabh Chaudhary, Jhilli Basu, Nitin Bansal, Subodh Kumar
Translating molecular insights into clinical success: alkaloid-based therapies for leukemia
- Review
Pouya Goleij, Mohammad Amin Khazeei Tabari, Aryan Rezaee, Pantea Majma Sanaye, Maria Daglia, Dorsa Alijanzadeh, Khalaf F. Alsharif, Alan Prem Kumar, Haroon Khan
Unraveling the mechanisms of glioblastoma’s resistance: investigating the influence of tumor suppressor p53 and non-coding RNAs
- Review
Qamar A. Alshammari, Saud O. Alshammari, Abdulkarim Alshammari, Moaddey Alfarhan, Fahad Hassan Baali
Advancements in nanotheranostics for glioma therapy
- Review
Liza Sahoo, Safal Kumar Paikray, Nigam Sekhar Tripathy, Donald Fernandes, Fahima Dilnawaz
Clopidogrel protects against gentamicin-induced nephrotoxicity through targeting oxidative stress, apoptosis, and coagulation pathways
- Open Access
- Research
Asmaa A. Akila, Rania A. Gad, Mohamed Gamal El-Din Ewees, Manal Abdul-Hamid, Eman S. Abdel-Reheim
Reappraisal of the mechanism of cardiovascular responses to sympathomimetic amines in anaesthetised rats: dual α1-adrenoceptor and trace amine receptor mechanisms
- Open Access
- Research
Kenneth J. Broadley
Beneficial effects of apigenin on ovarian histological changes and angiogenesis gene expression in rat model of polycystic ovary syndrome
- Research
Sanaz Lotfi Samani, Mahsa Yadi, Behrouz Aflatoonian, Fatemeh Zarehmehrjerdi, Zeynab Hafizibarjin, Mohammad Ebrahim Rezvani, Mahin Izadi
Betaine alleviates cerebellar endoplasmic reticulum stress and oxidative imbalance in a cuprizone model of multiple sclerosis in rat
- Research
Samaneh Rahdar, Zahra Basir, Mohammad Reza Tabandeh, Zohreh Ghotbeddin, Kaveh Khazaeel
Identification of RTP4 facilitating ovarian cancer by bioinformatics analysis and experimental validation
- Research
Chunyun Fang, Wenling Han, Chen Tang, Junjing Shen, Bin Ni
The crucial role of beta-catenin in the osteoprotective effect of semaglutide in an ovariectomized rat model of osteoporosis
- Open Access
- Research
Mohannad Hakam Hamed Abo-Elenin, Rehab Kamel, Shahira Nofal, Amany Ali Eissa Ahmed
The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation
- Research
Hayder Ridha-Salman, Adeeb Ahmed Al-Zubaidy, Alaa Hamza Abbas, Dhuha M Hassan, Samir A Malik
Incidence, characteristics, and risk factors of hypofibrinogenemia induced by generic tigecycline: a retrospective study
- Open Access
- Research
Chaoqun Ma, Xiaolei Ren, Ning Pang, Yingkun Liu, Meifang Chen, Xiaohong Zhang, Yi Liu, Lin Huang
Deoxyelephantopin induces apoptosis and cell cycle arrest in GL261 glioblastoma cells
- Research
Chun-Wen Lan, Hsin-Hung Chen, Jim Jinn-Chyuan Sheu
Advertisements for prescription-free drugs and dietary supplements in the Deutsche Apotheker Zeitung (German Pharmacist Journal)
- Open Access
- Research
Kristian Kuschel, Roland Seifert
A PDE1 inhibitor, vinpocetine, ameliorates epithelial-mesenchymal transition and renal fibrosis in adenine-induced chronic kidney injury in rats by targeting the DNMT1/Klotho/β-catenin/Snail 1 and MMP-7 pathways
- Open Access
- Research
Amira Mohammed Abdelfattah, Zeinab A. Mohammed, Aliaa Talaat, Walaa Samy, Mamdouh Eldesoqui, Reham I. Elgarhi
Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes
- Open Access
- Research
Claudia Mittendorff, Issam Abu-Taha, Lena Kassler, Tobias Hustedt, Stephanie Wolf, Johannes G. Bode, Markus Kamler, Dobromir Dobrev, Anke C. Fender
Carvacrol improves cognitive dysfunction by decreasing amyloid-β accumulation and regulating neuroinflammation in ovariectomized renovascular hypertensive rats
- Research
Duygu Bayraktar, Büşra Ertaş, Yasemin Aydın, Göksel Şener
Protective effect of sinomenine against CCl4-induced acute liver injury through regulation of mitochondrial biogenesis
- Research
Alireza Shahmohammadi, Seyed-Mohamad-Sadegh Mirahmadi, Ali-Mohammad Rousta, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model
- Open Access
- Research
Samuel Abiodun Kehinde, Abosede Temitope Olajide, Tolulope Peter Fatokun, Dalia Fouad, Najah R. Hadi, Ahmed M. Elgazzar, Adewale Segun James, Mohamed H. Mazhar Ashour
Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses
- Research
Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan
Cardioprotective effects of GPER agonist in ovariectomized diabetic rats: reversing ER stress and structural changes
- Research
Mohammad Amin Ghaffari Sirizi, Mansour Esmailidehaj, Seyed-Mahdi Mohamadi-Zarch, Maryam Yadeghari, Hossein Azizian
Behavioural and neurochemical alterations following acute inflammation induced by intraperitoneal and intratracheal injection with lipopolysaccharide in mice
- Research
Yasuhisa Izushi, Shouki Tanaka, Teppei Ueda, Soichiro Ushio, Yuichi Tasaka, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura
Insufficient correctness of package inserts for psychotropic drugs in Germany
- Open Access
- Research
Adina Arning, Roland Seifert
Cimifugin improves intestinal barrier dysfunction by upregulating SIRT1 to regulate the NRF2/HO-1 signaling pathway
- Research
Hui Zhang, Zhekun Xiong, Yanshan He, Huixia Su, Yali Jiao
Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence
- Open Access
- Research
Lilly Josephine Bindel, Roland Seifert
Effect and mechanism of Lycium barbarum polysaccharide on gastrointestinal motility in slow transit constipation
- Research
Yan Liu, Bo Yang, Haiying Liu, Liwei Guo, Xiaoling Liu
Knockdown of SIGLEC1 inhibits osteogenic differentiation to alleviate ankylosing spondylitis progression by suppressing the TGF-β1/SMAD signaling pathway
- Research
Jia Chen, Xichao Yang, Yumin Huang, Xue Cao, Zhenbiao Wu, Yuan Feng
Protective effects of silymarin on preventing vancomycin nephrotoxicity in infectious patients: a randomized, double-blinded, placebo-controlled, pilot clinical trial
- Research
Ava Karimian, Iman Karimzadeh, Mojtaba Shafiekhani, Reza Heidari, Fatemeh Masjedi, Fatemeh Izadi, Nazanin Barshan-Tashnizi, Sandra L. Kane-Gill, Laleh Mahmoudi
Identification of the active constituents and molecular mechanism of Eulophia nuda extract in the treatment of osteoarthritis by network pharmacology, molecular modelling and experimental assays
- Research
Sucheesmita Padhee, Debajani Mohanty, Swagat Mohanty, Ambika Sahoo, Sudipta Jena, Jeetendranath Patnaik, Pratap Chandra Panda, Chitta Ranjan Deb, Asit Ray, Sanghamitra Nayak
Antibacterial and antibiofilm activities of bacteriocin produced by a new strain of Enterococcus faecalis BDR22
- Research
Bandita Dutta, Debarati Basu, Dibyajit Lahiri, Moupriya Nag, Rina Rani Ray
Kaempferol attenuates cyclosporine-induced renal tubular injury via inhibiting the ROS-ASK1-MAPK pathway
- Research
Yaowu Zhang, Qijing Wu, Huali Fu, Jieya Pang, Yiyuan Zhang, Hui Zhou, Ling Zhuang, Xiaobo Zhang, Lianhua Chen, Qianqian Yang
Study on the mechanism of activating SIRT1/Nrf2/p62 pathway to mediate autophagy-dependent ferroptosis to promote healing of diabetic foot ulcers
- Research
Qinglin Han, Yuming Gu, Yongquan Qian
Potential mechanisms of ZiGongDing in treating HPV-induced cervical intraepithelial neoplasia: a network pharmacology and experimental verification study
- Research
Li Wan, Kan Chen, Xiaorong Ma, Lu Han, Qun Xie, Lihong Wang, Xinmei Wang
Unlocking relief: formulation, characterization, and in vivo assessment of salicylic acid–loaded microemulgel for psoriasis management
- Research
Viswanath Baboy Lotlikar, Sanjay Sharma, Vaishali Y. Londhe
Determination of beneficial effects of cuminaldehyde on hyperglycemia associated kidney malfunctions
- Research
Abhishek Kumar Das, Sumit Ghosh, Parames C. Sil
Nasal administration of mitochondria relieves depressive- and anxiety-like behaviors in male mice exposed to restraint stress through the suppression ROS/NLRP3/caspase-1/IL-1β signaling pathway
- Research
Vida Mafikandi, Fatemehsadat Seyedaghamiri, Naeimeh Hosseinzadeh, Parviz Shahabi, Ali Reza Shafiee-Kandjani, Soraya Babaie, Leila Maghsoumi-Norouzabad, Fereshteh Farajdokht, Leila Hosseini
Exploring the hepatoprotective potential of the probiotic Lactiplantibacillus plantarum E1K2R2 and its exopolysaccharide-postbiotic on ibuprofen-induced acute liver injury in rats
- Research
Nadia Aliouche, Mohamed Sifour, Widad Kebsa, Houria Ouled-Haddar
Bioavailability enhancement of atazanavir sulphate using mixed micelles: in vitro characterization and in vivo pharmacokinetic study
- Research
Nidhi Pandya, Prabha Singh
Development and characterization of formulations based on combinatorial potential of antivirals against genital herpes
- Open Access
- Research
Mahesh Gaikwad, Amal George, Aparna Sivadas, Kavitha Karunakaran, Sudheesh N, Siddappa N. Byradeddy, Chiranjay Mukhopadhyay, Piya Paul Mudgal, Madhur Kulkarni
Ligand-human serum albumin analysis: the near-UV CD and UV-Vis spectroscopic studies
- Open Access
- Research
Wojciech Rogóż, Aleksandra Owczarzy, Karolina Kulig, Małgorzata Maciążek-Jurczyk
Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus-induced renal injury in male Wistar rats
- Research
Halimat Amin Abdulrahim, Adeyemi Fatai Odetayo, Emmanuel Aduragbemi Owootori, Joshua Damrah Bulus, Fatimoh Bolanle Jimoh, Emmanuel Oluwamuyiwa Gabriel, Iyanu Feranmi Odiete, Luqman Aribidesi Olayaki
Proapoptotic and antimigration properties of osthole in combination with LY294002 against human glioma cells
- Open Access
- Research
Joanna Sumorek-Wiadro, Justyna Kapral-Piotrowska, Adrian Zając, Aleksandra Maciejczyk, Monika Hułas-Stasiak, Krystyna Skalicka-Woźniak, Wojciech Rzeski, Bożena Pawlikowska-Pawlęga, Joanna Jakubowicz-Gil
Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory
- Open Access
- Research
Mohammed M. Elseweidy, Nouran G. Harb, Abdelmoniem A. Ali, Reda M. Abd El-Aziz, Rania A. Elrashidy
Correction: Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model
- Open Access
- Correction
Samuel Abiodun Kehinde, Abosede Temitope Olajide, Tolulope Peter Fatokun, Dalia Fouad, Najah R. Hadi, Ahmed M. Elgazzar, Adewale Segun James, Mohamed H. Mazhar Ashour
Correction: Development and characterization of formulations based on combinatorial potential of antivirals against genital herpes
- Open Access
- Correction
Mahesh Gaikwad, Amal George, Aparna Sivadas, Kavitha Karunakaran, Sudheesh N, Siddappa N. Byrareddy, Chiranjay Mukhopadhyay, Piya Paul Mudgal, Madhur Kulkarni
Correction: Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes
- Open Access
- Correction
Claudia Mittendorff, Issam Abu-Taha, Lena Kassler, Tobias Hustedt, Stephanie Wolf, Johannes G. Bode, Markus Kamler, Dobromir Dobrev, Anke C. Fender
