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Naunyn-Schmiedeberg's Archives of Pharmacology

Ausgabe 4/2025

Inhalt (97 Artikel)

Melatonin and retinal cell damage: molecular and biological functions

  • Review

Jingwen Sun, Yan Liu, Zhangming Chen

Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?

  • Review

Popat S. Kumbhar, Revati Chavan, Snehal Darekar, Kaustubh Kolekar, Anvitha Sequeira, Sukriti Vishwas, Guarav Gupta, Keshav Raj Paudel, Sachin Kumar Singh, Kamal Dua, John Disouza, Vandana Patravale

Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility

  • Review

Ahmed S. Doghish, Elsayed G. E. Elsakka, Hebatallah Ahmed Mohamed Moustafa, Alaa Ashraf, Sherif S. Abdel Mageed, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Hanan Elimam, Nehal I. Rizk, Sarah A. Omran, Shimaa A. Farag, Donia G. Youssef, Ahmed I. Abulsoud

Alpha-lipoic acid, as an effective agent against toxic elements: a review

  • Review

Farzad Vafaee, Mahla Derakhshani, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh

A comprehensive review on the green synthesis of silver nanoparticles from marine sources

  • Review

Janagandhan Palanisamy, Vinothkumar Suruli Palanichamy, Ganesan Vellaichamy, Parthasarathi Perumal, Jayaraman Vinayagam, Seshan Gunalan, Senthilkumar Gnanavadivel Prabhakaran, Purushoth Prabhu Thiraviam, Fasna Musthafa, Ashok Kumar Balaraman, Suresh Rathinasamy

Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities

  • Open Access
  • Review

Sherif S. Abdel Mageed, Hanan Elimam, Ahmed E. Elesawy, Ahmed I. Abulsoud, Ahmed Amr Raouf, Manar Mohammed El Tabaa, Osama A. Mohammed, Mohamed Bakr Zaki, Mai A. Abd-Elmawla, Walaa A. El-Dakroury, Safwat Abdelhady Mangoura, Mahmoud A. Elrebehy, Mohammed S. Elballal, Aya A. Mohamed, Alaa Ashraf, Mustafa Ahmed Abdel-Reheim, Ali M. S. Eleragi, Hussein Abdellatif, Ahmed S. Doghish

Flavopiridol: a promising cyclin-dependent kinase inhibitor in cancer treatment

  • Review

Uttam Singh Baghel, Priyanka Kriplani, Neelam M. Patel, Manpreet Kaur, Kapil Sharma, Monika Meghani, Abhay Sharma, Deeksha Singh, Bhawani Singh, William N. Setzer, Javad Sharifi-Rad, Daniela Calina

Molecular, cellular, and metabolic insights of cinnamon (Cinnamomum zeylanicum) advantages in diabetes and related complications: condiment or medication?

  • Review

Anahita Sadat Beheshti, Mohammad Mahdi Qazvini, Mahsa Abeq, Ermia Abedi, Mohammad Saleh Fadaei, Mohammad Reza Fadaei, Vafa Baradaran Rahimi, Vahid Reza Askari

Therapeutic potential of synthetic and natural iron chelators against ferroptosis

  • Review

Nupura Manish Prabhune, Bilal Ameen, Sudharshan Prabhu

Genistein in focus: pharmacological effects and immune pathway modulation in cancer

  • Review

Pouya Goleij, Mohammad Amin Khazeei Tabari, Mohanna Khandan, Mohadeseh Poudineh, Aryan Rezaee, Sarvin Sadreddini, Pantea Majma Sanaye, Haroon Khan, Danaé S Larsen, Maria Daglia

Current mechanistic insights into Withaferin A: a promising potential adjuvant anticancer agent from Withania somnifera

  • Review

Muhammad Farrukh Nisar, Chunpeng Wan, Dietrich Büsselberg, Daniela Calina, Javad Sharifi-Rad

Therapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations

  • Review

Abdulsalam Alhalmi, Saima Amin, Tanya Ralli, Khaled Saeed Ali, Kanchan Kohli

RETRACTED ARTICLE: Effect of Danhong injection on pharmacokinetics and pharmacodynamics of rivaroxaban in rats

  • Research

Weihong Yin, Jiao Li, Zhaoyang Han, Siwen Wang, Fan Wu, Chao Yu, Xueying Yan, Mingyu Cui

Safety assessment of novel oxadiazole derivatives in acute and sub-acute toxicity studies

  • Research

Syeda Rida Zainab, Jehan Zeb Khan, Humaira Nadeem, Muhammad Khalid Tipu, Nadeem Irshad

The chemokine receptor type 5 inhibitor maraviroc alleviates sepsis-associated liver injury by regulating MAPK/NF-κB signaling

  • Open Access
  • Research

Jun Shao, Tianwei Wang, Chengbin Tang, Jiangquan Yu, Ying Chen, Xin Guo, Haoran Wang, Lulu Zhou, Guozhong Zhang, Yuping Li, Hailong Yu, Ruiqiang Zheng

Network pharmacological analysis and experimental verification of Zisheng Tongmai decoction in the treatment of premature ovarian failure

  • Research

Jiaru Wu, Mengjie Wen, Zecheng Wang, Kun Yu, Xinyue Jin, Chenxu Liu, Qiuhang Song, Guohong Zhang, Beibei Wu, Yunfeng Li

5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice

  • Research

Jingjing Wang, Xiaoxin Wang, Mingjie Jiang, Tao Lang, Leilei Wan, Juanjuan Dai

Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with metabolic syndrome: the potential role of dipeptidyl peptidase-4

  • Open Access
  • Research

Nourhan O. Shoier, Salah A. Ghareib, Hend Kothayer, Amira Ebrahim Alsemeh, Shaimaa S. El-Sayed

Galangin prevents gentamicin-induced nephrotoxicity by modulating oxidative damage, inflammation and apoptosis in rats

  • Research

Mohammad H. Abukhalil, Zina Al-Alami, Hayman A. A. Altaie, Saleem H. Aladaileh, Sarah I. Othman, Osama Y. Althunibat, Manal A. Alfwuaires, Afaf F. Almuqati, Bader Alsuwayt, Hassan A. Rudayni, Ahmed A. Allam, Ayman M. Mahmoud

Exploring the bioactive ingredients of three traditional Chinese medicine formulas against age-related hearing loss through network pharmacology and experimental validation

  • Open Access
  • Research

Wenying Shi, Qi Zhao, Hongwei Gao, Yaxin Yang, Zhiyong Tan, Na Li, Hongjie Wang, Yonghua Ji, You Zhou

Sex differences in the orofacial antinociceptive effect of metformin and the role of transient receptor potential channels

  • Research

Sacha Aubrey Alves Rodrigues Santos, Marina de Barros Mamede Vidal Damasceno, Barry John Sessle, Antônio Eufrásio Vieira-Neto, Gerlânia de Oliveira Leite, Francisco Ernani Alves Magalhães, Kaio César Simiano Tavares, Samara Casemiro Benevides, Adriana Rolim Campos

Exploring the anti-NSCLC mechanism of phillyrin targeting inhibition of the HSP90-AKT pathway

  • Research

Qiong Duan, Ruochen Li, Mingxiao Wang, Zhenting Cui, Xia Zhu, Fanghong Chen, Feng Han, Jianxin Ma

Network pharmacology-based strategy to reveal the mechanism of pinocembrin against ovarian cancer

  • Research

Guanghui Wang, Jianxiang Cheng, Meizhen Yao, Jing Li, Ting Chen, Jia Zhang, Wensheng Du, Youguo Chen

Immune cell traits and causal relationships with cholecystitis: a mendelian randomization analysis

  • Research

Ze-fa Xiao, Wei-hao Chai, Xiao-long Shu, Hong-rui Yuan, Fei Guo

Self-nanoemulsifying drug delivery system for nebulization: fabrication and evaluation for systemic delivery of atorvastatin

  • Research

Muhammad Danish Saeed, Kifayat Ullah Shah, Muhammad Fahad, Shefaat Ullah Shah, Syed Faisal Badshah, Hassan Shah, Irfan Anjum, Gamal A. Shazly, Mohammed Bourhia

VSIG-3/IGSF11 silencing in A2058 melanoma cells simultaneously suppresses melanoma progression and induces anti-tumoral cytokine profile in human T cells: In silico and in vitro study

  • Research

Najibeh Shekari, Dariush Shanehbandi, Elham Baghbani, Sahar Safaei, Javad Masoumi, Behzad Baradaran, Seyed Amir Jalali

Protective effect of aspirin and gentisic acid, a plant-derived phenolic acid, on acrylamide-induced neurotoxicity by inhibiting apoptosis and autophagy

  • Research

Yasaman Hosseinzadeh, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh

Pre-clinical study of IR808 dye for cervical cancer in vitro and in vivo imaging

  • Research

Xiaohui Teng, Hongbiao Chen, Han Yang, Hongli Liu, Yanlong Wang, Zhiying Su, Chu Tang

A single-dose, randomized, crossover bioequivalence study of levamlodipine besilate tablets in healthy subjects

  • Research

Qiaohuan Deng, Debin Yang, Yang Cheng, Zhengzhi Liu, Yannan Zhou, Yanli Wang, Zhengjie Su, Haimiao Yang

The negative chronotropic effects of (±)-propranolol and (±)-4-NO2-propranolol in the rat isolated right atrium are due to blockade of the 6-nitrodopamine receptor

  • Research

Denis Lima Oliveira, Vinicius Francisco Cardoso, Jose Britto-Júnior, Vivian Fuguhara, Francesco Frecentese, Rosa Sparaco, Vincenzo Santagada, Giuseppe Caliendo, André Sampaio Pupo, Edson Antunes, Gilberto De Nucci

Doxepin as OCT2 inhibitor ameliorates inflammatory response and modulates PI3K/Akt signaling associated with cisplatin-induced nephrotoxicity in rats

  • Open Access
  • Research

Mariam H. Fawzy, Yasser M. Moustafa, Dina M. Khodeer, Noha M. Saeed, Norhan M. El-Sayed

Pirfenidone mitigates demyelination and electrophysiological alterations in multiple sclerosis: Targeting NF-κB, sirt1, and neurotrophic genes

  • Open Access
  • Research

Reda A. A. Abo-Elsoud, Eman A. Ali, Marwa A. Al-Gholam, Mohamed S. Rizk, Rasha S. A. Elseadawy, Omnia Ameen

Possible protective effect of natural flavanone naringenin-reduced graphene oxide nanosheets on nonalcoholic fatty liver disease

  • Open Access
  • Research

Doaa Abdelmoneim, Ehab B. Eldomany, Mohamed El-Adl, Ahmed Farghali, Gehad El-Sayed, El Said El-Sherbini

Inhibitory effects characteristics of polysaccharide of Polygonati Rhizome on cytochrome P450 enzymes

  • Research

Yan Duan, Xiaohong Wang, Ruidong Wang, Tian Zuo, Yue Du, Jian Zai, Lijun Zhu, Qi Zhan, Yao Fu

Glycosylation of chrysin with β-d-glucose tetraacetate (LQFM280) enhances its in vitro and in vivo neuroprotective effects against the toxicity induced by 3-nitropropionic acid

  • Research

Robbert Mota Pereira, Hericles Mesquita Campos, Pâmela Yasmin de Oliveira Ferreira, Nkaa Uchenna, Yohanny Souza Silva, Victor Ifeanyi Okoh, Letizia Pruccoli, Evilanna Lima Arruda, Luciano Morais Lião, Pedro Augusto Alves Mota, Jacqueline Alves Leite, Raphaela de Castro Georg, David Henriques da Matta, Fernanda Cristina Alcantara dos Santos, Elson Alves Costa, Andrea Tarozzi, Ricardo Menegatti, Paulo César Ghedini

Diacerein ameliorates amiodarone-induced pulmonary fibrosis via targeting the TGFβ1/α-SMA/Smad3 pathway

  • Open Access
  • Research

Hadir Farouk, Passant E. Moustafa, Marwa S. Khattab, Salma A. El-Marasy

Development of a new micellar formulation of carvedilol and curcumin to enhance blood pressure reduction in a spontaneously hypertensive rat model

  • Research

Yanina Alejandra Santander Plantamura, Miguel Allo, Jennifer Riedel, Pedro Fuentes, Ana Sol Riesco, Ezequiel Bernabeu, Mariana Garcés, Pablo Evelson, Susana Gorzalczany, Andrea Carranza, Christian Höcht, Diego Chiappetta

Diacerein and myo-inositol alleviate letrozole-induced PCOS via modulation of HMGB1, SIRT1, and NF-kB: A comparative study

  • Open Access
  • Research

Suzan A. Khodir, Eman Sweed, Shaimaa Mohamed Motawea, Marwa A. Al-Gholam, Sherin Sobhy Elnaidany, Mohamed Zakaria Sayer Dayer, Omnia Ameen

Pyrazolyl amide-chalcones conjugates: Synthesis and antikinetoplastid activity

  • Open Access
  • Research

Devesh S. Agarwal, Richard M. Beteck, Dorien Mabille, Guy Caljon, Lesetja J. Legoabe

Long-term enzyme replacement therapy in Fabry patients protects against oxidative and inflammatory process

  • Research

Alana Pimentel Moura, Tatiane Grazieli Hammerschmidt, Gilian Guerreiro, Camila Aguilar, Jéssica Lamberty Faverzani, Franciele Fátima Lopes, Fabiano de Oliveira Poswar, Roberto Giugliani, Marion Deon, Carmen Regla Vargas

Mitigating effects of agmatine on myocardial infarction in rats subjected to isoproterenol

  • Research

Daniel Elieh-Ali-Komi, Fatemeh Yarmohammadi, Maryam Nezamabadi, Mohammad Reza Khirehgesh, Mitra Kiani, Khodabakhsh Rashidi, Ehsan Mohammadi-Noori, Nahid Salehi, Ahmad Reza Dehpour, Amir Kiani

Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models

  • Research

Rishabh Chaudhary, Mohd Akhtar Azam, Bhavana Dowand, Alpana Singh, Mujeeba Rehman, Vipul Agarwal, Anand Kumar, Arjun Singh Kaushik, Sukriti Srivastava, Siddhi Srivastava, Vikas Mishra

Ameliorative effects of osthole on acrylamide-induced neurotoxicity in PC12 cells: Role of oxidative stress, apoptosis and ERK pathways

  • Research

Leili Kachranlouei, Hossein Hosseinzadeh, Gholamreza Karimi, Fatemeh Rajabian, Soghra Mehri

Enhanced behavioral impact of optimized bupropion-encapsulated bilosomes over traditional niosomes treating depression

  • Research

Karthick Harini, Koyeli Girigoswami, Mohammed Vajagathali, Debosreeta Bose, Anbazhagan Thirumalai, Venkatakrishnan Kiran, Pazhani Durgadevi, Agnishwar Girigoswami

Effect of ophthalmic preparation of methyldopa on induced ocular hypertension in rabbits

  • Research

Fouad Kadhim Gatea, Zeena Ayad Hussein, Haitham Mahmood Kadhim, Ahmed Rahma Abu-Raghif

Differential uptake of arginine derivatives by the human heteromeric amino acid transporter b0,+AT-rBAT (SLC7A9-SLC3A1)

  • Open Access
  • Research

Sofna Banjarnahor, Lorenz A. Scherpinski, Max Keller, Jörg König, Renke Maas

Unveiling the interaction, cytotoxicity and antibacterial potential of pyridine derivatives: an experimental and theoretical approach with bovine serum albumin

  • Research

Rosalin Das, Patitapaban Mohanty, Pragyan P. Dash, Swagatika Mishra, Ajit K. Bishoyi, Lokanath Mishra, Laxmipriya Prusty, Devi P. Behera, Debasmita Dubey, Monalisa Mishra, Harekrushna Sahoo, Mohd S. Khan, Santosh K. Sethi, Bigyan R. Jali

Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages

  • Open Access
  • Research

Connan D. Masson, Fern Findlay-Greene, Filipa Henderson Sousa, Paul Henderson, Jennifer A. Fraser, Peter G. Barlow, Craig Stevens

Protective effects of astaxanthin solid lipid nanoparticle as a promising candidate against acute kidney injury in rats

  • Research

Akram Yarmohammadi, Elham Arkan, Houshang Najafi, Fatemeh Abbaszadeh, Khodabakhsh Rashidi, Sana Piri, Sajad Fakhri

Sarecycline for moderate to severe acne: a promising narrow-spectrum antibacterial drug

  • Research

Amr Elrosasy, Mohamed Abo Zeid, Esraa M. AlEdani, Amira A. Aboali, Aya M. Fayoud, Kareem Ibraheem, Maha Abdullah Alwaili, Samy Selim, Ahmed Hamdy Zabady

Enhancing orofacial pain relief: α-phellandrene complexed with hydroxypropyl-β-cyclodextrin mitigates orofacial nociception in rodents

  • Research

Brennda Gonzaga Machado, Fabíolla Rocha Santos Passos, Ângelo Roberto Antoniolli, Erik W. Menezes Pereira, Tiffany Karoline Barroso Santos, Brenda Souza Monteiro, Pollyana de Souza Siqueira Lima, Saulo Santos Matos, Marcelo Cavalcante Duarte, Adriano Antunes de Souza Araújo, Jackson Roberto Guedes da Silva Almeida, Raimundo Gonçalves Oliveira Júnior, Henrique Douglas Melo Coutinho, Lucindo J. Quintans-Júnior, Jullyana de Souza Siqueira Quintans

The effect of adipose-derived mesenchymal stem cells against high fructose diet induced liver dysfunction and dysbiosis

  • Open Access
  • Research

Marwa Abdeltawab Mohammed, Nesma Hussein Abel Hay, Maha Tarek Mohammed, Hoda Sayed Mahmoud, Manar Yehia Ahmed, Ahmed Abdelmenem, Dina Sayed Abdelrahim

Biochemical investigation of FOXP3 genetic polymorphism and its association with biochemical parameters in pre-eclampsia patients

  • Research

Muhammad Sajid Hamid Akash, Francis Victor, Kanwal Rehman, Amjad Hussain, Mudassar Shahid, Asif Shahzad

Fucoidan improves intestinal peristaltic function in rats with postoperative ileus

  • Research

Baoguo He, Zhenming Zhu, Zibin Tian, Dandan Wang, Yijing Li, Xiao Luan, Li Ma

Curcumin ameliorates heatstroke-induced lung injury by activating the PI3K/AKT pathway

  • Research

Yizhan Wu, Fei Guo, Jiajia Li, Wenhui Shi, Laiyang Song, Jiangwei Liu

ETS1 promotes cisplatin resistance of NSCLC cells by promoting GRP78 transcription

  • Research

Cong Liu, Junguang Jiang, Junfang Luo, Yang Zhang, Chao Yang, Jiang Shi

Obituary: Arnold Hasselblatt (1929 - 2024)

  • Open Access
  • Obituary

Ingo Rustenbeck, Hans-Georg Joost, Elke Oetjen, Wolfgang Poser

Retraction Note: Development and evaluation of methotrexate-loaded nanoemulsion formulation for topical treatment of psoriasis

  • Retraction Note

Sheikh Abdur Rashid, Faiza Naseem, Pervaiz Akhtar Shah, Hamna Batool Hashmi, Mudassar Mazher, Mohammad S. Mubarak, Javad Sharifi-Rad, Muhammad Badar

Retraction Note: Enhancement of cardiac angiogenesis in a myocardial infarction rat model using selenium alone and in combination with PTXF: the role of Akt/HIF-1α signaling pathway

  • Open Access
  • Retraction Note

Mohamed M. Elseweidy, Sousou I. Ali, Mohamed A. Shaheen, Asmaa M. Abdelghafour, Sally K. Hammad

Retraction Note to: Betaine alleviates doxorubicin-related cardiotoxicity via suppressing oxidative stress and inflammation via the NLRP3/SIRT1 pathway

  • Retraction Note

Yasaman Hamidavi Mohammadpour, Mohammad Javad Khodayar, Layasadat Khorsandi, Hadi Kalantar

Retraction Note: Modulatory effect of liraglutide on doxorubicin-induced testicular toxicity and behavioral abnormalities in rats: role of testicular-brain axis

  • Open Access
  • Retraction Note

Shorouk A. Alafifi, Sara A. Wahdan, Alzahraa A. Elhemiely, Doaa A. Elsherbiny, Samar S. Azab