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Naunyn-Schmiedeberg's Archives of Pharmacology

Ausgabe 5/2025

Inhalt (90 Artikel)

Natural products as drug leads: exploring their potential in drug discovery and development

  • Review

Kuldeep Singh, Jeetendra Kumar Gupta, Dilip Kumar Chanchal, Manoj Gangadhar Shinde, Shivendra Kumar, Divya Jain, Zainab M. Almarhoon, Asma M. Alshahrani, Daniela Calina, Javad Sharifi-Rad, Anjali Tripathi

Harnessing network pharmacology in drug discovery: an integrated approach

  • Review

Chandra Prakash Joshi, Ashish Baldi, Neeraj Kumar, Joohee Pradhan

Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application

  • Review

Maria Sharif, Muhammad Irfan, Kafila Kousar, Assem Mamurova, Lorena Duarte-Peña, Hector Hernández-Parra, Hernán Cortés, Sheila I. Peña-Corona, Khushbukhat Khan, Solomon Habtemariam, Gerardo Leyva-Gómez, Javad Sharifi-Rad

Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies

  • Open Access
  • Review

Ademola C. Famurewa, Roland E. Akhigbe, Mina Y. George, Yemi A. Adekunle, Precious A. Oyedokun, Tunmise M. Akhigbe, Amos A. Fatokun

Phytochemical compounds for treating hyperuricemia associated with gout: a systematic review

  • Review

Santenna Chenchula, Mohan Krishna Ghanta, Munirah Alhammadi, Arifullah Mohammed, Kuttiappan Anitha, Poojith Nuthalapati, Ganji Seeta Rama Raju, Yun Suk Huh, LVKS Bhaskar

Lycopene in male infertility

  • Review

Sina Vakili, Mohammad Samare-Najaf, Aliasghar Karimi, Bahia Namavar Jahromi, Mohsen Mohit, Mohammad Hashem Hashempur

Baicalin plays a protective role by regulating ferroptosis in multiple diseases

  • Review

Shiyun Guo, Qi Zhang, Hangwei Ge, Honggang Wang

Rhazes’ insights on abortion and abortogenic drugs in relation to modern concepts

  • Review

Mohammad Amrollahi-Sharifabadi, Jamal Rezaei Orimi, Syed Mohd Abbas Zaidi, Toheeb Olalekan Oladejo, Abdur Rahman, Sageer Abass, Sayeed Ahmad, Sahar Abdelaziz, Mohammad Bahrami-Tapehbour, Marwa M. M. Fawzy, Morteza Mojahedi

Disulfiram in liver diseases: a double-edged sword

  • Review

Wanyuan Xiong, Aiping Tian, Zibing Qian, Junfeng Li, Xiaorong Mao

The dual challenge of diabesity: pathophysiology, management, and future directions

  • Review

Ritika Sindhwani, Kundan Singh Bora, Subhajit Hazra

Exosomes in infectious diseases: insights into leishmaniasis pathogenesis, immune modulation, and therapeutic potential

  • Review

Abida, Hayaa M. Alhuthali, Jawaher Mohammad Alshehri, Afnan Alkathiri, Ruba Omar M. Almaghrabi, Sumaih Saeed Alsaeed, Shadin Abdullah Hamad Albebi, Raghad Mohammed Almethn, Bushra Alhumaidi Alfuraydi, Shahad Badia Alharbi, Mehnaz Kamal, Mohd Imran

New horizons for promising influences of sulforaphane in the management of metabolic syndrome: a mechanistic review

  • Review

Mohammad Masoumvand, Elmira Ramezani, Yaser Eshaghi Milasi, Vafa Baradaran Rahimi, Vahid Reza Askari

Efficacy of melatonin for treatment and prevention of neonatal necrotizing enterocolitis: a systematic review

  • Review

Anas Elgenidy, Hoda Atef Abdelsattar Ibrahim, Taher Elmozugi, Nagham N. Abdelhalim, Mohammed A. Al-kurdi, Paula G. Wassef, Carolin G. Zakaria, Yomna A. Elsalamony, Mohamed Nasr, Asmaa Abodaif, Abdelrahman Hussein, Abd-El-Monem Hassan, Ahmad Roshdy Ahmad, Amira Elhoufey, Mohsen Fageeh, Thamer A. M. Alruwaili, Hamad Ghaleb Dailah, Mohamad-Hani Temsah, Khaled Saad

The efficacy and safety of Empagliflozin on outcomes of patients with myocardial infarction undergoing primary PCI: a systematic review and meta-analysis

  • Review

Azin Alizadehasl, Hoda Hakimian, Leyla Abdolkarimi, Yasamin Afsari Zonooz, Ehsan Amini-Salehi, Seyedeh Fatemeh Hosseini Jebelli, Azam Yalameh Aliabadi

Effects of Tinospora cordifolia (giloy) on metabolic syndrome components: a mechanistic review

  • Review

Mehran Mansouri, Mohsen Imenshahidi, Maryam Rameshrad, Hossein Hosseinzadeh

Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer

  • Review

Tia Okselni, Abdi Wira Septama, Dian Juliadmi, Rizna Triana Dewi, Marissa Angelina, Tri Yuliani, Grace Serepina Saragih, Ariyanti Saputri

A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2024

  • Open Access
  • Review

Zinnet Sevval Aksoyalp, Gizem Kayki-Mutlu, Leszek Wojnowski, Martin C. Michel

In vitro, in vivo and in silico anticancer activity and toxicity of Usnic acid extracted from the mycobiont culture of Usnea baileyi

  • Research

Murugan Mariraj, Mallikarjun Gundappa, Shanmugam Velayuthaprabhu, Kamal Shah, Ponmurugan Ponnuchamy, Suresh Kumar Mendem, P Shivakumar Singh, Nagendra Singh Chauhan

Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway

  • Research

Jiamin Wang, Yudi Wang, Caisheng Huang, Yonghu Chen, Xuezheng Li, Zhe Jiang

Dabigatran attenuates methotrexate-induced hepatotoxicity by regulating coagulation, endothelial dysfunction, and the NF-kB/IL-1β/MCP-1 and TLR4/NLRP3 signaling pathways

  • Research

Ahmed M. El-Dessouki, Amany A. Alzokaky, Nahed A. Raslan, Samar Ibrahim, Heba Mohammed Refat M. Selim, Ahmed A. Al-Karmalawy

Effects of quercetin-immobilized albumin cerium oxide nanoparticles on glutamate toxicity: in vitro study

  • Research

Yesim Yeni, Sıdıka Genc, Hayrunnisa Nadaroglu, Ahmet Hacımuftuoglu

Chlorogenic acid improves urogenital dysfunction induced by exposure to ambient particulate matter

  • Research

Khojasteh Hoseinynejad, Mohammad Mehdi Abdi, Akram Ahangarpour, Seyyed Ali Mard

Substantial non-compliance of online pharmacy catalogues with guidelines

  • Open Access
  • Research

Lara Barlage, Roland Seifert

Antioxidant and anticancer activities of hesperetin and its novel formulations in KB cells

  • Research

Arunima Chauhan, Salwa, Gayatri Gopal Shedgaonkar, Lalit Kumar, Arka Karmakar, Salil Khajuria, Archana Parampalli Raghavendra, Ruchi Verma

Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat

  • Research

Seyed Hamidreza Rastegar-Moghaddam, Mahsan Akbarian, Arezoo Rajabian, Fatemeh Alipour, AmirHossein Hojjati Shargh, Reza Masoomi, Alireza Ebrahimzadeh bideskan, Mahmoud Hosseini

Radiation-induced nanogel engineering based on pectin for pH-responsive rutin delivery for cancer treatment

  • Open Access
  • Research

Khaled El-Adl, Mohamed M. Ghobashy, Amel F. M. Ismail, Ahmed El-morsy, Nabil A. Shoman

Oxindole derivatives alleviate paracetamol-induced nephrotoxicity and hepatotoxicity: biochemical, histological, and computational expressions

  • Research

Imad Ahmad, Waqas Alam, Abdul Saboor Pirzada, Hany W. Darwish, Rehman Zafar, Maria Daglia, Haroon Khan

Legal and scientific deficiencies of drug advertisements on German television

  • Open Access
  • Research

Malin Philipp, Roland Seifert

Long-term effects of sub-chronic exposure to L-NAME on reproductive system of male rats

  • Research

Reshma Gaonkar, Janvi Pritmani, Mamata Datar, Dipty Singh, Nafisa Balasinor, Kumari Nishi

RETRACTED ARTICLE: A double-edged sword effect of silver nanoparticles on angiogenesis in 4T1 breast cancer-bearing mice

  • Research

Hemen Moradi-Sardareh, Fataneh Esmaeili, Sara Momtahan, Sadra Samavarchi Tehrani, Maliheh Paknejad

Biofabricated zinc oxide nanoparticles mitigate acrylamide-induced immune toxicity and modulate immune-related genes and microRNA in rats

  • Research

Ayman A. Saleh, Ahmed Abdulwahab Bawahab, Duaa Abdullah Bafail, Manal E. Alosaimi, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Tarek Khamis, Mohamed M. M. Metwally, Badriyah S. Alotaibi, Mohamed El-Gamal, Naief Dahran, Ahlam Saleh Alamri, Naira ElAshmouny

Evaluation of pathways involved in the protective effect of trans sodium crocetinate against contrast-induced nephropathy in rats

  • Research

Fatemeh Rajabian, BiBi Marjan Razavi, Soghra Mehri, Sakineh Amouian, Mahboobeh Ghasemzadeh Rahbardar, Abolfazl Khajavi Rad, Hossein Hosseinzadeh

Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation

  • Research

Tingyu Pan, Jieyu Wu, Xirui Qiu, Dongwei Zhu, Jing Wang, Tingyuan Li, Zhichao Wang, Fanchao Feng, Yong Xu, Xianmei Zhou

Ribosomal protein S3A (RPS3A), as a transcription regulator of colony-stimulating factor 1 (CSF1), promotes glioma progression through regulating the recruitment and autophagy-mediated M2 polarization of tumor-associated macrophages

  • Research

Liang Zhang, Kun Wang, Fei Li, Lingxue Zhang, Lin Wu, Ru Tie, Kamulan Litifu, Yujie Fu, Simeng Liu, Jiaxin Ni, Pan Chang, Jun Xu, Haikang Zhao, Lingtong Liu

Antiplasmodial potential of compounds isolated from Ziziphus mucronata and their binding to Plasmodium falciparum HGXPRT using biophysical and molecular docking studies

  • Open Access
  • Research

Kgaugelo J. Masia, Ndumiso N. Mhlongo, Ofentse J. Pooe, Mohammed A. Ibrahim, Abidemi P. Kappo, Mthokozisi B. C. Simelane

Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis

  • Open Access
  • Research

Dalia O. Saleh, Nesma M. E. Abo El Nasr, Yosra A. Hussien, Marawan Abd El-Baset, Kawkab A. Ahmed

Global trends and biological activity hotspots of d-limonene in essential oils: a 30-year bibliometric study

  • Research

Haibin Wang, Qian Lu, Xiaochen Chen, Ying Qian, Biyun Qian, Hongsheng Tan

Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D

  • Research

Zijuan Xu, Jinling Luan, Fengyun Wan, Meijie Zhang, Fei Ding, Ling Yang, Shuxin Dai

Exploring the potential of a pH-sensitive hydrogel sponge: interpenetrating network of tragacanth and pectin for controlled delivery of levosulpiride

  • Research

Muhammad Umer Ashraf, Muhammad Awais Iqbal, Kashif Barkat, Irfan Anjum, Muhammad Naveed Mushtaq, Rabia Gul, Muhammad Aamir, Samir Ibenmoussa, Ahmad Mohammad Salamatullah, Mohammed Bourhia, Gamal A. Shazly, Gezahign Fentahun Wondmie

Activation of sirtuin 3 and maintenance of mitochondrial homeostasis by artemisinin protect against diclofenac-induced kidney injury in rats

  • Open Access
  • Research

Doaa Hellal, Sarah Ragab Abd El-Khalik, Heba M. Arakeep, Doaa A. Radwan, Hend S. Abo Safia, Eman A. E. Farrag

Protective effect of Dulaglutide, a GLP1 agonist, on acetic acid-induced ulcerative colitis in rats: involvement of GLP-1, TFF-3, and TGF-β/PI3K/NF-κB signaling pathway

  • Open Access
  • Research

Raghda N. El Mahdy, Manar A. Nader, Manar G. Helal, Sally E. Abu-Risha, Marwa E. Abdelmageed

Disinformation on dietary supplements by German influencers on Instagram

  • Open Access
  • Research

Jan-Niklas Ricke, Roland Seifert

Toxicity study of silica nanoparticles following 94-day repeated oral administration in Sprague Dawley rats

  • Research

Xiqian Cao, Bin Xie, Mingxiao Xu, Jinfeng Li, Xiaoyu Dai, Yijun Tian, Jiqianzhu Zhang, Yun Chen, Lang Yan, Bin Zhang, Wenjing Shi, Lijun Ren

Safety evaluation and modulatory effects on innate immune system of pyrazoline-derived compounds

  • Research

Fernanda Capitanio Goldoni, Larissa Benvenutti, Roberta Nunes, Carlos Rafael Vaz, Louise Garcia, Keyla Furtado, Lorena dos Santos Bubniak, Fátima de Campos Buzzi, Rogério Corrêa, Nara Lins Meira Quintão, José Roberto Santin

Quercetin is a potential therapy for post-infarction NETosis formation

  • Research

Y. Goshovska, D. Pashevin, S. Goncharov, T. Lapikova-Bryhinska, O. Lisovyi, V. Nagibin, G. Portnichenko, L. Tumanovska, V. Dosenko

In vitro effects of crocin on the possible anticancer properties of Lactococcus lactis against colorectal adenocarcinoma cells

  • Research

Faranak Gholipour, Mahdi Entezar, Mohammad Amini, Somayeh Vandghanooni, Behzad Baradaran, Morteza Eskandani, Amir Ali Mokhtarzadeh

Critical analysis of Echinacea preparations marketed in Germany

  • Open Access
  • Research

Carina Groß, Roland Seifert

Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways

  • Research

Muhammad Torequl Islam, Md. Sakib Al Hasan, Raihan Chowdhury, Emon Mia, Imam Hossen Rakib, Noshin Tasnim Yana, Heba A. S. El-Nashar, Siddique Akber Ansari, Irfan Aamer Ansari, Md. Amirul Islam, Zainab M. Almarhoon, William N. Setzer, Javad Sharifi-Rad

Tauroursodeoxycholic acid mitigates depression-like behavior and hippocampal neuronal damage in a corticosterone model of female mice

  • Research

Wei Shen, Zikang Li, Yanlin Tao, Houyuan Zhou, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu

Sulfasalazine improves neuronal function in mice with ischemic stroke by inhibiting the STING/NF-κB pathway

  • Research

Xinyu Li, Huamin Ding, Jing Jing, Shuyu Qian, Yulin Ma, Mengting Lv, Yuan Gao, Yuefan Zhang, Tiejun Li

Lutein protection against doxorubicin-induced liver damage in rats is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities

  • Research

Jerome Ndudi Asiwe, Godwin D. Yovwin, Mercy Oluwalani Alawode, Theodora Isola, Emuesiri Kohworho Umukoro, Vincent Ugochukwu Igbokwe, Nicholas Asiwe

RETRACTED ARTICLE: Antibiofilm activity of exopolysaccharide-mediated ZnO nanoparticle against Pseudomonas aeruginosa biofilm

  • Research

Rosalin Nath, Dibyajit Lahiri, Moupriya Nag, Debanjana Mahapatra, Manoswinee Bhattacharya, Kakoli Dutta, Debasmita Bhattacharya

Correlation between the utilization of sodium-glucose cotransporter-2 (SGLT2) inhibitors and the risk of dementia: a nationwide population-based study in Taiwan

  • Open Access
  • Research

Wu-Lung Chuang, Stella Chin-Shaw Tsai, Yi-Chun Yang, Tsai-Ling Hsieh, Heng-Jun Lin, Yu-Han Huang, Fuu-Jen Tsai, Kuang-Hsi Chang

Modulating the tumor microenvironment in a mouse model of colon cancer using a combination of HIF-1α inhibitors and Toll-Like Receptor 7 agonists

  • Open Access
  • Research

Leila Rostamizadeh, Mina Ramezani, Hannaneh Monirinasab, Kobra Rostamizadeh, Mehdi Sabzichi, Seied Rafi Bahavarnia, Karim Osouli-Bostanabad, Fatemeh Ramezani, Ommoleila Molavi

Rosiridin prevents cisplatin-induced renal toxicity by inhibiting caspase-3/NF-κB/ Bcl-2 signaling pathways in rats and in silico study

  • Research

Imran Kazmi, Hisham N. Altayb, Fahad A. Al-Abbasi, Khalid Saad Alharbi, Naif A. R. Almalki, Ehssan Moglad, Salwa D. Al-Qahtani, Azizah Salim Bawadood, Nadeem Sayyed

Pirfenidone promotes cell cycle arrest and apoptosis of triple‑negative breast cancer cells by suppressing Hedgehog/GLI1 signaling

  • Research

Sheng-Yu Shi, Liang-Wei Zhao, Chong-Bing Liu, Hua-Ming Xiao, Zhong-Jun Jiang

Therapeutic potency of kaempferol against Naja haje venom induced neurotoxicity, inflammation, biological activities, and antioxidant system damage: a pre-clinical antivenom evaluation

  • Research

Babafemi Siji Ajisebiola, Busayo Dayo Adeniyi, Musa Olanrewaju Alakoso, Success Toyosi Fapohunda, Kelvin Ikechukwu Nwanze, Akindele Oluwatosin Adeyi

Protective effect of deinoxanthin in sorafenib-induced nephrotoxicity in rats with the hepatocellular carcinoma model

  • Research

Nilgun Karasu, Mehmet Kuzucu, Ozge Cengiz Mat, Mustafa Gul, Arzu Yay, Munis Dundar

ADAMDEC1 promotes cervical squamous cell carcinoma by enhancing the JAK/STAT signaling pathway through modulation of TYMP

  • Research

Beibei Wang, Qingsong Zhang, Lihua Wang, Huiwen Su, Li Zhou, Rong Zhang, Qiangkun Wan

Edaravone’s reno-protective effects against chronic heat-stress exposure

  • Research

Laiali T. Alquraan, Karem H. Alzoubi, Sanaa Jaber, Omar F. Khabour, Bahaa Al-Trad, Aseel Al-Shwaheen, Ghada Alomari, Suzie Y. Rababa’h, Majed M. Masadeh

Anti-diabetic drug pioglitazone reduces Islet amyloid aggregation overload in the Drosophila neuronal cells

  • Research

Khushboo Sharma, Pooja Rai, Shashank Kumar Maurya, Madhu G. Tapadia

The effect of acetylcholinesterase inhibitor rivastigmine in pentylenetetrazole-induced kindling model of epilepsy in rats

  • Research

Elif Türkdönmez Ak, Büşra Okuyucu, Burcu Hatipoğlu, Gökhan Arslan

Pyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells

  • Research

Danli Chen, Jianjun Yang, Lingxuan Ren, Zihan Zheng, Zhen Jin, Jiazheng Wen, Jianyu He, Rongcheng Ding, Jianjiang Wang, Rong Lin, Qiang Song

Treatment of cancer-associated fibroblast-like cells with celecoxib enhances the anti-cancer T helper 1/Treg responses in breast cancer

  • Research

Arash Samoudi, Firoozeh Abolhasani-Zadeh, Ali Afgar, Elnaz Jalilian, Hamid Zeinalynezhad, Ladan Langroudi

Bacopaside-I ameliorates motor dysfunction and neurodegeneration in rat model of Parkinson’s disease

  • Research

Babita Singh, Shivani Pandey, Mohammad Rumman, Mrinal Gupta, Abbas Ali Mahdi