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Naunyn-Schmiedeberg's Archives of Pharmacology

Ausgabe 6/2025

Inhalt (94 Artikel)

Radiolabeled HER2-targeted molecular probes in breast cancer imaging: current knowledge and future prospective

  • Review

Fatemeh Movahed, Ouldouz Navaei, Shiva Taghlidi, Maryam Nurzadeh, Maryam Eslami gharaati, Maryam Rabiei

Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development

  • Review

Sajjad Eslamkhah, Elif Sibel Aslan, Cuneyd Yavas, Nermin Akcalı, Lutfiye Karcıoglu Batur, Asmaa Abuaisha, Erva Esma Yildirim, Mustafa Solak, Kenneth N. White

Current status and trend of global research on the pharmacological effects of emodin family: bibliometric study and visual analysis

  • Review

Miao Luo, Luorui Shang, Jiao Xie, Tao Zhou, Chengyi He, David Fisher, Khrystyna Pronyuk, Erkin Musabaev, Nguyen Thi Thu Hien, Huan Wang, Lei Zhao

The clinical impact of chronopharmacology on current medicine

  • Open Access
  • Review

Mert Kaşkal, Mustafa Sevim, Gökay Ülker, Caner Keleş, Berna Terzioğlu Bebitoğlu

MircoRNAs predict and modulate responses to chemotherapy in leukemic patients

  • Review

Doha El-Sayed Ellakwa, Mohamed Ahmed Abdelmalek, Mostafa M. Mostafa, Takwa E. Ellakwa, Al-Hassan Soliman Wadan

MiRNAs: main players of cancer drug resistance target ABC transporters

  • Review

Forogh Mohammadi, Masoumeh Nejatollahi, Farhad Sheikhnia, Yaser Ebrahimi, Mahya Mohammadi, Vahid Rashidi, Shahin Alizadeh-Fanalou, Bita Azizzadeh, Maryam Majidinia

Morin, as a natural flavonoid, provides promising influences against cardiovascular diseases

  • Review

Reza Khademi, Ali Mirzaei, Amirhossein Mirzaei, Farid Reza Edjlali, Vahid Reza Askari, Vafa Baradaran Rahimi

An update on selective estrogen receptor modulator: repurposing and formulations

  • Review

Riya Patel, Vanessa James, Bhupendra Prajapati

Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance

  • Open Access
  • Review

Hanan Elimam, Mohamed Bakr Zaki, Mai A. Abd-Elmawla, Hebatallah A. Darwish, Abdulrahman Hatawsh, Nora M. Aborehab, Sherif S. Abdel Mageed, Rewan Moussa, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Ahmed S. Doghish

Nanoparticle innovations in targeted cancer therapy: advancements in antibody–drug conjugates

  • Review

Muhammad Sami Abdelhamid, Al-Hassan Soliman Wadan, Hager Adel Saad, Walaa A. El-Dakroury, Ahmed W. Hageen, Deyaa H. Mohammed, Sohaila Mourad, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Ahmed S. Doghish

Innovating alopecia treatment: nanostructured lipid carriers as advanced delivery platforms

  • Review

Poonam Kushwaha, Shazia Usmani, Mohd. Sufiyan, Priyanka Singh

Recent advances in therapeutic strategies of Erdheim-Chester disease

  • Review

Rohit Doke, Rahul Lokhande, Kalyani Chande, Kuldeep Vinchurkar, Bhupendra G. Prajapati

“Methyl jasmonate: bridging plant defense mechanisms and human therapeutics”

  • Review

Garima Sharma, Badruddeen, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahmad, Prakash Kumar Sharma

A complete sojourn on nanotechnological advancements and nanocarrier applications in psoriasis management

  • Review

Ritik Kumar Thakur, Aman Kumar, Kaushal Aggarwal, Nayan Sood, Satyam Khare, Preeti Patel, Balak Das Kurmi

Exosome: an overview on enhanced biogenesis by small molecules

  • Review

Amir Bavafa, Maryam Izadpanahi, Elham Hosseini, Mehrdad Hajinejad, Mahsa Abedi, Fatemeh Forouzanfar, Sajad Sahab-Negah

Pharmacological, computational, and mechanistic insights into triptolide’s role in targeting drug-resistant cancers

  • Review

Md Sadique Hussain, Somdutt Mujwar, M. Arockia Babu, Kavita Goyal, Dinesh Kumar Chellappan, Poonam Negi, Thakur Gurjeet Singh, Haider Ali, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta, Ashok Kumar Balaraman

Unveiling the therapeutic journey of snail mucus in diabetic wound care

  • Review

Ritika Mishra, Thakur Gurjeet Singh, Rohit Bhatia, Ankit Awasthi

Effectiveness and safety of the use of sodium nitrite in patients with hypertension and pulmonary hypertension: a scoping review

  • Review

Jéssyca Milene Ribeiro, Aleksander Brandão Santana, Letícia de Oliveira Marusso, Danielle Aparecida Ferreira de Oliveira Marrafon, Tiago Marques dos Reis, Pedro Luiz Rosalen, Larissa Helena Lobo Torres, José Eduardo Tanus-Santos, Carla Speroni Ceron

Lowering LDL cholesterol by PCSK9 inhibition: a new era of gene silencing, RNA, and alternative therapies

  • Review

Mitali Paryani, Nikita Gupta, Sanjay Kumar Jain, Shital Butani

Revealing the promising era of silk-based nanotherapeutics: a ray of hope for chronic wound healing treatment

  • Review

Jovita Kanoujia, Neha Raina, Ankita Kishore, Monika Kaurav, Hardeep Singh Tuli, Akhilesh Kumar, Madhu Gupta

Pomegranate as a natural remedy for gastric ulcers prevention: a review of its gastroprotective mechanisms and pharmacological benefits

  • Review

Mohammad Yasin Zamanian, Zhanna R. Gardanova, Ahmed Hjazi, Subasini Uthirapathy, S. Renuka Jyothi, Debasish Shit, Piyus Kumar Pathak, Suman Saini, Ahmad Jahdari, Maryam Golmohammadi

Clozapine is a functional antagonist at cardiac human H2-histamine receptors

  • Open Access
  • Research

Jonas M. A. Schlicht, Undine Ahlrep, Britt Hofmann, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs

Synthesis of platinum nanoparticles functionalized with glutamine and conjugated with thiosemicarbazone and their cytotoxic effects on MDA-MB-231 breast cancer cell line and evaluation of CASP-8 gene expression

  • Research

Nabeel Rahi Mashkoor, Salwan Ali Abed, Arash Davoudi, Zahraa Aqeel Adel Jassim, Zainab Yousif Faraj, Fatemeh Akbari, Fahimeh Abedini Bajgiran, Mohammad Hedayati, Ali Salehzadeh

Piperazine ferulate impact on diabetes-induced testicular dysfunction: unveiling genetic insights, MAPK/ERK/JNK pathways, and TGF-β signaling

  • Research

Basel A. Abdel-Wahab, Ehab A. M. El-Shoura, Mohammed S. Habeeb, Nayef A. Aldabaan, Yasmine H. Ahmed, Dalia Zaafar

Development and in vitro tuning of empagliflozin-containing dissolvable microneedle patch for enhanced transdermal delivery

  • Research

Aqib Javed, Rai Muhammad Sarfraz, Asif Mahmood, Zulcaif Ahmad, Muhammad Rouf Akram, Hira Ijaz, Shammas Ali, Anam Shahzadi

Loc646329 sponges miR-21 to reduce RAS/MAP kinase signaling pathway in oral squamous cell carcinoma (OSCC)

  • Research

Akhtar Adereh, Parya Amini, Azadeh Fateh, Ferdos Faghihkhorasani, Nastaran Khdakarim, Seyed Mehdi Marashi, Shana Ahadi, Parnian Nayebzadeh, Amir Khanmirzaei

Testicular weight deficits, altered variables of antioxidant defense system, spermatogenesis impairment, and inflammation induced by busulfan injection are ameliorated by gallic acid administration in rats

  • Research

Sunny O. Abarikwu, Chinedu J. Okonkwo, Ogechukwu E. Ezim, Victoria C. Obinna, Chisom E. Nebeolisa, Lauritta C. Ndufeiya-Kumasi

LncRNA MKLN1-AS promotes glioma tumorigenesis and growth via activating the Hippo pathway through miR-126-5p/TEAD1 axis

  • Research

Shouren Chen, Songjie Tu, Yan Huang, Hong Lin, Yuzhe Wang, Xuejun Dai

Neuroprotective effect of niacin in a rat model of obesity induced by high-fat-rich diet

  • Open Access
  • Research

Natasha Manzoor, Noreen Samad, Sheraz Ahmed Bhatti, Ali Irfan, Sadaf Ahmad, Gamal A. Shazly, Yousef A. Bin Jardan

Exploring the clinical significance of TPX2 in pancreatic cancer: from biomarker to immunotherapy

  • Research

Zhengguang Zhang, Zixian Liu, Ying Yao, Min Li, Cunsi Shen, Fuqiong Zhou

Examination of the effects of capecitabine treatment on the HT-29 colorectal cancer cell line and HCG 11, HCG 15, and HCG 18 lncRNAs in CRC patients before and after chemotherapy

  • Research

Abdulrasool M. Hussein m.s Alkharsan, Reza Safaralizadeh, Mohammad Khalaj-Kondori, Mohammadali HosseinpourFeizi

Tropisetron attenuates D-galactose-induced heart aging in male mice: activation of sirtuin1

  • Research

Atefeh Mirshafa, Mohammad Shokrzadeh, Fereshteh Talebpour Amiri, Hamidreza Mohammadi, Ebrahim Mohammadi, Ehsan Zamani, Mona Alinia, Fatemeh Shaki

Dressing membrane composites of PVA/chitosan/MgO nanoparticles for wound healing applications in rat model

  • Research

Ebtesam A. Mohamad, Amany M. Gad, Rana H. Abd El-Rhman, Manal T. H. Moselhey, Noha G. Madian

Zinc oxide fabricated by rutin as potent anti-leukemia nanostructure

  • Research

Fatemeh Azizi Alidoust, Hossein Zahmatkesh, Behnam Rasti, Hojjatolah Zamani, Mirsasan Mirpour, Amir Mirzaie

Potentiation and in vivo evaluation of anti-obesity activity of berberine through encapsulation in guar-acacia gum nanocomplexes

  • Research

Jyoti Bakshi, Prity Lather, Assim Verma, Deepika Lather, Sapna Grewal, Dinesh Dhingra, Santosh Kumari

RETRACTED ARTICLE: Therapeutic potential of 3-acetyl coumarin against polycystic ovarian syndrome induced by letrozole using female rats

  • Research

Saliha Shahbaz, Ali Sharif, Bushra Akhtar, Aisha Mobashar, Gamal A. Shazly, Amira Metouekel, Mohammed Bourhia

RETRACTED ARTICLE: Combined Ribociclib and NU7026 administration enhances radio-sensitivity by inhibiting DNA repair in prostate cancer

  • Research

Jinbo Sun, Yong Wang, Shanjin Ma, Wei Zhang, Longfei Yang, Bo Zhang, Qisheng Tang

Gold nanoparticles mediate suppression of angiogenesis and breast cancer growth via MMP-9/NF-κB/mTOR and PD-L1/PD-1 signaling: integrative in vitro validation and network pharmacology insights

  • Research

Alaa Elmetwalli, Tarek El-Sewedy, Mervat G. Hassan, Mohamed O. Abdel-Monem, Jihan Hassan, Nadia F. Ismail, Afrah Fatthi Salama, Junjiang Fu, Nasser Mousa, Deema Kamal Sabir, Ola El-Emam, Ghada Hamdy, Ali H. El-Far

A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway

  • Research

Meiqi Zhang, Ruotong Liu, Wentao Jiang, Hanxue Li, Siyi Zhang, Wenhao Cheng, Xiaoqing Ye, Jingliang He, Yuanyuan Liu, Aixin Jing, Yizhuo Song, Dan Wang, Xing Liu, Boyu Zhang, Xiujun Wang, Jing Ji

Assessment of sinapic acid’s protective effects against ethanol-induced gastric ulcers in rats

  • Research

Fazile Nur Ekinci Akdemir, Mustafa Can Güler, Ersen Eraslan, Ayhan Tanyeli, Serkan Yildirim

The “specific” P-glycoprotein inhibitor zosuquidar (LY335979) also weakly inhibits human organic cation transporters

  • Open Access
  • Research

Gzona Bajraktari-Sylejmani, Rajamanikkam Kamaraj, Dirk Theile, Petr Pávek, Johanna Weiss

Insight into dysregulated VEGF-related genes in diabetic retinopathy through bioinformatic analyses

  • Research

Xiaoguang Wang, Xianglian He, Zhen Li, Tao Mu, Lin Pang, Weiguo Ma, Xuejun Hu

Stimulation of histamine H1-receptors produces a positive inotropic effect in the human atrium

  • Open Access
  • Research

Thanh Hoai Pham, Lina Maria Rayo Abella, Katarina Hadova, Jan Klimas, Stefan Dhein, Steffen Pockes, Jonas Manfred Albert Schlicht, Britt Hofmann, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs

Exploring the anti-biofilm and gene regulatory effects of anti-inflammatory drugs on Candida albicans

  • Research

Somayeh Yazdanpanah, Mojtaba Shafiekhani, Mina Emami, Hossein Khodadadi, Keyvan Pakshir, Kamiar Zomorodian

Targeted delivery of chrysin and 5-fluorouracil on MDA-MB-231 cancer cells by a peptide-functionalized l-DOPA-imprinted polymer

  • Research

Sedighe Yosefi, Majid Sirati-Sabet, Abbas Pakdel, Zahra Nabizadeh, Parviz Kokhaei, Hamid Madanchi

Diosmin induces mitochondrial-mediated apoptosis and anti-inflammatory effects in Hep-2 cells: an integrated in vitro and in silico analysis

  • Research

Muthusamy Rajasekar, Kathiresan Suresh, Azhamuthu Theerthu, Ravichandran Pugazhendhi, Kathiresan Sivakumar

Network pharmacology and molecular docking to explore the potential mechanism of chlorogenic acid in septic acute liver injury and experimental validation of TLR4/NF-κB pathway in vivo

  • Open Access
  • Research

Shangping Fang, Hui Su, Jiameng Liu, Kecheng Zhai, Yangmengna Gao, Yu Xiang, Huan Li, Renke Sun, Huixian Cheng

Coagulation in familial hypercholesterolemic patients: effect of current hypolipidemic treatment and anticoagulants

  • Research

Jaka Fadraersada, Raúl Alva-Gallegos, Pavel Skořepa, František Musil, Kristýna Mrštná, Lenka Javorská, Kateřina Matoušová, Lenka Kujovská Krčmová, Markéta Paclíková, Alejandro Carazo, Milan Bláha, Vladimír Blaha, Přemysl Mladěnka

Myrtenol-loaded niosomes can prevent lung ischemia-reperfusion injury model in rats by balancing the Nrf2/Keap1 and NF-κB signaling pathways

  • Research

Mohammad Abbas Bejeshk, Hamid Najafipour, Mohammad Khaksari, Mohammad Hadi Nematollahi, Mohammad Amin Rajizadeh, Tania Dehesh, Fatemeh Bagheri, Gholamreza Sepehri

Echinatin inhibits osteoarthritis through the NF-κB signaling pathway

  • Research

Peng Zhan, Shiming Huang, Daohua Chen, Ying Li, Dongfeng Chen

Resveratrol polysaccharide is less cytotoxicity and inhibits UVA-, UVB-, and tertiary-butyl hydroperoxide-induced injury in human keratinocytes

  • Research

Yasukazu Saitoh, Shizuka Kanawa, Tsugumi Nohara, Ryoko Yamaguchi, Arisa Wakita, Chinatsu Ikeda, Hiroki Hamada

Chrysoeriol: a natural RANKL inhibitor targeting osteoclastogenesis and ROS regulation for osteoporosis therapy

  • Research

Hao Luo, Sijian Lin, Hao Lv, Wen Tan, Junlong Zhong, Jiachao Xiong, ZhiMing Liu, Qin Wu, Ming Chen, Kai Cao

Long-term forecast for antibacterial drug consumption in Germany using ARIMA models

  • Open Access
  • Research

Lilly Josephine Bindel, Roland Seifert

Berberine restrains non-small cell lung cancer cell growth, invasion and glycolysis via inactivating the SPC25/NUF2 pathway

  • Research

Meng Lv, Xiangrui Chen, Qiting Yang, Chushuan Huang, Yongbiao Lv, Tian Zhang, Junxiang Cai

Synergistic effects of sequential treatment with doxorubicin and zoledronic acid on anticancer effects in estrogen receptor-negative breast cancer cells

  • Research

Apisara Danpipat, Kitiya Rujimongkon, Patthamapon Adchariyasakulchai, Nanticha Wilawan, Wannarasmi Ketchart

Investigating the efficacy of gliclazide encapsulated hydrogel in the preclinical mice model for atopic dermatitis

  • Research

Kalpana Mamale, Shalini Shukla, Priyanka Mahale, Akshada Mhaske, Ravinder K. Kaundal, Rahul Shukla

Investigation of circulating miR-182-3p, miR -382-3p and miR -93, miR -142-3p involved in tamoxifen resistance and sensitivity in luminal-subtype breast cancer patients: a case–control study

  • Research

Elmira Aboutalebi Vand Beilankouhi, Zohreh Sanaat, Mohammad Ali Hosseinpour Feizi, Amir Mehdizadeh, Reza Safaralizadeh

Elucidating the anticancer potential of dendrobine in renal cell carcinoma treatment

  • Research

Xing Jia, Zixuan Chen, Xingyu Chen, Haojie Zhang, Zongrun Sun, Zhou Wang, Min Liu

Upregulation of WDR4 mediated by RBFOX2 promotes laryngeal cancer progression through the WDR4/m7G/lncRNA ZFAS1/RBFOX2 axis

  • Research

Baocai Lu, Xiao Li, Wenjie Miao, Qi Liu, Ruixue Li, Can Cui, Qingzu Gao, Rong Lian

Molecular and genetic analysis of methicillin-resistant Staphylococcus aureus (MRSA) in a tertiary care hospital in Saudi Arabia

  • Research

Mohd Saleem, Irfan Ahmad, Alharbi Mohammed Salem, Sumayyah Mohammad Almarshedy, Soha Abdallah Moursi, Azharuddin Sajid Syed Khaja, Ehab Rakha, Asim Azhar, Metab Nasser Ashammari, Homoud Almalaq, Kareemah Alshurtan, Mohd Shahid Khan

BDNF and GSK-3beta expression changes underlie the beneficial effects of crocin on behavioral alterations in a rat model of autism induced by prenatal valproic acid administration

  • Research

Seyedehfatemeh Hosseini, Mozhgan Ghadimi, Niloufar Reyhani, Sepideh Khazaei, Majid Rahmatkhah-Yazdi, Reza Soleimani-Farsani, Salar Vaseghi

Modulation of PI3K/AKT signaling and DFT modeling via selected pharmaceutical compounds attenuates carrageenan-induced inflammation and oxidative stress in rats

  • Research

Ahmed A. Abd-Rabou, Marwa Kamal, Hussam Y. Alharbi, Majed S. Aljohani, Mohamed A. El-Atawy, Mohamed S. Kishta

Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway

  • Research

Yue Li, Hailan Li, Minhui Sun, Hong Chen, Yao Xiao, Jieman Wang, Yuanyuan Zhang, Shuhua Fang, Junping Kou

Is it time for a paper mill blacklist?

  • Brief Report

Jaime A. Teixeira da Silva

New insight on the acute CCl4-induced hepatotoxicity model in rats

  • Brief Report

Dorcas Fernandes dos Anjos Melo, Marina Alves Coelho Silva, Naiara Raica Lopes de Oliveira, Jerônimo Raimundo de Oliveira Neto, Ruy de Souza Lino Júnior, Alessandro Carvalho Cruz, Luiz Carlos da Cunha

Retraction Note: Disabled-2, a versatile tissue matrix multifunctional scaffold protein with multifaceted signaling: Unveiling its potential in the cancer battle

  • Retraction Note

Nidhi N. Shah, Bhavarth P. Dave, Kashvi C. Shah, Disha D. Shah, Kunal G. Maheshwari, Mehul R. Chorawala, Priyajeet S. Parekh, Maharsh Jani

Retraction Note: Advances in microscopy characterization techniques for lipid nanocarriers in drug delivery: a comprehensive review

  • Retraction Note

Mohamed J. Saadh, Mohammed Ali Shallan, Uday Abdul-Reda Hussein, Amjed Qasim Mohammed, Saeb Jasim Al-shuwaili, Mukaram Shikara, Ahmed Ali Ami, Noor Alhuda Mohammad Ali Khalil, Irfan Ahmad, Huda Hayder Abbas, Ahmed Elawady