Ausgabe 7/2025
Inhalt (102 Artikel)
Authors must follow the editorial guidelines on the use of large language models in review papers
- Open Access
- Editorial
Roland Seifert, Erik Hartman, KeWei Wang, Daniela Yildiz
Schmiedeberg Medal for Thomas Wieland: an artist of G-protein signaling
- Open Access
- Laudation
Susanne Lutz, Friederike Cuello, Roland Seifert
From molecular to immuno-pharmacology: Schmiedeberg Medal for Klaus Resch
- Open Access
- Laudation
Michael U. Martin, Detlef Neumann, Michael Kracht
Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment
- Review
Sai Kiran S. S. Pindiprolu, Madhu Tanya Singh, Sai Varshini Magham, Chirravuri S. Phani Kumar, Nagasen Dasari, Ramakrishna Gummadi, Praveen Thaggikuppe Krishnamurthy
Evidence-based recommendations for comprehensive regulatory guidelines in medical devices: the imperative for global harmonization
- Review
Rimpi, Shweta J. Verma, Pinky, Ashish Baldi
The efficacy and safety of current treatment of vulvovaginal candidiasis: An umbrella review of systematic reviews and meta-analyses
- Review
Nasser Keikha, Bahman Fouladi, Mohammad Hossein Yadegari
The efficacy and safety of low-dose triple combination for hypertension treatment: a systematic review and meta-analysis of randomized controlled trials
- Open Access
- Review
Mohamed S. Elgendy, Hosam I. Taha, Ahmed Mazen Amin, Yehya Khlidj, Mohamed R. Ezz, Mohamed A. Elgamasy, Ahmed Almezaine, Mohamed A. Faheem, Islam Rajab, Mohamed Abuelazm
Therapeutic potential of traditional herbal plants and their polyphenols in alleviation of mercury toxicity
- Review
Saloni Agarwal, Swati Kaushik, Hiranmoy Saha, Debashish Paramanick, Mohd Mazhar, Parakh Basist, Rahmuddin Khan, Abdulsalam Alhalmi
Pinosylvin as a promising natural anticancer agent: mechanisms of action and future directions in cancer therapy
- Review
Phumudzo P. Tshikhudo, Tafadzwanashe Mabhaudhi, Neil A. Koorbanally, Fhatuwani N. Mudau, Daniela Calina, Javad Sharifi-Rad
A comprehensive literature review on the effects of saffron and its bioactive components on traumatic brain injury (TBI)
- Review
Seyed Mehrad Razavi, Yasamin Hosseini, Amirhossein Niknejad, Niusha Esmaealzadeh, Zahra Najafi Arab, Helia Mavaddat, Fatemeh Shahrahmani, Abolghasem Mortazavi, Saeideh Momtaz, Amir Hossein Abdolghaffari
A comprehensive review of medicinal plants and their beneficial roles in alleviating bisphenol A–induced organ toxicity
- Review
Shabnam Dolatabadi, Sara Rahimzadeh Oskuei, Soghra Mehri, Hossein Hosseinzadeh
Signaling pathways behind the biological effects of tanshinone IIA for the prevention of cancer and cardiovascular diseases
- Review
Homa Shahrokhi, Javad Asili, Zahra tayarani-najaran, Motahareh Boozari
Research progress of TRPV4 in pain over the past 20 years: a bibliometric analysis
- Review
Lele Huang, Qiwen Xuan, Ying Li, Jinghui Huang, Fanfu Fang
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications
- Open Access
- Review
Emad Gamil Khidr, Nourhan Ibrahim Morad, Shymaa Hatem, Ahmed M. El-Dessouki, Ahmed F. Mohamed, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Heba R. Ghaiad
Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect
- Review
Chou-Yi Hsu, Abdulsalam Najm Mohammed, Ahmed Hjazi, Subasini Uthirapathy, Jyothi S. Renuka, Abhayveer Singh, Thyagarajan, Subhashree Ray, Hanen Mahmod Hulail
Marine life as a source of anti-prostate cancer agents: an updated overview (2003–2023)
- Review
Amjad Hussain, Ammara Sohail, Muhammad Sajid Hamid Akash, Sarosh Iqbal, Kanwal Rehman, Muhammad Imran, Shoaib Khan, Muhammad Adnan Ayub, Daijie Wang, Dildar Ahmed, Mohammed Hadi Ali Al-Jumaili, Maria Bashir, Mariam Rasool
Cinobufagin: Unveiling the hidden bufadienolide’s promise in combating alimentary canal cancer development and progression – a comprehensive review
- Review
Beatriz Leme Boaro, Enzo Pereira de Lima, Durvanei Augusto Maria, Rose Eli Grassi Rici, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Eliana de Souza Bastos Mazuqueli Pereira, Caroline Barbalho Lamas, Claudia Rucco Penteado Detregiachi, Adriana Maria Ragassi Fiorini, Antonely de Cássio Alves de Carvalho, Lucas Fornari Laurindo, Sandra Maria Barbalho
Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review
- Review
Atefeh Motamedi-Manesh, Mahdieh Farzin Asanjan, Hamed Fallah, Shahrzad Gharibian, Alireza Taghavi, Zahra Haghighi Poode, Shahin Akhondzadeh, Salar Vaseghi
Efficacy, safety and mechanistic insights of pentoxifylline in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
- Open Access
- Review
Omar Kassar, NourAllah Farag, Abdullah Selim, Lamees Taman, Menna Alaa, Ahmed Elshahat, Moaz Elsayed Abouelmagd
Marine peptides in lymphoma: surgery at molecular level for therapeutic understanding
- Review
Salman Ahmed, Michael Aschner, Khalaf F. Alsharif, Mamdouh Allahyani, Guang Huang, Chunpeng Wan, Haroon Khan
Role of platelets and NETs in arterial thrombosis
- Review
Yaqi Zhang, Jingxue Ye, Shiyi Sun, Ruoyun Li, Shuang Tang, Min Wang, Guibo Sun
The potential of curcumin in mitigating acetaminophen-induced liver damage
- Review
Elham Einafshar, Pegah Bahrami, Fatemeh Pashaei, Paniz Naseri, Altin Ay Gharanjik, Atefe Mirteimoori, Nastaran Daraeebaf, Yegane Marami, Amirhossein Sahebkar, Hossein Hosseini
Exploring natural products as apoptosis modulators in cancers: insights into natural product-based therapeutic strategies
- Review
Biswajit Kumar Utpal, Hasna Bouenni, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Uppuluri Varuna Naga Venkata Arjun, Thukani Sathanantham Shanmugarajan, Ponnammal Ganesan Mahesh, Pathakota Roja, Ravi Kalyan Dodda, E. Thilagam, Mohammed Saeed Almahjari, Safia Obaidur Rab, Doukani Koula, Talha Bin Emran
Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus
- Review
Md. Faysal, Md Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam, Uppuluri Varuna Naga Venkata Arjun, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Sarandeep Shanmugam Prakash, Girija Dayalan, Saravanakumar Kasimedu, Y Bala Madhuri, Konatham Teja Kumar Reddy, Safia Obaidur Rab, Ali Audah Fahaid Al Fahaid, Talha Bin Emran
A comprehensive review on liraglutide and novel nanocarrier-based systems for the effective delivery of liraglutide
- Review
Ajay Pandey, Goutam Rath, Ruchi Chawala, Amit Kumar Goyal
Biological potential and therapeutic effectiveness with diverse signaling pathways of phyto-product chicoric acid: a comprehensive review with computational evidence
- Review
Muhammad Muzammil Nazir, Iqra Farzeen, Saima Zafar, Sehrish Fatima, Nimrah Zafar, Asma Ashraf, Sogolo Lucky Lebelo
A systematic review of efgartigimod as an effective treatment for myasthenic crisis
- Review
Ping Tang, Yi He, Kaiqiang Xiao, Liang Wang
Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation
- Review
Urooj Iqbal, Abdul Malik, Liza Ibrahim, Nabeela Tabassum Sial, Malik Hassan Mehmood
Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews
- Review
Pratibha Pandey, Meenakshi Verma, Gaurav Sanghvi, Roopashree R., Kamal Kant Joshi, Kavitha V., Subhashree Ray, Seema Ramniwas, Ajay Singh, Sorabh Lakhanpal, Fahad Khan
Senkyunolide I prevent chondrocytes from oxidative stress through Nrf2/HO-1 signaling pathway
- Research
Pengbin Li, Wenjuan Tang, Haiyan Wen, Siqi Zhou, Hui Cao
Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis
- Research
Hugo Giordano Tavares, Patrícia Ribeiro Orlando, Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Gabriela Silva, Alice dos Santos Nunes Ferreira, Bruna Caroline Chaves Garcia, Karen Rodrigues Lima, Etel Rocha Vieira, Leonardo Barros Dobbss, Marco Fabrício Dias-Peixoto, Alan Rodrigues Teixeira Machado, Luciano José Pereira, Eric Francelino Andrade
Resveratrol mitigates heat stress-induced testicular injury in rats: enhancing male fertility via antioxidant, antiapoptotic, pro-proliferative, and anti-inflammatory mechanisms
- Research
Mona Hafez Hafez, Sara El-Sayed El-kazaz, Mahmoud S. El-Neweshy, Mustafa Shukry, Heba I. Ghamry, Hossam G. Tohamy
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling
- Research
Chunmei Qian, Xing Zhang, Yu-Shi Tian, Lin Yuan, Qiao Wei, Yifu Yang, Midie Xu, Xiaoyu Wang, Menghong Sun
Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats
- Research
Bulent Durdu, Yasemin Durdu, Eray Metin Guler, Abdurrahim Kocyigit, Gulay Okay
Suppressing the progression of bladder cancer using cyclovirobuxine D based on network pharmacology and bioinformatics approaches
- Research
Ke Gao, Hanbing Jiang, Chao Zhang, Lin Li, Yuhong Qi, Nan Yang, Xiaoshun Li, Yongshun Wang, Bin Wu, Qiuju Shao, Guojun Wu
Sexual dysfunctions associated with antipsychotic drug intake: a retrospective analysis of the FDA adverse events reporting system (FAERS)
- Research
Johanna Engel, Lamin Jeridi, Lilly Auerbach, Oliver Zolk, Timo Greiner, Martin Heinze, Pichit Buspavanich, Michael Schneider
Tocilizumab alleviated lipopolysaccharide-induced acute lung injury by improving PI3K/AKT pathway
- Research
Junting Weng, Shuoyun Weng, Jitao Xu, Danjuan Liu, Rongjie Guo, Bingbing Shi, Min Chen
Exploring the impact of cuproptosis-related genes on immune infiltration in rheumatoid arthritis
- Research
Fang Xu, Xin-ran Hu, Yuan Wang, Xi-fan Mei
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
- Open Access
- Research
Sicheng Gao, Wanyi Zhang, Jinhua Dai, Weiye Hu, Yongyun Xu, Hailin Yang, Baiyang Ye, Hao Ouyang, Qinlin Tang, Gang Zhao, Junfeng Zhu
Ranolazine effectively improves clinical symptoms in patients with slow flow coronary arteries: a randomized, double-blind, placebo-controlled clinical trial
- Research
Bahram Shahri, Vahid Reza Askari, Lida Jarahi, Ali Shariatikia, Vafa Baradaran Rahimi
Doxorubicin treatment has a biphasic effect over time on dopamine release and impulsive behavior in Wistar rats
- Research
Kiersten J. Garcia, Jacob T. Theismann, Tadd D. Schneider, Robert S. LeComte, David P. Jarmolowicz, Michael A. Johnson
Weekly administration of betulinic acid prevents development of chronic renal failure from acute renal failure in folic acid-induced mouse model of kidney injury
- Research
Bency Elsa Johnson, C. V. Haritha, Karikalan Mathesh, Beena Vamadevan, Anshuk Sharma, V. A. Aneesha, Sunil E. Jadhav, Subhashree Parida, Thakur Uttam Singh, Madhu Cholenahalli Lingaraju
Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats
- Open Access
- Research
Mohamed M. Nazmy, Neveen A. Noor, Faten F. Mohammed, Yasser A. Khadrawy, Nasr M. Radwan
Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities
- Open Access
- Research
Gözde Atila Uslu, Hamit Uslu, Taha Abdulkadir Çoban, Mustafa Özkaraca, Ali Sefa Mendil, Serpil Aygörmez
The impact of graphene oxide nanoparticles on the migratory behavior of metastatic human breast cancer cell, MDA-MB-231
- Research
Sahar Khakpour Naeimi, Saeed Hesami Takallou, Hakimeh Zali, Zahra Niknam
Liraglutide mitigates dexamethasone-induced fatty acid synthase (FASN) and the cluster of differentiation36 (CD36) expression: a potential treatment for glucocorticoid-induced non-alcoholic fatty liver disease (NAFLD)
- Open Access
- Research
Dahshan Hassan Selim, Hamada Ahmed Mokhlis, Abdelrahman M. Elsayed, Abdel-Aziz S. Shatat, Salama Abdou Salama, Raed Shahat Ismail
Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens
- Open Access
- Research
Mona M. Soliman, Ahmed H. M. Elwahy, Ahmed M. Sayed, Mahmoud Ibrahim, Mohamed A. Dawoud, Shahd Hisham Mohamed Ali, Menna Tallah S. Nady, Nada A. Hassan, Wessam Saad, Ismail A. Abdelhamid
Pharmacokinetics and bioequivalence evaluation of two oral formulations of topiramate tablets in healthy Chinese male volunteers under fasting and fed conditions
- Research
Yamin Liu, Yubin Wang, Minhui Wang, Yaqin Wang, Ping Wu, Xiaocui Xia, Wanyu Wang, Lin Zhang, Pengfei Du, Jianbang Wu, Jie Shen, Yuanwei Jia
In silico and in vitro evaluation of the potential genotoxic impurities of vildagliptin
- Open Access
- Research
Muhammed Hamitoğlu, Gulcin Tugcu, Ayşe Gökçen Kılıç, Gülşah Esen, Ahmet Aydin
Synergistic effect of canine FGF-21 combined with insulin in the treatment of canine diabetes
- Research
Wenying Sun, Yaoqun Wang, Ziran Liu, Qing Wu, Xiaochen Guo, Zhitong Li, Xinyu Li, Chunxu Shi, Rui Gao, Lin Bai, Jingming Wang, Yuhan Zhang, Lu Li, Guiping Ren
Oral supplementation of curcumin-encapsulated chitosan nanoconjugates as an innovative strategy for mitigating nickel-mediated hepatorenal toxicity in rats
- Open Access
- Research
Eman I. Hassanen, Neven H. Hassan, Sally Mehanna, Ahmed M. Hussien, Marwa A. Ibrahim, Faten F. Mohammed, Khaled Y. Farroh
Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation
- Research
Zuocai Huang, Zhonghang Gu, Yuanjuan Zeng, Dongxing Zhang
The anti-dyskinetic effect of the clinic-ready mGluR2 positive allosteric modulator AZD8529 in the 6-OHDA-lesioned rat
- Research
Judy Shaqfah, Woojin Kang, Fleur Gaudette, Marianne Khalil, Cynthia Kwan, Sébastien Belliveau, Élodie Bourgeois-Cayer, Adjia Hamadjida, Dominique Bédard, Francis Beaudry, Philippe Huot
Akkermansia muciniphila relieves inflammatory response in DSS-induced ulcerative colitis in mice through regulating macrophage polarization via SCFAs-SLC52A2/FFAR2 pathway
- Research
Lin Zhang, Junxi Wang, Ye Xu, Kaiyan Wei, Wei Lin, Huixiang Hu, Yijuan Liu
Geraniol modulates inflammatory and antioxidant pathways to mitigate intestinal ischemia–reperfusion injury in male rats
- Research
Seyedeh Mahdieh Khoshnazar, Mohammad Mohagheghi, Sahar Rahimi, Shahriar Dabiri, Nader Shahrokhi, Sara Shafieipour
Quantitative structure–activity relationship (QSAR) hazard assessment of the banned pesticides by the National Agency for Food and Drugs Administration and Control
- Research
Hashim Ndaman Muhammad, Abdullahi Sani Yahaya, Hamdalat Folake Muritala
RNA-Seq transcriptomic landscape profiling of spontaneously hypertensive rats in youth treated with a ARNI versus ARB
- Research
Jian Ma, Xumin Xin, Yuewang Jia, Haijun Deng, Mengmeng Liu, Yonghong Jiang, Jianlin Du
Comparative efficacy of combined myo-inositol and D-chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospective clinical trial
- Research
Meena Gul, Hina Khan, Bushra Rauf, Syed Murtaza Shah Bukhari, Ehtesham Ehtesham, Muhammad Omar Malik, Fawad Ali Shah, Fawaz E. Alanazi, Mohsin Shah
Evaluation of drug-drug interaction between rosuvastatin and tacrolimus and the risk of hepatic injury in rats
- Research
Lulu Huang, Chen Ning, Jiake He, Mingcheng Wang, Xijing Chen, Xiaohui Guo, Lin Zhong
Ameliorative impact of sacubitril/valsartan on paraquat-induced acute lung injury: role of Nrf2 and TLR4/NF-κB signaling pathway
- Open Access
- Research
Nourhane M. Elemam, Manar A. Nader, Marwa E. Abdelmageed
Protective effect of valsartan alone and in combination with neprilysin inhibitor (valsartan + sacubitril) against hepatic ischemia–reperfusion injury: targeting angiotensin II receptor-neprilysin and modulating SMAD-4/NF-κβ/JNK pathways in rats
- Research
Deiaa E. Elsayed Abouzed, Duaa Abdullah Bafail, Shereen Mahmoud Refaie, Moustafa O. Aboelez, Asmaa A. Elsayed, L. O. Mallasiy, Nervana M. K. Bayoumy, Hanan Hagar
Evaluating the efficacy of nano-cyclosporine A in mice model of ulcerative colitis: a meta-analysis
- Research
Aqsa Mehreen, Faiza Batool, Uzma Azeem Awan, Nadia Shabnam, Adnan Haider, Shaista Aslam, Madiha Ghazanfar, Fakhar Ud-Din, Muhammad Irfan Siddique, Muhammad Naeem, Rida Fatima Saeed
Evidence for the anxiolytic- and antidepressant-like effects of three semi-synthetic derivatives of xylopic acid in mice
- Research
Charles Kwaku Benneh, Wonder Kofi Mensah Abotsi, Priscilla Kolibea Mante, Robert Peter Biney, John Peter Fetse, Mustapha Kobina Abeka, Donatus Wewura Adongo, Eric Woode
Apigenin exhibits memory enhancing activity through the restoration of oxido-endocrine balance and upregulation of BDNF/ERK/CREB signalling pathways in stressed mice
- Research
Juliet N. Olayinka, Anthony T. Eduviere, Maureen O. Okosun, Manuchim C. Amadi, Joshua O. Ikpen
Tirzepatide mitigates cognitive decline in zebrafish model of type 2 diabetes mellitus induced by high-fat diet
- Research
Sakshi Misra, Prabha Rajput, Amandeep Kaur
Monotropein represses the proliferation and angiogenesis via the AKT/NF-κB pathway in lung cancer
- Research
Bao-ning Cai, Bo Ma, Sheng Zhang, Wei He
Ginkgolide B regulates apoptosis, oxidative stress, and mitochondrial dysfunction in MPP+-induced SK-N-SH cells by targeting HDAC4/JNK pathway
- Research
Xu Ding, Dongming Tan, Zhao Wang, Hongying Yin
Causal associations between immune cells and psychiatric disorders: a bidirectional mendelian randomization analysis
- Research
Yi Li, Guanchao Sun, Yingshu Cui, Shuaifei Ji, Ting Kan
Disclosing the impact of metformin and methotrexate in adjuvant arthritis in female rats: molecular docking and biochemical insights on visfatin
- Research
Ahmed Mostafa Mahmoud, Esam Mohamed Abu Alfadl, Ahmed R. H. Ahmed, Azza M. A. Abouelella, Omar Alshazly, Mamdouh F. A. Mohamed, Hasan El Allaf, Rasha M. Allam
Nephrotoxic effect of cypermethrin ameliorated by nanocurcumin through antioxidative mechanism
- Research
Saeed Alshahrani, Mohammad Ashafaq, Abdulmajeed M. Jali, Yosif Almoshari, Mohammad Intakhab Alam, Hamad Al Shahi, Ayed A. Alshamrani, Sohail Hussain
Tinosinenside A inhibits neuroinflammation and protects HT22 cells by suppressing the TLR4/NF-κB/NLRP3 signaling pathway in BV2 cells
- Research
Yongyan Xie, Yinfang Qin, Jingjing Wang, Ziwei Xu, Liping Chen, Yunxia Kuang, Ruwei Yang, Liping Huang
Nitric oxide synthase inhibitors reduce the formation of neutrophil extracellular traps and alleviate airway inflammation in the mice model of asthma
- Research
Fei Wang, Zhen Liu, Wen-Xuan Li, Xiao-Ming Wang, Ju Yang, Zhu-Hui Zhao, Zhi-Jun Jie
Gold nanocomposites in colorectal cancer therapy: characterization, selective cytotoxicity, and migration inhibition
- Research
Kin Fai Tan, Le Yi Chia, Marwan Abdelmahmoud Abdelkarim Maki, Shiau-Chuen Cheah, Lionel Lian Aun In, Palanirajan Vijayaraj Kumar
Oral and topical spironolactone in acne treatment: A meta-analysis of effectiveness and safety
- Research
Esraa M. AlEdani, Mohamed Abo Zeid, Kareem Khalefa, Ahmed W. Abbas, Amira A. Aboali, Hager Ahmed Shawky Raslan, Zaid Shakhatreh, Ibrahim Abdelnasar Yakout, Amr Elrosasy
Fluvoxamine may reverse the decrease in filtering capacity that occurs in acute kidney injury by increasing IL-10 and ACE expressions and preserving AQ-2, AQ-4, CL-5, and ZO-1 expressions
- Open Access
- Research
Nasif Fatih Karakuyu, Tugce Camlica, Halil Asci, Adem Milletsever, Arzu Ulusoy, Fatih Mehmet Gonuler, Atila Altuntas
The novel piperine derivative MHJ-LN inhibits breast cancer by inducing apoptosis via p53 activation
- Research
Hongyu Ren, Qi Gao, Mengmeng Wang, Luyao Zhang, Sen Wang, Xingyu Zhang, Hanxue Li, Xiaoqing Ye, Lili Zhou, Chongyun Zhou, Xiuming Li, Kaile Zeng, Jing Ji
Chlorantraniliprole (Coragen® 20% SC) exposure induced reproductive toxicity mediated by oxidative stress, apoptosis, and sperm quality deficient in male Wistar rats
- Open Access
- Research
Shrouq Adel Mahmoud, Abd El-Wahab El-Ghareeb, Heba Ali Abd El-Rahman
Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach
- Open Access
- Research
Lamiaa A. Shaala, Diaa T. A. Youssef, Mahmoud A. Ramadan, Azza A. Khalifa, Reham S. Ibrahim, Fred Valeriote, Ismail Celik, Hend M. Dawood
Phase 1 studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 690517 (vicadrostat), a novel aldosterone synthase inhibitor, in healthy male volunteers
- Open Access
- Research
Friedrich Schulze, Jennifer Schaible, Markus Goettel, Yuko Tanaka, Kathrin Hohl, Armin Schultz, In-Jin Jang
Metformin alleviates doxorubicin-induced hepatic damage by modulating oxidative stress: a molecular, biochemical, and histopathological approach in a rat model
- Research
Shabnam lal-Shahsavar, Naime Majidi Zolbanin, Abbas Jafari, Morteza Ghasemnejad-Berenji
Enhanced anticancer efficacy of aluminum-curcumin complex compared to curcumin in colorectal cancer cells
- Research
Narges Jabbari, Abdolreza Sabokrouh
Inhibition of protein phosphatases attenuates A1-adenosine receptor-stimulation induced negative inotropic effects of cAMP-increasing agents in the isolated human atrium
- Open Access
- Research
Rebecca Schwarz, Britt Hofmann, Ulrich Gergs, Joachim Neumann
Pharmacokinetic comparison of a fixed-dose combination of telmisartan/rosuvastatin/ezetimibe/amlodipine 80/20/10/5 mg and a loose-dose combination of ezetimibe/rosuvastatin 10/20 mg and telmisartan/amlodipine 80/5 mg in healthy male subjects
- Research
Sooyoun Lee, Hyun Chul Kim, Kyung Tae Kim, Seung-Hyun Kang, SeungHwan Lee, Kyung-Sang Yu, Soyoung Lee
Sustainable streptomycin-based Ag nanoparticle synthesis and study of the cytotoxicity
- Research
Balázs Kakasi, Flóra Judit Varga, Márk Hopotószki, Erik Hopotószki, Imran Uddin
A quinoline derivative exerts antineoplastic efficacy against solid tumour by inducing apoptosis and anti-angiogenesis both in vitro and in vivo
- Research
Pradeepa Kumar C, Banumathi, N. D. Satyanarayan, Sakshith Raghavendra Prasad, Rajeshwara N. Achur, B. T. Prabhakar
Novel mechanistic insights of the potential role of gasotransmitters and autophagy in the protective effect of metformin against hepatic ischemia/reperfusion injury in rats
- Open Access
- Research
Ahmed O. Abdel-Zaher, Marwa H. Bakr, Yomna H. Gad, Alaa T. Abdelhafez
Rutin engages opioid/benzodiazepine receptors towards anti-neuropathic potential in a rat model of chronic constriction injury: relevance to its antioxidant and anti-inflammatory effects
- Research
Kimia Zamani, Sajad Fakhri, Amir Kiani, Fatemeh Abbaszadeh, Mohammad Hosein Farzaei
Enhanced inflammatory and oxidative response mitigation by acetyl-L-carnitine in a rat model of pelvic inflammatory disease
- Research
Sidra Sultan, Ushna Zoofeen, Inayat Shah, Syed Murtaza Shah Bukhari, Naveed Sharif, Syed Kazim Shah Bukhari, Momin Khan, Syed Hamid Habib, Fawad Ali Shah, Mariam K. Alamoudi, Mohsin Shah
Assessments of protodioscin’s antinociceptive and antidiarrheal properties: in vivo and in silico investigations on macromolecule binding affinity and modulatory effects
- Research
Pompa Rani Ghosh, Md. Sakib Al Hasan, Razina Rouf, Raihan Chowdhury, Balkrishnan Yadav, Emon Mia, Md. Tanvir Islam, Md. Rakibul Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Md. Shimul Bhuia, Muhammad Torequl Islam
Considerations on the sustainability of hypercholesterolemia treatment in the context of new drugs on the market: data from Campania, Italy
- Research
Francesco Ferrara, Andrea Zovi, Roberto Langella, Angela Panico, Manlio Scognamiglio, Ugo Trama, Eduardo Nava, Maurizio Capuozzo, Ferdinando Primiano, Giuseppe Russo
Deubiquitinase USP28 promotes the malignant progression and radio-resistance of hepatocellular carcinoma by stabilizing WDHD1
- Research
Wu Wen, Zhenhua Zhou, Chao Chen, Ming Chen
Population pharmacokinetics of levetiracetam in Chinese adult epilepsy patients with varying renal function: exposure simulation and individualized dosing adjustments
- Research
Rongrong Wang, Ze Li, Shu Li, Yaoyu Zhang, Le Cai, Tinglin Ren, Rongyan Li, Xingang Li, Tianlin Wang
RBM15-mediated m6A modification of XPR1 promotes the malignant progression of lung adenocarcinoma
- Research
Changpeng Sun, Hongjun Guan, Jinjin Li, Yinfeng Gu
Bovine serum albumin nanoparticles encapsulating Dasatinib and Celecoxib for oral cancer: Preparation, characterization, and in-vitro evaluation
- Open Access
- Research
Ghadeer AbouBakr Aly, Sally A. Sabra, Medhat Haroun, Maged W. Helmy, Nermine Moussa
Targeting the sigma-1 receptor with pridopidine induces functional neurorestoration in spinal cord ischemia-reperfusion injury
- Open Access
- Research
Eman Sweed, Suzan A. Khodir, Shaimaa Mohamed Motawea, Hala El-Haron, Basma Abdelnaby Mostafa, Mona S. Elkholy, Mohammud Salim, Doaa Z. M. Shebl
Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation
- Open Access
- Research
Nehal A. Kamel, Dina W. Bashir, Ebtihal M. M. El-Leithy, Adel F. Tohamy, Maha M. Rashad, Ghada E. Ali, Abdel Aleem A. El-Saba
The neurotoxic effects of lead acetate and the abrogating actions of 6-gingerol-rich extract of ginger via modulation of antioxidant defence system, pro-inflammatory markers, and apoptotic cascade
- Research
Maryam Tayo Ayinla, Abraham Olufemi Asuku
Efforts of the Pharmaceuticals and Medical Devices Agency of Japanese regulatory agency in supporting biosimilar development and disseminate information
- Brief Report
Ryosuke Kuribayashi, Aya Hariu, Yuka Saino, Kayo Shinohara
Correction: Rutin-loaded chitosan nanoparticles alleviated Freund’s adjuvant induced rheumatoid arthritis via modulating oxidative stress and inflammatory parameters in Wistar rats
- Correction
Mohammad Mehdi Gravandi, Zahra Pourmanouchehri, Leila Behbood, Sajad Fakhri, Ehsan Mohammadi-Noori, Mohsen Zhaleh, Sahel Shirvani, Amir Kiani, Mohammad Hosein Farzaei
Retraction Note: Zoledronic acid-loaded lipidic nanoparticles enhance apoptosis and attenuate invasiveness by inhibiting epithelial to mesenchymal transition (EMT) in HepG2 cancer cells
- Retraction Note
Mehdi Sabzichi, Omolbanin Oladpour, Jamal Mohammadian, Mohsen Rashidi, Mahla Hosseinzadeh, Alireza Mardomi, Bahman Ramezani, Marjan Ghorbani, Fatemeh Ramezani
