Ausgabe 8/2025
Inhalt (100 Artikel)
Cytokines in age-related eye diseases: pathogenesis and potential targets for innovative therapies
- Review
Tingting Zhang, Ming Liu
Acetylsalicylic acid and cancer: updates on the new potential of a nature-inspired drug
- Review
Abdur Rauf, Ahmed Olatunde, Md. Rezaul Islam, Zubair Ahmad, Nabia Hafeez, Hassan A. Hemeg, Muhammad Imran, Mohammad S. Mubarak, Giovanni Ribaudo
MicroRNAs in HIV infection: dual regulators of viral replication and host immunity
- Review
Reda M. Mansour, Gharieb S. El-Sayyad, Nehal I. Rizk, Sherif S. Abdel Mageed, Mohamed Salah Basiouny, Salma A. El-Sayed, Salma Zaki Fayez, Moustafa Mahmoud Abdelaziz, Khaled Abuelhaded, Haidy Adel Fahmy, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Ahmed S. Doghish
Tailored therapies for triple-negative breast cancer: current landscape and future perceptions
- Review
Yumna Khan, Sana Rizvi, Ali Raza, Amna Khan, Sadique Hussain, Najeeb Ullah Khan, Saud O. Alshammari, Qamar A. Alshammari, Abdulkarim Alshammari, Doha El-Sayed Ellakwa
Research advances in polyphenols from Chinese herbal medicine for the prevention and treatment of chronic obstructive pulmonary disease: a review
- Review
Yang Zhang, Lijuan Wang, Jinyi Zeng, Wen Shen
Potential role of thymoquinone to treat gastrointestinal cancers: insights into its molecular mechanisms
- Review
Tina Rahjoo, Alireza Motamedzadeh, Felora Ferdosi, Ehsan Dadgostar, Michael Aschner, Hamed Mirzaei, Sina Ghesmatpour, Fatemeh Nabavizadeh, Fatemeh Rahmati-Dehkordi, Omid Reza Tamtaji
miRNAs as emerging predictors of tamoxifen resistance in breast cancer
- Review
Elmira Aboutalebi Vand Beilankouhi, Reza Safaralizadeh, Babak Nejati, Zohreh Sanaat, Jalil Vaez gharamaleki, Ali Esfahani, Nasrin Gholami, Parvin Sarbakhsh, Jamal Mohammadian, Amir Mehdizadeh
The appearance of bitter taste receptors — inspiration from structure, expression, function, and mechanism
- Review
Furong Yang, Ming Zhang, Xiangdong Pu, Chuanpu Shen
Different aspects of Pseudomonas aeruginosa biofilm: an in-depth analysis from formation to detection
- Review
Neha Rawat, Sunita Sheoran, Jalaluddin Khan, Rahmuddin Khan, Nafaa Alzobaidi, Abdulsalam Alhalmi
Natural compounds as regulators of miRNAs: exploring a new avenue for treating brain cancer
- Review
Ahmed S. Doghish, Walaa A. El-Dakroury, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Shaza H. Aly, Abdullah M. M. Elbadry, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Nehal I. Rizk, Esraa M. Mosalam, Amany S. EL-Khouly, Sherif S. Abdel Mageed
Efficacy and safety of edaravone dexborneol in acute ischemic stroke: systematic review and meta-analysis of randomized controlled trials
- Review
Muataz Kashbour, Abdelrahman Shata, Mohamed Wagdy, Asmaa Zakria Alnajjar, Mohamed A. Aldemerdash, Husam Tarakhan, Moaz Elsayed Abouelmagd
Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies
- Review
Md Sadique Hussain, Ahsas Goyal, Kavita Goyal, Renuka Jyothi S., Jayshree Nellore, Moyad Shahwan, A. Rekha, Haider Ali, Muralikrishnan Dhanasekaran, Ronan MacLoughlin, Kamal Dua, Gaurav Gupta
Emerging therapeutic application of clemastine: a review of recent patents updates
- Review
Simran Soni, Ginpreet Kaur
The adipokines in oral cancer pathogenesis and its potential as a new therapeutic approach
- Review
Xue Wang, Jiapeng Wang, Xuemei Zhao, Jiayin Zhang, Yan Zhang
The role of TLRs (microbe recognition receptor) in gastric cancer: An update
- Review
Saade Abdalkareem Jasim, Sumaya Ayad Abdulrazzaq, H. Malathi, Suhaib Iqbal, Gaurav Sanghvi, E. Yulchiev, Subhashree Ray, S. Sunitha, Jawad Kadhim Ahmed, Ahmed Hussein Zwamel
Current advancement of immune function paradox of tumour-infiltrating cells and their immunotherapeutic targets: a mini-review
- Review
Veena V Tom, Ann Mary Jose, Sumit Mallick, Athira Sasidharan, Rakshita Pawar, Yogish Somayaji, Ronald Fernandes
Research progress on the bioactivity of platycodin D from Platycodon grandifloras
- Review
Ying Song, Xin Lv, Chuanbo Ding, Xinglong Liu, Yuanyuan Han, Shengyue Chen, Min Li, Ting Zhao
Unlocking the potential of THR-β agonist therapies: resmetirom’s chemistry, biology, and patent insights
- Review
Khushi Dahiya, Mahesh Palkar, Sanjay Sharma
Efficacy and safety of GLP-1 agonists in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
- Open Access
- Review
Mark Messak, Ahmed Abdelmageed, Abdelrahman A. Senbel, Youssef A. Khattab, Youssef Mandour, Omar Shaker, Ahmed Hamed Rehan, Samir Oransa, Mohamed Nasr, Abdullah Emad Shabeeb, Ziyad Rezq, Fares Hossam, Moaz Elsayed Abouelmagd
Pharmacological aspects of FDA-approved novel drug therapies against cancer in 2023: a comprehensive review
- Review
Kavita Sangwan, Parveen Kumar Goyal, Vipasha Sharma
Role of human microbiota in facilitating the metastatic journey of cancer cells
- Review
Himisa Shah, Princy Patel, Abhay Nath, Umang Shah, Ruma Sarkar
Harnessing bee venom for inflammatory diseases management: from traditional medicine to nanotechnology
- Review
Vandna Bhardwaj, Naresh Thakur, Priyanka Kumari
Ameliorative and protective effects of coenzyme Q10 against natural and chemical toxicity: a narrative review
- Review
Majid Keshavarzi, Karim Naraki, Bibi Marjan Razavi, Hossein Hosseinzadeh
Novel drug delivery systems in topical treatment of atopic dermatitis
- Review
Meghna Dabhadkar, Madhur Kulkarni
Unlocking the therapeutic potential of the NFAT pathway in kidney diseases
- Review
Shruti Shreya, Neha Dagar, Anil Bhanudas Gaikwad
Oxidative phosphorylation and breast cancer progression: insights into PGC-1α’s role in mitochondrial function
- Review
Rihab Akasha, Jerlyn Apatan Enrera, Syeda Bushra Fatima, A. M. Hegazy, Weiam Hussein, Muhammad Nawaz, Maali D. Alshammari, Sultan Almuntashiri, Najah Albadari, Mohammed Khaled Bin Break, Rahamat Unissa Syed
Innovative nanodelivery systems for targeted breast cancer therapy: overcoming drug delivery challenges and exploring future perspectives
- Review
Dandan Su, Xiaolin Lai, Zhizhe Lin, Youfa Xu, Zhiqin Fu, Jianming Chen, Xin Wu
A comprehensive review on diabetic cardiomyopathy (DCM): histological spectrum, diagnosis, pathogenesis, and management with conventional treatments and natural compounds
- Open Access
- Review
Ahmed R. Abdullah, Mahmoud A. Seliem, Emad Gamil Khidr, Ayah M. Sobhy, Riham A. El-Shiekh, Mohamed S. Abd El Hafeez, Ahmed A. El-Husseiny
Unlocking the microbial treasure trove: advances in Streptomyces derived secondary metabolites in the battle against cancer
- Review
Adrija Mukherjee, Ruma Sarkar
T lymphocyte-based immune response and therapy in hepatocellular carcinoma: focus on TILs and CAR-T cells
- Review
Thikra Majid Muhammed, Saade Abdalkareem Jasim, Ahmed Hussein Zwamel, Safia Obaidur Rab, Suhas Ballal, Abhayveer Singh, Anima Nanda, Subhashree Ray, Ahmed Hjazi, Hatif Abdulrazaq Yasin
Nanobiotechnology: traditional re-interpreting personalized medicine through targeted therapies and regenerative solutions
- Review
Sayantani Chattopadhyay, Arunava Goswami, Moumita Sil
MED12 dysregulation: insights into cancer and therapeutic resistance
- Review
Ritesh Bhole, Jagruti Shinkar, Sonali Labhade, Pawan Karwa, Harshad Kapare
Effect of NADPH oxidase inhibitor apocynin on human lung cancer A549 cells via Bcl-2, Bax, caspase-3, and NF-κB signaling pathway
- Open Access
- Research
Betul Apaydın Yıldırım, Tuba Dogan, İsmail Bolat, Ali Can Ozcan, Rabia Kocak
Inhibitory effects of cornuside on human liver cytochrome P450 enzymes
- Research
Yanmo Yang, Ke Zhang, Mi Zhou
Combining network pharmacology and RNA sequencing to reveal the mechanism of emodin for the treatment of human neuroblastoma
- Research
Hai-mei Jiang, Shang-yi Huang, Dan Huang, Yan Zhao, Yi Yuan, Hai-fu Huang, Ying Tang, Jin-fang Zhang
How strong the interaction really are? Application of nanoITC in the analysis of the interaction between newly synthesized substances with potential anticancer activity and model carrier proteins
- Research
Aleksandra Owczarzy, Wojciech Rogóż, Karolina Kulig, Andrzej Zięba, Małgorzata Maciążek-Jurczyk
Febuxostat protects from Doxorubicin induced hepatotoxicity in rats via regulation of NF-κB p65/NLRP3 inflammasome and SIRT-1/AMPK pathways
- Open Access
- Research
Ahmed M. El-Dessouki, Eman H. Yousef, Nahed A. Raslan, Asmaa I. Alwakeel, Samar Ibrahim, Amany A. Alzokaky
7-Geranyloxycoumarin modulated metastatic potential of osteosarcoma cells via interaction with MMPs and JAK1/2
- Research
Fatemehsadat Hosseini, Abdolreza Ahmadi, Zahra Nasiri Sarvi, Mehrdad Iranshahi, Fatemeh B. Rassouli
Metformin reverses 5-FU chemoresistance by downregulating DKK1, WNT5A, and ABCB1 expressions in gastric cancer: An experimental and bioinformatic study
- Research
Vahid Asghariazar, Mohammad Vakili Ojarood, Mohammad Amin Vatankhah, Reza Panahizadeh, Hamed Mohammadi Haris, Nowruz Najafzadeh, Parya Khakbaz, Narges Soozangar, Farhad Jeddi
Investigation of the inhibitory effects of the telomere-targeted compounds on glutathione S-transferase P1
- Open Access
- Research
Mehmet Ozcan, Ayse Burus, Ilgen Mender, Z. Gunnur Dikmen, Sergei M. Gryaznov, Turgut Bastug, Yasemin Bayazit
Polystyrene nanoplastics exacerbate gentamicin-induced nephrotoxicity in adult rat by activating oxidative stress, inflammation and apoptosis pathways
- Research
Khadija Boukholda, Awatef Elwej, Sabrine Ben Slimen, Abir Mhadhbi, Rim Marrekchi, Ons Boudawara, Bülent Kaya, Michèle Bouchard, Hamadi Fetoui
Most European countries will miss EU targets on antibacterial use by 2030: historical analysis of European and OECD countries, comparison of community and hospital sectors and forecast to 2040
- Open Access
- Research
Lilly Josephine Bindel, Roland Seifert
Pioglitazone improves learning and memory in a rat model of cholinergic dysfunction induced by scopolamine, the roles of oxidative stress and neuroinflammation
- Research
Arezoo Rajabian, Zahra Kioumarsi Darbandi, Mahdieh Aliyari, Rasul Saberi, Sabiheh Amirahmadi, Hamideh Amini, Hossein Salmani, Pouya Youseflee, Mahmoud Hosseini
TFAP2A facilitates the metastasis and radioresistance of esophageal cancer by promoting EGFR transcription
- Research
Jinjin Yuan, Junqi Liu, Ruitai Fai, Zongwen Liu
NMDA glutamatergic receptor-signalling in the ventrolateral columns of the periaqueductal grey matter mediates riparin A-induced antinociception to noxious heat stimulation
- Research
Raphaela Gonçalves Barros, Luiz Luciano Falconi-Sobrinho, Marcelo Lourenço da Silva, Norberto Cysne Coimbra, Rene Oliveira Beleboni
Wogonin attenuates inflammation and oxidative stress in acute lung injury via regulating PPARα, AKT, and NRF2
- Research
Hui Yang, Yunran Hu, Long Cheng, Yuan Xiong, Yuan Xu, Changxing Gao, Ming Qian, Lin Zhou
Molecular characterization of metallo-beta-lactamase producers among carbapenem-resistant Pseudomonas aeruginosa from clinical samples in a tertiary care hospital, Lucknow, India
- Research
Nadeem Ahmad, Areena Hoda Siddiqui, Amita Arya, Mohd Shahid Khan
α-Hederin inhibited pancreatic cancer cell malignant progression by inhibiting LDHA-mediated glycolysis
- Research
Jingjing Li, Jiao Liu, Yue Wu, Yi Sun, Gang Huang, Mingming Jin
Patient-derived tumor xenograft animal model of gastric cancer in precision chemotherapy
- Research
Yiyin Zhang, Yongming Yang, Jiayi Zhou, Qianqian Yu, Lixia Chen, Lili Zhao, Yongsheng Meng, Jing Wang, Lei Yan, Ziyang Huang, Shuchen Song, Wenqi Bai, Ruifang Sun, Xihua Yang
Gallic acid alleviates omeprazole-induced depressive behavior and memory impairment
- Open Access
- Research
Noreen Samad, Natasha Manzoor, Ali Irfan, Arslan Khalid, Umer Ejaz, Bakar Bin Khatab Abbas, Syed Aun Muhammad, Gamal A. Shazly, Saima Khaliq, Yousef A. Bin Jardan
Obtusifolin improves cisplatin-induced hepatonephrotoxicity via the Nrf2/HO-1 signaling pathway
- Open Access
- Research
Selcan Cesur, Berrin Yalinbas-Kaya, Ali Tureyen, Fahriye Zemheri-Navruz, Hasan Huseyin Demirel, Sinan Ince
Prolonged administration of letrozole induces polycystic ovary syndrome leading to osteoporosis in rats: model development and validation studies
- Research
Zakiya Usmani, Sheeraz Ahmad, Zeba Usmani, Taru Mishra, Abul Kalam Najmi, Saima Amin, Aayeena Altaf, Showkat Rasool Mir
Quinic acid alleviates liver toxicity induced by acetaminophen in mice via anti-oxidative and anti-inflammatory effects
- Research
Saeedeh Shariati, Shokooh Mohtadi, Mohammad Javad Khodayar, Maryam Salehcheh, Reza Azadnasab, Esrafil Mansouri, Mehrnoosh Moosavi
3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
- Research
Mahima Verma, Shireen Fatima, Asad Syed, Abdallah M. Elgorban, Islem Abid, Ling Shing Wong, Mohd Sajid Khan, Irfan Ahmad Ansari
Evaluation of the iodoacetic acid effects on adipose-derived mesenchymal stem cells and alteration of their osteogenic differentiation potential by inducing oxidative stress
- Research
Nastaran Ansari Noghlebari, Atieh Hajarizadeh, Niloofar MohammadEbrahim, Malathi H., Vikrant Abbot, Atreyi Pramanik, Elaheh Esmaeili
The role of resveratrol in delivering antioxidant, anti-inflammatory, and anti-apoptotic defense against nephrotoxicity generated by titanium dioxide
- Open Access
- Research
Feyza Basak, Tansu Kusat, Tahir Kahraman, Yusuf Ersan
Evidence-based investigation of the efficacy and safety of venetoclax-containing regimens versus chemoimmunotherapy in chronic lymphocytic leukemia
- Research
Pu Yao, Jiao Zhang, Xiaowen Wang, Changsheng Jia, Lin Cheng
Identification and potential mechanism of a novel gastric cancer suppressor tRF-24-6VR8K09LE9
- Research
Yelan Tang, Kan Ni, Kangfeng Jin, Wei Feng, Shaoqing Ju, Rongrong Jing, Wei Zong
Rosmarinic acid promotes mitochondrial fission and induces ferroptosis in triple-negative breast cancer cells
- Research
Chufei Xie, Liujia Chan, Yuheng Pang, Yuefeng Shang, Wenjing Wang, Lichun Zhao
Exploring anticancer potential of betanin in DMBA-induced oral squamous cell carcinoma: an in silico and experimental study
- Research
Ramachandhiran Duraisamy, Vinothkumar Veerasamy, Vaitheeswari Balakrishnan, Saranya Jawaharlal, Srinivasan Subramani, Vigil Anbiah Sathiavakoo
Novel insights into bexarotene's role in preventing cholestasis: mechanisms and implications
- Research
Thamer Abdulla Mohammed, Munaf H. Zalzala
Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2/Keap1/HO-1 and PPARγ signaling
- Research
El-Shaimaa A. Arafa, Emad H. M. Hassanein, Rasha M. Hussein, Wafaa R. Mohamed
Bioinformatics tools and experimental analysis combination for production of specific scFv against CD133
- Research
Rezvan Mohammadi, Bahram Kazemi, Fatemeh Yarian, Hamidreza Moosavian, Alireza Farsinejad
Exploring the molecular mechanism of icariin improving spinal cord injury through network pharmacology combined with experimental verification
- Research
Mengmeng Zhou, Zehua Jiang, Maosen Zhang, Sa Feng, Boyuan Ma, Shunli Kan, Xuanhao Fu, Rusen Zhu
Comparison of the nephroprotective effect of [6]-gingerol and the [6]-gingerol-β-cyclodextrin complex against cisplatin-induced AKI
- Research
Dayara de Oliveira Silva, Mikael Almeida Lima, Thiago Miranda de Freitas, Francisco Cleber Silva Ferreira, Antônio Klingem Leite de Freitas, Mário Rogério Lima Mota, James Almada da Silva, Marco Antonio de Freitas Clementino, Alexandre Havt
The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro
- Open Access
- Research
Ayse Burus, Mehmet Ozcan, Hande Canpinar, Ozlem Bozdemir, Naciye Dilara Zeybek, Yasemin Bayazit
From computational screening to zebrafish testing: repurposing of doxazosin, donepezil, and dolutegravir for neuroprotective potential in Alzheimer’s disease
- Research
Karishma M. Rathi, Vaishali R. Undale, Ravindra D. Wavhale, Firdous Sayed Mohammed, Pawan N. Karwa, Harsh Patil
Network pharmacology analysis and animal experiment validation of inflammation inhibition by Swertiamarin in treating Ulcerative colitis
- Research
Tang Jiafeng, Wang Lijuan, Wei Lan, You Yiqing, Yang Shiyu, Zeng Tao, Dang Tingting, Sun Haoli, Li Xiaoshan, Zhang Yan
Micelle nanogel–based drug delivery system for lutein in ocular administration
- Research
Reeshma Shetty, Jobin Jose, Naseer Maliyakkal, Sandeep D. S., Renjith P. Johnson, Akshay Bandiwadekar, Gopika Gopan, Sanjay R. Ugare, Namitha K. Preman
Investigation of the sensitivity of human A549 cells to paclitaxel and sesquiterpene lactone alantolactone via apoptosis induction
- Open Access
- Research
Irem Bayar, Yalcin Erzurumlu, Senem Akkoc, Zafer Bulut, Mehmet Nizamlioglu
The ameliorative effect of myo-inositol on apoptosis-related genes expression in cumulus cells of women with polycystic ovary syndrome undergoing ICSI and its relationship with the quality of oocyte and embryo
- Research
Zeynab Yazdanpanah, Mitra Heydari Nasrabadi, Ebrahim Cheraghi, Masoud Salehipour
Insulin like growth factor binding protein 7 activate JNK/ERK signaling to aggravate uranium-induced renal cell cytotoxicity
- Research
Ling Peng, Xi Chen, An-qun Wang, Gang Xie, Bin Zhang, Jia-fu Feng
TRPM6 in murine kidneys—of targets and antibodies
- Open Access
- Research
Colya N. Englisch, Coline M. Diebolt, Emilie Kirstein, Vanessa Wahl, Philipp Wartenberg, Dirk Schaudien, Anja Beckmann, Matthias W. Laschke, Gabriela Krasteva-Christ, Thomas Gudermann, Vladimir Chubanov, Ulrich Boehm, Thomas Tschernig
Synthesis and biological evaluation of thiourea-tethered benzodiazepinones as anti-proliferative agents targeting JAK-3 kinase
- Research
Bharti Dhawan, Mohammad Sarwar Alam, Hinna Hamid, Anubha Yadav, Gowsia Akhter, Mohd Jamal Dar, Ozair Alam, Yogisha S
Long-term forecasting and evaluation of medicine consumption for the ATC class H with a focus on thyroid hormones in OECD countries using ARIMA models
- Open Access
- Research
Lilly Josephine Bindel, Roland Seifert
Tacrolimus population pharmacokinetic model–informed precision dosing in adult liver transplant patients
- Research
Jiana Hou, Siyu Yang, Wei Liu, Yanxia Lu, Jian Wei, Xingang Li
The intervention of NLRP3 inflammasome inhibitor: oridonin against azoxymethane and dextran sulfate sodium–induced colitis-associated colorectal cancer in male BALB/c mice
- Research
Gurpreet Kaur, Priyanka Tiwari, Shivani Singla, Archna Panghal, Gopabandhu Jena
Effect of palliative radiotherapy and cyclin-dependent kinase 4/6 inhibitor on breast cancer cell lines
- Open Access
- Research
Marwa Sharaky, Shereen M. El Kiki, Heba Effat, Heba H. Mansour
Protective effect of orientin on diabetic nephropathy in rat models of high-fat diet and streptozotocin-induced diabetes
- Research
Raad Saad Luty, Adeeb Ahmed Al-Zubaidy, Arif Sami Malik, Hayder Ridha-Salman, Alaa Hamza Abbas
Toxicological assessment of exposure to pharmaceutical effluents in rats for 28 days by repeated oral dose
- Research
Sudhakar Chatakondu, Naresh Dumala, Rekhadevi Perumalla Venkata
Protective effects of diacerein against quinolinic acid–induced Huntington’s disease–like symptoms in adult zebrafish by targeting GSK-3β signalling
- Research
Falguni Goel, Vaishali Dobhal, Shamsher Singh
Devil’s claw (Harpagophytum procumbens): is the buzz in Google justified?
- Open Access
- Research
Finn Erik Bargsten, Roland Seifert
Effect of solid lipid nanoparticles loaded with valproate and metformin on pentylenetetrazole-induced epilepsy in rats
- Research
R. Abinaya, V. K. Kalaichelvan, K. Gopalasatheeskumar
All-trans retinoic acid enhances anti-proliferative effect of dual PI3K and mTOR inhibitor NVP-BEZ235 in triple negative breast cancer
- Open Access
- Research
Suranur Ayvaz, Zeynep Busra Bolat
2-Aminomethyl phenothiazine, its alkyl and triphenylphosphonium derivatives suppress erastin-induced ferroptosis in BT-474 cells but exhibit distinct cytotoxic activities
- Research
Mikhail V. Dubinin, Anna I. Ilzorkina, Darya A. Nedopekina, Natalia V. Mikina, Natalia V. Belosludtseva, Rezeda R. Khalitova, Jun Moni Kalita, Eldar V. Davletshin, Anna Yu. Spivak, Damiki Laloo, Konstantin N. Belosludtsev
The Gender Award Gap in German medical societies 2000–2023: the Fritz-Külz-Award as an example
- Open Access
- Research
Thorsten Halling, Viola Mambrey, Jessica Marie Steinert, Roland Seifert, Annegret Dreher, Chantal Marazia, Adrian Loerbroks, Nils Hansson
Eupatilin mitigates ICH-induced brain injury via SOX2/SLC7A11 regulation of ferroptosis
- Research
Youkui Shen, Yanqiu Wang, Feifei Liu
Modulation of AMPK by esomeprazole and canagliflozin mitigates methotrexate-induced hepatotoxicity: involvement of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt signaling pathways
- Open Access
- Research
Ahmed M. El-Dessouki, Mohamed E. Kaml, Mohammed F. EL-Yamany
Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications
- Research
Shoyaeb Ahammed, Raihan Chowdhury, Md. Sakib Al Hasan, Emon Mia, Md. Showkoth Akbor, Md. Tahajul Islam, Rokibul Islam Chowdhury, Md. Sabbir Hossain, Irfan Aamer Ansari, Siddique Akber Ansari, Md. Amirul Islam, Zainab M. Almarhoon, Javad Sharifi-Rad, William N. Setzer, Muhammad Torequl Islam
Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination
- Research
Siyao Shen, Guifeng Xue, Zhigang Zeng, Liang Peng, Weidong Nie, Xiaochun Zeng
Effect of sakuranetin against cyclophosphamide-induced immunodeficiency mice: role of IFN-γ/TNF-α/IgG/IgM/interleukins
- Research
Khalid Saad Alharbi, Sattam Khulaif Alenezi, Tariq Alsahli, Muhammad Afzal, Mohammad Jaffar Sadiq Mantargi, Imran Kazmi, Nadeem Sayyed
PFDN1 silencing disrupts critical cancer pathways in triple-negative breast cancer: investigating migration, cell cycle, and apoptosis as a new target therapy
- Research
Abdulrahman M. Alokda, Ahmed Abdelmagied Soffar, Amany I. Yousef, Fawziya A. R. Ibrahim, Tarek El-Sewedy, Alaa Elmetwalli
Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats
- Research
Mohammed A. Al-Khawlani, Wafa M. Al-Madhagi, Ahmed M. Sabati, Saleh A. M. A. ALomaisi, Maged Al-Najar
Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies
- Research
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous, Noshin Tasnim Yana, Emon Mia, Imam Hossen Rakib, Irfan Aamer Ansari, Siddique Akber Ansari, Md. Amirul Islam, Md. Shimul Bhuia
Computational pharmacology-based molecular mechanism investigation of cinnamaldehyde intervention in nephrotic syndrome
- Open Access
- Research
Yaoying Zeng, Qiang Li, Zhen Xie, Jieyu Zhu, Shaoli Chen, Jijia Sun, Guangli Du
Erbium oxide nanoparticles induce potent cell death, genomic instability and ROS-mitochondrial dysfunction-mediated apoptosis in U937 lymphoma cells
- Open Access
- Research
Hanan R. H. Mohamed, Yusuf Ahmed Elberry, Hagar Magdy, Maryam Ismail, Maivel Michael, Nourhan Eltayeb, Gehan Safwat
Long noncoding RNA MATN1-AS1 contributes to oxaliplatin resistance of gastric cancer cells through miR-518b/ZNF281 axis
- Research
Xiuhuan Qiu, Licheng Zhang, Fengying Guo, Ruixiang Guo
No evidence for paradoxical effects of tocilizumab in rodents
- Open Access
- Brief Report
Christoph Garbers
Using cluster analysis to investigate consumption patterns in cases positive to ketamine: a national 7‐year study
- Brief Report
Shyh-Yuh Wei, Chien-Chou Su, Hsuan-Yun Hu, Chih-Hsin Pan
