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Naunyn-Schmiedeberg's Archives of Pharmacology

Ausgabe 9/2025

Inhalt (102 Artikel)

NLRP3 inflammasome-based therapies by natural products: a new development in the context of cancer therapy

  • Review

Hamza Abu Owida, Ahmed Yaseen Abed, Farag M. A. Altalbawy, Malathi H., Vikrant Abbot, Sanoeva Matlyuba Jakhonkulovna, Suleiman Ibrahim Mohammad, Asokan Vasudevan, Reem Mohsin Khalaf, Ahmed Hussein Zwamel

Mapping molecular landscapes in triple-negative breast cancer: insights from spatial transcriptomics

  • Review

Fares Saeed H. Al-Mansour, Hassan H. Almasoudi, Ali Albarrati

Omentin-1 as a promising biomarker and therapeutic target in hypertension and heart failure: a comprehensive review

  • Review

Mohammad Yasin Zamanian, Saba Maleki, Enwa Felix Oghenemaro, Mandeep Singh, Maryam Mohammadi, Ahmad Hussen Alkhayyat, Ibrokhim B. Sapaev, Parjinder Kaur, Niyousha Shirsalimi, Amritesh Nagarwal

Circular RNAs: driving forces behind chemoresistance and immune evasion in bladder cancer

  • Review

Mohamed J. Saadh, Wael Sheet Hussein, Ali Fawzi Al-Hussainy, Ashok Kumar Bishoyi, M. M. Rekha, Mayank Kundlas, V. Kavitha, Zafar Aminov, Sada Ghalib Taher, Mariem Alwan, Mahmood Jawad, Hiba Mushtaq

Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy

  • Review

Gulshan Sharma, Rohil Panwar, Sanskriti Saini, Hardeep Singh Tuli, Karan Wadhwa, Rakesh Pahwa

Insecticides and testicular health: mechanisms of injury and protective natural products

  • Open Access
  • Review

Samar F. Darwish, Yasser M. Moustafa, Sherif S. Abdel Mageed, Ghaneya S. Hassan, Safwat Abdelhady Mangoura, Shaza H. Aly, Mai A. Mansour, Ahmed Amr Raouf, Al-Aliaa M. Sallam, Sylvia F. Fawzi, Asmaa M. Atta, Ola Elazazy, Walaa A. El-Dakroury, Aya A. El-Demerdash, El-Zahra M. Esmat, Mahmoud A. Elrebehy, Ahmed S. Doghish

Natural compounds and programmed necrosis: pioneering a new frontier in cancer treatments

  • Review

Md. Al Amin, Hasna Bouhenni, Mehrukh Zehravi, Sherouk Hussein Sweilam, Trupti Pratik Durgawale, Mohammad Shamim Qureshi, Sumit Durgapal, M. Akiful Haque, Rajeshwar Vodeti, Deepadarshan Urs, Mst Maharunnasa Shatu, Safia Obaidur Rab, Koula Doukani, Talha Bin Emran

Beyond the pill: incrimination of nuclear factor-kappa B and their targeted phytomedicine for pulmonary fibrosis

  • Review

Akarsha Balnadupete, Fathimath Muneesa Moideen, Aleena Varughese, Kirana Mugaranja, Jeena T. M., Rakshitha Charavu, Yashodhar Bhandary

The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review

  • Review

Mohanna Khandan, Mohammad Amin Khazeei Tabari, Seyed Mostafa Rahimi, Mahmoud Hassani, Abouzar Bagheri

Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature

  • Open Access
  • Review

Al-Hassan Soliman Wadan, Ahmed H. Shaaban, Mohamed Z. El-Sadek, Salah Abdelfatah Mostafa, Ahmed Sherief Moshref, Ahmed El-Hussein, Doha El-Sayed Ellakwa, Samah S. Mehanny

Therapeutic innovations: targeting ROS production in AML with natural and synthetic compounds

  • Review

Mohammed Hashim Mohammed, Raed Fanoukh Aboqader Al-Aouadi, Subasini Uthirapathy, Gaurav Sanghvi, Rekha M M, Resan Shakir Abdulamer, G. V. Siva Prasad, Mayank Kundlas, Fayzulla Khamraev, Muhammad Ikram Ullah

Effects of Crocus sativus and its active constituents on cytochrome P450: a review

  • Review

Pooneh Bathaei, Mohsen Imenshahidi, Nasser Vahdati-Mashhadian, Hossein Hosseinzadeh

Innovative approaches in breast cancer therapy: repurposing nanocarriers for enhanced outcomes

  • Review

Sana Naaz Siddiqui, Md. Faheem Haider, Md Azizur Rahman

The role of irisin in exercise-induced muscle and metabolic health: a narrative review

  • Review

Sumaya Nadhim Mohammed, Mohannad Hamid Jasim, Shahad Hisham Mahmood, Eman Naji Saleh, Alireza Hashemzadeh

Roles of anoikis in hepatocellular carcinoma therapy and the assessment of anoikis-regulatory molecules as therapeutic targets

  • Review

Hongyu Wang, Yawen Yang, Gan Zhang, Guang Yang, Ying Wang, Lu Liu, Juan Du

Targeting EZH2 in autoimmune diseases: unraveling epigenetic regulation and therapeutic potential

  • Review

Hashem Ahmed Abu Harirah, Mohammed Hashim Mohammed, Sami Ahmed Zaher Basha, Subasini Uthirapathy, Subbulakshmi Ganesan, Aman Shankhyan, Girish Chandra Sharma, Anita Devi, Abed J. Kadhim, Naher H. S.

Regulation of immune-mediated chemoresistance in cancer by lncRNAs: an in-depth review of signaling pathways

  • Review

Saade Abdalkareem Jasim, Farag M. A. Altalbawy, Subasini Uthirapathy, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Anita Devi, Alexey Yumashev, Yasser Fakri Mustafa, Munther Kadhim Abosaoda

Comprehensive review of leonurine: harnessing its therapeutic potential for chronic diseases

  • Review

Mukesh Kumar Manickasamy, Uzini Devi Daimary, Anjana Sajeev, Mohamed Abbas, Mohammed S. Alqahtani, Ayman Abdulhammed, Ajaikumar B. Kunnumakkara

Comprehensive insights into pancreatic cancer treatment approaches and cutting-edge nanocarrier solutions: from pathology to nanomedicine

  • Review

Rohit Sharma, Sourabh Kumar, Kumari Komal, Rashmi Ghosh, Shubham Thakur, Ravi Raj Pal, Manish Kumar

Targeting diabetes with flavonoids from Indonesian medicinal plants: a review on mechanisms and drug discovery

  • Review

Tubagus Rayyan Fitra Sinuhaji, Sintha Ramadhani, Volta Kellik Setiawan, Umi Baroroh

Emerging new immune checkpoint inhibitors in solid tumor immunotherapy

  • Review

Amirhoushang Poorkhani, Mahboubeh Tajaldini, Farahnazsadat Ahmadi, Arash Tahmasebifar, Mahboobeh Azadehrah, Malihe Azadehrah, Amir Ghamoushiramandi, Rouzbeh Shams Amiri, Vahid Khori

Chemoimmunotherapy synergism: mechanisms and clinical applications

  • Review

Rahaman Shaik, Sai Manasa Chittepu, Meghana Tarapatla, Fathima Begum, Srujan Vempati, Abhistika Royyala

Cytokine-mediated regulation of immune cell metabolic pathways in the tumor microenvironment

  • Review

Alireza Soleimani Mamalo, Mohammadreza Pashaei, Mohammad Valilo, Masoud Ojarudi

The bioactivity of atraric acid as an inducer of cellular senescence in prostate cancer cells is retained by lipophilic derivatives

  • Open Access
  • Research

Adina Asara Baniahmad, Golnaz Atri Roozbahani, Manfred Jung, Aria Baniahmad

Gallic acid’s protective mechanisms against acrylamide-induced pulmonary injury: in vivo and in silico insights into the Nrf-2/HO-1/NFκB pathway modulation

  • Open Access
  • Research

Merve Bolat, Samet Tekin, İsmail Bolat, Aslıhan Atasever, Burak Çinar, Yusuf Dağ, Emin Şengül, Serkan Yildirim, Mohamad Warda, Fikret Çelebi

Trans-sodium crocetinate attenuates acute kidney injury induced by rhabdomyolysis in rats: focusing on PI3K/AKT, apoptosis, and autophagy pathways

  • Research

Tahereh Aminifard, Soghra Mehri, Abolfazl Khajavirad, Zahra Moosavi, Sara Hosseinian, Hossein Hosseinzadeh

Exploring mechanisms of britannin against colorectal cancer based on experimentally validated network pharmacology

  • Research

Xiaoli Liu, Qiuxia Ye, Mengdi Hao, Huimin Li, Dajin Yuan, Wenbin Huang, Wenjie Li, Lei Ding

Potential prognostic biomarker of OSBPL10 in pan-cancer associated with immune infiltration

  • Research

Jiapeng Qi, Kun Yu, Bei Liu, Yan Wang, Wei Wang, Ran An, Chaojun Wang, Na Li, Dongqian Xu, Lin Liu

Neuroprotective effects of semaglutide and metformin against rotenone-induced neurobehavioral changes in male diabetic rats

  • Open Access
  • Research

Esraa A. Salem, Saad Misfer Alqahtani, Ehab A. M. El-Shoura, Sameh S. Zaghlool, Lobna A. Abdelzaher, Sally A. M. Mohamed, Ibrahim S. Alalhareth, Alzahraa A. M. Sheref

Calycosin alleviates ovariectomy-induced osteoporosis by promoting BMSCs autophagy via the PI3K/Akt/mTOR pathway

  • Research

Shouyu Xiang, Yinji Luo, Wei Liu, Cheng Tang, Tianyu Zhu, Lai Tian, Tiansheng Zheng, Long Ling, Mingyang Jia, Xing Li, Yanming Cao

Ligandrol lowers endurance and negatively affects lipid and hormonal profile of male rats

  • Open Access
  • Research

Veselin Vasilev, Katerina Georgieva, Desislava Arabadzhiyska, Slavi Delchev, Fanka Gerginska, Marina Komrakova, Kai O. Boeker, Arndt F. Schilling, Nikolay Boaydjiev

Bromopride stimulates 5-HT4-serotonin receptors in the human atrium

  • Open Access
  • Research

Lina Maria Rayo Abella, Joachim Neumann, Britt Hofmann, Ulrich Gergs

The role and mechanism of quercetin in improving late-onset hypogonadism through network analysis and experimental validation

  • Research

Xiaodong Wu, Hui Zhao, Xinshuang Huang, Peng Lu, Runqi Zhang, Qingbo Guan, Chunxiao Yu

Suppression of necroptosis-driven cell death and inflammation in hypoxic neuroblastoma (SH-SY5Y) cells by necrostatin-1

  • Research

Amal Majed H. Alenad, Mohd Shahnawaz Khan, Nojood Al-twaijry, Majed S. Alokail, Leon Bernet Shano, Subramani Karthikeyan, Huma Naz, Bigyan Ranjan Jali

An oligosaccharide isolated from Rosa canina ameliorates lipid profile and liver damage in MASLD modeled rabbits: in vivo and in silico studies

  • Research

Gholamreza Bahrami, Soraya Sajadimajd, Farnoush Kazemi, Fatemeh Yarmohammadi, Seyed Shahram Miraghaee

Melatonin augments anti-tumor activity and alleviates nephrotoxicity of gemcitabine in a pancreatic cancer xenograft model targeting P62/Keap1 pathway

  • Open Access
  • Research

Samar Ibrahim, Eman H. Yousef, Ahmed M. El-Dessouki, Nahed A Raslan, Amany A. Alzokaky

Cilostazol alleviates imatinib-induced myocardial injury in rats by modulating the TGF-β1/MAPK, SHC/Grb2/SOS signaling pathways and upregulating miRNA-195-5P

  • Research

Basel A. Abdel-Wahab, Ehab A. M. El-Shoura, Saad Misfer Alqahtani, Hebatallah M. Saad, Marwa B. Bakir, Dalia Zaafar

Friedelin: A natural compound exhibited potent antibacterial, anti-inflammatory, and wound healing properties against MRSA-infected wounds

  • Open Access
  • Research

Riham A. El-Shiekh, Mai Hussin Radi, Rana Elshimy, Essam Abdel-Sattar, Ali M. El-Halawany, Marwa A. Ibrahim, Merhan E. Ali, Eman I. Hassanen

Overexpression of KIF2C amplifies tamoxifen resistance and lung metastasis of breast cancer through PLK1/C-Myc pathway

  • Research

Rui Tian, Jilin Kong, Hongyan Zang, Shuyan Li, Xiangjuan Liu, Yan Cheng, Gaofeng Ni, Liguo Gong

Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India

  • Research

Vijay Kumar, G S Sri Bharathi, Mohit Bhatia, Sankha Shubhra Chakrabarti, Upinder Kaur, Jai Krishn Mishra

D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats

  • Open Access
  • Research

Nergis Ulaş, Hilal Üstündağ, Seçkin Özkanlar, Elif Erbaş, Adem Kara, Yunusemre Özkanlar

Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology

  • Research

Yu-Ting Bai, Yi-Qi Wang, Yan-Min Liu, Zi-Xuan Gong, Suya Wugeng, Wen-Lu Guo, Meng-Zhen Shi, Xiao-Qian Liu, Xiao-Ling Su

Klotho mediates the association between serum testosterone and severe abdominal aortic calcification: a cross-sectional study from the NHANES database

  • Research

Shengwei Lai, Handai Qin, Xinhao Wang, Guanchao Sun, Long Cao, Zheqi Fan, Hongpeng Zhang, Wei Guo

Apoptotic and senolytic effects of hERG/Eag1 channel blockers in combination with temozolomide in human glioblastoma cells

  • Open Access
  • Research

Bodo Haas, Inken Roth, Luisa Säcker, Maria Wos-Maganga, Lea Beltzig, Bernd Kaina

Bibliometric and visual analysis of drug-specific immunotherapy from 1990 to 2024

  • Open Access
  • Research

Zhengjiu Cui, Xiaorui Chen, Siming Zhai, Yuanyuan Wang, Chanchan Hu, Bin Yuan

Effect of dexpanthenol on glycerol-induced acute kidney injury by targeting the PGC-1α/SIRT3 pathway

  • Open Access
  • Research

Fadimana Koyuncu, Filiz Alkaya Solmaz, Kanat Gulle, Ilter Ilhan, Muhammet Yusuf Tepebasi, Eyyup Sabri Ozden, Pakize Kirdemir

Clebopride stimulates 5-HT4-serotonin receptors in the human atrium

  • Open Access
  • Research

Lina Maria Rayo Abella, Joachim Neumann, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs

Nanoformulation of valsartan-loaded tablet attenuates L-NAME-induced hypertension: role of Nrf2/PPARγ/AT1 signaling pathway

  • Open Access
  • Research

Hanan Elimam, Khalid M. El-Say, Tarek A. Ahmed, Sylvie Marleau, Zakaria El-Khayat, Mona El-Banna, Jihan Hussein

Bioequivalence study of perampanel oral suspension in healthy Chinese subjects under fasting and fed conditions

  • Research

Mupeng Li, Yaxing Li, Fangfang Liu, Qian Huang, Xinchu Yi, Jing Xiao, Chunyan Gan, Yangyun Han, Lianlian Fan

Isoliquiritigenin alleviates radiation-induced intestinal injury in lung cancer by inhibiting TNF-α/caspase3 signaling pathway

  • Research

Ya-ping Chen, Liang-liang Shi, Yang-yang Li, Yi-Ming Zhang, Shang-zu Zhang, Hong-dou Hou, Yan Chen, Qi-hong Zhuo, Yong-qi Liu, Ben-jun Wei, Li-ying Zhang

MiR-362-3p mediates IFNα-induced antiviral viability against Enterovirus 71 (EV71)

  • Research

San Wang, Lan Chen, Zongtao Wu, Yingbo Zou, Yunrong Li, Xiang He, Yusong Zhang, Bo Huang

Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways

  • Research

Jing Ji, Ying Li, Tian Xu, Qi Shao, Zijin Sun, Simin Chen, Di Zhang, Qingguo Wang, Xueqian Wang, Chongyang Ma, Fafeng Cheng

Formulation and evaluation of polymeric nanoparticles to improve in vivo chemotherapeutic efficacy of mangiferin against breast cancer

  • Research

Pratik Chakraborty, Ananya Das, Sharmistha Chatterjee, Aparajita Bairagi, Hiranmoy Bhattacharya, Chiranjib Bhattacharyya, Nabanita Chatterjee, Parames C. Sil, Saikat Dewanjee

Bioinformatics-based identification of mirdametinib as a potential therapeutic target for idiopathic pulmonary fibrosis associated with endoplasmic reticulum stress

  • Research

Junwei Chen, Yuhan Du, Qi Yu, Dongyu Liu, Jinming Zhang, Tingyue Luo, Haohua Huang, Shaoxi Cai, Hangming Dong

B-AP15 inhibited colon cancer cell proliferation by decreasing CDK6, Cyclin A, Cyclin E, c-Myc, and VEGF gene expression

  • Research

Thanet Sophonnithiprasert, Sasiwan Konjanthet, Nattanicha Narinnork, Napat Prompat, Soottawat Benjakul, Jirakrit Saetang, Siriphorn Chimplee, Nadeeya Mad-adam, Potchanapond Graidist, Thidarath Rattanaburee

Safranal restores RUNX3-mediated immunoregulation by inhibiting the NLRP3 inflammasome in allergic asthma

  • Research

Xuefeng Zhang, Xuanyi Li, Peng Wang, Shuqin Zhao, Yuanyuan Zhao

The active ingredients and targets of Kouqiangjie formula on periodontitis: a multi-approach study

  • Research

Yeke Wu, Jiawei Li, Min Liu, Ranran Gao, Yunfei Xie, Huijing Li, Li Li

Identification of key immune genes of drug-induced liver injury induced by tolvaptan based on bioinformatics

  • Research

Xiyun Yang, Yuxuan Ming, Zhihui Zhou, Xinyi Zhou, Chaolong Rao

Investigating the therapeutic potential of tryptophan and vitamin A in modulating immune responses in celiac disease: an experimental study

  • Research

Fatemeh Asgari, Abdolrahim Nikzamir, Kaveh Baghaei, Andrea Masotti, Mohammad Rostami-Nejad

Harnessing the metastatic potential of human osteosarcoma cells by natural coumarin galbanic acid

  • Research

Abdolreza Ahmadi, Fatemehsadat Hosseini, Zahra Nasiri Sarvi, Mehrdad Iranshahi, Fatemeh B. Rassouli

Outpatient utilization trend of bronchodilator and anti-inflammatory agents in the pandemic and beyond

  • Open Access
  • Research

N. Ipek Kirmizi Sonmez, Onur Gultekin, Ahmet Akici, Yelda Basbug, Volkan Aydin

Protective potential of bempedoic acid as an AMPK activator in tamoxifen-induced steatohepatitis in rats

  • Open Access
  • Research

Mona Mosaad, Elsayed K. El-Sayed, Engy M. El Morsy

Potent cytotoxicity and induction of ROS-mediated genomic instability, mitochondrial dysfunction, and apoptosis by Y2O3 NPs in Hep-G2 hepatic cancer cells

  • Open Access
  • Research

Hanan R. H. Mohamed, Rawan Essam, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Gehan Safwat, Ayman Diab

Toxicological evaluation of Isosecotanapartholide from Artemisia vulgaris L.: oral acute and sub-acute toxicity in BALB/c mice

  • Research

Nameirakpam Bunindro Singh, Kabrambam Dasanta Singh, Arunkumar S. Koijam, Jharna Chakravorty, Sarita Jena, Saurabh Chawla, Pulok Kumar Mukherjee, Yallappa Rajashekar

The targeting of YAP by kaempferol regulates bone homeostasis and improves osteoporosis in rats

  • Research

Wencheng Liu, Rifu Liu, Yue Yang, Lixue Cheng, Xiaobing Feng, Qinglei Li

Nano-carrier, design, synthesis, in silico ADMET, anti-proliferative assessments and docking of [1,2,4]triazolo[4,3-a]quinoxalines as Topo-II inhibitors and DNA intercalators

  • Research

Ahmed K. B. Aljohani, Sara A. Almadani, Marwa Alsulaimany, Naif Aljuhani, Waad A. Samman, Adel H. Al-Shareef, Read Alghamdi, Saeed M. Tayeb, Hussam Y. Alharbi, Majed S. Aljohani, Khaled El‐Adl, Mo’men Salem

A sesquiterpene lactone, tomentosin, as a novel anticancer agent: orchestrating apoptosis, autophagy, and ER stress in colorectal cancer

  • Open Access
  • Research

Sümeyra Çetinkaya, Ebru Güçlü, İlknur Çınar Ayan, Hasibe Vural, Hatice Gül Dursun

Anti-miRNA- 155 - 5p enhances the cytotoxic efficacy of temozolomide in brain cancer stem cells

  • Open Access
  • Research

Lütfiye Ozpak, Bakiye Göker Bağca, Çiğir Biray Avci, Cumhur Gündüz, Burak Durmaz

DGPT news: Rudolf Buchheim Award 2024

  • Open Access
  • Short Communication

Rebekka Lambrecht

DGPT news: Fritz Külz Award 2024

  • Open Access
  • Short Communication

Edda S. F. Matthees

Analysis of bibliometric research featured in Naunyn–Schmiedeberg’s Archives of Pharmacology

  • Brief Report

Siddig Ibrahim Abdelwahab, Abdullah Farasani, Jobran M. Moshi, Saeed Alshahrani, Waseem Hassan

The 11th International Conference on cGMP 2024: recent trends and developments in cGMP research —meeting report

  • Open Access
  • Meeting Report

Miriam M. Cortese-Krott, Friederike Cuello, Jan R. Kraehling, Michael Russwurm

Retraction Note: CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation

  • Retraction Note

Alireza Mardomi, Nabiallah Mohammadi, Fatemeh Ahmadzadeh, Saeid Abediankenari

Retraction Note: Effect of Danhong injection on pharmacokinetics and pharmacodynamics of rivaroxaban in rats

  • Retraction Note

Weihong Yin, Jiao Li, Zhaoyang Han, Siwen Wang, Fan Wu, Chao Yu, Xueying Yan, Mingyu Cui