Navigating the Diagnostic Labyrinth of Scrofuloderma Orbit in Conjunction with Jungling’s Disease

Tuberculosis (TB) manifests in various forms, including extrapulmonary tuberculosis (EPTB), which poses diagnostic dilemmas due to its wide-ranging clinical presentations. When TB affects the bones of the hands and feet, it can present a diagnostic labyrinth for clinicians. In such cases, the differential diagnosis may include Jungling’s bone disease, adding complexity to the diagnostic process. We present the case of a 12-year-old female with an 8-week history of swelling over the left lower eyelid, initially suggestive of an osteolytic lesion. There was no family history of tuberculosis. The vaccination status was completed as per the age of the patient. Further investigations revealed mesenteric and retroperitoneal lymphadenopathy, raising suspicion of Langerhans cell histiocytosis. However, histopathological examination confirmed granulomatous inflammation consistent with tuberculosis. Concurrently, the patient developed swelling over the distal metaphyseal joint of the right foot with early onset pain, prompting consideration of Jungling’s bone disease in the differential diagnosis. Scrofuloderma, a rare manifestation of tuberculosis (TB), mimicked ocular TB (OTB) in our case, underscoring the complexity of diagnosis. Orbital involvement of TB, especially in pediatric patients, is uncommon, making it challenging to recognize. The manifestation of Jungling’s bone disease further contributes to the rarity and complexity of the diagnosis. Additionally, the presence of submandibular lymphadenopathy added to the diagnostic challenge, emphasizing the necessity for comprehensive evaluation in such cases. This case underscores the importance of considering unusual presentations of TB, especially in endemic regions. Prompt diagnosis and treatment are crucial to prevent morbidity and highlight the significance of a multidisciplinary approach in managing such cases.