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Endocrine

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12.07.2021 | Original Article

NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways

verfasst von: Yujun Li, Junrong Liang, Hui Dang, Rui Zhang, Pu Chen, Yuan Shao

Erschienen in: Endocrine | Ausgabe 1/2022

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Abstract

Purpose

The Nuclear Receptor Coactivator (NCOA3, also known as SRC-3, AIB1, p/CIP, RAC3, ACTR, and TRAM1), acts as an oncogene in multiple tumors, but its biological function in thyroid cancer remains unclear. This study was designed to explore the role of NCOA3 in thyroid cancer.

Methods

The study assessed NCOA3 expression in thyroid cancer and their matched non-cancerous thyroid tissues at mRNA and protein levels. Then we evaluated the effect of NCOA3 on malignant activities of thyroid cancer cells. To better understand the oncogenic role of NCOA3 in thyroid tumorigenesis, we tested the effect of NCOA3 on major proteins related to thyroid cancer.

Results

Our data demonstrated that protein expression of NCOA3 was significantly upregulated in thyroid cancer tissues. NCOA3 knockdown inhibited cell proliferation and invasion, and induced cell cycle arrest and apoptosis in thyroid cancer. Conversely, ectopic expression of NCOA3 promoted cell proliferation and invasiveness in thyroid cancer. Mechanistically, NCOA3 could improve the survival and invasiveness of thyroid cancer cells through the modulation of the ErbB, AKT, ERK, and β-catenin pathways.

Conclusion

Collectively, these findings suggest that NCOA3 is critical in the initiation and development of thyroid cancer, and might be a possible marker for prognosis and therapy.

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Titel: NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways
verfasst von: Yujun Li
Junrong Liang
Hui Dang
Rui Zhang
Pu Chen
Yuan Shao
Publikationsdatum: 12.07.2021
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-021-02819-6

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NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways

Abstract

Purpose

Methods

Results

Conclusion

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