Skip to main content
Erschienen in: Pediatric Surgery International 9/2009

01.09.2009 | Original Article

Neck nodule and thyroid cancer in young without radiation exposure history

Erschienen in: Pediatric Surgery International | Ausgabe 9/2009

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim of this study was to analyze the results of histopathological studies in neck masses observed in young patients. The neck masses were detected using ultrasonography and fine-needle aspiration cytology (FNAC).

Methods

In this retrospective study, we analyzed 234 young patients who were surgically treated for neck masses at Chang Gung Medical Center in Linkou. The mean age of the 234 young patients was 16.3 ± 4.0 years (range 1–20 years). Neck ultrasonography studies were conducted using a real-time ultrasonographic machine and a 10 MHz transducer. FNAC was performed for the suspected neck nodules.

Results

Of the 234 cases, 187 (79.9%) were surgically confirmed to be benign lesions, including four cases that were diagnosed as atypical adenoma. Malignant thyroid masses were identified in 47 patients. Surgery confirmed 22 cases to be lesions that were non-thyroid in origin, including those developing from a cyst, soft tissue, and with a lymphatic origin. Diagnostic accuracies of the FNAC and frozen section examination were found to be 91.1 and 97.7%, respectively.

Conclusions

In the study population, 20.1% of the neck masses were malignant. Except in cases of follicular thyroid neoplasm, neck ultrasonography with FNAC could effectively identify the thyroid or non-thyroid origin of these masses with high-diagnostic accuracy.
Literatur
1.
Zurück zum Zitat Amrikachi M, Ponder TB, Wheeler TM, Smith D, Ramzy I (2005) Thyroid fine-needle aspiration biopsy in children and adolescents: experience with 218 aspirates. Diagn Cytopathol 32:189–192PubMedCrossRef Amrikachi M, Ponder TB, Wheeler TM, Smith D, Ramzy I (2005) Thyroid fine-needle aspiration biopsy in children and adolescents: experience with 218 aspirates. Diagn Cytopathol 32:189–192PubMedCrossRef
2.
Zurück zum Zitat Daneshbod Y, Banani A, Kumar PV (2006) Aberrant thymus and parathyroid gland presenting as a recurrent lateral neck mass: a case report. Ear Nose Throat J 85:452–453PubMed Daneshbod Y, Banani A, Kumar PV (2006) Aberrant thymus and parathyroid gland presenting as a recurrent lateral neck mass: a case report. Ear Nose Throat J 85:452–453PubMed
3.
Zurück zum Zitat Brignardello E, Corrias A, Isolato G et al (2008) Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series. J Clin Endocrinol Metab 93:4840–4843PubMedCrossRef Brignardello E, Corrias A, Isolato G et al (2008) Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series. J Clin Endocrinol Metab 93:4840–4843PubMedCrossRef
4.
Zurück zum Zitat O’Kane P, Shelkovoy E, McConnell RJ et al (2008) Differences in sonographic conspicuity according to papillary thyroid cancer subtype: results of the Ukrainian–American cohort study after the Chornobyl accident. AJR Am J Roentgenol 191:W293–W298PubMedCrossRef O’Kane P, Shelkovoy E, McConnell RJ et al (2008) Differences in sonographic conspicuity according to papillary thyroid cancer subtype: results of the Ukrainian–American cohort study after the Chornobyl accident. AJR Am J Roentgenol 191:W293–W298PubMedCrossRef
5.
Zurück zum Zitat Kuo SF, Chao TC, Chang HY et al (2009) The role of radioactive iodine therapy in young patients with papillary thyroid cancer. Clin Nucl Med 34:4–6PubMedCrossRef Kuo SF, Chao TC, Chang HY et al (2009) The role of radioactive iodine therapy in young patients with papillary thyroid cancer. Clin Nucl Med 34:4–6PubMedCrossRef
6.
Zurück zum Zitat Popovtzer A, Shpitzer T, Bahar G, Feinmesser R, Segal K (2006) Thyroid cancer in children: management and outcome experience of a referral center. Otolaryngol Head Neck Surg 135:581–584PubMedCrossRef Popovtzer A, Shpitzer T, Bahar G, Feinmesser R, Segal K (2006) Thyroid cancer in children: management and outcome experience of a referral center. Otolaryngol Head Neck Surg 135:581–584PubMedCrossRef
7.
Zurück zum Zitat Schlumberger M, De Vathaire F, Travagli JP et al (1987) Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab 65:1088–1094PubMedCrossRef Schlumberger M, De Vathaire F, Travagli JP et al (1987) Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab 65:1088–1094PubMedCrossRef
8.
Zurück zum Zitat Lin JD, Huang BY, Weng HF et al (1997) Thyroid ultrasonography with the fine needle aspiration cytology for the diagnosis of thyroid cancer. J Clin Ultrasound 25:111–118PubMedCrossRef Lin JD, Huang BY, Weng HF et al (1997) Thyroid ultrasonography with the fine needle aspiration cytology for the diagnosis of thyroid cancer. J Clin Ultrasound 25:111–118PubMedCrossRef
9.
Zurück zum Zitat Magnanti BL, Tevfik Dorak M, et al (2009) Geographical analysis of thyroid cancer in young people from northern England: evidence for a sustained excess in females in Cumbria. Eur J Cancer [Epub ahead of print] Magnanti BL, Tevfik Dorak M, et al (2009) Geographical analysis of thyroid cancer in young people from northern England: evidence for a sustained excess in females in Cumbria. Eur J Cancer [Epub ahead of print]
10.
Zurück zum Zitat Kim DW, Lee EJ, Kim SH et al (2009) Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules: comparison in efficacy according to nodule size. Thyroid 19:27–31PubMedCrossRef Kim DW, Lee EJ, Kim SH et al (2009) Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules: comparison in efficacy according to nodule size. Thyroid 19:27–31PubMedCrossRef
11.
Zurück zum Zitat Porterfield JR Jr, Grant CS, Dean DS et al (2008) Reliability of benign fine needle aspiration cytology of large thyroid nodules. Surgery 144:963–968PubMedCrossRef Porterfield JR Jr, Grant CS, Dean DS et al (2008) Reliability of benign fine needle aspiration cytology of large thyroid nodules. Surgery 144:963–968PubMedCrossRef
12.
Zurück zum Zitat Inskip PD (2001) Thyroid cancer after radiotherapy for childhood cancer. Med Pediatr Oncol 36:568–573PubMedCrossRef Inskip PD (2001) Thyroid cancer after radiotherapy for childhood cancer. Med Pediatr Oncol 36:568–573PubMedCrossRef
13.
Zurück zum Zitat Elisei R, Romei C, Vorontsova T et al (2001) RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86:3211–3216PubMedCrossRef Elisei R, Romei C, Vorontsova T et al (2001) RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86:3211–3216PubMedCrossRef
14.
Zurück zum Zitat Nishiyama RH, Schmidt RW, Batsakis JG (1962) Carcinoma of thyroid gland in children and adolescents. J Am Med Assoc 181:1034–1038 Nishiyama RH, Schmidt RW, Batsakis JG (1962) Carcinoma of thyroid gland in children and adolescents. J Am Med Assoc 181:1034–1038
15.
Zurück zum Zitat Hrafnkelsson J, Jonasson JG, Sigurdsson G et al (1988) Thyroid cancer in Iceland 1955–1984. Acta Endocrinol 118:566–572PubMed Hrafnkelsson J, Jonasson JG, Sigurdsson G et al (1988) Thyroid cancer in Iceland 1955–1984. Acta Endocrinol 118:566–572PubMed
16.
Zurück zum Zitat Tallroth E, Bäckdahl M, Einhorn J et al (1986) Thyroid carcinoma in children and adolescents. Cancer 58:2329–2332PubMedCrossRef Tallroth E, Bäckdahl M, Einhorn J et al (1986) Thyroid carcinoma in children and adolescents. Cancer 58:2329–2332PubMedCrossRef
17.
Zurück zum Zitat Quimby EH, Werner SC (1949) Late radiation effects in roentgen therapy for hyperthyroidism. J Am Med Assoc 140:1046–1047 Quimby EH, Werner SC (1949) Late radiation effects in roentgen therapy for hyperthyroidism. J Am Med Assoc 140:1046–1047
18.
Zurück zum Zitat Samuel AM, Sharma SM (1991) Differentiated thyroid carcinomas in children and adolescents. Cancer 67:2186–2190PubMedCrossRef Samuel AM, Sharma SM (1991) Differentiated thyroid carcinomas in children and adolescents. Cancer 67:2186–2190PubMedCrossRef
19.
Zurück zum Zitat Belge G, Thode B, Bartnitzke S, Bullerdiek J (1994) Cytogenetic biclonality corresponding to multiphasic differentiation in an atypical thyroid adenoma. Cancer Genet Cytogenet 78:102–104PubMedCrossRef Belge G, Thode B, Bartnitzke S, Bullerdiek J (1994) Cytogenetic biclonality corresponding to multiphasic differentiation in an atypical thyroid adenoma. Cancer Genet Cytogenet 78:102–104PubMedCrossRef
20.
Zurück zum Zitat Sarquis MS, Weber F, Shen L et al (2006) High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab 91:262–269PubMedCrossRef Sarquis MS, Weber F, Shen L et al (2006) High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. J Clin Endocrinol Metab 91:262–269PubMedCrossRef
21.
Zurück zum Zitat Tzen CY, Huang YW, Fu YS (2003) Is atypical follicular adenoma of the thyroid a preinvasive malignancy? Hum Pathol 34:666–669PubMedCrossRef Tzen CY, Huang YW, Fu YS (2003) Is atypical follicular adenoma of the thyroid a preinvasive malignancy? Hum Pathol 34:666–669PubMedCrossRef
22.
Zurück zum Zitat Chennupati SK, Schipor I, Mirza N (2006) Microdebrider decompression of schwannoma: a novel method of excising a neck mass. Laryngoscope 116:2086–2088PubMedCrossRef Chennupati SK, Schipor I, Mirza N (2006) Microdebrider decompression of schwannoma: a novel method of excising a neck mass. Laryngoscope 116:2086–2088PubMedCrossRef
23.
Zurück zum Zitat Al-Shaikhi A, Kay S, Laberge JM (2003) External jugular venous aneurysm: an unusual cause of neck mass in a young child. J Pediatr Surg 38:1557–1559PubMedCrossRef Al-Shaikhi A, Kay S, Laberge JM (2003) External jugular venous aneurysm: an unusual cause of neck mass in a young child. J Pediatr Surg 38:1557–1559PubMedCrossRef
24.
Zurück zum Zitat Kim HS, Lee HK, Weon YC, Kim HJ (2005) Alveolar soft-part sarcoma of the head and neck: clinical and imaging features in five cases. Am J Neuroradiol 26:1331–1335PubMed Kim HS, Lee HK, Weon YC, Kim HJ (2005) Alveolar soft-part sarcoma of the head and neck: clinical and imaging features in five cases. Am J Neuroradiol 26:1331–1335PubMed
25.
Zurück zum Zitat Wang J, Heffner DK, Venegas R, French SW (1999) Atypical chondroma of the cricoid cartilage: fine needle aspiration cytology and histopathologic findings. Diagn Cytopathol 20:164–166PubMedCrossRef Wang J, Heffner DK, Venegas R, French SW (1999) Atypical chondroma of the cricoid cartilage: fine needle aspiration cytology and histopathologic findings. Diagn Cytopathol 20:164–166PubMedCrossRef
Metadaten
Titel
Neck nodule and thyroid cancer in young without radiation exposure history
Publikationsdatum
01.09.2009
Erschienen in
Pediatric Surgery International / Ausgabe 9/2009
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-009-2416-9

Weitere Artikel der Ausgabe 9/2009

Pediatric Surgery International 9/2009 Zur Ausgabe

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.