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01.12.2016 | Case report | Ausgabe 1/2016 Open Access

BMC Ophthalmology 1/2016

Necrotizing herpetic retinopathy in an immune-compromised pediatric patient with minimal signs of inflammation: case report

BMC Ophthalmology > Ausgabe 1/2016
Soon Il Choi, Jae Ryun Kim, Ho Ra


To report a case of necrotizing herpetic retinopathy(NHR) in an immuno-compromised pediatric patient.

Case presentation

An 11-year-old boy presented with a minimal ocular foreign-body sensation and peripheral visual-field defect, as well as mild upper respiratory symptoms. He had undergone the Fontan operation for a ventricular septal defect and single ventricle during infancy, and had been taking oral steroids for 1 year immediately prior to his presentation to treat protein-losing enteropathy. Initially, a case of either cytomegalovirus (CMV) retinitis or acute retinal necrosis (ARN) was suspected, and an intravenous course of ganciclovir and acyclovir was therefore initiated. During treatment, varicella-zoster virus (VZV) was detected in the anterior chamber, and ARN was confirmed when both serum and aqueous humor were found by polymerase chain reaction (PCR) to be positive for VZV DNA. A peripheral retinal break and detachment developed after medical treatment, and a vitrectomy was performed.


Typically, ARN is found in both healthy individuals and subclinically immuno-compromised patients of any age. CMV retinitis is somewhat more typical for immuno-compromised patients. Herein, we report a case of NHR in a pediatric patient with poor general condition and showing minimal signs of inflammation.
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