Skip to main content
Erschienen in: The journal of nutrition, health & aging 6/2019

12.05.2019

Negative Association of Serum Uric Acid with Peripheral Blood Cellular Aging Markers

verfasst von: J. Yu, H. Liu, S. He, P. Li, C. Ma, F. Ping, H. Zhang, W. Li, Q. Sun, M. Ma, Y. Liu, L. Lv, Lingling Xu, Yuxiu Li

Erschienen in: The journal of nutrition, health & aging | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Objectives

We aimed to explore the association between serum UA and cellular aging markers.

Design

The current cross-sectional analysis was based on data collected within a type 2 diabetes project.

Settings

Serum uric acid (UA), which has both antioxidant and pro-oxidant properties, is thought to be involved in cellular aging processes.

Participants

There are 536 participants included in total, 65.3% of which are women. The average serum UA in women was 267.8 umol/l, lower than in men of 337.7 umol/l (P<0.001).

Measurements

Serum UA, blood lipid profile, HbA1c, plasma glucose and insulin were determined. The peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) were assessed using a real-time PCR assay. Logistic regressions were used to analyze the associations between serum UA and cellular aging markers.

Results

In Spearman’s correlation analysis, there were significantly negative correlations between serum UA and LTL in both women and men (r=−0.162, P=0.006; and r=−0.232, P=0.004, respectively). The logistic regression adjusted for age, BMI, WC, daily energy intake, HbA1c, TG, and LDL-C revealed that the ORs of shorter LTL comparing the extreme serum UA quintiles was 5.52 (95% CI 1.69–18.02; P for trend =0.025) in women and 6.49 (95% CI 1.38–30.45; P for trend =0.108) in men. Furthermore, the OR (95% CI) for shorter LTL per 1 SD increment in serum UA was 1.51(1.10–2.07) in women and 1.64(1.01–2.65) in men. In regard to mtDNAcn, the association between elevated serum UA and lower mtDNAcn only reached significance in men when comparing the second and fifth quintiles with reference quintile (OR=3.73(1.07–13.04) and 3.76(1.01–14.09), separately, and P for trend=0.066).

Conclusions

Our results indicate a significant negative association between serum UA and peripheral blood cellular aging markers. Serum UA might play a role in promoting cellular aging.
Literatur
2.
Zurück zum Zitat Mengel-From J, Thinggaard M, Dalgård C et al. Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly. Hum Genet. 2014;133(9):1149–1159CrossRefPubMedPubMedCentral Mengel-From J, Thinggaard M, Dalgård C et al. Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly. Hum Genet. 2014;133(9):1149–1159CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Yu M, Sánchez-Lozada LG, Johnson RJ, Kang D. Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens. 2010:1 Yu M, Sánchez-Lozada LG, Johnson RJ, Kang D. Oxidative stress with an activation of the renin–angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens. 2010:1
4.
Zurück zum Zitat Révész D, Verhoeven JE, Milaneschi Y et al. Dysregulated physiological stress systems and accelerated cellular aging. Neurobiol Aging. 2014;35(6):1422–1430CrossRefPubMed Révész D, Verhoeven JE, Milaneschi Y et al. Dysregulated physiological stress systems and accelerated cellular aging. Neurobiol Aging. 2014;35(6):1422–1430CrossRefPubMed
5.
Zurück zum Zitat Dei Cas A, Spigoni V, Franzini L et al. Lower endothelial progenitor cell number, family history of cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length in healthy young adults. Nutrition, Metabolism and Cardiovascular Diseases. 2013;23(3):272–278CrossRefPubMed Dei Cas A, Spigoni V, Franzini L et al. Lower endothelial progenitor cell number, family history of cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length in healthy young adults. Nutrition, Metabolism and Cardiovascular Diseases. 2013;23(3):272–278CrossRefPubMed
6.
Zurück zum Zitat de Vos-Houben JMJ, Ottenheim NR, Kafatos A et al. Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete. Mech Ageing Dev. 2012;133(6):373–377CrossRefPubMed de Vos-Houben JMJ, Ottenheim NR, Kafatos A et al. Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete. Mech Ageing Dev. 2012;133(6):373–377CrossRefPubMed
7.
Zurück zum Zitat Zhou M, Zhu L, Cui X et al. Reduced peripheral blood mtDNA content is associated with impaired glucose-stimulated isletβ cell function in a Chinese population with different degrees of glucose tolerance. Diabetes/Metabolism Research and Reviews. 2016;32(7):768–774CrossRefPubMedPubMedCentral Zhou M, Zhu L, Cui X et al. Reduced peripheral blood mtDNA content is associated with impaired glucose-stimulated isletβ cell function in a Chinese population with different degrees of glucose tolerance. Diabetes/Metabolism Research and Reviews. 2016;32(7):768–774CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Zhou M, Zhu L, Cui X et al. Influence of diet on leukocyte telomere length, markers of inflammation and oxidative stress in individuals with varied glucose tolerance: a Chinese population study. Nutr J. 2015;15(1) Zhou M, Zhu L, Cui X et al. Influence of diet on leukocyte telomere length, markers of inflammation and oxidative stress in individuals with varied glucose tolerance: a Chinese population study. Nutr J. 2015;15(1)
10.
11.
Zurück zum Zitat Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458CrossRefPubMed Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458CrossRefPubMed
12.
Zurück zum Zitat von Zglinicki T, Bürkle A, Kirkwood TBL. Stress, DNA damage and ageing — an integrative approach. Exp Gerontol. 2001;36(7):1049–1062CrossRefPubMed von Zglinicki T, Bürkle A, Kirkwood TBL. Stress, DNA damage and ageing — an integrative approach. Exp Gerontol. 2001;36(7):1049–1062CrossRefPubMed
13.
Zurück zum Zitat von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27(7):339–344CrossRefPubMed von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27(7):339–344CrossRefPubMed
14.
Zurück zum Zitat Bekaert S, De Meyer T, Rietzschel ER et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell. 2007;6(5):639–647CrossRefPubMed Bekaert S, De Meyer T, Rietzschel ER et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell. 2007;6(5):639–647CrossRefPubMed
15.
Zurück zum Zitat Panel M, Ghaleh B, Morin D. Mitochondria and aging: A role for the mitochondrial transition pore? Aging Cell. 2018:e12793 Panel M, Ghaleh B, Morin D. Mitochondria and aging: A role for the mitochondrial transition pore? Aging Cell. 2018:e12793
16.
Metadaten
Titel
Negative Association of Serum Uric Acid with Peripheral Blood Cellular Aging Markers
verfasst von
J. Yu
H. Liu
S. He
P. Li
C. Ma
F. Ping
H. Zhang
W. Li
Q. Sun
M. Ma
Y. Liu
L. Lv
Lingling Xu
Yuxiu Li
Publikationsdatum
12.05.2019
Verlag
Springer Paris
Erschienen in
The journal of nutrition, health & aging / Ausgabe 6/2019
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-019-1200-3

Weitere Artikel der Ausgabe 6/2019

The journal of nutrition, health & aging 6/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.