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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.04.2015 | Assisted Reproduction Technologies

Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device

verfasst von: Hideyuki Iwahata, Shu Hashimoto, Masayasu Inoue, Tomoko Inoue, Keijiro Ito, Yoshiharu Nakaoka, Nao Suzuki, Yoshiharu Morimoto

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 4/2015

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Abstract

Purpose

Closed vitrification poses a risk of adversely affecting embryo development, while it may minimize the risk of contamination. We assessed the effects of closed-system human embryo vitrification on fetal development after implantation, neonatal outcome, and clinical safety.

Methods

This was a retrospective cohort study conducted at a private fertility clinic. A total of 875 vitrified-warmed blastocysts that were single-transferred under hormone-replacement cycles between November 2011 and December 2013 were randomly divided into two groups (closed vitrification, n 313; open vitrification, n 562) after receiving the patients’ consent forms. Developmental competence after implantation, including gestational age, birth weight, sex, Apgar score, and anomalies of newborns, after the transfer of blastocysts vitrified by closing vitrification was compared with that obtained in the case of open vitrification.

Results

There were no significant differences between the use of closed and open vitrification systems in embryo development after implantation, gestational age, birth weight, sex ratio, Apgar score, and congenital anomalies of newborns.

Conclusion

Human embryos can be vitrified using a closed vitrification system without impairment of neonatal development.

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Titel: Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device
verfasst von: Hideyuki Iwahata
Shu Hashimoto
Masayasu Inoue
Tomoko Inoue
Keijiro Ito
Yoshiharu Nakaoka
Nao Suzuki
Yoshiharu Morimoto
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 4/2015
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-015-0431-4

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Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device

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