Skip to main content
main-content

07.01.2021 | Original Article | Ausgabe 1/2021

Comparative Clinical Pathology 1/2021

Nephro-protective efficacy of Blighia sapida stem bark ether fractions on experimentally induced diabetes nephropathy

Zeitschrift:
Comparative Clinical Pathology > Ausgabe 1/2021
Autoren:
Damilola A. Omoboyowa, Kayode O. Karigidi, Temitope C. Aribigbola
Wichtige Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Studies suggest that Blighia sapida (B. sapida) possesses hypoglycemic potential. The potentials of B. sapida to ameliorate diabetic complications including diabetic nephropathy are yet to be established. This present research therefore investigated the role of B. sapida in renal functions of STZ-induced diabetes rats. Petroleum and diethyl ether fractions of B. sapida’s (PEFBS and DEFBS) stem bark were used in this study. Diabetes was induced by intraperitoneal injection of 50 mg/kg b. w. of STZ singly. Short-term effects of PEFBS and DEFBS at 100 mg/kg and 200 mg/kg b. w. and metformin (5 mg/kg b.w) were studied in diabetic-induced rats administered once per day for 2 weeks. The renal functions were assessed by biochemical, histological, and gene expression analysis using standard procedure. PEFBS and DEFBS significantly (P < 0.05) reduced the concentration of blood glucose of diabetic-induced rats after days 7, 11, and 14 of treatment compared to diabetic rats administered 2 ml/kg b. w. of normal saline. The PEFBS and DEFBS at 100 mg/kg and 200 mg/kg b.w. downregulated NGAL, KIM-1, and cystatin c genes in kidney tissues of diabetic-induced rats compared to diabetic rats administered 2 ml/kg b. w. of normal saline. Also, concomitant significant reduction in urea and protein concentration in diabetic rats treated with 100 mg/kg b.w of PEFBS and DEFBS and 200 mg/kg b.w of PEFBS were observed compared to diabetic rats administered 2 ml/kg b. w. of normal saline. These results suggested that B. sapida stem bark does not only possess hypoglycemic efficacy but was able to protect kidney functions during diabetes pathogenesis. Therefore, it could be used therapeutically against processes associated with nephrotic dysfunction in STZ-induced diabetes rats.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2021

Comparative Clinical Pathology 1/2021 Zur Ausgabe

Neu im Fachgebiet Pathologie

14.04.2021 | Schwerpunkt: Neue WHO-Klassifikationen und Digitales Lernen | Ausgabe 3/2021

Digitale Lehre im Fach Pathologie

06.04.2021 | Nierenkarzinom | Schwerpunkt: Neue WHO-Klassifikationen und Digitales Lernen | Ausgabe 3/2021

Histologische Subtypen des Nierenzellkarzinoms

Übersicht und neue Entwicklungen

06.04.2021 | Sarkome | Schwerpunkt: Neue WHO-Klassifikationen und Digitales Lernen | Ausgabe 3/2021

Neues in der aktuellen WHO-Klassifikation (2020) für Weichgewebssarkome