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Erschienen in: Der Nervenarzt 10/2021

20.09.2021 | Nervenheilkundliche Therapieverfahren | CME

Komplexes regionales Schmerzsyndrom – ein Update

verfasst von: MD Dr. med. Cora Rebhorn, PhD Dr. Violeta Dimova, MD Univ.-Prof. Dr. Frank Birklein

Erschienen in: Der Nervenarzt | Ausgabe 10/2021

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Zusammenfassung

Das komplexe regionale Schmerzsyndrom (CRPS) ist eine Schmerzerkrankung, die sich an Hand oder Fuß nach Verletzung entwickelt. Derzeit wird zwischen 2 CRPS-Typen, dem CRPS I ohne und dem CRPS II mit Nervenläsion sowie zwischen einem initial warmen und einem initial kalten Subtyp in Abhängigkeit vom klinischen Erscheinungsbild differenziert. Nach einem Trauma ist eine gewisse Entzündungsreaktion als physiologisch zu betrachten. Beim akuten CRPS persistiert diese Entzündung über Monate und wird von diversen Entzündungsmediatoren im peripheren Gewebe und im Blut unterhalten. Diese anhaltende Entzündung führt zu einer Sensibilisierung des nozizeptiven Systems, lässt Somazellen proliferieren und ruft eine gestörte Endothelfunktion hervor. Das Behandlungskonzept zielt auf eine Antagonisierung der pathophysiologischen Komponenten ab und umfasst eine antiinflammatorische und analgetische Behandlung sowie die Verhinderung der Nichtnutzung und die Wiederherstellung der sensomotorischen Funktion der erkrankten Extremität.
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Metadaten
Titel
Komplexes regionales Schmerzsyndrom – ein Update
verfasst von
MD Dr. med. Cora Rebhorn
PhD Dr. Violeta Dimova
MD Univ.-Prof. Dr. Frank Birklein
Publikationsdatum
20.09.2021
Verlag
Springer Medizin
Erschienen in
Der Nervenarzt / Ausgabe 10/2021
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-021-01186-x