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Pediatric Cardiology

Erschienen in:

01.02.2006

Nesiritide Use for Critically Ill Children Awaiting Cardiac Transplantation

verfasst von: R. Sehra, K. Underwood

Erschienen in: Pediatric Cardiology | Ausgabe 1/2006

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Abstract

Background

This study aimed to explore the effects of nesiritide in children awaiting cardiac transplantation.

Methods

At the discretion of the attending physician, nesiritide was added to standard therapy for seven children (median age, 11 months) and continued until clinical improvement or transplantation. Blood pressure and urine output data were compared with data from the day before nesiritide institution. Safety parameters were assessed throughout the study.

Results

Urine output increased from 2.6 to 3.6 ml/kg/h (p = 0.04). No significant blood pressure changes or adverse effects related to nesiritide were noted.

Conclusion

Nesiritide may be safe and effective for children with severe heart failure.

Bufler, J, Emerman, C, Peacock, WF, Mathur, VS, Young, JB: 2004on behalf of the VMAC Study Investigators: The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failureNephrol Dial Transplant19391399CrossRef

Emerman, CL 2002Safety and efficacy of nesiritide for the treatment of decompensated heart failureRev Cardiovasc Med3S28S34PubMed

Emerman, CL, Peacock, WF, Silver, MA: 2003on behalf of the PROACTION study group Nesiritide added to standard care results in favorable reductions in systolic blood pressure and heart rate compared to standard care alone [abstract 221]J Card Fail9S61CrossRef

Gajarski, RJ, Rosenblatt, H, Frazier, OH 1998Pediatric cardiac transplantationGarson, AJBricker, JTFisher, DJNeish, SR eds. The science and practice of pediatric cardiologyWilliams & Wilkins:Baltimore. 25152540

Marshall, J, Berkenbosch, JW, Russo, P, Tobias, JD 2004Preliminary experience with nesiritide in the pediatric populationIntensive Care Med19164170CrossRef

McBride, BF, White, CMI: 2003Acute decompensated heart failure: A contemporary approach to pharmacotherapeutic managementPharmacotherapy239971020CrossRefPubMed

Moazami, N, Damiano, RJ, Bailey, MS, et al. 2003Nesiritide (BNP) in the management of postoperative cardiac patientsAnn Thorac Surg7519741976CrossRefPubMed

Morrow, WR: 2000Cardiomyopathy and heart transplantation in childrenCurr Opin Cardiol15216223CrossRefPubMed

Ohuchi, H, Takasugi, H, Ohashi, H, et al. 2003Stratification of pediatric heart failure on the basis of neurohormonal and cardiac autonomic nervous activities in patients with congenital heart diseaseCirculation10823682376CrossRefPubMed

10.

Tann, SM: 2003B-natriuretic peptide improves hemodynamics and renal function in heart transplant patients immediately after surgery [abstract 257]J Heart Lung Transplant22S157CrossRef

11.

Tann SM, Uber W, VanBakel AB, et al.: (2002) Nesiritide as an adjunct to the treatment of decompensated heart failure immediately after cardiac transplantation [poster 710]. Presented at the American Transplant Congress, Washington, DC, April 26–May 1

12.

Witteles R, Matsuda K, Fowler M: (2003) Utility of prolonged B-type natriuretic peptide infusions in patients prior to heart transplantation [abstract 176]. Presented at the American Transplant Congress 2003, Washington, DC, June 1

Titel: Nesiritide Use for Critically Ill Children Awaiting Cardiac Transplantation
verfasst von: R. Sehra
K. Underwood
Publikationsdatum: 01.02.2006
Verlag: Springer New York
Erschienen in: Pediatric Cardiology / Ausgabe 1/2006
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-005-0984-6

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Springer Medizin

Nesiritide Use for Critically Ill Children Awaiting Cardiac Transplantation

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

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Conclusion

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