Skip to main content
Erschienen in: Der Ophthalmologe 2/2018

13.11.2017 | Trockenes Auge | Leitthema

Neue aktuelle und zukünftige Therapieoptionen in der Behandlung des trockenen Auges

verfasst von: Prof. Dr. E. M. Messmer

Erschienen in: Die Ophthalmologie | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das trockene Auge wurde im Mai 2017 vom „Dry Eye Workshop – DEWSII“ neu definiert. Dementsprechend handelt es sich um eine „multifaktorielle Erkrankung der Augenoberfläche, gekennzeichnet durch einen Verlust der Homöostase des Tränenfilms und verbunden mit okulären Symptomen“. Die aktuelle Definition umfasst ätiologische Faktoren wie eine Instabilität und Hyperosmolarität des Tränenfilms, Entzündung und Schädigung der Augenoberfläche sowie – als neuen Aspekt im Vergleich zur alten Definition – neuronale Störungen. Aktuelle und zukünftige Therapieoptionen zielen auf die Behandlung der oben beschriebenen pathogenetischen Ereignisse ab. Neue Tränenersatzprodukte, Medikamente und Instrumente zur Tränenfilmstimulation, innovative antientzündliche Therapien, Medikamente zur Beeinflussung der kornealen Innervation und neue Methoden zur Behandlung der meibom-Drüsen-Dysfunktion stehen bereits jetzt oder in der nahen Zukunft zur Verfügung.
Literatur
1.
Zurück zum Zitat Messmer EM (2015) The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int 112:71–81 (quiz 82)PubMedPubMedCentral Messmer EM (2015) The pathophysiology, diagnosis, and treatment of dry eye disease. Dtsch Arztebl Int 112:71–81 (quiz 82)PubMedPubMedCentral
2.
Zurück zum Zitat Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–589CrossRefPubMed Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–589CrossRefPubMed
3.
Zurück zum Zitat Heiligenhaus A, Koch JM, Kruse FE, Schwarz C, Waubke TN (1995) Diagnosis and and differentiation of dry eye disorders. Ophthalmologe 92:6–11PubMed Heiligenhaus A, Koch JM, Kruse FE, Schwarz C, Waubke TN (1995) Diagnosis and and differentiation of dry eye disorders. Ophthalmologe 92:6–11PubMed
4.
Zurück zum Zitat Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD (2012) Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea 31:472–478CrossRefPubMed Lemp MA, Crews LA, Bron AJ, Foulks GN, Sullivan BD (2012) Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study. Cornea 31:472–478CrossRefPubMed
5.
Zurück zum Zitat Tong L, Chaurasia SS, Mehta JS, Beuerman RW (2010) Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore. Invest Ophthalmol Vis Sci 51:3449–3454CrossRefPubMed Tong L, Chaurasia SS, Mehta JS, Beuerman RW (2010) Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore. Invest Ophthalmol Vis Sci 51:3449–3454CrossRefPubMed
6.
Zurück zum Zitat Jones L, Downie LE, Korb D et al (2017) TFOS DEWS II management and therapy report. Ocul Surf 15:575–628CrossRefPubMed Jones L, Downie LE, Korb D et al (2017) TFOS DEWS II management and therapy report. Ocul Surf 15:575–628CrossRefPubMed
7.
Zurück zum Zitat Barabino S, Rolando M, Nardi M, Bonini S, Aragona P, Traverso CE (2014) The effect of an artificial tear combining hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome: a new treatment for dry eye. Eur J Ophthalmol 24:173–178CrossRefPubMed Barabino S, Rolando M, Nardi M, Bonini S, Aragona P, Traverso CE (2014) The effect of an artificial tear combining hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome: a new treatment for dry eye. Eur J Ophthalmol 24:173–178CrossRefPubMed
8.
Zurück zum Zitat Cohen S, Martin A, Sall K (2014) Evaluation of clinical outcomes in patients with dry eye disease using lubricant eye drops containing polyethylene glycol or carboxymethylcellulose. Clin Ophthalmol 8:157–164PubMed Cohen S, Martin A, Sall K (2014) Evaluation of clinical outcomes in patients with dry eye disease using lubricant eye drops containing polyethylene glycol or carboxymethylcellulose. Clin Ophthalmol 8:157–164PubMed
9.
Zurück zum Zitat Diaz-Valle D, Arriola-Villalobos P, Garcia-Vidal SE et al (2012) Effect of lubricating eyedrops on ocular light scattering as a measure of vision quality in patients with dry eye. J Cataract Refract Surg 38:1192–1197CrossRefPubMed Diaz-Valle D, Arriola-Villalobos P, Garcia-Vidal SE et al (2012) Effect of lubricating eyedrops on ocular light scattering as a measure of vision quality in patients with dry eye. J Cataract Refract Surg 38:1192–1197CrossRefPubMed
10.
Zurück zum Zitat Doughty MJ (2014) Fluorescein-tear breakup time as an assessment of efficacy of tear replacement therapy in dry eye patients: a systematic review and meta-analysis. Ocul Surf 12:100–111CrossRefPubMed Doughty MJ (2014) Fluorescein-tear breakup time as an assessment of efficacy of tear replacement therapy in dry eye patients: a systematic review and meta-analysis. Ocul Surf 12:100–111CrossRefPubMed
11.
Zurück zum Zitat Lee JH, Ahn HS, Kim EK, Kim TI (2011) Efficacy of sodium hyaluronate and carboxymethylcellulose in treating mild to moderate dry eye disease. Cornea 30:175–179CrossRefPubMed Lee JH, Ahn HS, Kim EK, Kim TI (2011) Efficacy of sodium hyaluronate and carboxymethylcellulose in treating mild to moderate dry eye disease. Cornea 30:175–179CrossRefPubMed
12.
Zurück zum Zitat Zhang Y, Potvin R, Gong L (2013) A study of the short-term effect of artificial tears on contrast sensitivity in patients with Sjogren’s syndrome. Invest Ophthalmol Vis Sci 54:7977–7982CrossRefPubMed Zhang Y, Potvin R, Gong L (2013) A study of the short-term effect of artificial tears on contrast sensitivity in patients with Sjogren’s syndrome. Invest Ophthalmol Vis Sci 54:7977–7982CrossRefPubMed
14.
Zurück zum Zitat Schmidt TA, Sullivan DA, Knop E et al (2013) Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface. JAMA Ophthalmol 131:766–776CrossRefPubMed Schmidt TA, Sullivan DA, Knop E et al (2013) Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface. JAMA Ophthalmol 131:766–776CrossRefPubMed
15.
Zurück zum Zitat Alquraini A, Garguilo S, D’Souza G et al (2015) The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid. Arthritis Res Ther 17:353CrossRefPubMedPubMedCentral Alquraini A, Garguilo S, D’Souza G et al (2015) The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid. Arthritis Res Ther 17:353CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Iqbal SM, Leonard C, Regmi SC et al (2016) Lubricin/Proteoglycan 4 binds to and regulates the activity of toll-like receptors in vitro. Sci Rep 6:18910CrossRefPubMedPubMedCentral Iqbal SM, Leonard C, Regmi SC et al (2016) Lubricin/Proteoglycan 4 binds to and regulates the activity of toll-like receptors in vitro. Sci Rep 6:18910CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Lambiase A, Sullivan BD, Schmidt TA et al (2017) A two-week, randomized, double-masked study to evaluate safety and efficacy of Lubricin (150 mug/mL) eye drops versus sodium hyaluronate (HA) 0.18 % eye drops (Vismed(R)) in patients with moderate dry eye disease. Ocul Surf 15:77–87CrossRefPubMed Lambiase A, Sullivan BD, Schmidt TA et al (2017) A two-week, randomized, double-masked study to evaluate safety and efficacy of Lubricin (150 mug/mL) eye drops versus sodium hyaluronate (HA) 0.18 % eye drops (Vismed(R)) in patients with moderate dry eye disease. Ocul Surf 15:77–87CrossRefPubMed
18.
Zurück zum Zitat Kamiya K, Nakanishi M, Ishii R et al (2012) Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Eye (Lond) 26:1363–1368CrossRef Kamiya K, Nakanishi M, Ishii R et al (2012) Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: a prospective, randomized, multicenter study. Eye (Lond) 26:1363–1368CrossRef
19.
Zurück zum Zitat Koh S, Ikeda C, Takai Y, Watanabe H, Maeda N, Nishida K (2013) Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye. Jpn J Ophthalmol 57:440–446CrossRefPubMed Koh S, Ikeda C, Takai Y, Watanabe H, Maeda N, Nishida K (2013) Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye. Jpn J Ophthalmol 57:440–446CrossRefPubMed
20.
Zurück zum Zitat Matsumoto Y, Ohashi Y, Watanabe H, Tsubota K (2012) Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial. Ophthalmology 119:1954–1960CrossRefPubMed Matsumoto Y, Ohashi Y, Watanabe H, Tsubota K (2012) Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial. Ophthalmology 119:1954–1960CrossRefPubMed
21.
Zurück zum Zitat Nakamura M, Imanaka T, Sakamoto A (2012) Diquafosol ophthalmic solution for dry eye treatment. Adv Ther 29:579–589CrossRefPubMed Nakamura M, Imanaka T, Sakamoto A (2012) Diquafosol ophthalmic solution for dry eye treatment. Adv Ther 29:579–589CrossRefPubMed
22.
Zurück zum Zitat Shimazaki-Den S, Iseda H, Dogru M, Shimazaki J (2013) Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. Cornea 32:1120–1125CrossRefPubMed Shimazaki-Den S, Iseda H, Dogru M, Shimazaki J (2013) Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. Cornea 32:1120–1125CrossRefPubMed
23.
Zurück zum Zitat Takamura E, Tsubota K, Watanabe H, Ohashi Y (2012) A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol 96:1310–1315CrossRefPubMedPubMedCentral Takamura E, Tsubota K, Watanabe H, Ohashi Y (2012) A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol 96:1310–1315CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Kinoshita S, Awamura S, Nakamichi N, Suzuki H, Oshiden K, Yokoi N (2014) A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye. Am J Ophthalmol 157:576–583.e1CrossRefPubMed Kinoshita S, Awamura S, Nakamichi N, Suzuki H, Oshiden K, Yokoi N (2014) A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye. Am J Ophthalmol 157:576–583.e1CrossRefPubMed
25.
Zurück zum Zitat Samudre S, Lattanzio FA Jr., Lossen V et al (2011) Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Invest Ophthalmol Vis Sci 52:6265–6270CrossRefPubMedPubMedCentral Samudre S, Lattanzio FA Jr., Lossen V et al (2011) Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated. Invest Ophthalmol Vis Sci 52:6265–6270CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Vijmasi T, Chen FY, Balasubbu S et al (2014) Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci 55:5401–5409CrossRefPubMedPubMedCentral Vijmasi T, Chen FY, Balasubbu S et al (2014) Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease. Invest Ophthalmol Vis Sci 55:5401–5409CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Gumus K, Pflugfelder SC (2017) Intranasal tear neurostimulation: an emerging concept in the treatment of dry eye. Int Ophthalmol Clin 57:101–108CrossRefPubMed Gumus K, Pflugfelder SC (2017) Intranasal tear neurostimulation: an emerging concept in the treatment of dry eye. Int Ophthalmol Clin 57:101–108CrossRefPubMed
28.
Zurück zum Zitat Hyden D, Arlinger S (2007) On the sneeze-reflex and its control. Rhinology 45:218–219PubMed Hyden D, Arlinger S (2007) On the sneeze-reflex and its control. Rhinology 45:218–219PubMed
29.
Zurück zum Zitat Friedman NJ, Butron K, Robledo N, Loudin J, Baba SN, Chayet A (2016) A nonrandomized, open-label study to evaluate the effect of nasal stimulation on tear production in subjects with dry eye disease. Clin Ophthalmol 10:795–804PubMedPubMedCentral Friedman NJ, Butron K, Robledo N, Loudin J, Baba SN, Chayet A (2016) A nonrandomized, open-label study to evaluate the effect of nasal stimulation on tear production in subjects with dry eye disease. Clin Ophthalmol 10:795–804PubMedPubMedCentral
30.
Zurück zum Zitat Brinton M, Kossler AL, Patel ZM et al (2017) Enhanced tearing by electrical stimulation of the anterior ethmoid nerve. Invest Ophthalmol Vis Sci 58:2341–2348CrossRefPubMedPubMedCentral Brinton M, Kossler AL, Patel ZM et al (2017) Enhanced tearing by electrical stimulation of the anterior ethmoid nerve. Invest Ophthalmol Vis Sci 58:2341–2348CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Gumus K, Schuetzle KL, Pflugfelder SC (2017) Randomized controlled crossover trial comparing the impact of sham or Intranasal tear neurostimulation on conjunctival goblet cell degranulation. Am J Ophthalmol 177:159–168CrossRefPubMed Gumus K, Schuetzle KL, Pflugfelder SC (2017) Randomized controlled crossover trial comparing the impact of sham or Intranasal tear neurostimulation on conjunctival goblet cell degranulation. Am J Ophthalmol 177:159–168CrossRefPubMed
32.
Zurück zum Zitat Marsh P, Pflugfelder SC (1999) Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome. Ophthalmology 106:811–816CrossRefPubMed Marsh P, Pflugfelder SC (1999) Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome. Ophthalmology 106:811–816CrossRefPubMed
33.
Zurück zum Zitat Pflugfelder SC, Maskin SL, Anderson B et al (2004) A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5 %, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol 138:444–457CrossRefPubMed Pflugfelder SC, Maskin SL, Anderson B et al (2004) A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5 %, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol 138:444–457CrossRefPubMed
35.
Zurück zum Zitat Leonardi A, Van Setten G, Amrane M et al (2016) Efficacy and safety of 0.1 % cyclosporine A cationic emulsion in the treatment of severe dry eye disease: a multicenter randomized trial. Eur J Ophthalmol 26:287–296CrossRefPubMed Leonardi A, Van Setten G, Amrane M et al (2016) Efficacy and safety of 0.1 % cyclosporine A cationic emulsion in the treatment of severe dry eye disease: a multicenter randomized trial. Eur J Ophthalmol 26:287–296CrossRefPubMed
36.
Zurück zum Zitat Brown MM, Brown GC, Brown HC, Peet J, Roth Z (1960) Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. Arch Ophthalmol 2009(127):146–152 Brown MM, Brown GC, Brown HC, Peet J, Roth Z (1960) Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. Arch Ophthalmol 2009(127):146–152
37.
Zurück zum Zitat Straub M, Bron AM, Muselier-Mathieu A, Creuzot-Garcher C (2016) Long-term outcome after topical ciclosporin in severe dry eye disease with a 10-year follow-up. Br J Ophthalmol 100:1547–1550CrossRefPubMedPubMedCentral Straub M, Bron AM, Muselier-Mathieu A, Creuzot-Garcher C (2016) Long-term outcome after topical ciclosporin in severe dry eye disease with a 10-year follow-up. Br J Ophthalmol 100:1547–1550CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Wilson SE, Perry HD (2007) Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment. Ophthalmology 114:76–79CrossRefPubMed Wilson SE, Perry HD (2007) Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment. Ophthalmology 114:76–79CrossRefPubMed
39.
Zurück zum Zitat Donnenfeld ED, Karpecki PM, Majmudar PA et al (2016) Safety of Lifitegrast ophthalmic solution 5.0 % in patients with dry eye disease: a 1‑year, multicenter, randomized, placebo-controlled study. Cornea 35:741–748CrossRefPubMedPubMedCentral Donnenfeld ED, Karpecki PM, Majmudar PA et al (2016) Safety of Lifitegrast ophthalmic solution 5.0 % in patients with dry eye disease: a 1‑year, multicenter, randomized, placebo-controlled study. Cornea 35:741–748CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Semba CP, Torkildsen GL, Lonsdale JD et al (2012) A phase 2 randomized, double-masked, placebo-controlled study of a novel integrin antagonist (SAR 1118) for the treatment of dry eye. Am J Ophthalmol 153:1050–1060.e1CrossRefPubMed Semba CP, Torkildsen GL, Lonsdale JD et al (2012) A phase 2 randomized, double-masked, placebo-controlled study of a novel integrin antagonist (SAR 1118) for the treatment of dry eye. Am J Ophthalmol 153:1050–1060.e1CrossRefPubMed
41.
Zurück zum Zitat Sheppard JD, Torkildsen GL, Lonsdale JD et al (2014) Lifitegrast ophthalmic solution 5.0 % for treatment of dry eye disease: results of the OPUS-1 phase 3 study. Ophthalmology 121:475–483CrossRefPubMed Sheppard JD, Torkildsen GL, Lonsdale JD et al (2014) Lifitegrast ophthalmic solution 5.0 % for treatment of dry eye disease: results of the OPUS-1 phase 3 study. Ophthalmology 121:475–483CrossRefPubMed
42.
Zurück zum Zitat Tauber J, Karpecki P, Latkany R et al (2015) Lifitegrast ophthalmic solution 5.0 % versus placebo for treatment of dry eye disease: results of the randomized phase III OPUS-2 study. Ophthalmology 122:2423–2431CrossRefPubMed Tauber J, Karpecki P, Latkany R et al (2015) Lifitegrast ophthalmic solution 5.0 % versus placebo for treatment of dry eye disease: results of the randomized phase III OPUS-2 study. Ophthalmology 122:2423–2431CrossRefPubMed
43.
Zurück zum Zitat Takeuchi H, Okuyama K, Konno O et al (2005) Optimal dose and target trough level in cyclosporine and tacrolimus conversion in renal transplantation as evaluated by lymphocyte drug sensitivity and pharmacokinetic parameters. Transplant Proc 37:1745–1747CrossRefPubMed Takeuchi H, Okuyama K, Konno O et al (2005) Optimal dose and target trough level in cyclosporine and tacrolimus conversion in renal transplantation as evaluated by lymphocyte drug sensitivity and pharmacokinetic parameters. Transplant Proc 37:1745–1747CrossRefPubMed
44.
Zurück zum Zitat Moscovici BK, Holzchuh R, Sakassegawa-Naves FE et al (2015) Treatment of Sjogren’s syndrome dry eye using 0.03 % tacrolimus eye drop: prospective double-blind randomized study. Cont Lens Anterior Eye 38:373–378CrossRefPubMed Moscovici BK, Holzchuh R, Sakassegawa-Naves FE et al (2015) Treatment of Sjogren’s syndrome dry eye using 0.03 % tacrolimus eye drop: prospective double-blind randomized study. Cont Lens Anterior Eye 38:373–378CrossRefPubMed
45.
Zurück zum Zitat Labbe A, Liang Q, Wang Z et al (2013) Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations. Invest Ophthalmol Vis Sci 54:5144–5150CrossRefPubMed Labbe A, Liang Q, Wang Z et al (2013) Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations. Invest Ophthalmol Vis Sci 54:5144–5150CrossRefPubMed
46.
Zurück zum Zitat Galor A, Levitt RC, Felix ER, Martin ER, Sarantopoulos CD (2015) Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond) 29:301–312CrossRef Galor A, Levitt RC, Felix ER, Martin ER, Sarantopoulos CD (2015) Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye (Lond) 29:301–312CrossRef
47.
Zurück zum Zitat Rosenthal P, Borsook D (2012) The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf 10:2–14CrossRefPubMed Rosenthal P, Borsook D (2012) The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf 10:2–14CrossRefPubMed
48.
Zurück zum Zitat Craig JP, Nichols KK, Akpek EK et al (2017) TFOS DEWS II definition and classification report. Ocul Surf 15:276–283CrossRefPubMed Craig JP, Nichols KK, Akpek EK et al (2017) TFOS DEWS II definition and classification report. Ocul Surf 15:276–283CrossRefPubMed
49.
Zurück zum Zitat Lambiase A, Micera A, Pellegrini G et al (2009) In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression. Invest Ophthalmol Vis Sci 50:4622–4630CrossRefPubMed Lambiase A, Micera A, Pellegrini G et al (2009) In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression. Invest Ophthalmol Vis Sci 50:4622–4630CrossRefPubMed
50.
Zurück zum Zitat Coassin M, Lambiase A, Costa N et al (2005) Efficacy of topical nerve growth factor treatment in dogs affected by dry eye. Albrecht Von Graefes Arch Klin Exp Ophthalmol 243:151–155CrossRef Coassin M, Lambiase A, Costa N et al (2005) Efficacy of topical nerve growth factor treatment in dogs affected by dry eye. Albrecht Von Graefes Arch Klin Exp Ophthalmol 243:151–155CrossRef
51.
Zurück zum Zitat Bonini S, Rama P, Olzi D, Lambiase A (2003) Neurotrophic keratitis. Eye (Lond) 17:989–995CrossRef Bonini S, Rama P, Olzi D, Lambiase A (2003) Neurotrophic keratitis. Eye (Lond) 17:989–995CrossRef
52.
Zurück zum Zitat Jain P, Li R, Lama T, Saragovi HU, Cumberlidge G, Meerovitch K (2011) An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye. Exp Eye Res 93:503–512CrossRefPubMed Jain P, Li R, Lama T, Saragovi HU, Cumberlidge G, Meerovitch K (2011) An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye. Exp Eye Res 93:503–512CrossRefPubMed
53.
Zurück zum Zitat Meerovitch K, Torkildsen G, Lonsdale J et al (2013) Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye. Clin Ophthalmol 7:1275–1285CrossRefPubMedPubMedCentral Meerovitch K, Torkildsen G, Lonsdale J et al (2013) Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye. Clin Ophthalmol 7:1275–1285CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Finis D, Hayajneh J, Konig C, Borrelli M, Schrader S, Geerling G (2014) Evaluation of an automated thermodynamic treatment (LipiFlow(R)) system for meibomian gland dysfunction: a prospective, randomized, observer-masked trial. Ocul Surf 12:146–154CrossRefPubMed Finis D, Hayajneh J, Konig C, Borrelli M, Schrader S, Geerling G (2014) Evaluation of an automated thermodynamic treatment (LipiFlow(R)) system for meibomian gland dysfunction: a prospective, randomized, observer-masked trial. Ocul Surf 12:146–154CrossRefPubMed
55.
Zurück zum Zitat Greiner JV (2016) Long-Term (3 year) Effects of a single thermal pulsation system treatment on meibomian gland function and dry eye symptoms. Eye Contact Lens 42:99–107CrossRefPubMed Greiner JV (2016) Long-Term (3 year) Effects of a single thermal pulsation system treatment on meibomian gland function and dry eye symptoms. Eye Contact Lens 42:99–107CrossRefPubMed
56.
Zurück zum Zitat Lane SS, DuBiner HB, Epstein RJ et al (2012) A new system, the LipiFlow, for the treatment of meibomian gland dysfunction. Cornea 31:396–404CrossRefPubMed Lane SS, DuBiner HB, Epstein RJ et al (2012) A new system, the LipiFlow, for the treatment of meibomian gland dysfunction. Cornea 31:396–404CrossRefPubMed
57.
Zurück zum Zitat Craig JP, Chen YH, Turnbull PR (2015) Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci 56:1965–1970CrossRefPubMed Craig JP, Chen YH, Turnbull PR (2015) Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci 56:1965–1970CrossRefPubMed
59.
Zurück zum Zitat Vegunta S, Patel D, Shen JF (2016) Combination therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) can improve dry eye symptoms and meibomian gland function in patients with refractory dry eye: a retrospective analysis. Cornea 35:318–322CrossRefPubMed Vegunta S, Patel D, Shen JF (2016) Combination therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) can improve dry eye symptoms and meibomian gland function in patients with refractory dry eye: a retrospective analysis. Cornea 35:318–322CrossRefPubMed
Metadaten
Titel
Neue aktuelle und zukünftige Therapieoptionen in der Behandlung des trockenen Auges
verfasst von
Prof. Dr. E. M. Messmer
Publikationsdatum
13.11.2017
Verlag
Springer Medizin
Erschienen in
Die Ophthalmologie / Ausgabe 2/2018
Print ISSN: 2731-720X
Elektronische ISSN: 2731-7218
DOI
https://doi.org/10.1007/s00347-017-0608-6

Weitere Artikel der Ausgabe 2/2018

Der Ophthalmologe 2/2018 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.