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Erschienen in: Medical Oncology 3/2011

01.09.2011 | Original Paper

Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma

verfasst von: Lei Zhang, Yonggeng Zhao, Cheng-guo Wang, Zhou Fei, Yuan Wang, Lexiang Li, Liang Li, Hai-ning Zhen

Erschienen in: Medical Oncology | Ausgabe 3/2011

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Abstract

Neuritin, a new member of the neurotrophic factor family, plays an important role in promoting neuronal survival, differentiation, function, and repair. However, whether neuritin is expressed in human astrocytoma and involved in their proliferation, apoptosis, and angiogenesis remains unclear. The expression of neuritin messenger RNA, protein and the relationship with proliferation, apoptosis, and angiogenesis were examined in human astrocytoma samples and three glioma cell lines by immunohistochemistry, Western blot, and quantitative real-time RT–PCR and so on. And neuritin immunoreactivity score(IRS), proliferative index (PI), apoptotic index (AI), overall daily growth (ODG), and microvessel density (MVD) in brain astrocytoma were measured. The results showed that neuritin was overexpressed in human astrocytoma samples, and the overexpression correlated positively with the malignancy of astrocytomas as reflected by changes in proliferation, apoptosis, and angiogenesis markers. In our study, we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma, and can be used as a target for biological therapy.
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Metadaten
Titel
Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma
verfasst von
Lei Zhang
Yonggeng Zhao
Cheng-guo Wang
Zhou Fei
Yuan Wang
Lexiang Li
Liang Li
Hai-ning Zhen
Publikationsdatum
01.09.2011
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 3/2011
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-010-9537-9

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