nach oben

Metabolic Brain Disease

Erschienen in:

28.06.2017 | Original Article

Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles

verfasst von: Kadry M. Sadek, Mohamed A. Lebda, Tarek K. Abouzed, Sherif M. Nasr, Moustafa Shoukry

Erschienen in: Metabolic Brain Disease | Ausgabe 5/2017

Einloggen, um Zugang zu erhalten

Abstract

Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliorative effect of Se-NPs with diameters of 3–5 nm and 10–20 nm against cadmium chloride (CdCl₂)-induced neuro- and nephrotoxicity in rats. Rats were treated with Se-NPs (0 or 0.5 mg/kg BW, s.c.) one hour prior to the CdCl₂ (0 or 5 mg/kg BW, p.o.). Pretreatment with Se-NPs significantly decreased CdCl₂-induced elevation of serum kidney and brain damage biomarkers; lipid peroxidation; the percent of DNA fragmentation and nearly normalized the activity of acetylcholinesterase (AchE) and significantly increased the activity and expression of antioxidant biomarkers in the RNA and protein levels. Se-NPs also attenuated CdCl₂-induced upregulation of kidney and brain pro-apoptotic B-cell CLL/lymphoma 2 associated X (Bax) RNA and protein levels with preventing the increased body burden of Cd and the altered Fe and Cu homeostasis. Histopathological analysis confirmed the biochemical and molecular outcomes. Our data stated that Se-NPs appear to be effective in ameliorating the adverse neurological and nephrotoxic effects induced by CdCl₂ partially through the scavenging of free radicals, metal ion chelation, averting apoptosis and altering the cell-protective pathways. The results indicated that Se-NPs could potentially included as an additive to Cd-based industries to control Cd-induced brain and renal injury.

Nur mit Berechtigung zugänglich

Akyol O et al (2002) The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients. The possible role of oxidant/antioxidant imbalance Progress in neuro-psychopharmacology & biological psychiatry 26:995–1005CrossRef

Alshabanah OA, Hafez MM, Al-Harbi MM, Hassan ZK, Al Rejaie SS, Asiri YA, Sayed-Ahmed MM (2010) Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation. Oxidative Med Cell Longev 3:428–433CrossRef

Amstad PA, Liu H, Ichimiya M, Berezesky IK, Trump BF, Buhimschi IA, Gutierrez PL (2001) BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production. Redox report : communications in free radical research 6:351–362. doi:10.1179/135100001101536535 CrossRefPubMed

Azab SS, Abdel-Daim M, Eldahshan OA (2013) Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract. Med Chem Res 22:4269–4277CrossRef

Bagchi D et al (2000) Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148:187–197CrossRefPubMed

Bajt ML, Cover C, Lemasters JJ, Jaeschke H (2006) Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 94:217–225CrossRefPubMed

Barker-Treasure C, Coll K, Belot N, Longmore C, Bygrave K, Avey S, Clothier R (2015) Non-animal Replacements for Acute Toxicity Testing Alternatives to laboratory animals. ATLA 43:199–203PubMed

Becker K, Gromer S, Schirmer RH, Müller S (2000) Thioredoxin reductase as a pathophysiological factor and drug target. Eur J Biochem 267:6118–6125CrossRefPubMed

Becker S, Soukup J, Gallagher J (2002) Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages. Toxicol in Vitro 16:209–218CrossRefPubMed

Borges LP, Borges VC, Moro AV, Nogueira CW, Rocha JBT, Zeni G (2005) Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats. Toxicology 210:1–8CrossRefPubMed

Casalino E, Sblano C, Landriscina C (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346:171–179CrossRefPubMed

Celi P (2010) The role of oxidative stress in small ruminants' health and production. Rev Bras Zootec 39:348–363CrossRef

Chen L, Liu L, Luo Y, Huang S (2008) MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 105:251–261CrossRefPubMed

Chen L et al (2011) Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med 50:624–632CrossRefPubMed

Collins JF, Prohaska JR, Knutson MD (2010) Metabolic crossroads of iron and copper. Nutr Rev 68:133–147CrossRefPubMedPubMedCentral

Copeland PR (2003) Regulation of gene expression by stop codon recoding: selenocysteine. Gene 312:17–25CrossRefPubMedPubMedCentral

Damek-Poprawa M, Sawicka-Kapusta K (2003) Damage to the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworks and zinc smelters in Poland. Toxicology 186:1–10CrossRefPubMed

Das TK, Wati MR, Fatima-Shad K (2015) Oxidative stress gated by Fenton and Haber Weiss reactions and its association with Alzheimer’s disease. Archives of Neuroscience 2:e20078

Demelash A, Karlsson J-O, Nilsson M, Bjorkman U (2004) Selenium has a protective role in caspase-3-dependent apoptosis induced by H2O2 in primary cultured pig thyrocytes. Eur J Endocrinol 150:841–849CrossRefPubMed

Demİr TA, Akar T, AkyÜz F, IŞikli B, Kanbak G (2005a) Nickel and cadmium concentrations in plasma and Na+/K+ ATPase activities in erythrocyte membranes of the people exposed to cement dust emissions. Environ Monit Assess 104:437–444CrossRefPubMed

Demir TA, Isikli B, Urer SM, Berber A, Akar T, Canbek M, Kalyoncu C (2005b) Nickel exposure and its effects. Biometals 18:7–13CrossRefPubMed

Desi I, Nagymajtenyi L, Schulz H (1998) Behavioural and neurotoxicological changes caused by cadmium treatment of rats during development. J Appl Toxicol 18:63–70CrossRefPubMed

Dringen R (2000) Metabolism and functions of glutathione in brain. Prog Neurobiol 62:649–671CrossRefPubMed

Eder E, Espinosa-Gonzalez J, Mayer A, Reichenberger K, Boerth D (2006) Autoxidative activation of the nematocide 1, 3-dichloropropene to highly genotoxic and mutagenic derivatives: Consideration of genotoxic/carcinogenic mechanisms. Chem Res Toxicol 19:952–959CrossRefPubMed

El-Demerdash F, Elagamy E (2009) Biological effects in Tilapia nilotica fish as indicators of pollution by cadmium and mercury. Int J Environ Health Res 9:173–186CrossRef

El-Demerdash F, Yousef M, Elagamy E (2001) Influence of paraquat, glyphosate, and cadmium on the activity of some serum enzymes and protein electrophoretic behavior (in vitro). J Environ Sci Health B 36:29–42CrossRefPubMed

El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH (2004) Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food Chem Toxicol 42:1563–1571CrossRefPubMed

Ercal N, Penugonda S (2004) Toxic metals and oxidative stress part II: Role of antioxidants in metal-induced oxidative damage

Erejuwa OO, Sulaiman SA, Wahab MSA, Salam SKN, Salleh MSM, Gurtu S (2011) Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats. Int J Mol Sci 12:829–843CrossRefPubMedPubMedCentral

Halliwell B (2001) Role of free radicals in the neurodegenerative diseases. Drugs Aging 18:685–716CrossRefPubMed

Hemann M, Lowe S (2006) The p53-Bcl-2 connection. Cell Death Differ 13:1256–1259CrossRefPubMedPubMedCentral

Huang YH et al (2006) Effects of cadmium on structure and enzymatic activity of Cu, Zn-SOD and oxidative status in neural cells. J Cell Biochem 98:577–589CrossRefPubMed

Imai H, Nakagawa Y (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med 34:145–169CrossRefPubMed

Jafari M, Rabbani A (2000) Dose and time dependent effects of caffeine on superoxide release, cell survival and DNA fragmentation of alveolar macrophages from rat lung. Toxicology 149:101–108CrossRefPubMed

Jang J-H, Surh Y-J (2003) Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function. Biochem Pharmacol 66:1371–1379CrossRefPubMed

Jiang L-F, Yao T-M, Zhu Z-L, Wang C, Ji L-N (2007) Impacts of Cd (II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica et Biophysica Acta (BBA)-Proteins and. Proteomics 1774:1414–1421

Kalishwaralal K, Jeyabharathi S, Sundar K, Muthukumaran A (2016) A novel one-pot green synthesis of selenium nanoparticles and evaluation of its toxicity in zebrafish embryos. Artificial cells, nanomedicine, and biotechnology 44:471–477CrossRefPubMed

Kamiyama T et al (2005) Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels. Res Commun Mol Pathol Pharmacol 88:177–186

Kanter M, Coskun O, Budancamanak M (2005) Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol 11:6684CrossRefPubMedPubMedCentral

Kaplan M et al (2009) The effect of melatonin on cadmiuminduced renal injury in chronically exposed rats. Turk J Urol 35:139–147

Kawamoto S, Kawamura T, Miyazaki Y, Hosoya T (2006) Effects of atorvastatin on hyperlipidemia in kidney disease patients. Nihon Jinzo Gakkai Shi 49:41–48

Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG (2010) Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160:1577–1579CrossRefPubMedPubMedCentral

Kim SH, Johnson VJ, Shin T-Y, Sharma RP (2004) Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-κB signaling pathways. Exp Biol Med 229:203–213CrossRef

Klaassen CD, Liu J, Diwan BA (2009) Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 238:215–220CrossRefPubMedPubMedCentral

Kowalczyk E et al (2003) Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium. ACTA BIOCHIMICA POLONICA-ENGLISH EDITION 50:543–548

Koyuturk M, Yanardag R, Bolkent S, Tunali S (2006) Influence of combined antioxidants against cadmium induced testicular damage. Environ Toxicol Pharmacol 21:235–240CrossRefPubMed

Lazarus M, Orct T, Aladrović J, Ljubić BB, Jurasović J, Blanuša M (2011) Effect of selenium pre-treatment on antioxidative enzymes and lipid peroxidation in Cd-exposed suckling rats. Biol Trace Elem Res 142:611–622CrossRefPubMed

Lazarus M, Orct T, Jurasoviæ J, Blanuša M (2009) The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats. Biometals 22:973–983CrossRefPubMed

Manubolu M, Goodla L, Ravilla S, Thanasekaran J, Dutta P, Malmlöf K, Obulum VR (2014) Protective effect of Actiniopteris radiata (Sw.) Link. against CCl 4 induced oxidative stress in albino rats. J Ethnopharmacol 153:744–752CrossRefPubMed

Masubuchi Y, Suda C, Horie T (2005) Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 42:110–116CrossRefPubMed

Méndez-Armenta M, Barroso-Moguel R, Villeda-Hernández J, Nava-Ruız C, Rıos C (2001) Histopathological alterations in the brain regions of rats after perinatal combined treatment with cadmium and dexamethasone. Toxicology 161:189–199CrossRefPubMed

Miyamoto Y et al (2003) Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. Biol Chem 384:567–574CrossRefPubMed

Mohammed E, Hashem K, Rheim M (2014) Biochemical study on the impact of Nigella sativa and virgin olive oils on cadmium-induced nephrotoxicity and neurotoxicity in rats. Journal of Investigational Biochemistry 3:71–78CrossRef

Mourad IM, Noor NA (2011) Aspartame (a widely used artificial sweetener) and oxidative stress in the rat cerebral cortex. Int J Pharm Biomed Sci 2:4–10

Ng T et al (2005) Rose (Rosa rugosa)-flower extract increases the activities of antioxidant enzymes and their gene expression and reduces lipid peroxidation. Biochem Cell Biol 83:78–85CrossRefPubMed

Novelli EL, Vieira EP, Rodrigues NL, Ribas BO (2008) Risk assessment of cadmium toxicity on hepatic and renal tissues of rats. Environ Res 79:102–105CrossRef

Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839CrossRefPubMedPubMedCentral

Ortuno J, Ros G, Periago M, Martinez C, Lopez G (2006) Selenium bioavailability and methods of evaluation. Food Sci Technol Int 2:135–150CrossRef

Patrick L (2002) Mercury toxicity and antioxidants: part i: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity-mercury toxicity. Toxicol Appl Pharmacol 7:456–471

Peng D, Zhang J, Liu Q, Taylor EW (2007) Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J Inorg Biochem 101:1457–1463CrossRefPubMed

Ramakrishnan R, Elangovan P, Pari L (2017) Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats. Appl Biochem Biotechnol. doi:10.1007/s12010-017-2430-7

Rana SV, Verma S (2006) Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats. Biol Trace Elem Res 51:161–168CrossRef

Renugadevi J, Prabu SM (2010) Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol 62:171–181CrossRefPubMed

Sadek K (2014b) Chemotherapeutic efficacy of an ethanolic Moringa oleifera leaf extract against chromium-induced testicular toxicity in rats. Andrologia 46:1047–1054CrossRefPubMed

Sadek K, Abouzed T, Nasr S (2015) Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model. Can J Physiol Pharmacol 94:394–401CrossRefPubMed

Sadek K, Saleh E (2014a) Fasting ameliorates metabolism, immunity, and oxidative stress in carbon tetrachloride-intoxicated rats. Human & experimental toxicology:0960327114527629

Sadek K, Saleh E, Nasr S (2017) Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats: Hepatoprotection at molecular level. Human & Experimental Toxicology:0960327117693066

Sadek KM (2012a) Antioxidant and immunostimulant effect of Carica papaya Linn. aqueous extract in acrylamide intoxicated rats. Acta Informatica Medica 20:180CrossRef

Sadek KM (2012b) Barley phenolic compounds impedes oxidative stress in lead acetate intoxicated rabbits. Oxidants and Antioxidants in Medical Science 1:141–146CrossRef

Sadek KM, Abouzed TK, Ayoub MA (2014c) Oxidative and Hormonal Disruptions Underlie Bisphenol A-Induced Testicular Toxicity in Male Rabbits World Academy of Science, Engineering and Technology. International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering 8:1232–1238

Satarug S, Garrett SH, Sens MA, Sens DA (2011) Cadmium, environmental exposure, and health outcomes. Ciencia & saude coletiva 16:2587–2602CrossRef

Schubert D, Dargusch R, Raitano J, Chan S-W (2006) Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem Biophys Res Commun 342:86–91CrossRefPubMed

Shaw B, Panigrahi A (2000) Brain AChE activity studies in some fish species collected from a mercury contaminated estuary. Water Air Soil Pollut 53:327–334

Shimizu S, Eguchi Y, Kosaka H, Kamiike W (2005) Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 374:811CrossRef

Sk UH, Bhattacharya S (2006) Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates. Environ Toxicol Pharmacol 22:298–308CrossRefPubMed

Szymonik-Lesiuk S, Czechowska G, Stryjecka-Zimmer M, SŁomka M, Mądro A, CeliŃski K, Wielosz M (2003) Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepato-Biliary-Pancreat Surg 10:309–315CrossRef

Thévenod F (2003) Nephrotoxicity and the proximal tubule. Nephron Physiology 93:p87–p93CrossRefPubMed

Waalkes MP (2003) Cadmium carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 533:107–120CrossRefPubMed

Wong K-L, Cachia R, Klaassen CD (1980) Comparison of the toxicity and tissue distribution of cadmium in newborn and adult rats after repeated administration. Toxicol Appl Pharmacol 56:317–325CrossRefPubMed

Yamauchi Y, Nakakita M, Tanaka H, Asami S, Yoshikawa H (2000) Relationship between renal dysfunction and bone metabolism disorder in male rats after long-term oral quantitative cadmium administration. Ind Health 38:339–355CrossRefPubMed

Yu R, Xia T, Wang A, Chen X (2006) Effects of selenium and zinc on renal oxidative stress and apoptosis induced by fluoride in rats. Biomed Environ Sci 19:439PubMed

Yuan Y et al (2013) Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PLoS One 8:e64330CrossRefPubMedPubMedCentral

Zhang J, Wang H, Bao Y, Zhang L (2004) Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci 75:237–244CrossRefPubMed

Zheng JL, Yuan SS, Wu CW, Lv ZM, Zhu AY (2017) Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquatic toxicology (Amsterdam, Netherlands) 182:113–119. doi:10.1016/j.aquatox.2016.11.017 CrossRef

Titel: Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles
verfasst von: Kadry M. Sadek
Mohamed A. Lebda
Tarek K. Abouzed
Sherif M. Nasr
Moustafa Shoukry
Publikationsdatum: 28.06.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 5/2017
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0053-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

23.04.2024 | Demenz | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2017

Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation

Genetic study of the PAH locus in the Iranian population: familial gene mutations and minihaplotypes

Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen

Aspartame and Soft Drink-Mediated Neurotoxicity in Rats: Implication of Oxidative Stress, Apoptotic Signaling Pathways, Electrolytes and Hormonal Levels

The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?

Non-alcoholic Wernicke’s encephalopathy with cortical involvement and polyneuropathy following gastrectomy

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Hustenstiller lindert Agitation bei Alzheimer

Update Neurologie