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Erschienen in: Surgery Today 12/2020

19.03.2020 | Review Article

Neuroendocrine tumors of the lung: clinicopathological and molecular features

verfasst von: Akira Iyoda, Yoko Azuma, Atsushi Sano

Erschienen in: Surgery Today | Ausgabe 12/2020

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Abstract

In 1970, neuroendocrine tumors of the lung were classified into three categories: typical carcinoid (TC), atypical carcinoid (AC), and small cell lung carcinoma (SCLC). The third edition of the World Health Organization (WHO) classification in 1999 defined large cell neuroendocrine carcinoma (LCNEC) as a variant of large cell carcinomas, whereas the fourth edition of the WHO classification redefined LCNEC as a neuroendocrine tumor. Currently, neuroendocrine tumors of the lung are classified into four main categories: TC, AC, LCNEC, and SCLC. Although the treatments for TC, AC, and SCLC have not changed remarkably, the treatment strategy for LCNEC is not yet established because of its reclassification from a variant of “large cell carcinoma” to a new category of “neuroendocrine tumor”. In this review article, we discuss the pathological findings, biological behavior, and treatment of neuroendocrine tumors of the lung.
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Metadaten
Titel
Neuroendocrine tumors of the lung: clinicopathological and molecular features
verfasst von
Akira Iyoda
Yoko Azuma
Atsushi Sano
Publikationsdatum
19.03.2020
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 12/2020
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-01988-7

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