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Erschienen in: Der Chirurg 4/2016

15.01.2016 | Neuroendokrine Tumoren | Leitthema

Chirurgische Therapie gastroduodenaler neuroendokriner Neoplasien

verfasst von: Prof. Dr. V. Fendrich, D. K. Bartsch

Erschienen in: Die Chirurgie | Ausgabe 4/2016

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Zusammenfassung

Gastroduodenale neuroendokrine Neoplasien (NEN) haben in den letzten 35 Jahren an Häufigkeit zugenommen. Zeitgleich hat sich auch die Prognose der Patienten wesentlich verbessert, da die Mehrzahl dieser Tumoren heute in einem frühen Stadium festgestellt wird. NEN des Magens sind die häufigsten Neoplasien neuroendokrinen Ursprungs im Gastrointestinaltrakt. In der Diagnostik nehmen sie eine Sonderstellung ein, da neben dem Staging und Grading unterschiedliche pathophysiologische Grundlagen (Typen) für die Einteilung herangezogen werden können. Diese unterscheiden sich in ihrem biologischen Verhalten und beeinflussen damit die Therapiekonzepte. Da über 90 % der duodenalen NEN asymptomatisch sind und in der Regel auch in einem kurativen Stadium entdeckt werden, ist stets die Resektion des Tumors anzustreben. Die Möglichkeiten der Resektion reichen von lokalen endoskopischen Verfahren über lokale chirurgische Verfahren (Duodenotomie mit Exzision) bis hin zur pankreaserhaltenden Duodenektomie oder pyloruserhaltenden bzw. klassischen Whipple-Operation. In diesem Beitrag werden die verschiedenen chirurgischen Therapieansätze vorgestellt.
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Metadaten
Titel
Chirurgische Therapie gastroduodenaler neuroendokriner Neoplasien
verfasst von
Prof. Dr. V. Fendrich
D. K. Bartsch
Publikationsdatum
15.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Chirurgie / Ausgabe 4/2016
Print ISSN: 2731-6971
Elektronische ISSN: 2731-698X
DOI
https://doi.org/10.1007/s00104-015-0138-1