Skip to main content
Erschienen in: Head and Neck Pathology 4/2020

Open Access 03.02.2020 | Original Paper

Neuroepithelial Structures of the Oral Soft Tissues Including the Juxtaoral Organ of Chievitz: A Literature Review and Audit of Diagnosed Cases

verfasst von: Robert Kennedy

Erschienen in: Head and Neck Pathology | Ausgabe 4/2020

Abstract

The juxtaoral organ of Chievitz (JOOC) is a part of microanatomy composed of bland epithelial islands closely associated with small nerves and usually described within the soft tissue on the lingual aspect of the posterior mandible. Similar structures are documented in the posterior tongue. There is a risk of misinterpretation as carcinoma showing perineural invasion. An audit was undertaken of diagnosed cases of the JOOC and similar neuroepithelial structures identified within the oral soft tissues of surgical specimens. Nineteen cases were identified. Epithelial islands ranged < 0.5–4 mm in maximum dimension and lay in close association with small nerves. Epithelial cells showed a squamoid appearance but were without keratinisation. There was no atypia and mitotic figures were not seen. In 53% of cases the epithelial cells showed cytoplasmic clearing, in 26% of cases there was brown pigment and in 11% of cases there were calcifications. In 53% of cases, these neuroepithelial structures lay within the soft tissue lingual to the mandible in the retromolar area, 26% of the structures were placed buccal to the mandible, 11% of the structures lay adjacent to the maxillary tuberosity and 11% of the structures were within the posterior tongue.
Hinweise

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Introduction

The juxtaoral organ of Chievitz (JOOC) is a part of normal microanatomy rarely encountered within resection specimens. It is a neuroepithelial structure composed of bland islands of epithelium in intimate association with nerve fibres and is described as located lingual to the angle of the mandible. While the structure’s physiological function remains obscure, its clinical importance arises from the risk of misinterpretation as carcinoma showing perineural invasion. The literature relating to neuroepithelial structures within the oral soft tissue is reviewed, and an audit of cases diagnosed at a single institute is presented.

Materials and Methods

Literature Review

The English language literature was surveyed to identify descriptions of neuroepithelial structures including the JOOC within the oral soft tissues in adults and children. The PubMed database was searched using the terms: JOOC; neuroepithelial structures AND oral. Cases without details of the anatomical site or without photomicrographs of interpretable quality were excluded. Cases with features suggestive of an alternate diagnosis were also excluded as detailed in the results section. All other cases were included.

Audit

A text search was made of the Guy’s Hospital (London) oral pathology database using the terms Chievitz and neuroepithelial. The audit standard was set to be that the clinical presentation and microscopic appearances should be in keeping with published reports and therefore that diagnosis could be considered as correct. No immunohistochemistry was performed as part of the audit. In one case immunohistochemistry was available as it was undertaken at the time of reporting.

Results

Literature Review

Three series (more than one case included) of the JOOC (Table 1) were identified from the available English literature. Each involved targeted sampling of the soft tissue on the medial aspect of the angle of the mandible with the intent of finding the JOOC. The specimens utilised in these three series were surgical resections [1], cadavers and autopsy specimens [2, 3]. In total these studies examined 64 specimens and the JOOC was found in 34 of these. The JOOC was identified in males and females and in all age groups including neonates. The JOOC was described as small nests of squamoid cells in close association with small nerves. There was no keratinisation and no atypia. Cytoplasmic clearing and duct-like spaces nests were described in several cases. Melanin pigment was present in 1 case and calcification in 2 cases. The finding of the JOOC medial to the angle of the mandible and with these histological features is further supported by four single case reports [47] (Table 2).
Table 1
Published case series of the JOOC and other neuroepithelial structures
Site
Specimen type
No. of cases
Age
Sex
Constant microscopic features
Inconstant microscopic features
Refs
Deep to medial pterygoid over angle of mandible
Autopsy specimens
14
26–84 years
Sex not specified
Nests of bland squamoid cells close to small nerves
No keratin formation
Clear cytoplasm in peripheral cells
Lumen formation (1 case)
[3]
Medial to mandible in area of internal
oblique ridge
Autopsy and cadaver specimens
11
Neonate-over 50 years
Sex not specified
Nests of bland squamoid cells close to small nerves
Peripheral nuclear palisading
Lumen formation
Calcification (2 cases)
Melanin pigment (1 case)
[2]
Medial to mandible where the ascending ramus joins the body
Carcinoma resection specimen
9
49–90 years
2 M:1F
Nests of bland squamoid cells close to small nerves
No keratinisation
Intercellular bridges
Lumen formation (3 cases)
[1]
Posterior tongue
Incidental findings in biopsies (3 cases)
Finding in a biopsy of a firm painful area (1 case)
4
59–68 years
2 M:1F
Islands of squamoid islands close to subepithelial nerve plexus of taste buds
No keratinisation
Clear cytoplasm and intercellular bridges (1 case)
Peripheral nuclear palisading and lumen formation (1 case)
[8]
Table 2
Published single case reports of the JOOC and other neuroepithelial structures
Site
Specimen type
Age
Sex
Microscopic features
Refs
Retromolar trigone
Carcinoma resection
50 F
Nests of bland squamoid cells close to small nerves
Foci of calcification
[4]
Retromolar trigone
Carcinoma resection
46 F
Nests of bland squamoid cells close to small nerves
Some cells show clear cytoplasm
[5]
Medial aspect angle of mandible
Carcinoma resection
35 M
Nests of squamoid cells
closely placed to small nerves and resembling
Pacinian corpuscles
[6]
Medial pterygoid region
Carcinoma resection
44 F
Nests of bland squamoid cells close to small nerves
[7]
Lingual gingivae lower molar region
Biopsy of firm irritating area
24 F
Nests of bland squamoid cells close to small nerves
Areas of degeneration resulted in microcystic changes
The structure was described as a hamartoma
[10]
Base of tongue
Biopsy of described slight abnormality
39 M
Nests of bland squamoid cells close to small nerves
[9]
There is a single case report of the JOOC on the medial of the mandibular angle showing structures resembling Pacinian corpuscles. These were described as ovoid-to-spherical lamellar structures demonstrating an inner core immunoreactive for neurofilament protein and outer core of flattened cells positive for epithelial membrane antigen [6].
Immunohistochemistry studies of the JOOC are otherwise very limited [7]. The epithelial cells of the JOOC are shown to label with a pancytokeratin antibody (AE1/3). Central epithelial cells are positive for CK19 and peripheral basal cells are positive for high molecular-weight keratin (34bE12). There is no expression of CK7, CK20 or S100 and the Ki-67 labelling index is < 1%.
Palazzolo et al. [8] published a series of 4 cases showing neuroepithelial structures in the posterior tongue appearing as squamoid islands without keratinisation and lying subjacent to the surface epithelium. Clear cytoplasm and intercellular bridges were present in one of the cases. In another case, peripheral palisading and focal areas of cystic degeneration or duct-like structures were observed. The islands lay in close association with the subepithelial nerve plexus of taste buds. The patients were between 59 and 68 years of age with an even gender distribution. Three cases were incidental findings in biopsies undertaken in a search for a primary site of metastatic carcinoma. One case was identified in a biopsy of a firm area of the tongue base associated with pain. A further case report [9] describes a similar neuroepithelial structure also in the posterior tongue. The patient was a 39 year old male and the neuroepithelial structure was found in a biopsy taken from what was described as an area of slight abnormality.
A neuroepithelial hamartoma has been described in the lower molar lingual gingivae of a 24 year old female [10]. The report documents islands of squamoid epithelium within a collagenous stroma in close association with small nerves. In this case keratin pearl formation was seen focally in addition to microcysts. The descriptions were supported by good quality black and white photomicrographs, although the size of the hamartoma was not clear.
Exclusions from this literature review include reports of tumours of the JOOC that either did not include photomicrographs [11], included photomicrographs that were not of interpretable quality with for example nerves not being identifiable [1214] or had features out of keeping with the JOOC including firm adherence to skin, keratotic pearls, isolated spindle cells and no reactivity with pancytokeratin immunostaining [15]. A hyperplasia of the JOOC was described in the bucco-temporal region in an autopsy specimen with no relevant history [16]. One of the islands was 4 mm in diameter and it was this that was designated as a hyperplasia. However, no nerves were described or could be identified in the photomicrographs and therefore the case was excluded.

Audit

Nineteen diagnosed neuroepithelial structures were identified in the oral pathology archive (Table 3). The ages of patients demonstrating neuroepithelial structures including the JOOC ranged from 46 to 75 years old (mean age of 61 years). The male to female ratio was 2:1. Case 2 was an incidental finding in a resection of a clear cell odontogenic carcinoma. Case 3 was found within an excision from an area associated with pain on biting. Case 16 (Fig. 1) was an incidental finding in a resection of a mucoepidermoid carcinoma. Case 15 was present within a frozen section taken in the management of an osteosarcoma. The remaining cases were incidental findings in resections of squamous cell carcinoma.
Table 3
Audited cases of the JOOC and other neuroepithelial structures
 
Site and demographics
Microscopic appearance
No. of epithelial islands
Max di
1
Medial to mandible
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Brown pigment within fibrous tissue
4
 < 0.5 mm
2
Medial to mandible,
8 mm below epithelium
Deep to muscle
Female, 5th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
1
0.5 mm
3
Medial to mandible
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
14
1.5 mm
4
Medial to mandible
Deep to muscle
Male, 8th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
Brown pigment within fibrous tissue
4
0.5 mm
5
Medial to mandible
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
31
2 mm
6
Medial to mandible
Deep to muscle
Male, 8th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Central calcification
7
3.5 mm
7
11 mm medial to mandible
Deep to muscle
Deepest aspect level with inferior border of mandible
Male, 8th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Concentric central calcification
Brown pigment within fibrous tissue
9
4 mm
8
Medial to mandible
5.5 mm below epithelium
Deep to muscle
Female, 5th decade of life
Squamoid islands within 0.5 mm of small nerves (approximately 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
Brown pigment within fibrous tissue
11
2.5 mm
9
Medial to mandible
9 mm below epithelium
Deep to muscle
Male, 6th decade of life
Squamoid islands within 0.5 mm of small nerves (approximately 0.5 mm in diameter)
5
 < 0.5
10
Medial to mandible (retromolar region)
7 mm below epithelium
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
4
0.5 mm
11
Posterior tongue
1 mm below epithelium
Within lamina propria of circumvallate papilla
Male, 6th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
14
0.5 mm
12
Posterior tongue
 < 0.5 mm below epithelium
Female, 6th decade of life
Squamoid islands close to taste buds
 > 90
1.5 mm
13
Buccal to mandible
9 mm below epithelium
Deep to muscle
Female, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within central cells
3
 < 0.5 mm
14
Buccal to mandible
7 mm below epithelium
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
4
0.5 mm
15
Buccal to mandible within submasseteric space
Male, 6th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
1
 < 0.5 mm
16
Buccal to mandible
6 mm below epithelium
Deep to muscle
Female, 6th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
14
0.5 mm
17
Buccal to mandible
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within central and peripheral cells
3
0.5 mm
18
5 mm posterobuccal to maxillary tuberosity
4 mm below epithelium
Deep to muscle
Female, 6th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
Brown pigment within fibrous tissue
2
0.5 mm
19
Superoposterior to maxillary tuberosity
5 mm below epithelium
Deep to muscle
Male, 7th decade of life
Squamoid islands within 0.5 mm of small nerves (< 0.5 mm in diameter)
Clear cytoplasm within peripheral cells
7
0.5 mm

Anatomical Site

Ten cases (53%) were located within the soft tissue lingual to the mandible deep to muscle layers (Figs. 2 and 3). Five cases were described as buccal to the mandible (Fig. 1) and except for one case where assessment was not possible, were again localised below muscle. One of the cases buccal to the mandible (case 15) was a frozen section described as being taken from the submasseteric space and one of these cases (case 13) was an excision of the buccal mucosa that did not include the mandible. The remaining cases described as buccal to the mandible did include the mandible itself. Two cases were described as adjacent to the maxillary tuberosity and again lay below muscle. The precise relation of the location in these cases to the mandible was not clear. Two cases were in the posterior tongue and these lay within the lamina propria (Fig. 4).

Microscopic Appearance

In all cases the neuroepithelial structures appeared as well circumscribed rounded epithelial nests and islands numbering from 1 to more than 90 (Fig. 4). The maximum dimension ranged from < 0.5 mm (Fig. 5) to 4 mm (Fig. 2a). Islands and nests were located within fibrous tissue and lay within 0.5 mm of small nerves. In case 12 the neuroepithelial structure was observed in the posterior tongue and lay close to the taste buds (Fig. 4). There was a consistent squamoid appearance, the more central cells in the islands showing moderate amounts of usually eosinophilic cytoplasm and small rounded nuclei. The more peripheral cells often had a basal cell appearance with less abundant cytoplasm and slightly darker staining nuclei. There was no keratinisation and no mucin formation. There was no cytological atypia and no mitotic nor apoptotic figures.
Cytoplasmic clearing was present in 10 of the 19 cases (53%) (Fig. 3). Brown pigment was seen in 5 of the 19 cases (26%) (Figs. 2a, 3) and in one of these (case 7) immunohistochemistry had been undertaken at the time of reporting showing expression of cytokeratin (antibody to AE1/3) but no S100 expression, confirming an epithelial rather than melanocytic phenotype (Fig. 2b). Calcification was present in 2 cases (11%) (Fig. 2a). The cases in the posterior tongue showed no cytoplasmic clearing, no melanin pigment and no calcification (Fig. 4). In 7 cases there was an inflammatory infiltrate including neutrophils, lymphocytes and plasma cells. These were intermingled amongst the epithelial nests but in all cases, this was in keeping with a background of inflammation in surrounding areas. In no cases did the neuroepithelial structures themselves appear to attract an inflammatory response. Case 3 was a small specimen taken from an area associated with pain on biting. The specimen showed normal muscle, minor salivary glands and fibroadipose tissue within which was the neuroepithelial structure showing the same features as in the other cases. There was no inflammation and no evidence of any neural pathology.

Discussion

All the cases in the audit showed neuroepithelial structures with microscopic features consistent with descriptions in the literature including a size up to 4 mm and an association with small nerves together with an absence of atypia and keratinisation. The audit standard of correct diagnosis was therefore met. Eighteen of the 19 cases were incidental findings within excision specimens as would be expected for a normal part of microanatomy. The finding of one case within a small excision from an area associated with pain on biting may also have been an incidental finding. It remains possible that some dysfunction of the neuroepithelial structure was the cause of the symptoms although the microscopic features were entirely typical and there was no evidence of inflammation. The most commonly described location was lingual to the mandible and this is in keeping with published cases. Two cases were described as adjacent to the maxillary tuberosity, although the relation of these sites to the mandible was not precisely clear. Five examples were described as buccal to the mandible but did show the typical histological features. The occurrence of neuroepithelial structures in the posterior tongue seen in two cases is previously documented. The largest previous series undertook targeted sampling of the tissues lingual to the mandible. The greater variation in anatomical location found in this audit is consistent with the cases being surgical resections rather than targeted samples.
In conclusion, neuroepithelial structures including the JOOC are most commonly located lingual to the mandible but can also be found buccal to the mandible and within the posterior tongue. The neuroepithelial structures appear as small (< 0.5–4 mm in maximum dimension) islands of squamoid epithelium in close association with small nerves or the taste buds. Cytoplasmic clearing, brown pigmentation and calcification are variably present. There is an absence of keratinisation, cytological atypia and mitotic activity. Attention to these details allows proper identification of benign neuroepithelial structures and avoidance of misinterpretation as carcinoma showing neural invasion.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

This is an audit and literature review with no identifiable patient details included. This is an audit and therefore does not require board review.

Research Involving Human and Animal Rights

This is a retrospective audit. This article does not contain any studies with human participants or animals performed by any of the authors.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://​creativecommons.​org/​licenses/​by/​4.​0/​.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de.

© Springer Medizin

Bis 11. April 2024 bestellen und im ersten Jahr 50 % sparen!

e.Dent – Das Online-Abo der Zahnmedizin

Online-Abonnement

Mit e.Dent erhalten Sie Zugang zu allen zahnmedizinischen Fortbildungen und unseren zahnmedizinischen und ausgesuchten medizinischen Zeitschriften.

Jetzt e.Dent zum Sonderpreis bestellen

e.Dent bis 11. April 2024 bestellen und im ersten Jahr 50 % sparen!

Literatur
1.
Zurück zum Zitat Lutman GB. Epithelial nests in intraoral sensory nerve endings simulating perineural invasion in patients with oral carcinoma. Am J Clin Pathol. 1974;61(2):275–84.CrossRef Lutman GB. Epithelial nests in intraoral sensory nerve endings simulating perineural invasion in patients with oral carcinoma. Am J Clin Pathol. 1974;61(2):275–84.CrossRef
2.
Zurück zum Zitat Danforth RA, Baughman RA. Chievitz's organ: a potential pitfall in oral cancer diagnosis. Oral Surg Oral Med Oral Pathol. 1979;48(3):231–6.CrossRef Danforth RA, Baughman RA. Chievitz's organ: a potential pitfall in oral cancer diagnosis. Oral Surg Oral Med Oral Pathol. 1979;48(3):231–6.CrossRef
3.
Zurück zum Zitat Tschen JA, Fechner RE. The juxtaoral organ of Chievitz. Am J Surg Pathol. 1979;3(2):147–50.CrossRef Tschen JA, Fechner RE. The juxtaoral organ of Chievitz. Am J Surg Pathol. 1979;3(2):147–50.CrossRef
4.
Zurück zum Zitat Wadhwan V, Venkatesh A, Aggarwal P, Reddy V, Sharma P. Juxtaoral organ of Chievitz: a histopathological masquerade. Indian J Med Paediatr Oncol. 2015;36(3):193.CrossRef Wadhwan V, Venkatesh A, Aggarwal P, Reddy V, Sharma P. Juxtaoral organ of Chievitz: a histopathological masquerade. Indian J Med Paediatr Oncol. 2015;36(3):193.CrossRef
5.
Zurück zum Zitat Sancheti SM, Sawaimoon S, Zameer M. Juxtaoral organ of Chievitz, an obscure anatomical structure masquerading as perineural invasion of mucoepidermoid carcinoma: case report and review of literature. Int J Surg Pathol. 2015;23(6):461–3.CrossRef Sancheti SM, Sawaimoon S, Zameer M. Juxtaoral organ of Chievitz, an obscure anatomical structure masquerading as perineural invasion of mucoepidermoid carcinoma: case report and review of literature. Int J Surg Pathol. 2015;23(6):461–3.CrossRef
6.
Zurück zum Zitat Ide F, Mishima K, Saito I. Pacinian corpuscle in the juxtaoral organ of Chievitz. J Oral Pathol Med. 2004;33:443–4.PubMed Ide F, Mishima K, Saito I. Pacinian corpuscle in the juxtaoral organ of Chievitz. J Oral Pathol Med. 2004;33:443–4.PubMed
7.
Zurück zum Zitat Kusafuka K, Kameya T. Juxtaoral organ of Chievitz, radiologically suspicious for invasion of lingual squamous cell carcinoma. Pathol Int. 2007;57(11):754–6.CrossRef Kusafuka K, Kameya T. Juxtaoral organ of Chievitz, radiologically suspicious for invasion of lingual squamous cell carcinoma. Pathol Int. 2007;57(11):754–6.CrossRef
8.
Zurück zum Zitat Palazzolo MJ, Craig B, Fowler CB, Kelly R, Magliocca KR, Gnepp DR. Neuroepithelial structures associated with the subepithelial nerve plexus of taste buds: a fortuitous finding resembling the juxtaoral organ of Chievitz. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:497–501.CrossRef Palazzolo MJ, Craig B, Fowler CB, Kelly R, Magliocca KR, Gnepp DR. Neuroepithelial structures associated with the subepithelial nerve plexus of taste buds: a fortuitous finding resembling the juxtaoral organ of Chievitz. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:497–501.CrossRef
9.
Zurück zum Zitat Cheng E, Cohen MA, Scognamiglio T. Neuroepithelial structure resembling the juxtaoral organ of Chievitz: usual morphology in an unusual location. Int J Surg Pathol. 2016;24(8):721–2.CrossRef Cheng E, Cohen MA, Scognamiglio T. Neuroepithelial structure resembling the juxtaoral organ of Chievitz: usual morphology in an unusual location. Int J Surg Pathol. 2016;24(8):721–2.CrossRef
10.
Zurück zum Zitat Mesa M, Baden E, Grodjesk J, Dolinsky HB. Neuroepithelial hamartoma of the oral cavity. Oral Surg Oral Med Oral Pathol. 1994;78(5):627–30.CrossRef Mesa M, Baden E, Grodjesk J, Dolinsky HB. Neuroepithelial hamartoma of the oral cavity. Oral Surg Oral Med Oral Pathol. 1994;78(5):627–30.CrossRef
11.
Zurück zum Zitat Saucy P, Cimone G, Carpenter B. An unusual intraoral mass in a child: the organ of Chievitz. J Pediatr Surg. 1990;25(11):1200.CrossRef Saucy P, Cimone G, Carpenter B. An unusual intraoral mass in a child: the organ of Chievitz. J Pediatr Surg. 1990;25(11):1200.CrossRef
12.
Zurück zum Zitat Vadmal MS, Rossi MB, Teichberg S, Hajdu SI. Intraoral tumor of Chievitz in a child. Pediatr Dev Pathol. 1998;1:230–3.CrossRef Vadmal MS, Rossi MB, Teichberg S, Hajdu SI. Intraoral tumor of Chievitz in a child. Pediatr Dev Pathol. 1998;1:230–3.CrossRef
13.
Zurück zum Zitat Be´nateau H, Rigau V, Comoz F, Benchemam Y, Galateau F, Compe`re J-F. Tumour of the juxtaoral organ case report and literature review. Int J Oral Maxillofac Surg. 2003;32:101–3.CrossRef Be´nateau H, Rigau V, Comoz F, Benchemam Y, Galateau F, Compe`re J-F. Tumour of the juxtaoral organ case report and literature review. Int J Oral Maxillofac Surg. 2003;32:101–3.CrossRef
14.
Zurück zum Zitat Ide F, Mishima K, Saito I. Juxtaoral organ of Chievitz presenting clinically as a tumour. J Clin Pathol. 2003;56(10):789–90.CrossRef Ide F, Mishima K, Saito I. Juxtaoral organ of Chievitz presenting clinically as a tumour. J Clin Pathol. 2003;56(10):789–90.CrossRef
15.
Zurück zum Zitat Roşu Ş, Neamţu C, Totolici B. Unusual lesion of the temporal region, benign tumor of the Chievitz's organ: a case report. Rom J Morphol Embryol. 2014;55(2 Suppl):683–5.PubMed Roşu Ş, Neamţu C, Totolici B. Unusual lesion of the temporal region, benign tumor of the Chievitz's organ: a case report. Rom J Morphol Embryol. 2014;55(2 Suppl):683–5.PubMed
16.
Zurück zum Zitat Leibl W, Pflüger H, Kerjaschki D. A case of nodular hyperplasia of the juxtaoral organ in man. Virchows Arch A Pathol Anat Histol. 1976;371(4):389–91.CrossRef Leibl W, Pflüger H, Kerjaschki D. A case of nodular hyperplasia of the juxtaoral organ in man. Virchows Arch A Pathol Anat Histol. 1976;371(4):389–91.CrossRef
Metadaten
Titel
Neuroepithelial Structures of the Oral Soft Tissues Including the Juxtaoral Organ of Chievitz: A Literature Review and Audit of Diagnosed Cases
verfasst von
Robert Kennedy
Publikationsdatum
03.02.2020
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 4/2020
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-020-01131-5

Weitere Artikel der Ausgabe 4/2020

Head and Neck Pathology 4/2020 Zur Ausgabe

Neu im Fachgebiet Pathologie