nach oben

Erschienen in:

2018 | OriginalPaper | Buchkapitel

10. Neurologische Komplikationen entzündlicher Darmerkrankungen

verfasst von : Oliver Bachmann, Natascha Wehnert

Erschienen in: Autoimmunerkrankungen in der Neurologie

Verlag: Springer Berlin Heidelberg

Einloggen, um Zugang zu erhalten

Zusammenfassung

Mit einigen entzündlichen Darmerkrankungen sind neurologische Symptome assoziiert, die zum Teil das Krankheitsbild wesentlich mit charakterisieren und die Diagnosestellung erleichtern oder überhaupt erst ermöglichen. In anderen Fällen ist die Verknüpfung schwer zu belegen und läuft somit Gefahr, übersehen zu werden – insbesondere, wenn neurologische Symptome den intestinalen vorausgehen oder umgekehrt bzw. andere mögliche Ursachen bestehen. Neurologische Komplikationen sind sowohl bei den chronisch entzündlichen Darmerkrankungen im engeren Sinne als auch bei der Zöliakie und auch beim durch grampositive Bakterien verursachten Morbus Whipple beschrieben. Dieses Kapitel fasst die Literatur zu neurologischen Komplikationen der genannten entzündlichen Darmerkrankungen hinsichtlich ihrer Charakteristika, Diagnostik, Abgrenzung anderer Ursachen und therapeutischer Strategien zusammen.

Addolorato G, Di Giuda D, De Rossi G, Valenza V, Domenicali M, Caputo F et al (2004) Regional cerebral hypoperfusion in patients with celiac disease. Am J Med 116(5):312–317CrossRefPubMed

Akbayir N, Calis AB, Alkim C, Sokmen HM, Erdem L, Ozbal A et al (2005) Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation. Dig Dis Sci 50(10):1938–1945CrossRefPubMed

Anderson M (2000) Neurology of Whipple’s disease. J Neurol Neurosurg Psychiatry 68(1):2–5CrossRefPubMedPubMedCentral

van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M et al (2005) Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn‘s disease. New Engl J Med 353(4):362–368CrossRefPubMed

Bachmann O, Langer F, Rademacher J (2010) Pulmonary manifestations of inflammatory bowel disease. Der Internist 51(Suppl 1):264–268CrossRefPubMed

Barbado FJ, Vazquez JJ, Gil A, Ortiz Vazquez J (1980) Vasculitis and ulcerative colitis. Gastroenterol 79(2):417–418

Baron BW, Jeon HR, Glunz C, Peterson A, Cohen R, Hanauer S et al (2002) First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange. J Clin Apheresis 17(4):204–206CrossRefPubMed

Baumgart DC, Sandborn WJ (2007) Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369(9573):1641–1657CrossRefPubMed

Berden JH, Hoitsma AJ, Merx JL, Keyser A (1985) Severe central-nervous-system toxicity associated with cyclosporin. Lancet 1(8422):219–220CrossRefPubMed

Bernstein CN, Wajda A, Blanchard JF (2005) The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterol 129(3):827–836CrossRef

Boulos A, Rolain JM, Raoult D (2004) Antibiotic susceptibility of Tropheryma whipplei in MRC5 cells. Antimicrob Agents Chemother 48(3):747–752CrossRefPubMedPubMedCentral

Burk K, Bosch S, Muller CA, Melms A, Zuhlke C, Stern M et al (2001a) Sporadic cerebellar ataxia associated with gluten sensitivity. Brain: J Neurol 124(5):1013–1019CrossRef

Burk K, Melms A, Schulz JB, Dichgans J (2001b) Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 50(6):827–828CrossRefPubMed

Carmona MA, Jaume Anselmi F, Ramirez Rivera J (2000) Cerebral thrombosis and vasculitis: an uncommon complication of ulcerative colitis. Bol Asoc Med P R 92(1–3):9–11PubMed

Colombel JF, Loftus EV Jr, Tremaine WJ, Egan LJ, Harmsen WS, Schleck CD et al (2004) The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic experience in 500 patients. Gastroenterol 126(1):19–31CrossRef

Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A (2011) Evidence-based guideline update: plasmapheresis in neurologic disorders: report of the therapeutics and technology assessment subcommittee of the American academy of Neurology. Neurol 76(3):294–300CrossRef

Dimitrova AK, Ungaro RC, Lebwohl B, Lewis SK, Tennyson CA, Green MW et al (2013) Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 53(2):344–355CrossRefPubMed

Druschky A, Heckmann J, Engelhardt A, Neundorfer (1996) Myositis – a rare complication of Crohn disease. Fortschr Neurol Psychiatr 64(10):422–424CrossRefPubMed

Duffy LF, Daum F, Fisher SE, Selman J, Vishnubhakat SM, Aiges HW et al (1985) Peripheral neuropathy in Crohn’s disease patients treated with metronidazole. Gastroenterol 88(3):681–684CrossRef

Elsehety A, Bertorini TE (1997) Neurologic and neuropsychiatric complications of Crohn‘s disease. S Med J 90(6):606–610CrossRef

Felber J, Aust D, Baas S, Bischoff S, Blaker H, Daum S et al (2014) Results of a S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and Metabolic Diseases (DGVS) in conjunction with the German Coeliac Society (DZG) regarding coeliac disease, wheat allergy and wheat sensitivity. Z Gastroenterol 52(7):711–743CrossRefPubMed

Ferrante M, de Hertogh G, Hlavaty T, D‘Haens G, Penninckx F, D‘Hoore A et al (2006) The value of myenteric plexitis to predict early postoperative Crohn’s disease recurrence. Gastroenterol 130(6):1595–1606CrossRef

Ferro JM, Oliveira S (2014) Neurologic manifestations of gastrointestinal and liver diseases. Curr Neurol Neurosci Rep 14(10):487CrossRefPubMed

Feurle GE, Moos V, Schneider T, Fenollar F, Raoult D (2012) The combination of chloroquine and minocycline, a therapeutic option in cerebrospinal infection of Whipple‘s disease refractory to treatment with ceftriaxone, meropenem and co-trimoxazole. J Antimicrob Chemother 67(5):1295–1296CrossRefPubMed

Figueroa JJ, Loftus EV Jr, Harmsen WS, Dyck PJ, Klein CJ (2013) Peripheral neuropathy incidence in inflammatory bowel disease: a population-based study. Neurol 80(18):1693–1697CrossRef

Final report on the safety assessment of Ricinus (2007) Communis (Castor) Seed Oil, Hydrogenated Castor Oil, Glyceryl Ricinoleate, Glyceryl Ricinoleate SE, Ricinoleic Acid, Potassium Ricinoleate, Sodium Ricinoleate, Zinc Ricinoleate, Cetyl Ricinoleate, Ethyl Ricinoleate, Glycol Ricinoleate, Isopropyl Ricinoleate, Methyl Ricinoleate, and Octyldodecyl Ricinoleate. Int J Toxicol 26(Suppl 3):31–77

Finnie IA, Shields R, Sutton R, Donnelly R, Morris AI (1994) Crohn‘s disease and myasthenia gravis: a possible role for thymectomy. Gut 35(2):278–279CrossRefPubMedPubMedCentral

Freeman HJ (2008) Neurological disorders in adult celiac disease. Can J Gastroenterol = J Can gastroenterol 22(11):909–911CrossRef

Galldiks N, Burghaus L, Vollmar S, Cizek J, Impekoven P, Thomas A et al (2004) Novel neuroimaging findings in a patient with cerebral Whipple‘s disease: a magnetic resonance imaging and positron emission tomography study. J Neuroimaging 4(4):372–376CrossRef

Gelfenbeyn M, Goodkin R, Kliot M (2006) Sterile recurrent spinal epidural abscess in a patient with Crohn’s disease: a case report. Surg Neurol 65(2):178–184CrossRefPubMed

Gerard A, Sarrot-Reynauld F, Liozon E, Cathebras P, Besson G, Robin C et al (2002) Neurologic presentation of Whipple disease: report of 12 cases and review of the literature. Med 81(6):443–457CrossRef

Gobbele R, Reith W, Block F (2000) Cerebral vasculitis as a concomitant neurological illness in Crohn’s disease. Der Nervenarzt 71(4):299–304CrossRefPubMed

Gobbi G, Bouquet F, Greco L, Lambertini A, Tassinari CA, Ventura A et al (1992) Coeliac disease, epilepsy, and cerebral calcifications. The Italian Working Group on Coeliac Disease and Epilepsy. Lancet 340(8817):439–443CrossRefPubMed

Gondim FA, Brannagan TH 3rd, Sander HW, Chin RL, Latov N (2005) Peripheral neuropathy in patients with inflammatory bowel disease. Brain: J Neurol 128(4):867–879CrossRef

Gower-Rousseau C, Reumaux D, Bellard M, Delecourt L, Ribet M, Colombel JF (1993) Remission of myasthenia gravis after proctocolectomy in a patient with ulcerative colitis. Am J Gastroenterol 88(7):1136–1138PubMed

Gupta G, Gelfand JM, Lewis JD (2005) Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gastroenterol 129(3):819–826CrossRef

Hadjivassiliou M, Aeschlimann P, Sanders DS, Maki M, Kaukinen K, Grunewald RA et al (2013) Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurol 80(19):1740–1745CrossRef

Hadjivassiliou M, Boscolo S, Davies-Jones GA, Grunewald RA, Not T, Sanders DS et al (2002) The humoral response in the pathogenesis of gluten ataxia. Neurol 58(8):1221–1226CrossRef

Hadjivassiliou M, Davies-Jones GA, Sanders DS, Grunewald RA (2003) Dietary treatment of gluten ataxia. J Neurol Neurosurg Psychiatry 74(9):1221–1224CrossRefPubMedPubMedCentral

Hadjivassiliou M, Duker AP, Sanders DS (2014) Gluten-related neurologic dysfunction. Handb Clin Neurol 120:607–619CrossRefPubMed

Hadjivassiliou M, Sanders DD, Aeschlimann DP (2015) Gluten-related disorders: gluten ataxia. Dig Dis 33(2):264–268CrossRefPubMed

Hadjivassiliou M, Sanders DS, Grunewald RA, Woodroofe N, Boscolo S, Aeschlimann D (2010) Gluten sensitivity: from gut to brain. Lancet Neurol 9(3):318–330CrossRefPubMed

Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson C, Grunewald RA (2008) Gluten ataxia. Cerebellum 7(3):494–498CrossRefPubMed

Hagel S, Epple HJ, Feurle GE, Kern WV, Lynen Jansen P, Malfertheiner P et al (2015) S2k-guideline gastrointestinal infectious diseases and Whipple’s disease. Z Gastroenterol 53(5):418–459CrossRefPubMed

von Herbay A, Ditton HJ, Schuhmacher F, Maiwald M (1997) Whipple‘s disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid. Gastroenterol 113(2):434–441CrossRef

Heuer DK, Gager WE, Reeser FH (1982) Ischemic optic neuropathy associated with Crohn‘s disease. J Clin Neuroophthalmol 2(3):175–181PubMed

Humbert P, Monnier G, Billerey C, Birgen C, Dupond JL (1989) Polyneuropathy: an unusual extraintestinal manifestation of Crohn’s disease. Acta Neurol Scand 80(4):301–306CrossRefPubMed

Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M et al (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40(4):395–402CrossRefPubMedPubMedCentral

Johns DR (1991) Cerebrovascular complications of inflammatory bowel disease. Am J Gastroenterol 86(3):367–370PubMed

Karajeh MA, Hadjivassiliou M, Hurlstone P, Grundman MJ (2004) Neurological sequelae of Crohn’s disease: opportunity to study common etiological pathways. J Gastroenterol Hepatol 19(9):1093–1094CrossRefPubMed

Lagier JC, Fenollar F, Lepidi H, Giorgi R, Million M, Raoult D (2014) Treatment of classic Whipple‘s disease: from in vitro results to clinical outcome. J Antimicrob Chemother 69(1):219–227CrossRefPubMed

Lagier JC, Fenollar F, Lepidi H, Raoult D (2010) Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple‘s disease. J Antimicrob Chemother 65(9):2005–2012CrossRefPubMed

Lam MC, Bressler B (2014) Vedolizumab for ulcerative colitis and Crohn‘s disease: results and implications of GEMINI studies. Immunother 6(9):963–971CrossRef

Le Blay P, Rakotonirainy H, Lagier JC, Raoult D, Puechal X, Pers YM (2014) A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency. Jt Bone spine: Rev Rhum 81(3):260–262CrossRef

Levenstein S, Prantera C, Varvo V, Scribano ML, Andreoli A, Luzi C et al (2000) Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am J Gastroenterol 95(5):1213–1220CrossRefPubMed

Lossos A, River Y, Eliakim A, Steiner I (1995) Neurologic aspects of inflammatory bowel disease. Neurol 45(3 Pt 1):416–421CrossRef

Louis ED (2003) Whipple disease. Curr Neurol Neurosci Rep 3(6):470–475CrossRefPubMed

Louis ED, Lynch T, Kaufmann P, Fahn S, Odel J (1996) Diagnostic guidelines in central nervous system Whipple‘s disease. Ann Neurol 40(4):561–568CrossRefPubMed

Luostarinen L, Himanen SL, Luostarinen M, Collin P, Pirttila T (2003) Neuromuscular and sensory disturbances in patients with well treated coeliac disease. J Neurol Neurosurg Psychiatry 74(4):490–494CrossRefPubMedPubMedCentral

Mahnel R, Marth T (2004) Progress, problems, and perspectives in diagnosis and treatment of Whipple’s disease. Clin Exp Med 4(1):39–43CrossRefPubMed

Manzel K, Tranel D, Cooper G (2000) Cognitive and behavioral abnormalities in a case of central nervous system Whipple disease. Arch Neurol 57(3):399–403CrossRefPubMed

Masuda H, Ishii U, Aoki N, Nakayama H, Sato F, Karube H et al (2002) Ulcerative colitis associated with Takayasu’s disease in two patients who received proctocolectomy. J Gastroenterol 37(4):297–302CrossRefPubMed

Menard DB, Haddad H, Blain JG, Beaudry R, Devroede G, Masse S (1976) Granulomatous myositis and myopathy associated with crohn’s colitis. N Engl J Med 295(15):818–819CrossRefPubMed

Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T et al (2004) Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 53(4):542–548CrossRefPubMedPubMedCentral

Moos V, Feurle GE, Schinnerling K, Geelhaar A, Friebel J, Allers K et al (2013) Immunopathology of immune reconstitution inflammatory syndrome in Whipple’s disease. J Immunol 190(5):2354–2361CrossRefPubMed

Murai H, Tokunaga H, Kubo I, Kawajiri M, Iwaki T, Taniwaki T et al (2006) Myeloradiculitis caused by Cryptococcus neoformans infection in a patient with ulcerative colitis: a neuropathological study. J Neurol Sci 247(2):236–238CrossRefPubMed

Nelson J, Barron MM, Riggs JE, Gutmann L, Schochet SS Jr (1986) Cerebral vasculitis and ulcerative colitis. Neurol 36(5):719–721CrossRef

Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP (2005) Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig Dis Sci 50(2):235–240CrossRefPubMed

Panani AD, Grigoriadou M, Magira E, Roussos C, Raptis SA (2006) Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis. Clin Rheumatol 25(1):35–37CrossRefPubMed

Purrmann J, Arendt G, Cleveland S, Borchard F, Furst W, Gemsa R et al (1992) Association of Crohn’s disease and multiple sclerosis. Is there a common background? J Clin Gastroenterol 14(1):43–46CrossRefPubMed

Qureshi JA, Staugaitis SM, Calabrese LH (2002) Neutrophilic myositis: an extra-intestinal manifestation of ulcerative colitis. J Clin Rheumatol 8(2):85–88CrossRefPubMed

Rashtak S, Ettore MW, Homburger HA, Murray JA (2008) Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease. Clin Gastroenterol Hepatol 6(4):426–432; quiz 370CrossRefPubMedPubMedCentral

Reinshagen M, Folsch UR (2004) Extraintestinal manifestations in ulcerative colitis. Z Gastroenterol 42(9):1024–1028PubMed

Richard S, Fairise A, Lacour JC, Ducrocq X (2010) Cerebral venous thrombosis in inflammatory bowel diseases. Inflamm Bowel Dis 16(3):366–367CrossRefPubMed

Romero Aroca P, Salvat Serra M, Perena Soriano F, Martinez Salcedo I (2001) Anterior optic neuritis do to ulcerative colitis. Arch Soc Esp Oftalmologia 76(3):189–191

Scheid R, Teich N (2007) Neurologic manifestations of ulcerative colitis. Eur J Neurol 14(5):483–493CrossRefPubMed

van de Scheur MR, van der Waal RI, van Bodegraven AA, Volker-Dieben HJ, Starink TM, van der Waal I (2002) Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn’s disease. J Clin Gastroenterol 34(5):557–559CrossRefPubMed

Schnider PJ, Reisinger EC, Gerschlager W, Muller C, Berger T, Krejs GJ et al (1996) Long-term follow-up in cerebral Whipple’s disease. Eur J Gastroenterol Hepatol 8(9):899–903PubMed

Shen TC, Lebwohl B, Verma H, Kumta N, Tennyson C, Lewis S et al (2012) Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease. J Clin Neuromuscul Dis 13(3):137–145CrossRefPubMed

Tarabar D, Hirsch A, Rubin DT (2016) Vedolizumab in the treatment of Crohn’s disease. Expert Rev Gastroenterol Hepatol 10(3):283–290CrossRefPubMed

Thomas CW Jr, Weinshenker BG, Sandborn WJ (2004) Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn’s disease. Inflamm Bowel Dis 10(1):28–31CrossRefPubMed

Watkinson G (1986) Sulphasalazine: a review of 40 years’ experience. Drugs 32(Suppl 1):1–11CrossRefPubMed

Weber P, Husemann S, Vielhaber H, Zimmer KP, Nowak-Gottl U (1999) Coagulation and fibrinolysis in children, adolescents, and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 28(4):418–422CrossRefPubMed

West J, Logan RF, Hill PG, Lloyd A, Lewis S, Hubbard R et al (2003) Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 52(7):960–965CrossRefPubMedPubMedCentral

Whipple G (1907) A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 18:382–393

WJ SRaS (Hrsg) (2004) Inflammatory bowel diseases: saunders

Yesilova Z, Naharci I, Uygun A, Ulas HU, Dagalp K (2006) Motor axonal polyneuropathy in the course of ulcerative colitis: a case report. Turk J Gastroenterol 17(1):58–61PubMed

Zois CD, Katsanos KH, Kosmidou M, Tsianos EV (2010) Neurologic manifestations in inflammatory bowel diseases: current knowledge and novel insights. J Crohn’s Colitis 4(2):115–124CrossRef

Titel: Neurologische Komplikationen entzündlicher Darmerkrankungen
verfasst von: Oliver Bachmann
Natascha Wehnert
Verlag: Springer Berlin Heidelberg
Buch: Autoimmunerkrankungen in der Neurologie
Print ISBN: 978-3-662-55529-3

Electronic ISBN: 978-3-662-55530-9

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-662-55530-9_10

Neu in den Fachgebieten Neurologie und Psychiatrie

23.04.2024 | Demenz | Nachrichten

Springer Medizin

10. Neurologische Komplikationen entzündlicher Darmerkrankungen

Zusammenfassung

Neu in den Fachgebieten Neurologie und Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

Springer Medizin

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Neu in den Fachgebieten Neurologie und Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

Parkinson-Therapie im Wandel – aktuelle Leitlinie im Fokus

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein