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Acta Neurologica Belgica

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14.11.2017 | Review

Neuromodulatory procedures for gait disorders in Parkinson’s disease

verfasst von: Patrick Santens

Erschienen in: Acta Neurologica Belgica | Ausgabe 1/2018

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Abstract

The neurophysiology of gait is complex and involves numerous structures in the central nervous system. Gait disorders occur frequently in Parkinson’s disease (PD), and their management may become cumbersome, especially in the more advanced stages. Neuromodulatory treatments, including deep brain stimulation, cortical stimulation and spinal cord stimulation, are reviewed with respect to their effectiveness to improve gait in PD patients. Although positive effects have been reported for all of these procedures, many issues remain in view of methodological heterogeneity, variability in outcome measures and sample size. Gait in PD remains a difficult issue with a tremendous impact on quality of life, for which future research is badly needed.

Smulders K, Dale ML, Carlson-Kuhta P, Nutt JG, Horak FB (2016) Pharmacological treatment in Parkinson’s disease: effects on gait. Parkinsonism Relat Disord 31:3–13. https://doi.org/10.1016/j.parkreldis.2016.07.006 CrossRefPubMedPubMedCentral

Stuart S, Lord S, Hill E, Rochester L (2016) Gait in Parkinson’s disease: a visuo-cognitive challenge. Neurosci Biobehav Rev 62:76–88. https://doi.org/10.1016/j.neubiorev.2016.01.002 CrossRefPubMed

Galna B, Lord S, Burn DJ, Rochester L (2015) Progression of gait dysfunction in incident Parkinson’s disease: impact of medication and phenotype. Mov Disord 30:359–367. https://doi.org/10.1002/mds.26110 CrossRefPubMed

Thenganatt MA, Jankovic J (2014) Parkinson disease subtypes. JAMA Neurol 71:499–504. https://doi.org/10.1001/jamaneurol.2013.6233 CrossRefPubMed

Wu T, Hallett M, Chan P (2015) Motor automaticity in Parkinson’s disease. Neurobiol Dis 82:226–234. https://doi.org/10.1016/j.nbd.2015.06.014 CrossRefPubMedPubMedCentral

Curtze C, Nutt JG, Carlson-Kuhta P, Mancini M, Horak FB (2015) Levodopa is a double-edged sword for balance and gait in people with Parkinson’s disease. Mov Disord 30:1361–1370. https://doi.org/10.1002/mds.26269 CrossRefPubMedPubMedCentral

Giladi N (2008) Medical treatment of freezing of gait. Mov Disord 23(Suppl 2):S482–S488. https://doi.org/10.1002/mds.21914 CrossRefPubMed

Giladi N, Nieuwboer A (2008) Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov Disord 23(Suppl 2):S423–S425. https://doi.org/10.1002/mds.21927 CrossRefPubMed

Perez-Lloret S, Negre-Pages L, Damier P, Delval A, Derkinderen P, Destée A, Meissner WG, Schelosky L, Tison F, Rascol O (2014) Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease. JAMA Neurol 71(7):884–890. https://doi.org/10.1001/jamaneurol.2014.753 CrossRefPubMed

10.

Takakusaki K (2013) Neurophysiology of gait: from the spinal cord to the frontal lobe. Mov Disord 28(11):1483–1491. https://doi.org/10.1002/mds.25669 CrossRefPubMed

11.

Moro E, Schüpbach M, Wächter T, Allert N, Eleopra R, Honey CR, Rueda M, Schiess MC, Shimo Y, Valkovic P, Whone A, Stoevelaar H (2016) Referring Parkinson’s disease patients for deep brain stimulation: a RAND/UCLA appropriateness study. J Neurol 263:112–119. https://doi.org/10.1007/s00415-015-7942-x CrossRefPubMed

12.

Roper JA, Kang N, Ben J, Cauraugh JH, Okun MS, Hass CJ (2016) Deep brain stimulation improves gait velocity in Parkinson’s disease: a systematic review and meta-analysis. J Neurol 263:1195–1203. https://doi.org/10.1007/s00415-016-8129-9 CrossRefPubMed

13.

Collomb-Clerc A, Welter ML (2015) Effects of deep brain stimulation on balance and gait in patients with Parkinson’s disease: a systematic neurophysiological review. Neurophysiol Clin 45:371–388. https://doi.org/10.1016/j.neucli.2015.07.001 CrossRefPubMed

14.

Vercruysse S, Vandenberghe W, Münks L, Nuttin B, Devos H, Nieuwboer A (2014) Effects of deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson’s disease: a prospective controlled study. J Neurol Neurosurg Psychiatry 85:871–877. https://doi.org/10.1136/jnnp-2013-306336 CrossRefPubMed

15.

Xie J, Krack P, Benabid AL, Pollak P (2001) Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait. J Neurol 248:1068–1072CrossRefPubMed

16.

Ferraye MU, Debû B, Fraix V, Xie-Brustolin J, Chabardès S, Krack P, Benabid AL, Pollak P (2008) Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease. Neurology 70:1431–1437. https://doi.org/10.1212/01.wnl.0000310416.90757.85 CrossRefPubMed

17.

Farris SM, Giroux ML (2016) Rapid assessment of gait and speech after subthalamic deep brain stimulation. Surg Neurol Int 7(Suppl 19):S545–S550. https://doi.org/10.4103/2152-7806.187532 CrossRefPubMedPubMedCentral

18.

Schlenstedt C, Shalash A, Muthuraman M, Falk D, Witt K, Deuschl G (2017) Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. Eur J Neurol 24:18–26. https://doi.org/10.1111/ene.13167 CrossRefPubMed

19.

Fleury V, Pollak P, Gere J, Tommasi G, Romito L, Combescure C, Bardinet E, Chabardes S, Momjian S, Krainik A, Burkhard P, Yelnik J, Krack P (2016) Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait. Mov Disord 31:1389–1397. https://doi.org/10.1002/mds.26545 CrossRefPubMed

20.

Weiss D, Breit S, Wächter T, Plewnia C, Gharabaghi A, Krüger R (2011) Combined stimulation of the substantia nigra pars reticulata and the subthalamic nucleus is effective in hypokinetic gait disturbance in Parkinson’s disease. J Neurol 258:1183–1185. https://doi.org/10.1007/s00415-011-5906-3 CrossRefPubMed

21.

Weiss D, Walach M, Meisner C, Fritz M, Scholten M, Breit S, Plewnia C, Bender B, Gharabaghi A, Wächter T, Krüger R (2013) Nigral stimulation for resistant axial motor impairment in Parkinson’s disease? A randomized controlled trial. Brain 136(Pt 7):2098–2108. https://doi.org/10.1093/brain/awt122 CrossRefPubMedPubMedCentral

22.

Blumenfeld Z, Brontë-Stewart H (2015) High frequency deep brain stimulation and neural rhythms in Parkinson’s disease. Neuropsychol Rev 25:384–397. https://doi.org/10.1007/s11065-015-9308-7 CrossRefPubMed

23.

Moro E, Esselink RJ, Xie J, Hommel M, Benabid AL, Pollak P (2002) The impact on Parkinson’s disease of electrical parameter settings in STN stimulation. Neurology 59:706–713CrossRefPubMed

24.

Moreau C, Defebvre L, Destée A, Bleuse S, Clement F, Blatt JL, Krystkowiak P, Devos D (2008) STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology 71:80–84. https://doi.org/10.1212/01.wnl.0000303972.16279.46 CrossRefPubMed

25.

Khoo HM, Kishima H, Hosomi K, Maruo T, Tani N, Oshino S, Shimokawa T, Yokoe M, Mochizuki H, Saitoh Y, Yoshimine T (2014) Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial. Mov Disord 29:270–274. https://doi.org/10.1002/mds.25810 CrossRefPubMed

26.

Ricchi V, Zibetti M, Angrisano S, Merola A, Arduino N, Artusi CA, Rizzone M, Lopiano L, Lanotte M (2012) Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain Stimul 5:388–392. https://doi.org/10.1016/j.brs.2011.07.001 CrossRefPubMed

27.

Zibetti M, Moro E, Krishna V, Sammartino F, Picillo M, Munhoz RP, Lozano AM, Fasano A (2016) Low-frequency subthalamic stimulation in Parkinson’s disease: long-term outcome and predictors. Brain Stimul 9:774–779. https://doi.org/10.1016/j.brs.2016.04.017 CrossRefPubMed

28.

Gut NK, Winn P (2016) The pedunculopontine tegmental nucleus—a functional hypothesis from the comparative literature. Mov Disord 31:615–624. https://doi.org/10.1002/mds.26556 CrossRefPubMedPubMedCentral

29.

Golestanirad L, Elahi B, Graham SJ, Das S, Wald LL (2016) Efficacy and safety of pedunculopontine nuclei (PPN) deep brain stimulation in the treatment of gait disorders: a meta-analysis of clinical studies. Can J Neurol Sci 43:120–126. https://doi.org/10.1017/cjn.2015.318 CrossRefPubMed

30.

Mestre TA, Sidiropoulos C, Hamani C, Poon YY, Lozano AM, Lang AE, Moro E (2016) Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson’s disease. Mov Disord 31:1570–1574. https://doi.org/10.1002/mds.26710 CrossRefPubMed

31.

Defebvre LJ, Krystkowiak P, Blatt JL, Duhamel A, Bourriez JL, Périna M, Blond S, Guieu JD, Destée A (2002) Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson’s disease. Mov Disord 17:76–83CrossRefPubMed

32.

Bakker M, Esselink RA, Munneke M, Limousin-Dowsey P, Speelman HD, Bloem BR (2004) Effects of stereotactic neurosurgery on postural instability and gait in Parkinson’s disease. Mov Disord 19:1092–1099CrossRefPubMed

33.

Bastian AJ, Kelly VE, Perlmutter JS, Mink JW (2003) Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson’s disease. Mov Disord 18:1008–1017CrossRefPubMed

34.

Bronte-Stewart HM, Minn AY, Rodrigues K, Buckley EL, Nashner LM (2002) Postural instability in idiopathic Parkinson’s disease: the role of medication and unilateral pallidotomy. Brain 125:2100–2114CrossRefPubMed

35.

Roberts-Warrior D, Overby A, Jankovic J, Olson S, Lai EC, Krauss JK, Grossman R (2000) Postural control in Parkinson’s disease after unilateral posteroventral pallidotomy. Brain 123:2141–2149CrossRefPubMed

36.

Turnbull GI (2006) Changes in gait and symptoms after bilateral pallidotomy: a client with Parkinson’s disease. Physiother Res Int 11:173–179CrossRefPubMed

37.

Alvarez L, Macias R, Lopez G, Alvarez E, Pavon N, Rodriguez-Oroz MC, Juncos JL, Maragoto C, Guridi J, Litvan I, Tolosa ES, Koller W, Vitek J, DeLong MR, Obeso JA (2005) Bilateral subthalamotomy in Parkinson’s disease: initial and long-term response. Brain 128:570–583CrossRefPubMed

38.

Chung CL, Mak MK (2016) Effect of repetitive transcranial magnetic stimulation on physical function and motor signs in Parkinson’s disease: a systematic review and meta-analysis. Brain Stimul 9:475–487. https://doi.org/10.1016/j.brs.2016.03.017 CrossRefPubMed

39.

Santana MB, Halje P, Simplício H, Richter U, Freire MA, Petersson P, Fuentes R, Nicolelis MA (2014) Spinal cord stimulation alleviates motor deficits in a primate model of Parkinson disease. Neuron 84:716–722. https://doi.org/10.1016/j.neuron.2014.08.061 CrossRefPubMedPubMedCentral

40.

Pinto de Souza C, Hamani C, Oliveira Souza C, Lopez Contreras WO, Dos Santos Ghilardi MG, Cury RG, Reis Barbosa E, Jacobsen Teixeira M, Talamoni Fonoff E (2017) Spinal cord stimulation improves gait in patients with Parkinson’s disease previously treated with deep brain stimulation. Mov Disord 32:278–282. https://doi.org/10.1002/mds.26850 CrossRefPubMed

Titel: Neuromodulatory procedures for gait disorders in Parkinson’s disease
verfasst von: Patrick Santens
Publikationsdatum: 14.11.2017
Verlag: Springer International Publishing
Erschienen in: Acta Neurologica Belgica / Ausgabe 1/2018
Print ISSN: 0300-9009
Elektronische ISSN: 2240-2993
DOI: https://doi.org/10.1007/s13760-017-0862-z

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