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Dysphagia

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07.11.2020 | Review

RETRACTED ARTICLE: Neuromuscular Specializations of the Human Hypopharyngeal Muscles

verfasst von: Mohammed Elrabie Ahmed Mohammed, Liancai Mu, Hesham Mostafa Abdelfattah

Erschienen in: Dysphagia | Ausgabe 5/2021

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Abstract

The hypopharyngeal muscles in humans play a vital role in swallowing, speech, and respiration. Increasing evidence indicates that these muscles are specialized to perform life-sustaining upper aerodigestive functions. This review aims to provide current knowledge regarding the key structural, physiological, and biochemical features of the hypopharyngeal muscles, including innervation, contractile properties, histochemistry, biochemical properties, myosin heavy chain (MyHC) expression and regulation, and age-related alterations. These would clarify the unique neuromuscular specializations of the human hypopharyngeal muscles for a better understanding of the functions and pathological conditions of the pharynx and for the development of novel therapies to treat related upper airway disorders.

Ertekin C, Aydogdu I. Neurophysiology of swallowing. Clin Neurophysiol. 2003;114(12):2226–44. PubMedCrossRef

Cunningham ET, Jones B. Anatomical and physiological overview. In: Jones B, editor. Normal and abnormal swallowing. New York: Springer; 2003. p. 11–34. CrossRef

Dodds WJ, Stewart ET, Logemann JA. Physiology and radiology of the normal oral and pharyngeal phases of swallowing. AJR Am J Roentgenol. 1990;154(5):953–63. PubMedCrossRef

Miller AJ. The neurobiology of swallowing and dysphagia. Dev Disabil Res Rev. 2008;14(2):77–86. PubMedCrossRef

Vinney LA, Connor NP. Structure and function of the laryngeal and pharyngeal muscles. In: McLoon LK, Andrade F, editors. Craniofacial muscles. New York, NY: Springer; 2012. p. 141–66. CrossRef

Sciote JJ, Horton MJ, Rowlerson AM, Link J. Specialized cranial muscles: how different are they from limb and abdominal muscles? Cells Tissues Organs. 2003;174(1–2):73–86. PubMedCrossRef

McLoon LK, Thorstenson KM, Solomon A, Lewis MP. Myogenic precursor cells in craniofacial muscles. Oral Dis. 2007;13(2):134–40. PubMedCrossRef

Fischer MD, Budak MT, Bakay M, Gorospe JR, Kjellgren D, Pedrosa-Domellof F, Hoffman EP, Khurana TS. Definition of the unique human extraocular muscle allotype by expression profiling. Physiol Genomics. 2005;22(3):283–91. PubMedCrossRef

Spencer RF, Porter JD. Biological organization of the extraocular muscles. Prog Brain Res. 2006;151:43–80. PubMedCrossRef

10.

Shinners MJ, Goding GS, McLoon LK. Effect of recurrent laryngeal nerve section on the laryngeal muscles of adult rabbits. Otolaryngol Head Neck Surg. 2006;134(3):413–8. PubMedCrossRef

11.

Thomas LB, Harrison AL, Stemple JC. Aging thyroarytenoid and limb skeletal muscle: lessons in contrast. J Voice. 2008;22(4):430–50. PubMedCrossRef

12.

Bothe I, Dietrich S. The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis. Dev Dyn. 2006;235(10):2845–60. PubMedCrossRef

13.

Kuratani S. Craniofacial development and the evolution of the vertebrates: the old problems on a new background. Zoolog Sci. 2005;22(1):1–19. PubMedCrossRef

14.

Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, et al. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci USA. 2012;109(46):18839–44. PubMedPubMedCentralCrossRef

15.

Tzahor E. Heart and craniofacial muscle development: a new developmental theme of distinct myogenic fields. Dev Biol. 2009;327(2):273–9. PubMedCrossRef

16.

Mootoosamy RC, Dietrich S. Distinct regulatory cascades for head and trunk myogenesis. Development. 2002;129(3):573–83. PubMedCrossRef

17.

Standring S, Ellis H, Healy JC, Johnson D, Williams A, Colins P, et al editors. Gray’s anatomy. 39th ed. Amsterdam: Elsevier Churchill Livingstone Ltd; 2005. p. 295–7.

18.

Mu L, Sanders I. Neuromuscular specializations within human pharyngeal constrictor muscles. Ann Otol Rhinol Laryngol. 2007;116(8):604–17. PubMedCrossRef

19.

Bonington A, Mahon M, Whitmore I. A histological and histochemical study of the cricopharyngeus muscle in man. J Anat. 1988;156:27. PubMedPubMedCentral

20.

Mu L, Sanders I. The innervation of the human upper esophageal sphincter. Dysphagia. 1996;11(4):234–8. PubMedCrossRef

21.

Mu L, Sanders I. Newly revealed cricothyropharyngeus muscle in the human laryngopharynx. Anat Rec (Hoboken). 2008;291(8):927–38. CrossRef

22.

Mu L, Sanders I. Neuromuscular compartments and fiber-type regionalization in the human inferior pharyngeal constrictor muscle. Anat Rec. 2001;264(4):367–77. PubMedCrossRef

23.

Brownlow H, Whitmore I, Willan PL. A quantitative study of the histochemical and morphometric characteristics of the human cricopharyngeus muscle. J Anat. 1989;166:67–75. PubMedPubMedCentral

24.

Goyal RK, Martin SB, Shapiro J, Spechler SJ. The role of cricopharyngeus muscle in pharyngoesophageal disorders. Dysphagia. 1993;8(3):252–8. PubMedCrossRef

25.

Lang IM. Upper esophageal sphincter. GI Motility online. 2006.

26.

Mu L, Sanders I. Neuromuscular organization of the human upper esophageal sphincter. Ann Otol Rhinol Laryngol. 1998;107(5 Pt 1):370–7. PubMedCrossRef

27.

Ertekin C, Aydogdu I. Electromyography of human cricopharyngeal muscle of the upper esophageal sphincter. Muscle Nerve. 2002;26(6):729–39. PubMedCrossRef

28.

Kuna ST. Respiratory-related activation and mechanical effects of the pharyngeal constrictor muscles. Respir Physiol. 2000;119(2–3):155–61. PubMedCrossRef

29.

Rowe LD, Miller AJ, Chierici G, Clendenning D. Adaptation in the function of pharyngeal constrictor muscles. Otolaryngol Head Neck Surg. 1984;92(4):392–401. PubMedCrossRef

30.

O’Halloran KD, Herman JK, Bisgard GE. Respiratory-related pharyngeal constrictor muscle activity in awake goats. Respir Physiol. 1999;116(1):9–23. PubMedCrossRef

31.

Feroah TR, Forster HV, Pan LG, Rice T. Reciprocal activation of hypopharyngeal muscles and their effect on upper airway area. J Appl Physiol. 2000;88(2):611–26. PubMedCrossRef

32.

Rothstein RJ, Narce SL, deBerry-Borowiecki BE, Blanks RH. Respiratory-related activity of upper airway muscles in anesthetized rabbit. J Appl Physiol Respir Environ Exerc Physiol. 1983;55(6):1830–6. PubMed

33.

Kawasaki M, Ogura JH, Takenouchi S. Neurophysiologic observations of normal deglutition: II. Its relationship to allied phenomena. Laryngoscope. 1964;74:1766–80. PubMed

34.

Murakami Y. Respiratory activity of the external laryngeal muscles: an electromyographic study in the cat. Ventil Phonatory Control. 1974;82:430–48.

35.

Sherrey JH, Pollard MJ, Megirian D. Respiratory functions of the inferior pharyngeal constrictor and sternohyoid muscles during sleep. Exp Neurol. 1986;92(1):267–77. PubMedCrossRef

36.

Iizuka M. Respiratory activity in glossopharyngeal, vagus and accessory nerves and pharyngeal constrictors in newborn rat in vitro. J Physiol. 2001;532(Pt 2):535–48. PubMedPubMedCentralCrossRef

37.

Vilkman E, Sonninen A, Hurme P, Körkkö P. External laryngeal frame function in voice production revisited: a review. J Voice. 1996;10(1):78–92. PubMedCrossRef

38.

Hirano M. The function of the intrinsic laryngeal muscles in singing. In: Stevens K, Hirano M, editors. Vocal fold physiology. Tokyo: University of Tokyo Press; 1981. p. 155–67.

39.

Sakamoto Y. Interrelationships between the innervations from the laryngeal nerves and the pharyngeal plexus to the inferior pharyngeal constrictor. Surg Radiol Anat. 2013;35(8):721–8. PubMedCrossRef

40.

Mu L, Sanders I. Neuromuscular specializations of the pharyngeal dilator muscles: II. Compartmentalization of the canine genioglossus muscle. Anat Rec. 2000;260(3):308–25. PubMedCrossRef

41.

Mu L, Sanders I. Sensory nerve supply of the human oro- and laryngopharynx: a preliminary study. Anat Rec. 2020;258(4):406–20. CrossRef

42.

Kobler JB, Datta S, Goyal RK, Benecchi EJ. Innervation of the larynx, pharynx, and upper esophageal sphincter of the rat. J Comp Neurol. 1994;349(1):129–47. PubMedCrossRef

43.

Medda BK, Lang IM, Dodds WJ, Christl M, Kern M, Hogan WJ, Shaker R. Correlation of electrical and contractile activities of the cricopharyngeus muscle in the cat. Am J Physiol. 1997;273(2 Pt 1):G470–9. PubMed

44.

Brok HA, Copper MP, Stroeve RJ, de Visser BWO, Venker-van Haagen AJ, Schouwenburg PF. Evidence for recurrent laryngeal nerve contribution in motor innervation of the human cricopharyngeal muscle. Laryngoscope. 1999;109(5):705–8. PubMedCrossRef

45.

Fukushima SI, Shingai T, Kitagawa JI, Takahashi Y, Taguchi Y, Noda T, Yamada Y. Role of the pharyngeal branch of the vagus nerve in laryngeal elevation and UES pressure during swallowing in rabbits. Dysphagia. 2003;18(1):58–63. PubMedCrossRef

46.

Levitt MN, Dedo HH, Ogura JH. The cricopharyngeus muscle, an electromyographic study in the dog. Laryngoscope. 1965;75:122–36. PubMedCrossRef

47.

Lund WS. A study of the cricopharyngeal sphincter in man and in the dog. Ann R Coll Surg Engl. 1965;37(4):225–46. PubMedPubMedCentral

48.

Fukunaga Y, Higashino M, Osugi H, Tokuhara T, Kinoshita H. Function of the upper esophageal sphincter after denervation of recurrent laryngeal nerves and intramural nerves of the cervical esophagus in dogs. Nihon Geka Gakkai Zasshi. 1994;95(9):643–54. PubMed

49.

Wilson JA, Pryde A, White A, Maher L, Maran AGD. Swallowing performance in patients with vocal fold motion impairment. Dysphagia. 1995;10(3):149–54. PubMedCrossRef

50.

Sasaki CT, Sims HS, Kim YH, Czibulka A. Motor innervation of the human cricopharyngeus muscle. Ann Otol Rhinol Laryngol. 1999;108(12):1132–9. PubMedCrossRef

51.

Hammond CS, Davenport PW, Hutchison A, Otto RA. Motor innervation of the cricopharyngeus muscle by the recurrent laryngeal nerve. J Appl Physiol. 1997;83(1):89–94. PubMedCrossRef

52.

English AW, Wolf SL, Segal RL. Compartmentalization of muscles and their motor nuclei: the partitioning hypothesis. Phys Ther. 1993;73(12):857–67. PubMedCrossRef

53.

Segal RL, Wolf SL, DeCamp MJ, Chopp MT, English AW. Anatomical partitioning of three multiarticular human muscles. Acta Anat (Basel). 1991;142(3):261–6. CrossRef

54.

Korfage JA, Van Eijden TM. Regional differences in fibre type composition in the human temporalis muscle. J Anat. 1999;194(Pt 3):355–62. PubMedPubMedCentralCrossRef

55.

Lexell J, Jarvis JC, Currie J, Downham DY, Salmons S. Fibre type composition of rabbit tibialis anterior and extensor digitorum longus muscles. J Anat. 1994;185(Pt 1):95–101. PubMedPubMedCentral

56.

Wasicky R, Ziya-Ghazvini F, Blumer R, Lukas JR, Mayr R. Muscle fiber types of human extraocular muscles: a histochemical and immunohistochemical study. Invest Ophthalmol Vis Sci. 2000;41(5):980–90. PubMed

57.

Zaretsky LS, Sanders I. The three bellies of the canine cricothyroid muscle. Ann Otol Rhinol Laryngol Supp. 1992;156:3–16. CrossRef

58.

Burke RE. Motor units: anatomy, physiology, and functional organization. Compr Physiol. 2011;2:345–422.

59.

Porter JD, Baker RS. Muscles of a different “color”: the unusual properties of the extraocular muscles may predispose or protect them in neurogenic and myogenic disease. Neurology. 1996;46(1):30–7. PubMedCrossRef

60.

Dutta CR, Basmajian JV. Gross and histological structure of the pharyngeal constrictors in the rabbit. Anat Rec. 1960;137:127–34. PubMedCrossRef

61.

Hyodo M, Aibara R, Kawakita S, Yumoto E. Histochemical study of the canine inferior pharyngeal constrictor muscle: implications for its function. Acta Otolaryngol. 1998;118(2):272–9. PubMedCrossRef

62.

Desaki J. The morphological variability of neuromuscular junctions in the rat extraocular muscles: a scanning electron microscopical study. Arch Histol Cytol. 1990;53(3):275–81. PubMedCrossRef

63.

Taguchi A, Hyodo M, Yamagata T, Gyo K, Desaki J. Age-related remodeling of the hypopharyngeal constrictor muscle and its subneural apparatuses: a scanning electron microscopical study in rats. Dysphagia. 2004;19(4):241–7. PubMedCrossRef

64.

Salpeter MM. Vertebrate neuromuscular junctions: general morphology, molecular organization, and functional consequences. Neurol Neurobiol. 1987;23:1–54.

65.

Périé S, St Guily JL, Callard P, Sebille A. Innervation of adult human laryngeal muscle fibers. J Neurol Sci. 1997;149(1):81–6. PubMedCrossRef

66.

Hayakawa T, Kuwahara S, Maeda S, Tanaka K, Seki M. Calcitonin gene-related peptide immunoreactive neurons innervating the soft palate, the root of tongue, and the pharynx in the superior glossopharyngeal ganglion of the rat. J Chem Neuroanat. 2010;39(4):221–7. PubMedCrossRef

67.

Zelená J. Nerves and mechanoreceptors: the role of innervation in the development and maintenance of mammalian mechanoreceptors. New York: Springer; 1994.

68.

Nagai T. The occurrence and ultrastructure of a mechanoreceptor in the human cricopharyngeus muscle. Eur Arch Otorhinolaryngol. 1991;248(3):144–6. PubMedCrossRef

69.

Lazarov NE. Neurobiology of orofacial proprioception. Brain Res Rev. 2007;56(2):362–83. PubMedCrossRef

70.

De Carlos F, Cobo J, Macías E, Feito J, Cobo T, Calavia MG, Garcia-Suarez O, Vega JA. The sensory innervation of the human pharynx: searching for mechanoreceptors. Anat Rec (Hoboken). 2013;296(11):1735–46. CrossRef

71.

Lynch GS, Frueh BR, Williams DA. Contractile properties of single skinned fibres from the extraocular muscles, the levator and superior rectus, of the rabbit. J Physiol. 1994;475(2):337–46. PubMedPubMedCentralCrossRef

72.

Kristmundsdottir F, Mahon M, Froes MM, Cumming WJ. Histomorphometric and histopathological study of the human cricopharyngeus muscle: in health and in motor neuron disease. Neuropathol Appl Neurobiol. 1990;16(6):461–75. PubMedCrossRef

73.

Laurikainen E, Aitasalo K, Halonen P, Falck B, Kalimo H. Muscle pathology in idiopathic cricopharyngeal dysphagia. Enzyme histochemical and electron microscopic findings. Eur Arch Otorhinolaryngol. 1992;249(4):216–23. PubMedCrossRef

74.

Leese G, Hopwood D. Muscle fibre typing in the human pharyngeal constrictors and oesophagus: the effect of ageing. Acta Anat (Basel). 1986;127(1):77–80. CrossRef

75.

Ibebunjo C, Srikant CB, Donati F. Duration of succinylcholine and vecuronium blockade but not potency correlates with the ratio of endplate size to fibre size in seven muscles in the goat. Can J Anaesth. 1996;43(5 Pt 1):485–94. PubMedCrossRef

76.

Sundman E, Ansved T, Margolin G, Kuylenstierna R, Eriksson LI. Fiber-type composition and fiber size of the human cricopharyngeal muscle and the pharyngeal constrictor muscle. Acta Anaesthesiol Scand. 2004;48(4):423–9. PubMedCrossRef

77.

Zenker VW. Vocal muscle fibers and their motor end-plates. Res Poten Voice Physiol. 1964;55(6):439–45.

78.

Torigoe K, Nakamura T. Fine structure of myomyous junctions in the mouse skeletal muscles. Tissue Cell. 1987;19(2):243–50. PubMedCrossRef

79.

Hyodo M, Taguchi A, Yamagata T, Desaki J. A complex muscle fiber network in the cricothyroid muscle: a scanning electron microscopic study. Laryngoscope. 2007;117(4):600–3. PubMedCrossRef

80.

Hyodo M, Taguchi A, Yamagata T, Desaki J. Scanning electron microscopic study of the muscle fiber arrangement in the rat cricopharyngeal muscle. Acta Otolaryngol. 2005;125(9):976–80. PubMedCrossRef

81.

Periasamy M, Kalyanasundaram A. SERCA pump isoforms: their role in calcium transport and disease. Muscle Nerve. 2007;35(4):430–42. PubMedCrossRef

82.

Mu L, Su H, Wang J, Sanders I. Myosin heavy chain–based fiber types in the adult human cricopharyngeus muscle. Muscle Nerve. 2007;35(5):637–48. PubMedCrossRef

83.

Ryu S. A histochemical study of swallowing muscles in the inlet of the esophagus. Otologia Fukuoka. 1981;27:43–59.

84.

Ahmed ME, Bando H, Fuse S, Abdelfattah HM, Ahmed ME, Ahmed MAK, et al. Differential isoform expression of SERCA and myosin heavy chain in hypopharyngeal muscles. Acta Otorhinolaryngol Ital. 2019;39(4):220–9. CrossRef

85.

Mu L, Sanders I. Muscle fiber-type distribution pattern in the human cricopharyngeus muscle. Dysphagia. 2002;17(2):87–96. PubMedCrossRef

86.

Cook IJ, Dodds WJ, Dantas RO, Massey B, Kern MK, Lang IM, Brasseur JG, Hogan WJ. Opening mechanisms of the human upper esophageal sphincter. Am J Physiol. 1989;257(5):G748–59. PubMed

87.

McConnel FM, Cerenko D, Mendelsohn MS. Manofluorographic analysis of swallowing. Otolaryngol Clin North Am. 1988;21(4):625–35. PubMedCrossRef

88.

Randolph ME, Luo Q, Ho J, Vest KE, Sokoloff AJ, Pavlath GK. Ageing and muscular dystrophy differentially affect murine pharyngeal muscles in a region-dependent manner. J Physiol. 2014;592(23):5301–15. PubMedPubMedCentralCrossRef

89.

Shiotani A, Nakagawa H, Flint PW. Modulation of myosin heavy chains in rat laryngeal muscle. Laryngoscope. 2001;111(3):472–7. PubMedCrossRef

90.

Ciciliot S, Rossi AC, Dyar KA, Blaauw B, Schiaffino S. Muscle type and fiber type specificity in muscle wasting. Int J Biochem Cell Biol. 2013;45(10):2191–9. PubMedCrossRef

91.

Rosser BW, Norris BJ, Nemeth PM. Metabolic capacity of individual muscle fibers from different anatomic locations. J Histochem Cytochem. 1992;40(6):819–25. PubMedCrossRef

92.

Berchtold MW, Brinkmeier H, Muntener M. Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease. Physiol Rev. 2000;80(3):1215–65. PubMedCrossRef

93.

Lieber RL. Skeletal muscle structure, function, and plasticity. Philadelphia: Lippincott Williams & Wilkins; 2002.

94.

Kelly JH, Kuncl RW. Myology of the pharyngoesophageal segment: gross anatomic and histologic characteristics. Laryngoscope. 1996;106(6):713–20. PubMedCrossRef

95.

Relaix F, Zammit PS. Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage. Development. 2012;139(16):2845–56. PubMedCrossRef

96.

McLoon LK, Rowe J, Wirtschafter J, McCormick KM. Continuous myofiber remodeling in uninjured extraocular myofibers: myonuclear turnover and evidence for apoptosis. Muscle Nerve. 2004;29(5):707–15. PubMedPubMedCentralCrossRef

97.

Randolph ME, Phillips BL, Choo HJ, Vest KE, Vera Y, Pavlath GK. Pharyngeal satellite cells undergo myogenesis under basal conditions and are required for pharyngeal muscle maintenance. Stem Cells. 2015;33(12):3581–95. PubMedCrossRef

98.

Brack AS, Rando TA. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 2007;3(3):226–37. PubMedCrossRef

99.

Hikida RS, van Nostran S, Murray JD, Staron RS, Gordon SE, Kraemer WJ. Myonuclear loss in atrophied soleus muscle fibers. Anat Rec. 1997;247(3):350–4. PubMedCrossRef

100.

Mittelbronn M, Sullivan T, Stewart CL, Bornemann A. Myonuclear degeneration in LMNA null mice. Brain Pathol. 2008;18(3):338–43. PubMedPubMedCentralCrossRef

101.

Benninger MS, Gardner GM, Schwimmer C, Divi V. Neuroanatomy of the larynx. Diagnosis and treatment of voice disorders. San Diego: Plural Publishing; 2006.

102.

Shindo ML, Herzon GD, Hanson DG, Cain DJ, Sahgal V. Effects of denervation on laryngeal muscles: a canine model. Laryngoscope. 1992;102(6):663–9. PubMedCrossRef

103.

Nomoto M, Yoshihara T, Kanda T, Konno A, Kaneko T. Misdirected reinnervation in the feline intrinsic laryngeal muscles after long-term denervation. Acta Otolaryngol Suppl. 1993;506:71–4. PubMedCrossRef

104.

Kano S, Horowitz JB, Sasaki CT. Posterior cricoarytenoid muscle denervation. Arch Otolaryngol Head Neck Surgery. 1991;117(9):1019–20. CrossRef

105.

Andrade FH, Porter JD, Kaminski HJ. Eye muscle sparing by the muscular dystrophies: lessons to be learned? Microsc Res Tech. 2000;48(3–4):192–203. PubMedCrossRef

106.

Aydogdu I, Kiylioglu N, Tarlaci S, Tanriverdi Z, Alpaydin S, Acarer A, et al. Diagnostic value of “dysphagia limit” for neurogenic dysphagia: 17 years of experience in 1278 adults. Clin Neurophysiol. 2015;126(3):634–43. PubMedCrossRef

107.

Mu L, Sobotka S, Chen J, Su H, Sanders I, Adler CH, et al. Altered pharyngeal muscles in Parkinson disease. J Neuropath Exp Neurol. 2012;71(6):520–30. PubMedCrossRef

108.

Olszewski J. Causes, diagnosis and treatment of neurogenic dysphagia as an interdisciplinary clinical problem. Otolaryngol Pol. 2006;60(4):491–500. PubMed

109.

Wirtz PW, Sotodeh M, Nijnuis M, Van Doorn PA, Van Engelen BGM, et al. Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. J Neurol Neurosurg Psychiatr. 2002;73(6):766–8. CrossRef

110.

Higo R, Nito T, Tayama N. Videofluoroscopic assessment of swallowing function in patients with myasthenia gravis. J Neurol Sci. 2005;231(1–2):45–8. PubMedCrossRef

111.

Jaradeh S. Muscle disorders affecting oral and pharyngeal swallowing. GI Motility. 2006. https://doi.org/10.1038/gimo35. CrossRef

112.

Gidaro T, Negroni E, Perié S, Mirabella M, Lainé J, St Guily JL, et al. Atrophy, fibrosis, and increased PAX7-positive cells in pharyngeal muscles of oculopharyngeal muscular dystrophy patients. J Neuropathol Exp Neurol. 2013;72(3):234–43. PubMedCrossRef

113.

Périé S, Mamchaoui K, Mouly V, Blot S, Bouazza B, Thornell LE, et al. Premature proliferative arrest of cricopharyngeal myoblasts in oculo-pharyngeal muscular dystrophy: therapeutic perspectives of autologous myoblast transplantation. Neuromuscul Disord. 2006;16(11):770–81. PubMedCrossRef

114.

Dyck PJ, Chance PF, Lebo R, Carney JA (1993) Hereditary motor and sensory neuropathies. Peripheral Neuropathy. 1094–1140

115.

Mu L, Sobotka S, Chen J, Su H, Sanders I, Nyirenda T, et al. Parkinson disease affects peripheral sensory nerves in the pharynx. J Neuropathol Exp Neurol. 2013;72(7):614–23. PubMedCrossRef

116.

Schulze SL, Danielson SK, Rhee JS, Toohill RJ, Kulpa JI, Jaradeh SS. Morphology of the cricopharyngeal muscle in Zenker and control specimens. Ann Otol Rhinol Laryngol. 2002;111(7 Pt 1):573–8. PubMedCrossRef

117.

Kawashima K, Motohashi Y, Fujishima I. Prevalence of dysphagia among community-dwelling elderly individuals as estimated using a questionnaire for dysphagia screening. Dysphagia. 2004;19(4):266–71. PubMedCrossRef

118.

Roubenoff R, Hughes VA. Sarcopenia: current concepts. J Gerontol A. 2000;55(12):M716–24. CrossRef

119.

Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med. 2001;137(4):231–43. PubMedCrossRef

120.

Vandervoort AA. Aging of the human neuromuscular system. Muscle Nerve. 2002;25(1):17–25. PubMedCrossRef

121.

Purves-Smith FM, Solbak NM, Rowan SL, Hepple RT. Severe atrophy of slow myofibers in aging muscle is concealed by myosin heavy chain co-expression. Exp Gerontol. 2012;47(12):913–8. PubMedCrossRef

122.

Lexell J, Henriksson-Larsen K, Winblad B, Sjostrom M. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve. 1983;6(8):588–95. PubMedCrossRef

123.

Lexell J, Taylor CC, Sjöström M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci. 1988;84(2–3):275–94. PubMedCrossRef

124.

Deschenes MR. Effects of aging on muscle fibre type and size. Sports Med. 2004;34(12):809–24. PubMedCrossRef

125.

Lexell J, Downham DY. The occurrence of fibre-type grouping in healthy human muscle: a quantitative study of cross-sections of whole vastus lateralis from men between 15 and 83 years. Acta Neuropathol. 1991;81(4):377–81. PubMedCrossRef

126.

Larsson L. Motor units: remodeling in aged animals. J Gerontol A. 1995;50:91–5.

127.

Winegard KJ, Hicks AL, Sale DG, Vandervoort AA. A 12-year follow-up study of ankle muscle function in older adults. J Gerontol A. 1996;51(3):B202–7. CrossRef

128.

Bellew JW. Nonpathological changes in the neuromuscular system as a function of aging. Issues Aging. 1998;21(4):1998.

Titel: RETRACTED ARTICLE: Neuromuscular Specializations of the Human Hypopharyngeal Muscles
verfasst von: Mohammed Elrabie Ahmed Mohammed
Liancai Mu
Hesham Mostafa Abdelfattah
Publikationsdatum: 07.11.2020
Verlag: Springer US
Erschienen in: Dysphagia / Ausgabe 5/2021
Print ISSN: 0179-051X
Elektronische ISSN: 1432-0460
DOI: https://doi.org/10.1007/s00455-020-10212-0

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