Skip to main content
Erschienen in: DNP - Der Neurologe & Psychiater 5/2021

06.10.2021 | Multiple Sklerose | Zertifizierte Fortbildung

Neuromyelitis-optica-Spektrum-Erkrankung

NMOSD - vom ersten Schub zur optimalen Behandlung

verfasst von: PD Dr. med. Joachim Havla, Prof. Dr. med. Tania Kümpfel

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 5/2021

Einloggen, um Zugang zu erhalten

Auszug

Neuromyelitis-optica-Spektrum-Erkrankungen (NMOSD) zu erkennen und korrekt einzuordnen ist essenziell für die Behandlung. In diesem Übersichtsartikel werden am Beispiel der Optikusneuritis das Vorgehen im Rahmen der Diagnosestellung und die aktuellen Therapiekonzepte für die NMOSD dargelegt.
Literatur
1.
Zurück zum Zitat Bennett JL. Optic Neuritis. Continuum (Minneap Minn) 2019;25:1236-64 Bennett JL. Optic Neuritis. Continuum (Minneap Minn) 2019;25:1236-64
2.
Zurück zum Zitat Pache F, Wildemann B, Paul F, Jarius S. [Neuromyelitis optica]. Fortschr Neurol Psychiatr 2017;85:e1 Pache F, Wildemann B, Paul F, Jarius S. [Neuromyelitis optica]. Fortschr Neurol Psychiatr 2017;85:e1
3.
Zurück zum Zitat Jarius S, Wildemann B. [Aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis. A brief review]. Nervenarzt 2021;92:317-33 Jarius S, Wildemann B. [Aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis. A brief review]. Nervenarzt 2021;92:317-33
4.
Zurück zum Zitat Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85:177-89 Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85:177-89
5.
Zurück zum Zitat Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805-15 Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805-15
6.
Zurück zum Zitat Mori M, Kuwabara S, Paul F. Worldwide prevalence of neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry 2018;89:555-6 Mori M, Kuwabara S, Paul F. Worldwide prevalence of neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry 2018;89:555-6
7.
Zurück zum Zitat Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120(Pt 11): 2059-69 Barkhof F, Filippi M, Miller DH, Scheltens P, Campi A, Polman CH et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120(Pt 11): 2059-69
8.
Zurück zum Zitat Jarius S, Eichhorn P, Franciotta D, Petereit HF, Akman-Demir G, Wick M et al. The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature. J Neurol 2017; 264:453-66 Jarius S, Eichhorn P, Franciotta D, Petereit HF, Akman-Demir G, Wick M et al. The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature. J Neurol 2017; 264:453-66
9.
Zurück zum Zitat Trebst C, Berthele A, Jarius S, Kumpfel T, Schippling S, Wildemann B et al. [Diagnosis and treatment of neuromyelitis optica. Consensus recommendations of the Neuromyelitis Optica Study Group]. Nervenarzt 2011;82:768-77 Trebst C, Berthele A, Jarius S, Kumpfel T, Schippling S, Wildemann B et al. [Diagnosis and treatment of neuromyelitis optica. Consensus recommendations of the Neuromyelitis Optica Study Group]. Nervenarzt 2011;82:768-77
10.
Zurück zum Zitat Oertel FC, Outteryck O, Knier B, Zimmermann H, Borisow N, Bellmann-Strobl J et al. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation 2019;16:154 Oertel FC, Outteryck O, Knier B, Zimmermann H, Borisow N, Bellmann-Strobl J et al. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation 2019;16:154
11.
Zurück zum Zitat Havla J, Pakeerathan T, Schwake C, Bennett JL, Kleiter I, Felipe-Rucian A et al. Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well? J Neuroinflammation 2021;18:121 Havla J, Pakeerathan T, Schwake C, Bennett JL, Kleiter I, Felipe-Rucian A et al. Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well? J Neuroinflammation 2021;18:121
12.
Zurück zum Zitat Reindl M. Clinical course of MOG antibody-associated recurrent demyelinating diseases. J Neurol Neurosurg Psychiatry 2018;89:118 Reindl M. Clinical course of MOG antibody-associated recurrent demyelinating diseases. J Neurol Neurosurg Psychiatry 2018;89:118
13.
Zurück zum Zitat Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J et al. [MOG encephalomyelitis: international recommendations on diagnosis and antibody testing]. Nervenarzt 2018;89:1388-99 Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J et al. [MOG encephalomyelitis: international recommendations on diagnosis and antibody testing]. Nervenarzt 2018;89:1388-99
14.
Zurück zum Zitat Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016;13:280 Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016;13:280
15.
Zurück zum Zitat Jarius S, Lechner C, Wendel EM, Baumann M, Breu M, Schimmel M et al. Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients. J Neuroinflammation 2020; 17:262 Jarius S, Lechner C, Wendel EM, Baumann M, Breu M, Schimmel M et al. Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients. J Neuroinflammation 2020; 17:262
16.
Zurück zum Zitat Jarius S, Pellkofer H, Siebert N, Korporal-Kuhnke M, Hummert MW, Ringelstein M et al. Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients. J Neuroinflammation 2020;17:261 Jarius S, Pellkofer H, Siebert N, Korporal-Kuhnke M, Hummert MW, Ringelstein M et al. Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients. J Neuroinflammation 2020;17:261
17.
Zurück zum Zitat Majed M, Fryer JP, McKeon A, Lennon VA, Pittock SJ. Clinical utility of testing AQP4-IgG in CSF: Guidance for physicians. Neurol Neuroimmunol Neuroinflamm 2016;3:e231 Majed M, Fryer JP, McKeon A, Lennon VA, Pittock SJ. Clinical utility of testing AQP4-IgG in CSF: Guidance for physicians. Neurol Neuroimmunol Neuroinflamm 2016;3:e231
18.
Zurück zum Zitat Pache F, Wildemann B, Paul F, Jarius S. [Neuromyelitis optica]. Fortschr Neurol Psychiatr 2017;85:100-14 Pache F, Wildemann B, Paul F, Jarius S. [Neuromyelitis optica]. Fortschr Neurol Psychiatr 2017;85:100-14
19.
Zurück zum Zitat Outteryck O, Lopes R, Drumez E, Labreuche J, Lannoy J, Hadhoum N et al. Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome. Neurology 2020;95:e733-e44 Outteryck O, Lopes R, Drumez E, Labreuche J, Lannoy J, Hadhoum N et al. Optical coherence tomography for detection of asymptomatic optic nerve lesions in clinically isolated syndrome. Neurology 2020;95:e733-e44
20.
Zurück zum Zitat Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S et al. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis Journal 2015;21:678-88 Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S et al. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis Journal 2015;21:678-88
21.
Zurück zum Zitat Oertel FC, Zimmermann H, Paul F, Brandt AU. Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy. EPMA J 2018;9:21-33 Oertel FC, Zimmermann H, Paul F, Brandt AU. Optical coherence tomography in neuromyelitis optica spectrum disorders: potential advantages for individualized monitoring of progression and therapy. EPMA J 2018;9:21-33
22.
Zurück zum Zitat Havla J, Kumpfel T, Schinner R, Spadaro M, Schuh E, Meinl E et al. Myelin-oligodendrocyte-glycoprotein (MOG) autoantibodies as potential markers of severe optic neuritis and subclinical retinal axonal degeneration. J Neurol 2017;264:139-51 Havla J, Kumpfel T, Schinner R, Spadaro M, Schuh E, Meinl E et al. Myelin-oligodendrocyte-glycoprotein (MOG) autoantibodies as potential markers of severe optic neuritis and subclinical retinal axonal degeneration. J Neurol 2017;264:139-51
23.
Zurück zum Zitat Motamedi S, Oertel FC, Yadav SK, Kadas EM, Weise M, Havla J et al. Altered fovea in AQP4-IgG-seropositive neuromyelitis optica spectrum disorders. Neurology: Neuroimmunology & Neuroinflammation 2020;7:e805 Motamedi S, Oertel FC, Yadav SK, Kadas EM, Weise M, Havla J et al. Altered fovea in AQP4-IgG-seropositive neuromyelitis optica spectrum disorders. Neurology: Neuroimmunology & Neuroinflammation 2020;7:e805
24.
Zurück zum Zitat Liu J, Mori M, Zimmermann H, Brandt A, Havla J, Tanaka S et al. Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany. J Neurol Neurosurg Psychiatry 2020;92:377-83 Liu J, Mori M, Zimmermann H, Brandt A, Havla J, Tanaka S et al. Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany. J Neurol Neurosurg Psychiatry 2020;92:377-83
25.
Zurück zum Zitat Oertel FC, Havla J, Roca-Fernandez A, Lizak N, Zimmermann H, Motamedi S et al. Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study. J Neurol Neurosurg Psychiatry 2018;89:1259-65 Oertel FC, Havla J, Roca-Fernandez A, Lizak N, Zimmermann H, Motamedi S et al. Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study. J Neurol Neurosurg Psychiatry 2018;89:1259-65
26.
Zurück zum Zitat Aktas O, Kumpfel T. [From neuromyelitis optica to neuromyelitis optica spectrum disorder: from clinical syndrome to diagnistic classification]. Nervenarzt 2021;92:307-16 Aktas O, Kumpfel T. [From neuromyelitis optica to neuromyelitis optica spectrum disorder: from clinical syndrome to diagnistic classification]. Nervenarzt 2021;92:307-16
27.
Zurück zum Zitat Ayzenberg I, Kleiter I. [Treatment of antibody-mediated encephalomyelitis : Strategies for the treatment of neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease]. Nervenarzt 2021;92:334-48 Ayzenberg I, Kleiter I. [Treatment of antibody-mediated encephalomyelitis : Strategies for the treatment of neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease]. Nervenarzt 2021;92:334-48
28.
Zurück zum Zitat Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K et al. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions. Neurol Neuroimmunol Neuroinflamm 2018;5:e504 Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K et al. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions. Neurol Neuroimmunol Neuroinflamm 2018;5:e504
29.
Zurück zum Zitat Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K et al. Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response. J Neurol Neurosurg Psychiatry 2017;88:639-47 Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K et al. Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response. J Neurol Neurosurg Psychiatry 2017;88:639-47
30.
Zurück zum Zitat Huang Q, Wang J, Zhou Y, Yang H, Wang Z, Yan Z et al. Low-Dose Mycophenolate Mofetil for Treatment of Neuromyelitis Optica Spectrum Disorders: A Prospective Multicenter Study in South China. Front Immunol 2018;9:2066 Huang Q, Wang J, Zhou Y, Yang H, Wang Z, Yan Z et al. Low-Dose Mycophenolate Mofetil for Treatment of Neuromyelitis Optica Spectrum Disorders: A Prospective Multicenter Study in South China. Front Immunol 2018;9:2066
31.
Zurück zum Zitat Songwisit S, Kosiyakul P, Jitprapaikulsan J, Prayoonwiwat N, Ungprasert P, Siritho S. Efficacy and safety of mycophenolate mofetil therapy in neuromyelitis optica spectrum disorders: a systematic review and meta-analysis. Sci Rep 2020;10:16727 Songwisit S, Kosiyakul P, Jitprapaikulsan J, Prayoonwiwat N, Ungprasert P, Siritho S. Efficacy and safety of mycophenolate mofetil therapy in neuromyelitis optica spectrum disorders: a systematic review and meta-analysis. Sci Rep 2020;10:16727
32.
Zurück zum Zitat Tahara M, Oeda T, Okada K, Kiriyama T, Ochi K, Maruyama H et al. Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2020;19:298-306 Tahara M, Oeda T, Okada K, Kiriyama T, Ochi K, Maruyama H et al. Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2020;19:298-306
33.
Zurück zum Zitat Zhang C, Zhang M, Qiu W, Ma H, Zhang X, Zhu Z et al. Safety and efficacy of tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder (TANGO): an open-label, multicentre, randomised, phase 2 trial. Lancet Neurol 2020;19: 391-401 Zhang C, Zhang M, Qiu W, Ma H, Zhang X, Zhu Z et al. Safety and efficacy of tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder (TANGO): an open-label, multicentre, randomised, phase 2 trial. Lancet Neurol 2020;19: 391-401
34.
Zurück zum Zitat Palace J, Leite MI, Nairne A, Vincent A. Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers. Arch Neurol 2010;67:1016-7 Palace J, Leite MI, Nairne A, Vincent A. Interferon Beta treatment in neuromyelitis optica: increase in relapses and aquaporin 4 antibody titers. Arch Neurol 2010;67:1016-7
35.
Zurück zum Zitat Kleiter I, Hellwig K, Berthele A, Kumpfel T, Linker RA, Hartung HP et al. Failure of natalizumab to prevent relapses in neuromyelitis optica. Arch Neurol 2012;69:239-45 Kleiter I, Hellwig K, Berthele A, Kumpfel T, Linker RA, Hartung HP et al. Failure of natalizumab to prevent relapses in neuromyelitis optica. Arch Neurol 2012;69:239-45
36.
Zurück zum Zitat Azzopardi L, Cox AL, McCarthy CL, Jones JL, Coles AJ. Alemtuzumab use in neuromyelitis optica spectrum disorders: a brief case series. J Neurol 2016;263:25-9 Azzopardi L, Cox AL, McCarthy CL, Jones JL, Coles AJ. Alemtuzumab use in neuromyelitis optica spectrum disorders: a brief case series. J Neurol 2016;263:25-9
37.
Zurück zum Zitat Ayzenberg I, Schollhammer J, Hoepner R, Hellwig K, Ringelstein M, Aktas O et al. Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study. J Neurol 2016;263:575-82 Ayzenberg I, Schollhammer J, Hoepner R, Hellwig K, Ringelstein M, Aktas O et al. Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study. J Neurol 2016;263:575-82
38.
Zurück zum Zitat Min JH, Kim BJ, Lee KH. Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder. Mult Scler 2012;18:113-5 Min JH, Kim BJ, Lee KH. Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder. Mult Scler 2012;18:113-5
39.
Zurück zum Zitat Yamout BI, Beaini S, Zeineddine MM, Akkawi N. Catastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal 2017;23:1297-300 Yamout BI, Beaini S, Zeineddine MM, Akkawi N. Catastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal 2017;23:1297-300
40.
Zurück zum Zitat Traboulsee A, Greenberg BM, Bennett JL, Szczechowski L, Fox E, Shkrobot S et al. Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial. Lancet Neurol 2020; 19:402-12 Traboulsee A, Greenberg BM, Bennett JL, Szczechowski L, Fox E, Shkrobot S et al. Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial. Lancet Neurol 2020; 19:402-12
41.
Zurück zum Zitat Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM et al. Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial. Lancet 2019;394:1352-63 Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM et al. Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial. Lancet 2019;394:1352-63
42.
Zurück zum Zitat Pittock SJ, Berthele A, Fujihara K, Kim HJ, Levy M, Palace J et al. Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder. N Engl J Med 2019;381:614-25 Pittock SJ, Berthele A, Fujihara K, Kim HJ, Levy M, Palace J et al. Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder. N Engl J Med 2019;381:614-25
43.
Zurück zum Zitat Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B et al. Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder. N Engl J Med 2019;381:2114-24 Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B et al. Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder. N Engl J Med 2019;381:2114-24
Metadaten
Titel
Neuromyelitis-optica-Spektrum-Erkrankung
NMOSD - vom ersten Schub zur optimalen Behandlung
verfasst von
PD Dr. med. Joachim Havla
Prof. Dr. med. Tania Kümpfel
Publikationsdatum
06.10.2021
Verlag
Springer Medizin
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 5/2021
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-021-4735-1

Weitere Artikel der Ausgabe 5/2021

DNP - Der Neurologe & Psychiater 5/2021 Zur Ausgabe