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Erschienen in: Annals of Hematology 7/2017

30.03.2017 | Original Article

Neuropathic pain in patients with sickle cell disease: a cross-sectional study assessing teens and young adults

verfasst von: Fabricio Dias Antunes, Vynicius Goltran Sobral Propheta, Hulemar Andrade Vasconcelos, Rosana Cipolotti

Erschienen in: Annals of Hematology | Ausgabe 7/2017

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Abstract

Chronic pain conditions are little studied and may be underestimated in sickle cell disease (SCD). The aim of this study was to identify the occurrence and characteristics of neuropathic pain (NP) in SCD patients. A sample of 56 patients was chosen from a total of 554 patients submitted to the inclusion criteria between 2015 and 2016. The Leeds assessment of neuropathic symptoms and signs scale was used for detecting NP. The groups with and without NP were compared by sex, age, use of hydroxyurea, and sensory changes through Chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis tests. The average age was 20.6 years (SD ± 4.6), 51.8% of the patients were male, and 14 patients (25%) suffered from NP. Most commonly, the pain was reported to be in the lower back area (53.6%). Age was positively related to NP: the average age in the group with NP was 22.7 years (SD ± 4.1) and in the group without NP was 19.8 years (SD ± 4.5), p < 0.05. Higher rates of NP occurred in patients aged 19 years or older, compared with that in teens (p < 0.01). There was a positive association between NP and the use of hydroxyurea (p < 0.05). An association was found between NP and sensitive neurological changes (p < 0.01). Therefore, screening for NP may result in faster and more effective diagnoses and consequently initiate appropriate treatment.
Literatur
1.
Zurück zum Zitat Dover GJ, Platt OS (1998) Sickle cell disease. In: Nathan DG, Orkin SH (eds) Nathan and Oski’s hematology of infancy and childhood, 5th edn. W.B. Saunders, Philadelphia, pp 762–795 Dover GJ, Platt OS (1998) Sickle cell disease. In: Nathan DG, Orkin SH (eds) Nathan and Oski’s hematology of infancy and childhood, 5th edn. W.B. Saunders, Philadelphia, pp 762–795
2.
Zurück zum Zitat Adegbola M (2011) Genomics and pain research in sickle cell disease: an explanation of heterogeneity? International Scholarly Research Network (ISRN)-Nursing, open access Adegbola M (2011) Genomics and pain research in sickle cell disease: an explanation of heterogeneity? International Scholarly Research Network (ISRN)-Nursing, open access
3.
Zurück zum Zitat Wang K (2010) Painful conditioning stimuli of the craniofacial region evokes diffuse noxious inhibitory controls in men and women. J Orofacial Pain 24(3):255–261PubMed Wang K (2010) Painful conditioning stimuli of the craniofacial region evokes diffuse noxious inhibitory controls in men and women. J Orofacial Pain 24(3):255–261PubMed
4.
Zurück zum Zitat Tostes MA, Braga JA, Len CA (2009) Abordagem da crise dolorosa em crianças portadoras de doença falciforme. Rev Ciênc Méd 18(1):47–55 Tostes MA, Braga JA, Len CA (2009) Abordagem da crise dolorosa em crianças portadoras de doença falciforme. Rev Ciênc Méd 18(1):47–55
5.
Zurück zum Zitat Ballas S (2010) Current issues in sickle cell pain and its management. Hematology 97–105 Ballas S (2010) Current issues in sickle cell pain and its management. Hematology 97–105
6.
Zurück zum Zitat Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO et al (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70:1630–1635CrossRefPubMed Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO et al (2008) Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70:1630–1635CrossRefPubMed
7.
Zurück zum Zitat Bouhassira D, Lanteri-Minet M, Attal N, Laurent B, Touboul C (2008) Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 136:380–387CrossRefPubMed Bouhassira D, Lanteri-Minet M, Attal N, Laurent B, Touboul C (2008) Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 136:380–387CrossRefPubMed
8.
Zurück zum Zitat Torrance N, Smith BH, Bennett MI, Lee AJ (2006) The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain 7:281–289CrossRefPubMed Torrance N, Smith BH, Bennett MI, Lee AJ (2006) The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain 7:281–289CrossRefPubMed
9.
Zurück zum Zitat Brandow AM, Farley RA, Panepinto JA (2014) Neuropathic pain in patients with sickle cell disease. Pediatr Blood Cancer 61(3):512–517CrossRefPubMed Brandow AM, Farley RA, Panepinto JA (2014) Neuropathic pain in patients with sickle cell disease. Pediatr Blood Cancer 61(3):512–517CrossRefPubMed
10.
Zurück zum Zitat Porporatti AL, Conti PCR (2013) Avaliação de Pacientes com Odontalgia Atípica perante Teste Sensorial Quantitativo (QST) e Teste de Controle de Modulação da Dor (CPM). Tese de mestrado Porporatti AL, Conti PCR (2013) Avaliação de Pacientes com Odontalgia Atípica perante Teste Sensorial Quantitativo (QST) e Teste de Controle de Modulação da Dor (CPM). Tese de mestrado
11.
Zurück zum Zitat Platt O, Thorington BD, Brambilla DJ et al (1991) Pain in sickle cell disease: rates and risk factors. N Engl J Med 325:11–16CrossRefPubMed Platt O, Thorington BD, Brambilla DJ et al (1991) Pain in sickle cell disease: rates and risk factors. N Engl J Med 325:11–16CrossRefPubMed
12.
Zurück zum Zitat Koshy M, Entsuah R, Koranda A et al (1989) Leg ulcers in patients with sickle cell disease. Blood 74:1403–1408PubMed Koshy M, Entsuah R, Koranda A et al (1989) Leg ulcers in patients with sickle cell disease. Blood 74:1403–1408PubMed
13.
Zurück zum Zitat Grunau RVE, Craig KD (1987) Pain expression in neonates: facial action and cry. Pain 28(3):395–410CrossRefPubMed Grunau RVE, Craig KD (1987) Pain expression in neonates: facial action and cry. Pain 28(3):395–410CrossRefPubMed
14.
Zurück zum Zitat Chambers CT, Reid GJ, McGrath PJ, Finley GA (1996) Development and preliminary validation of a postoperative pain measure for parents. Pain 68(2–3):307–313CrossRefPubMed Chambers CT, Reid GJ, McGrath PJ, Finley GA (1996) Development and preliminary validation of a postoperative pain measure for parents. Pain 68(2–3):307–313CrossRefPubMed
15.
Zurück zum Zitat McGrath PJ, Finley GA (2000) A Medição da dor. In: A dor na infância. Anais Nestlé 59:14–22 McGrath PJ, Finley GA (2000) A Medição da dor. In: A dor na infância. Anais Nestlé 59:14–22
16.
Zurück zum Zitat Attal N, Fermanian C, Fermanian J, Lanteri-Minet M, Alchaar H, Bouhassira D (2008) Neuropathic pain: are there distinct subtypes depending on the aetiology or anatomical lesion? Pain 138:343–353CrossRefPubMed Attal N, Fermanian C, Fermanian J, Lanteri-Minet M, Alchaar H, Bouhassira D (2008) Neuropathic pain: are there distinct subtypes depending on the aetiology or anatomical lesion? Pain 138:343–353CrossRefPubMed
17.
Zurück zum Zitat Cruccu G, Sommer C, Anand P, Attal N, Baron R, et al. (2010) EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol Cruccu G, Sommer C, Anand P, Attal N, Baron R, et al. (2010) EFNS guidelines on neuropathic pain assessment: revised 2009. Eur J Neurol
18.
Zurück zum Zitat Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B et al (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 114:29–36CrossRefPubMed Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B et al (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 114:29–36CrossRefPubMed
19.
Zurück zum Zitat Freynhagen R, Baron R, Gockel U, Tölle TR (2006) painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 22(10):1911–1920CrossRefPubMed Freynhagen R, Baron R, Gockel U, Tölle TR (2006) painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 22(10):1911–1920CrossRefPubMed
20.
Zurück zum Zitat Bennett MI (2001) The LANSS pain scale: the Leeds assessment of neuropathic symptoms and signs. Pain 92:147–157CrossRefPubMed Bennett MI (2001) The LANSS pain scale: the Leeds assessment of neuropathic symptoms and signs. Pain 92:147–157CrossRefPubMed
21.
Zurück zum Zitat Edwards RR, Fillingim RB (2001) Effects of age on temporal summation and habituation of thermal pain: clinical relevance in healthy older and younger adults. J Pain 2:307–317CrossRefPubMed Edwards RR, Fillingim RB (2001) Effects of age on temporal summation and habituation of thermal pain: clinical relevance in healthy older and younger adults. J Pain 2:307–317CrossRefPubMed
23.
Zurück zum Zitat Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P et al (2010) EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 17:1113–1e88CrossRefPubMed Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P et al (2010) EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 17:1113–1e88CrossRefPubMed
24.
Zurück zum Zitat Dworkin RH, O’Connor AB, Backonja M, Farrar JT, Finnerup NB et al (2007) Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132:237–251CrossRefPubMed Dworkin RH, O’Connor AB, Backonja M, Farrar JT, Finnerup NB et al (2007) Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132:237–251CrossRefPubMed
25.
Zurück zum Zitat Wilkie DJ, Molokie R, Boyd-Seal D et al (2010) Patient-reported outcomes: descriptors of nociceptive and neuropathic pain and barriers to effective pain management in adult outpatients with sickle cell disease. J Natl Med Assoc 102:18–27CrossRefPubMedPubMedCentral Wilkie DJ, Molokie R, Boyd-Seal D et al (2010) Patient-reported outcomes: descriptors of nociceptive and neuropathic pain and barriers to effective pain management in adult outpatients with sickle cell disease. J Natl Med Assoc 102:18–27CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Chaparro LE, Wiffen PJ, Moore RA et al (2012) Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database Syst Rev 7:CD008943 Chaparro LE, Wiffen PJ, Moore RA et al (2012) Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database Syst Rev 7:CD008943
27.
Zurück zum Zitat Barreto FJN, Cipolotti R (2011) Depressive symptoms in children and adolescents with sickle cell anemia. J Bras Psiquiatr 60(4):277–283CrossRef Barreto FJN, Cipolotti R (2011) Depressive symptoms in children and adolescents with sickle cell anemia. J Bras Psiquiatr 60(4):277–283CrossRef
28.
Zurück zum Zitat Brandow AM, Stucky CL, Hillery CA et al (2013) Patients with sickle cell disease have increased sensitivity to cold and heat. Am J Hematol 88:37–43CrossRefPubMed Brandow AM, Stucky CL, Hillery CA et al (2013) Patients with sickle cell disease have increased sensitivity to cold and heat. Am J Hematol 88:37–43CrossRefPubMed
Metadaten
Titel
Neuropathic pain in patients with sickle cell disease: a cross-sectional study assessing teens and young adults
verfasst von
Fabricio Dias Antunes
Vynicius Goltran Sobral Propheta
Hulemar Andrade Vasconcelos
Rosana Cipolotti
Publikationsdatum
30.03.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Annals of Hematology / Ausgabe 7/2017
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-017-2984-z

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