Background
Material and method
Chemicals and reagents
Plant materials and extraction
Experimental animals
Thiopental sodium-induced sleeping time test
Hole cross test
Hole board test
Open field test
Statistical analysis
Result
Group | Dose (mg/kg) | Latent period (mins) | Duration of sleep (mins) | % Effect |
---|---|---|---|---|
Control | 10 ml/kg | 19.2 ± 3.44 | 44.11 ± 2.13 | 0 |
Standard | 1 | 3.8 ± 0.66 | 143.4 ± 13.19* | 325.1 |
Leave extract | 100 | 8.6 ± 0.93 | 57.8 ± 2.13 | 131.04 |
Leave extract | 200 | 6 ± 0.71 | 69.1 ± 5.39* | 156.65 |
Root extract | 100 | 13.2 ± 2.69 | 58.4 ± 3.87 | 132.4 |
Root extract | 200 | 6 ± 2.07 | 87.21 ± 7.40* | 197.71 |
Group | Dose (mg/kg) | Number of movement (% of movements Inhibition) | ||||
---|---|---|---|---|---|---|
0 min | 30 min | 60 min | 90 min | 120 min | ||
Control | 10 ml/kg | 7.8 ± 1.24 | 10 ± 0.95 | 11.2 ± 1.24 | 10 ± 1.30 | 10 ± 0.51 |
Standard | 1 | 7.8 ± 0.58 | 5.2 ± 0.58 (48%) | 3.4 ± 0.51 (69.6%) | 2.2 ± 0.58 (78%) | 0.8 ± 0.37 (92%) |
Leaf extract | 100 | 8.2 ± 0.58 | 5.4 ± 0.51 (46%) | 4.2 ± 0.37 (62.5%) | 3.8 ± 0.37* (62%) | 2.8 ± 0.37* (72%) |
Leaf extract | 200 | 8.2 ± 0.86 | 5.6 ± 0.51 (44%) | 4.2 ± 0.66* (62.5%) | 3.2 ± 0.49* (68%) | 2.6 ± 0.24* (74%) |
Root extract | 100 | 7 ± 0.71 | 5.2 ± 0.58 (48%) | 3.8 ± 0.58* (66%) | 3.6 ± 0.51 (64%) | 2.2 ± 0.37* (72%) |
Root extract | 200 | 8.2 ± 0.97 | 5.4 ± 0.81 (46%) | 3.8 ± 0.66* (66%) | 2.6 ± 0.68* (74%) | 1.4 ± 0.51* (86%) |
Group | Dose (mg/kg) | Number of head dips | % inhibition |
---|---|---|---|
Control | 10 ml/kg | 36 ± 2.14 | 0 |
Standard | 1 | 21.8 ± 2.06 | 39.44 |
Leave extract | 100 | 32.4 ± 1.91 | 10 |
Leave extract | 200 | 24.8 ± 2.33 | 31.11* |
Root extract | 100 | 27 ± 2.30 | 25* |
Root extract | 200 | 20 ± 3.46 | 44.44* |
Group | Dose (mg/kg) | Number of movement (% of Inhibition) | ||||
---|---|---|---|---|---|---|
0 min | 30 min | 60 min | 90 min | 120 min | ||
Control | 10 ml/kg | 61 ± 4.32 | 60.2 ± 4.41 | 66.6 ± 5.88 | 60.2 ± 6.06 | 51.2 ± 3.46 |
Standard | 1 | 55.8 ± 5.17 | 21 ± 1.87 (74.1%) | 15.6 ± 1.67 (76.6%) | 11.2 ± 1.46 (81.4%) | 7.4 ± 0.51 (85.5%) |
Leave extract | 100 | 54 ± 6.47 | 38 ± 3.49 (36.4%) | 32 ± 1.73 (51.9%) | 23.4 ± 1.29 (61.1%) | 16.2 ± 0.86* (68.4%) |
Leave extract | 200 | 52.8 ± 3.43 | 33.4 ± 4.48 (44.5%) | 22.4 ± 3.36 (66.4%) | 13 ± 1.41* (78.7%) | 8.2 ± 1.16* (84%) |
Root extract | 100 | 57.8 ± 2.99 | 35.6 ± 5.06 (40.9%) | 24.6 ± 2.99 (63.1%) | 15.2 ± 1.39* (74.8%) | 9 ± 0.95* (82.4%) |
Root extract | 200 | 58.2 ± 2.85 | 29.2 ± 2.82 (51.5%) | 15.8 ± 1.02* (76.2%) | 9.4 ± 1.60* (84.4%) | 6.2 ± 0.97* (87.9%) |