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Immunologic Research

Erschienen in:

03.03.2017 | Original Article

Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection

verfasst von: Xiaorong Wu, Xiong Zhou, Yuxiang Hu, Chao Liu, Jun Wang

Erschienen in: Immunologic Research | Ausgabe 3/2017

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Abstract

Increasing evidence suggests that respiratory syncytial virus (RSV) infection during the early life is an important risk factor for the development of asthma. RSV infection is associated with neurogenic inflammation in the airways along with the increased expression of nerve growth factor (NGF). However, the role of NGF in RSV infection is not clear. In this study, we infected the rat with RSV and treated these animals with anti-NGF neutralization antibody. We found that anti-NGF treatment significantly alleviated the lung inflammation as evidenced by decreased inflammatory infiltration and decreased airway resistance. Importantly, anti-NGF treatment resulted in increased Th1, but decreased Th2 immune responses, and facilitated the viral control in the tissues and blood. Therefore, NGF inhibited Th2 but increased Th1 responses in RSV infection. Pharmacological intervention of NGF signaling during severe RSV infections could prevent or decrease further asthma symptoms.

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Titel: Neutralization of nerve growth factor (NGF) inhibits the Th2 response and protects against the respiratory syncytial virus (RSV) infection
verfasst von: Xiaorong Wu
Xiong Zhou
Yuxiang Hu
Chao Liu
Jun Wang
Publikationsdatum: 03.03.2017
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 3/2017
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-017-8909-z

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