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Erschienen in: International Journal of Hematology 3/2019

03.12.2018 | Case Report

Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin

verfasst von: Jennifer Dotson, Adee Elhamdani, Ellen Petryna, Muhammad Omer Jamil, Mohamed Alsharedi

Erschienen in: International Journal of Hematology | Ausgabe 3/2019

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Abstract

Neutropenic enterocolitis mostly affects patients with acute myeloid leukemia (AML) who get treated with intensive chemotherapy which is associated with prolonged neutropenia; its pathogenesis is not well understood and the main factors in this life-threatening condition appear to be neutropenia, mucosal injury and a weakened immune system as a consequence of intensive chemotherapeutic agents. Midostaurin in combination with chemotherapy became the standard of care for FLT3 mutant AML since its approval by the United States Food and Drug Administration (FDA) in April 2017. Anecdotally in our institution, we noticed the common occurrence of neutropenic colitis in three out of three patients who were treated with midostaurin as part of induction chemotherapy for AML.
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Metadaten
Titel
Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin
verfasst von
Jennifer Dotson
Adee Elhamdani
Ellen Petryna
Muhammad Omer Jamil
Mohamed Alsharedi
Publikationsdatum
03.12.2018
Verlag
Springer Japan
Erschienen in
International Journal of Hematology / Ausgabe 3/2019
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-018-2558-4

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