Skip to main content
Erschienen in: Urolithiasis 5/2003

01.10.2003 | Original Paper

Neutrophil bactericidal function is defective in patients with recurrent urinary tract infections

verfasst von: C. Condron, D. Toomey, R. G. Casey, M. Shaffii, T. Creagh, D Bouchier-Hayes

Erschienen in: Urolithiasis | Ausgabe 5/2003

Einloggen, um Zugang zu erhalten

Abstract

Urinary tract infection (UTI), most frequently caused by Escherichia coli, is one of the most common bacterial infections in humans. It is a host inflammatory response to bacterial invasion in which large numbers of neutrophils are recruited into the bladder in response to cytokines secreted by the infected bladder epithelium. We hypothesise that an impaired host neutrophil response leads to susceptibility to recurrent UTI (rUTI). Therefore, the neutrophil inflammatory response of patients with a history of rUTI was compared to healthy controls. No difference in neutrophil adhesion receptor expression or complement receptor expression following bacterial stimulus was detected between the two groups. However, the expression of the IgG receptor CD16, bacterial phagocytosis and reactive oxygen intermediate (ROI) production were significantly reduced in UTI patient neutrophils compared to controls. Neutrophils from rUTI patients have a significantly reduced bactericidal function when compared to healthy controls, with the former showing a reduced capacity for activation. This reduced neutrophil function may result in defective bacterial clearance and lead to susceptibility to recurrent infection.
Literatur
1.
Zurück zum Zitat Abrutyn E, Berlin J, Mossey J, Pitsakis P, Levison M, Kaye D (1996) Does treatment of asymptomatic bacteriuria in old ambulatory women reduce subsequent symptoms of urinary tract infections? J Am Geriatr Soc 44:293 Abrutyn E, Berlin J, Mossey J, Pitsakis P, Levison M, Kaye D (1996) Does treatment of asymptomatic bacteriuria in old ambulatory women reduce subsequent symptoms of urinary tract infections? J Am Geriatr Soc 44:293
2.
Zurück zum Zitat Barry MC, Condron CM, Watson RW, Redmond HP, El Jack M, Watson RG, Bouchier Hayes D (1997). Pre-operative neutrophil and monocyte activation state predicts post-operative neutrophil and monocyte function. Eur J Surg 163: 739PubMed Barry MC, Condron CM, Watson RW, Redmond HP, El Jack M, Watson RG, Bouchier Hayes D (1997). Pre-operative neutrophil and monocyte activation state predicts post-operative neutrophil and monocyte function. Eur J Surg 163: 739PubMed
3.
Zurück zum Zitat Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033PubMed Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033PubMed
4.
Zurück zum Zitat Carlson KJ, Mulley AG (1986) Management of acute dysuria a decision analysis model of alternative strategies. Ann Intern Med 102: 244 Carlson KJ, Mulley AG (1986) Management of acute dysuria a decision analysis model of alternative strategies. Ann Intern Med 102: 244
5.
Zurück zum Zitat Condron C, Neary P, Toomey D, Redmond HP, Bouchier-Hayes D (2003) Taurine attenuates calcium-dependent, Fas-mediated neutrophil apoptosis. Shock 19: 564PubMed Condron C, Neary P, Toomey D, Redmond HP, Bouchier-Hayes D (2003) Taurine attenuates calcium-dependent, Fas-mediated neutrophil apoptosis. Shock 19: 564PubMed
6.
Zurück zum Zitat Demeters PA, Lo SK, Olsen-Egbert E, Wlaz A, Baggiolini M, Cohn ZA (1990) Neutrophil activating protein/interleukin-8 stimulates the binding activity of leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J Exp Med 171: 1155PubMed Demeters PA, Lo SK, Olsen-Egbert E, Wlaz A, Baggiolini M, Cohn ZA (1990) Neutrophil activating protein/interleukin-8 stimulates the binding activity of leukocyte adhesion receptor CD11b/CD18 on human neutrophils. J Exp Med 171: 1155PubMed
7.
Zurück zum Zitat Durand V, Pers JO, Renaudineau Y, Saraux A, Youinou P, Jamin C (2000) Differential effects of anti-Fc gamma RIIIb autoantibodies on polymorphonuclear neutrophil apoptosis and function. J Leukoc Biol 69: 233 Durand V, Pers JO, Renaudineau Y, Saraux A, Youinou P, Jamin C (2000) Differential effects of anti-Fc gamma RIIIb autoantibodies on polymorphonuclear neutrophil apoptosis and function. J Leukoc Biol 69: 233
8.
Zurück zum Zitat Eaton JW (1993) Defences against hypochlorous acid: parrying the neutrophil's rapier trust. J Lab Clin Med 121: 197PubMed Eaton JW (1993) Defences against hypochlorous acid: parrying the neutrophil's rapier trust. J Lab Clin Med 121: 197PubMed
9.
Zurück zum Zitat Frendeus B, Godaly C, Hang L, Karpman D, Svaborg C (2001) Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephriris. J Infect Dis 183 (Suppl): S56CrossRefPubMed Frendeus B, Godaly C, Hang L, Karpman D, Svaborg C (2001) Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephriris. J Infect Dis 183 (Suppl): S56CrossRefPubMed
10.
Zurück zum Zitat Gargan RA, Hamilton-Miller JM (1994) Opsonophagocytosis in infected urine: relation to pH and osmolality. J Urol 152: 1615PubMed Gargan RA, Hamilton-Miller JM (1994) Opsonophagocytosis in infected urine: relation to pH and osmolality. J Urol 152: 1615PubMed
11.
Zurück zum Zitat Gargan RA, Hamilton-Miller JM, Brumfitt W (1993) Effect of pH and osmolality on in vitro phagocytosis and killing by neutrophils in urine. Infect Immun 61: 8PubMed Gargan RA, Hamilton-Miller JM, Brumfitt W (1993) Effect of pH and osmolality on in vitro phagocytosis and killing by neutrophils in urine. Infect Immun 61: 8PubMed
12.
Zurück zum Zitat Granger DN, Kubes P (1994) The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55: 662PubMed Granger DN, Kubes P (1994) The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55: 662PubMed
13.
Zurück zum Zitat Haraoka M, Hang L, Frendeus B, Giodaly G, Burdick M, Strieter R, Svanborg C (1999) Neutrophil recruitment and resistance to mucosal infection with uropathogenic Escherichia coli. J Infect Dis 180: 1220CrossRefPubMed Haraoka M, Hang L, Frendeus B, Giodaly G, Burdick M, Strieter R, Svanborg C (1999) Neutrophil recruitment and resistance to mucosal infection with uropathogenic Escherichia coli. J Infect Dis 180: 1220CrossRefPubMed
14.
Zurück zum Zitat Hedges S, Agace W, Svensson M, Sjogren AC, Ceska M, Svanborg C (1994) Uroepithelial cells are part of a mucosal cytokine network. Infect Immun 62: 2315PubMed Hedges S, Agace W, Svensson M, Sjogren AC, Ceska M, Svanborg C (1994) Uroepithelial cells are part of a mucosal cytokine network. Infect Immun 62: 2315PubMed
15.
Zurück zum Zitat Hopkins WJ, Heisey DM, Lorentzen DF, Uehling DT (1998) A comparative study of major histocompatibility complex and red blood cell antigen phenotypes as risk factors for recurrent urinary tract infections in women. J Infect Dis 177: 1296PubMed Hopkins WJ, Heisey DM, Lorentzen DF, Uehling DT (1998) A comparative study of major histocompatibility complex and red blood cell antigen phenotypes as risk factors for recurrent urinary tract infections in women. J Infect Dis 177: 1296PubMed
16.
Zurück zum Zitat Kansas GS (1996) Selectins and their ligands: current concepts and controversies. Blood 88: 3259PubMed Kansas GS (1996) Selectins and their ligands: current concepts and controversies. Blood 88: 3259PubMed
17.
Zurück zum Zitat Kishimoto TK, Jutila MA, Berg EL, Butcher EC, (1989) Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238 Kishimoto TK, Jutila MA, Berg EL, Butcher EC, (1989) Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245: 1238
18.
Zurück zum Zitat Kobayashi T, Van der Pol WL, Van de Winkel JG, Hara K, Sugita N, Westerdaal NA, Yoshie H, Horigome T (2000) Relevance of IgG receptor IIIb (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis. J Periodont Res 35: 65PubMed Kobayashi T, Van der Pol WL, Van de Winkel JG, Hara K, Sugita N, Westerdaal NA, Yoshie H, Horigome T (2000) Relevance of IgG receptor IIIb (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis. J Periodont Res 35: 65PubMed
19.
Zurück zum Zitat Kunin CM (1994) Urinary tract infections in females. Clin Infect Dis 18: Kunin CM (1994) Urinary tract infections in females. Clin Infect Dis 18:
20.
Zurück zum Zitat Lefer AM (1999) Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion. Ann Thorac Surg 68: 1920CrossRefPubMed Lefer AM (1999) Role of the beta2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion. Ann Thorac Surg 68: 1920CrossRefPubMed
21.
Zurück zum Zitat Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ ((2000) Bad bugs and beleagured bladders; interplay between uropathogenic Escherichia coli and innate host defenses. Proc Natl Acad Sci U S A; 97: 8747 Mulvey MA, Schilling JD, Martinez JJ, Hultgren SJ ((2000) Bad bugs and beleagured bladders; interplay between uropathogenic Escherichia coli and innate host defenses. Proc Natl Acad Sci U S A; 97: 8747
22.
Zurück zum Zitat Nishimura H, Gogami A, Miyagawa Y, Nanbo A, Murakami Y, Baba T, Nagasawa S (2001) Bactericidal/permeability-increasing protein promotes complement activation for neutrophil-mediated phagocytosis on bacterial surface. Immunology 103: 519CrossRefPubMed Nishimura H, Gogami A, Miyagawa Y, Nanbo A, Murakami Y, Baba T, Nagasawa S (2001) Bactericidal/permeability-increasing protein promotes complement activation for neutrophil-mediated phagocytosis on bacterial surface. Immunology 103: 519CrossRefPubMed
23.
Zurück zum Zitat Schaeffer AJ, Jones JM, Dunn JK (1981) Association of in vitro Escherichia coli adherence to vaginal and buccal epithelial cells with susceptibility of women to recurrent urinary tract infections. N Engl J Med 304: 1062PubMed Schaeffer AJ, Jones JM, Dunn JK (1981) Association of in vitro Escherichia coli adherence to vaginal and buccal epithelial cells with susceptibility of women to recurrent urinary tract infections. N Engl J Med 304: 1062PubMed
24.
Zurück zum Zitat Schaeffer AJ , Radvany RM, Chmiel JS, (1993) Human leukocyte antigen in women with recurrent urinary tract infections. J Infect Dis 148: 604 Schaeffer AJ , Radvany RM, Chmiel JS, (1993) Human leukocyte antigen in women with recurrent urinary tract infections. J Infect Dis 148: 604
25.
Zurück zum Zitat Kubo S, Matsumoto T, Sakumoto M, Mochida O, Abe Y, Kumazawa J (1998) Effect of urine components on leukocyte chemiluminescence response. Renal Failure 20: 75PubMed Kubo S, Matsumoto T, Sakumoto M, Mochida O, Abe Y, Kumazawa J (1998) Effect of urine components on leukocyte chemiluminescence response. Renal Failure 20: 75PubMed
26.
Zurück zum Zitat Stamey TA, (1975) The role of introital enterobacteria in recurrent urinary infections. J Urol 109: 467 Stamey TA, (1975) The role of introital enterobacteria in recurrent urinary infections. J Urol 109: 467
27.
Zurück zum Zitat Stapleton AE, Stroud MR, Hakomori SJ, Stamm WE, (1998) The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor in vitro for uropathogenic Escherichia coli expressing pap-encoded adhesions. Infect Immun 66: 3856PubMed Stapleton AE, Stroud MR, Hakomori SJ, Stamm WE, (1998) The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor in vitro for uropathogenic Escherichia coli expressing pap-encoded adhesions. Infect Immun 66: 3856PubMed
28.
Zurück zum Zitat Sugita N, Kobayashi T, Ando Y, Yoshihara A, Yamamoto K, Van de Winkel JG, Miyazaki H, Yoshie H (2001) Increased frequency of Fc gamma RIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population. J Dent Res 80: 914PubMed Sugita N, Kobayashi T, Ando Y, Yoshihara A, Yamamoto K, Van de Winkel JG, Miyazaki H, Yoshie H (2001) Increased frequency of Fc gamma RIIIb-NA1 allele in periodontitis-resistant subjects in an elderly Japanese population. J Dent Res 80: 914PubMed
29.
Zurück zum Zitat Svanborg C. Godaly G (1997) Bacterial virulence in urinary tract infection Infect. Dis Clin N Am 11: 513 Svanborg C. Godaly G (1997) Bacterial virulence in urinary tract infection Infect. Dis Clin N Am 11: 513
30.
Zurück zum Zitat Svanborg C, Bergsten G, Fischer H, Frendeus B, Godaly G, Gustafsson E, Hang L, Hedlund M, Karpman D, Lundstedt AC, Samuelsson M, Samuelsson P, Svensson M, Wullt B (2001) The 'innate' host response protects and damages the infected urinary tract. Ann Med 33: 563PubMed Svanborg C, Bergsten G, Fischer H, Frendeus B, Godaly G, Gustafsson E, Hang L, Hedlund M, Karpman D, Lundstedt AC, Samuelsson M, Samuelsson P, Svensson M, Wullt B (2001) The 'innate' host response protects and damages the infected urinary tract. Ann Med 33: 563PubMed
31.
Zurück zum Zitat Svanborg-Eden C, Hagberg L, Briles D, McGhee J, Michalek S (1985) Susceptibility to Escherichia coli urinary tract infection and LPS responsiveness. In: Skamene E (ed) Genetic control of host resistance to infection and malignancy, vol 3. Alan R.Liss, New York, p 385 Svanborg-Eden C, Hagberg L, Briles D, McGhee J, Michalek S (1985) Susceptibility to Escherichia coli urinary tract infection and LPS responsiveness. In: Skamene E (ed) Genetic control of host resistance to infection and malignancy, vol 3. Alan R.Liss, New York, p 385
32.
Zurück zum Zitat Tambic A, Kes P, Milutinovic S, Rabatic S, Silobrcic V, (1992) Phagocytic function in patients with recurrent urinary tract infections. Acta Med Croat 46: 21 Tambic A, Kes P, Milutinovic S, Rabatic S, Silobrcic V, (1992) Phagocytic function in patients with recurrent urinary tract infections. Acta Med Croat 46: 21
33.
Zurück zum Zitat Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Komiyama Y, Takahashi H, Kobayashi Y (2001) FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Hum Immunol 62: 408CrossRefPubMed Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Komiyama Y, Takahashi H, Kobayashi Y (2001) FcgammaRIII b and FcgammaRIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy. Hum Immunol 62: 408CrossRefPubMed
34.
Zurück zum Zitat Walcheck B, Kahn J, Fisher JM, Wang BB, Fisk RS, Payan DG, Feehan C, Betageri R, Darlak K, Spatola AF, Kishimoto TK (1996) Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature 380: 720 Walcheck B, Kahn J, Fisher JM, Wang BB, Fisk RS, Payan DG, Feehan C, Betageri R, Darlak K, Spatola AF, Kishimoto TK (1996) Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature 380: 720
35.
Zurück zum Zitat Wang JH, Redmond HP, Watson RGW, Bouchier-Hayes D (1995) Restoration of 'tired' neutrophil function by aproptinin is dependant on the presence of taurine. Surg Forum 45: 573 Wang JH, Redmond HP, Watson RGW, Bouchier-Hayes D (1995) Restoration of 'tired' neutrophil function by aproptinin is dependant on the presence of taurine. Surg Forum 45: 573
36.
Zurück zum Zitat Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D (1996) The beneficial effect of taurine on the prevention of human endothelial cell death. Shock 6: 331PubMed Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D (1996) The beneficial effect of taurine on the prevention of human endothelial cell death. Shock 6: 331PubMed
Metadaten
Titel
Neutrophil bactericidal function is defective in patients with recurrent urinary tract infections
verfasst von
C. Condron
D. Toomey
R. G. Casey
M. Shaffii
T. Creagh
D Bouchier-Hayes
Publikationsdatum
01.10.2003
Verlag
Springer-Verlag
Erschienen in
Urolithiasis / Ausgabe 5/2003
Print ISSN: 2194-7228
Elektronische ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-003-0344-z

Weitere Artikel der Ausgabe 5/2003

Urolithiasis 5/2003 Zur Ausgabe

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.