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Current Osteoporosis Reports

Erschienen in:

13.08.2020 | Osteocytes (J Delgado-Calle and J Klein-Nulend, Section Editors)

New and Old Osteocytic Cell Lines and 3D Models

Erschienen in: Current Osteoporosis Reports | Ausgabe 5/2020

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Abstract

Purpose of Review

The aim of this review was to compile a list of tools currently available to study bone cells and in particular osteocytes. As the interest (and importance) in osteocyte biology has greatly expanded over the past decade, new tools and techniques have become available to study these elusive cells,

Recent Findings

Osteocytes are the main orchestrators of bone remodeling. They control both osteoblasts and osteoclast activities via cell-to cell communication or through secreted factors. Osteocytes are also the mechanosensors of the bone and they orchestrate skeletal adaptation to loads. Recent discoveries have greatly expanded our knowledge and understanding of these cells and new models are now available to further uncover the functions of osteocytes.

Summary

Novel osteocytic cell lines, primary cultures, and 3D scaffolds are now available to investigators to further unravel the functions and roles of these cells.

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Titel: New and Old Osteocytic Cell Lines and 3D Models
Publikationsdatum: 13.08.2020
Erschienen in: Current Osteoporosis Reports / Ausgabe 5/2020
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-020-00613-3

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