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19.05.2017 | Local-Regional Evaluation and Therapy (EP Mamounas, Section Editor) | Ausgabe 2/2017

Current Breast Cancer Reports 2/2017

New Approaches for Tailoring the Use of Radiotherapy in Early-Stage Breast Cancer

Zeitschrift:
Current Breast Cancer Reports > Ausgabe 2/2017
Autor:
Julia White
Wichtige Hinweise
This article is part of the Topical Collection on Local-Regional Evaluation and Therapy

Abstract

Purpose of Review

The majority of women diagnosed with early-stage breast cancer will undergo radiotherapy. Clinical decisions regarding the delivery of radiotherapy are typically based on clinical and pathologic factors. In contrast, systemic therapy clinical decisions incorporate specific breast cancer biology. This review will focus on how breast cancer biology may help tailor radiotherapy for early-stage patients.

Recent Findings

Radiotherapy for early-stage breast cancer is typically delivered for breast conservation. Regional nodal radiotherapy use in early-stage disease is expected to expand in the wake of recent clinical trial publications demonstrating improved disease-free survival in those with one to three axillary nodal metastases. There is a growing body of data demonstrating that intrinsic breast cancer subtypes and luminal multigene assays developed for systemic therapy are also associated with local regional recurrence.

Summary

Including tumor biology in addition to standard clinical and pathological factors may lead to a more tailored use of radiotherapy in early-stage breast cancer.

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