Erschienen in:
19.05.2017 | Local-Regional Evaluation and Therapy (EP Mamounas, Section Editor)
New Approaches for Tailoring the Use of Radiotherapy in Early-Stage Breast Cancer
verfasst von:
Julia White
Erschienen in:
Current Breast Cancer Reports
|
Ausgabe 2/2017
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Abstract
Purpose of Review
The majority of women diagnosed with early-stage breast cancer will undergo radiotherapy. Clinical decisions regarding the delivery of radiotherapy are typically based on clinical and pathologic factors. In contrast, systemic therapy clinical decisions incorporate specific breast cancer biology. This review will focus on how breast cancer biology may help tailor radiotherapy for early-stage patients.
Recent Findings
Radiotherapy for early-stage breast cancer is typically delivered for breast conservation. Regional nodal radiotherapy use in early-stage disease is expected to expand in the wake of recent clinical trial publications demonstrating improved disease-free survival in those with one to three axillary nodal metastases. There is a growing body of data demonstrating that intrinsic breast cancer subtypes and luminal multigene assays developed for systemic therapy are also associated with local regional recurrence.
Summary
Including tumor biology in addition to standard clinical and pathological factors may lead to a more tailored use of radiotherapy in early-stage breast cancer.