Skip to main content
Erschienen in: Current Reviews in Musculoskeletal Medicine 3/2018

20.06.2018 | Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)

New Innovations in the Treatment of PJI and Biofilms—Clinical and Preclinical Topics

verfasst von: Mariam Taha, Hesham Abdelbary, F. Patrick Ross, Alberto V. Carli

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement. A main source for antibiotic tolerance and treatment failure is bacterial production of biofilm—a resilient barrier against antibiotics, immune system, and mechanical debridement. The purpose of this review is to explore some novel approaches to treat PJI and biofilm-related infections.

Recent Findings

Innovative treatment strategies of bacterial and biofilm infections revolve around (a) augmenting current therapies, such as improving the delivery and efficiency of conventional antibiotics and enhancing the efficacy of antiseptics and (b) administrating completely new therapeutic modalities, such as using immunotherapy, nanoparticles, lytic bacteriophages, photodynamic therapy, novel antibiotics, and antimicrobial peptides.

Summary

Several promising treatment strategies for PJI are available to be tested further. The next requirement for most of the novel treatments is reproducing their effects in clinically representative animal models of PJI against clinical isolates of relevant bacteria.
Literatur
1.
Zurück zum Zitat Norman-Taylor FH, Palmer CR, Villar RN. Quality-of-life improvement compared after hip and knee replacement. J Bone Joint Surg Br Vol. 1996;78(1):74.CrossRef Norman-Taylor FH, Palmer CR, Villar RN. Quality-of-life improvement compared after hip and knee replacement. J Bone Joint Surg Br Vol. 1996;78(1):74.CrossRef
2.
Zurück zum Zitat Martinez-Cano JP, Herrera-Escobar JP, Arango Gutierrez AS, Sanchez Vergel A, Martinez-Rondanelli A. Prospective quality of life assessment after hip and knee arthroplasty: short- and mid-term follow-up results. Arthroplast Today. 2017;3(2):125.CrossRefPubMed Martinez-Cano JP, Herrera-Escobar JP, Arango Gutierrez AS, Sanchez Vergel A, Martinez-Rondanelli A. Prospective quality of life assessment after hip and knee arthroplasty: short- and mid-term follow-up results. Arthroplast Today. 2017;3(2):125.CrossRefPubMed
3.
Zurück zum Zitat Kapadia BH, Berg RA, Daley JA, Fritz J, Bhave A, Mont MA. Periprosthetic joint infection. Lancet (Lond Engl). 2016;387(10016):386.CrossRef Kapadia BH, Berg RA, Daley JA, Fritz J, Bhave A, Mont MA. Periprosthetic joint infection. Lancet (Lond Engl). 2016;387(10016):386.CrossRef
4.
Zurück zum Zitat Berend KR, Lombardi AV Jr, Morris MJ, Bergeson AG, Adams JB, Sneller MA. Two-stage treatment of hip periprosthetic joint infection is associated with a high rate of infection control but high mortality. Clin Orthop Relat Res. 2013;471(2):510.CrossRefPubMed Berend KR, Lombardi AV Jr, Morris MJ, Bergeson AG, Adams JB, Sneller MA. Two-stage treatment of hip periprosthetic joint infection is associated with a high rate of infection control but high mortality. Clin Orthop Relat Res. 2013;471(2):510.CrossRefPubMed
5.
Zurück zum Zitat Lamagni T. Epidemiology and burden of prosthetic joint infections. J Antimicrob Chemother. 2014;69(Suppl 1):i5.CrossRefPubMed Lamagni T. Epidemiology and burden of prosthetic joint infections. J Antimicrob Chemother. 2014;69(Suppl 1):i5.CrossRefPubMed
6.
Zurück zum Zitat Kurtz SM, Lau E, Watson H, Schmier JK, Parvizi J. Economic burden of periprosthetic joint infection in the United States. J Arthroplast. 2012;27(8 Suppl):61.CrossRef Kurtz SM, Lau E, Watson H, Schmier JK, Parvizi J. Economic burden of periprosthetic joint infection in the United States. J Arthroplast. 2012;27(8 Suppl):61.CrossRef
7.
Zurück zum Zitat Alp E, Cevahir F, Ersoy S, Guney A. Incidence and economic burden of prosthetic joint infections in a university hospital: a report from a middle-income country. J Infect Public Health. 2016;9(4):494.CrossRefPubMed Alp E, Cevahir F, Ersoy S, Guney A. Incidence and economic burden of prosthetic joint infections in a university hospital: a report from a middle-income country. J Infect Public Health. 2016;9(4):494.CrossRefPubMed
8.
Zurück zum Zitat Ciofu O, Rojo-Molinero E, Macia MD, Oliver A. Antibiotic treatment of biofilm infections. APMIS: Acta Pathol Microbiol Immunol Scand. 2017;125(4):304.CrossRef Ciofu O, Rojo-Molinero E, Macia MD, Oliver A. Antibiotic treatment of biofilm infections. APMIS: Acta Pathol Microbiol Immunol Scand. 2017;125(4):304.CrossRef
9.
Zurück zum Zitat Marculescu C, Berbari E, Hanssen AD, Steckelberg J, Harmsen S, Mandrekar J, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42(4):471.CrossRefPubMed Marculescu C, Berbari E, Hanssen AD, Steckelberg J, Harmsen S, Mandrekar J, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42(4):471.CrossRefPubMed
10.
Zurück zum Zitat Urish KL, Bullock AG, Kreger AM, Shah NB, Jeong K, Rothenberger SD. A multicenter study of irrigation and debridement in total knee arthroplasty periprosthetic joint infection: treatment failure is high. J Arthroplast. 2018;33(4):1154.CrossRef Urish KL, Bullock AG, Kreger AM, Shah NB, Jeong K, Rothenberger SD. A multicenter study of irrigation and debridement in total knee arthroplasty periprosthetic joint infection: treatment failure is high. J Arthroplast. 2018;33(4):1154.CrossRef
11.
Zurück zum Zitat Klement MR, Siddiqi A, Rock JM, Chen AF, Bolognesi MP, Seyler TM. Positive blood cultures in periprosthetic joint infection decrease rate of treatment success. J Arthroplast. 2018;33(1):200.CrossRef Klement MR, Siddiqi A, Rock JM, Chen AF, Bolognesi MP, Seyler TM. Positive blood cultures in periprosthetic joint infection decrease rate of treatment success. J Arthroplast. 2018;33(1):200.CrossRef
12.
Zurück zum Zitat Yoon HK, Cho SH, Lee DY, Kang BH, Lee SH, Moon DG, et al. Review of the literature on culture-negative periprosthetic joint infection: epidemiology, diagnosis and treatment. Knee Surg Relat Res. 2017;29(3):155.CrossRefPubMedPubMedCentral Yoon HK, Cho SH, Lee DY, Kang BH, Lee SH, Moon DG, et al. Review of the literature on culture-negative periprosthetic joint infection: epidemiology, diagnosis and treatment. Knee Surg Relat Res. 2017;29(3):155.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Wang J, Wang Q, Shen H, Zhang X. Comparable outcome of culture-negative and culture-positive periprosthetic hip joint infection for patients undergoing two-stage revision. Int Orthop. 2018;42(3):469.CrossRefPubMed Wang J, Wang Q, Shen H, Zhang X. Comparable outcome of culture-negative and culture-positive periprosthetic hip joint infection for patients undergoing two-stage revision. Int Orthop. 2018;42(3):469.CrossRefPubMed
14.
Zurück zum Zitat Dibartola AC, Swearingen MC, Granger JF, Stoodley P, Dusane DH. Biofilms in orthopedic infections: a review of laboratory methods. APMI: Acta Pathol Microbiol Immunol Scand. 2017;125(4):418.CrossRef Dibartola AC, Swearingen MC, Granger JF, Stoodley P, Dusane DH. Biofilms in orthopedic infections: a review of laboratory methods. APMI: Acta Pathol Microbiol Immunol Scand. 2017;125(4):418.CrossRef
15.
Zurück zum Zitat •• Swearingen MC, DiBartola AC, Dusane D, Granger J, Stoodley P. 16S rRNA analysis provides evidence of biofilms on all components of three infected periprosthetic knees including permanent braided suture. Pathog Dis 2016;74(7). This paper compared conventional bacterial culture techniques to 16S rRNA analysis of samples taken from patients undergoing revision knee replacement for infection. 16S sequencing identified multiple bacteria types on implant and suture material surfaces, demonstrating that the prevalence of polymicrobial infection is underestimated and that biofilm can form on all foreign materials inside the patient. •• Swearingen MC, DiBartola AC, Dusane D, Granger J, Stoodley P. 16S rRNA analysis provides evidence of biofilms on all components of three infected periprosthetic knees including permanent braided suture. Pathog Dis 2016;74(7). This paper compared conventional bacterial culture techniques to 16S rRNA analysis of samples taken from patients undergoing revision knee replacement for infection. 16S sequencing identified multiple bacteria types on implant and suture material surfaces, demonstrating that the prevalence of polymicrobial infection is underestimated and that biofilm can form on all foreign materials inside the patient.
16.
Zurück zum Zitat Huang Z, Wu Q, Fang X, Li W, Zhang C, Zeng H, Wang Q, Lin J, Zhang W. Comparison of culture and broad-range polymerase chain reaction methods for diagnosing periprosthetic joint infection: analysis of joint fluid, periprosthetic tissue, and sonicated fluid. Int Orthop. 2018. Huang Z, Wu Q, Fang X, Li W, Zhang C, Zeng H, Wang Q, Lin J, Zhang W. Comparison of culture and broad-range polymerase chain reaction methods for diagnosing periprosthetic joint infection: analysis of joint fluid, periprosthetic tissue, and sonicated fluid. Int Orthop. 2018.
17.
Zurück zum Zitat Rothenberg AC, Wilson AE, Hayes JP, O'Malley MJ, Klatt BA. Sonication of arthroplasty implants improves accuracy of periprosthetic joint infection cultures. Clin Orthop Relat Res. 1827;475(7):2017. Rothenberg AC, Wilson AE, Hayes JP, O'Malley MJ, Klatt BA. Sonication of arthroplasty implants improves accuracy of periprosthetic joint infection cultures. Clin Orthop Relat Res. 1827;475(7):2017.
18.
Zurück zum Zitat Tani S, Lepetsos P, Stylianakis A, Vlamis J, Birbas K, Kaklamanos I. Superiority of the sonication method against conventional periprosthetic tissue cultures for diagnosis of prosthetic joint infections. Eur J Orthop Surg Traumatol. 2018;28(1):51.CrossRefPubMed Tani S, Lepetsos P, Stylianakis A, Vlamis J, Birbas K, Kaklamanos I. Superiority of the sonication method against conventional periprosthetic tissue cultures for diagnosis of prosthetic joint infections. Eur J Orthop Surg Traumatol. 2018;28(1):51.CrossRefPubMed
19.
Zurück zum Zitat Janz V, Trampuz A, Perka CF, Wassilew GI. Reduced culture time and improved isolation rate through culture of sonicate fluid in blood culture bottles. Technol Health Care. 2017;25(4):635.CrossRefPubMed Janz V, Trampuz A, Perka CF, Wassilew GI. Reduced culture time and improved isolation rate through culture of sonicate fluid in blood culture bottles. Technol Health Care. 2017;25(4):635.CrossRefPubMed
20.
Zurück zum Zitat Clauss M. CORR insights((R)): sonication of arthroplasty implants improves accuracy of periprosthetic joint infection cultures. Clin Orthop Relat Res. 1837;475(7):2017. Clauss M. CORR insights((R)): sonication of arthroplasty implants improves accuracy of periprosthetic joint infection cultures. Clin Orthop Relat Res. 1837;475(7):2017.
21.
Zurück zum Zitat Wilson PD Jr, Salvati EA, Blumenfeld EL. The problem of infection in total prosthetic arthroplasty of the hip. Surg Clin North Am. 1975;55(6):1431.CrossRefPubMed Wilson PD Jr, Salvati EA, Blumenfeld EL. The problem of infection in total prosthetic arthroplasty of the hip. Surg Clin North Am. 1975;55(6):1431.CrossRefPubMed
22.
Zurück zum Zitat Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 2009;80(2):193.CrossRefPubMedPubMedCentral Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 2009;80(2):193.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Bertazzoni Minelli E, Benini A, Samaila E, Bondi M, Magnan B. Antimicrobial activity of gentamicin and vancomycin combination in joint fluids after antibiotic-loaded cement spacer implantation in two-stage revision surgery. J Chemother (Florence, Italy). 2015;27(1):17.CrossRef Bertazzoni Minelli E, Benini A, Samaila E, Bondi M, Magnan B. Antimicrobial activity of gentamicin and vancomycin combination in joint fluids after antibiotic-loaded cement spacer implantation in two-stage revision surgery. J Chemother (Florence, Italy). 2015;27(1):17.CrossRef
24.
Zurück zum Zitat Edelstein AI, Okroj KT, Rogers T, Della Valle CJ, Sporer SM. Nephrotoxicity after the treatment of periprosthetic joint infection with antibiotic-loaded cement spacers. J Arthroplasty. 2018. Edelstein AI, Okroj KT, Rogers T, Della Valle CJ, Sporer SM. Nephrotoxicity after the treatment of periprosthetic joint infection with antibiotic-loaded cement spacers. J Arthroplasty. 2018.
25.
Zurück zum Zitat Berliner ZP, Mo AZ, Porter DA, Grossman JM, Hepinstall MS, Cooper HJ, et al. In-hospital acute kidney injury after TKA revision with placement of an antibiotic cement spacer. J Arthroplast. 2017; Berliner ZP, Mo AZ, Porter DA, Grossman JM, Hepinstall MS, Cooper HJ, et al. In-hospital acute kidney injury after TKA revision with placement of an antibiotic cement spacer. J Arthroplast. 2017;
26.
Zurück zum Zitat Nelson CL, Jones RB, Wingert NC, Foltzer M, Bowen TR. Sonication of antibiotic spacers predicts failure during two-stage revision for prosthetic knee and hip infections. Clin Orthop Relat Res. 2014;472(7):2208.CrossRefPubMedPubMedCentral Nelson CL, Jones RB, Wingert NC, Foltzer M, Bowen TR. Sonication of antibiotic spacers predicts failure during two-stage revision for prosthetic knee and hip infections. Clin Orthop Relat Res. 2014;472(7):2208.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Schmolders J, Hischebeth GT, Friedrich MJ, Randau TM, Wimmer MD, Kohlhof H, et al. Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee. BMC Infect Dis. 2014;14:144.CrossRefPubMedPubMedCentral Schmolders J, Hischebeth GT, Friedrich MJ, Randau TM, Wimmer MD, Kohlhof H, et al. Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee. BMC Infect Dis. 2014;14:144.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Anagnostakos K, Furst O, Kelm J. Antibiotic-impregnated PMMA hip spacers: current status. Acta Orthop. 2006;77(4):628.CrossRefPubMed Anagnostakos K, Furst O, Kelm J. Antibiotic-impregnated PMMA hip spacers: current status. Acta Orthop. 2006;77(4):628.CrossRefPubMed
29.
Zurück zum Zitat Erivan R, Lecointe T, Villatte G, Mulliez A, Descamps S, Boisgard S. Complications with cement spacers in 2-stage treatment of periprosthetic joint infection on total hip replacement. Orthop Traumatol Surg Res: OTSR. 2017. Erivan R, Lecointe T, Villatte G, Mulliez A, Descamps S, Boisgard S. Complications with cement spacers in 2-stage treatment of periprosthetic joint infection on total hip replacement. Orthop Traumatol Surg Res: OTSR. 2017.
30.
Zurück zum Zitat Armstrong MD, Carli AV, Abdelbary H, Poitras S, Lapner P, Beaule PE. Tertiary care centre adherence to unified guidelines for management of periprosthetic joint infections: a gap analysis. Can J Surg Journal canadien de chirurgie. 2018;61(1):34.CrossRefPubMed Armstrong MD, Carli AV, Abdelbary H, Poitras S, Lapner P, Beaule PE. Tertiary care centre adherence to unified guidelines for management of periprosthetic joint infections: a gap analysis. Can J Surg Journal canadien de chirurgie. 2018;61(1):34.CrossRefPubMed
31.
Zurück zum Zitat Ruder JA, Springer BD. Treatment of periprosthetic joint infection using antimicrobials: dilute povidone-iodine lavage. J Bone Joint Infect. 2017;2(1):10.CrossRef Ruder JA, Springer BD. Treatment of periprosthetic joint infection using antimicrobials: dilute povidone-iodine lavage. J Bone Joint Infect. 2017;2(1):10.CrossRef
32.
Zurück zum Zitat Frisch NB, Kadri OM, Tenbrunsel T, Abdul-Hak A, Qatu M, Davis JJ. Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty. Arthroplast Today. 2017;3(4):294.CrossRefPubMedPubMedCentral Frisch NB, Kadri OM, Tenbrunsel T, Abdul-Hak A, Qatu M, Davis JJ. Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty. Arthroplast Today. 2017;3(4):294.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Riesgo AM, Park BK, Herrero CP, Yu S, Schwarzkopf R, Iorio R. Vancomycin povidone-iodine protocol improves survivorship of periprosthetic joint infection treated with irrigation and debridement. J Arthroplast. 2018;33(3):847.CrossRef Riesgo AM, Park BK, Herrero CP, Yu S, Schwarzkopf R, Iorio R. Vancomycin povidone-iodine protocol improves survivorship of periprosthetic joint infection treated with irrigation and debridement. J Arthroplast. 2018;33(3):847.CrossRef
34.
Zurück zum Zitat Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant–related staphylococcal infections: a randomized controlled trial. JAMA. 1998;279(19):1537.CrossRefPubMed Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant–related staphylococcal infections: a randomized controlled trial. JAMA. 1998;279(19):1537.CrossRefPubMed
35.
Zurück zum Zitat O'Reilly T, Kunz S, Sande E, Zak O, Sande M, Täuber MG. Relationship between antibiotic concentration in bone and efficacy of treatment of staphylococcal osteomyelitis in rats: azithromycin compared with clindamycin and rifampin. Antimicrob Agents Chemother. 1992;36(12):2693.CrossRefPubMedPubMedCentral O'Reilly T, Kunz S, Sande E, Zak O, Sande M, Täuber MG. Relationship between antibiotic concentration in bone and efficacy of treatment of staphylococcal osteomyelitis in rats: azithromycin compared with clindamycin and rifampin. Antimicrob Agents Chemother. 1992;36(12):2693.CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Joukhadar C, Stass H, Müller-Zellenberg U, Lackner E, Kovar F, Minar E, et al. Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother. 2003;47(10):3099.CrossRefPubMedPubMedCentral Joukhadar C, Stass H, Müller-Zellenberg U, Lackner E, Kovar F, Minar E, et al. Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother. 2003;47(10):3099.CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, et al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017;11:1729.CrossRefPubMedPubMedCentral Greimel F, Scheuerer C, Gessner A, Simon M, Kalteis T, Grifka J, et al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017;11:1729.CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Koziel J, Maciag-Gudowska A, Mikolajczyk T, Bzowska M, Sturdevant DE, Whitney AR, et al. Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One. 2009;4(4):e5210.CrossRefPubMedPubMedCentral Koziel J, Maciag-Gudowska A, Mikolajczyk T, Bzowska M, Sturdevant DE, Whitney AR, et al. Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One. 2009;4(4):e5210.CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, et al. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus. Nature. 2015;527(7578):323.CrossRefPubMed Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, et al. Novel antibody–antibiotic conjugate eliminates intracellular S. aureus. Nature. 2015;527(7578):323.CrossRefPubMed
41.
Zurück zum Zitat Surewaard BG, Deniset JF, Zemp FJ, Amrein M, Otto M, Conly J, Omri A, Yates RM, Kubes P. Identification and treatment of the Staphylococcus aureus reservoir in vivo. J Exp Med : JEM. 2016 20160334. Surewaard BG, Deniset JF, Zemp FJ, Amrein M, Otto M, Conly J, Omri A, Yates RM, Kubes P. Identification and treatment of the Staphylococcus aureus reservoir in vivo. J Exp Med : JEM. 2016 20160334.
42.
Zurück zum Zitat •• Zaidi S, Misba L, Khan AU. Nano-therapeutics: a revolution in infection control in post antibiotic era. Nanomedicine. 2017;13(7):2281. This paper provides an up to date, thorough overview of the possible applications of nano-therapeutics for infectious disease, summarizing advantages and limitations of nanoparticle-based platforms. CrossRefPubMed •• Zaidi S, Misba L, Khan AU. Nano-therapeutics: a revolution in infection control in post antibiotic era. Nanomedicine. 2017;13(7):2281. This paper provides an up to date, thorough overview of the possible applications of nano-therapeutics for infectious disease, summarizing advantages and limitations of nanoparticle-based platforms. CrossRefPubMed
43.
Zurück zum Zitat Liu Y, Busscher HJ, Zhao B, Li Y, Zhang Z, van der Mei HC, et al. Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano. 2016;10(4):4779.CrossRefPubMed Liu Y, Busscher HJ, Zhao B, Li Y, Zhang Z, van der Mei HC, et al. Surface-adaptive, antimicrobially loaded, micellar nanocarriers with enhanced penetration and killing efficiency in staphylococcal biofilms. ACS Nano. 2016;10(4):4779.CrossRefPubMed
44.
Zurück zum Zitat Bazzaz BSF, Khameneh B, Zarei H, Golmohammadzadeh S. Antibacterial efficacy of rifampin loaded solid lipid nanoparticles against Staphylococcus epidermidis biofilm. Microb Pathog. 2016;93:137.CrossRef Bazzaz BSF, Khameneh B, Zarei H, Golmohammadzadeh S. Antibacterial efficacy of rifampin loaded solid lipid nanoparticles against Staphylococcus epidermidis biofilm. Microb Pathog. 2016;93:137.CrossRef
45.
Zurück zum Zitat Chetoni P, Burgalassi S, Monti D, Tampucci S, Tullio V, Cuffini AM, et al. Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: pharmacokinetic studies on rabbits. Eur J Pharm Biopharm. 2016;109:214.CrossRefPubMed Chetoni P, Burgalassi S, Monti D, Tampucci S, Tullio V, Cuffini AM, et al. Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: pharmacokinetic studies on rabbits. Eur J Pharm Biopharm. 2016;109:214.CrossRefPubMed
46.
Zurück zum Zitat Hippler R, Kersten H, Schmidt M, Schoenbach KH. Low temperature plasmas: fundamentals, technologies and techniques: Wiley-VCH. 2008. Hippler R, Kersten H, Schmidt M, Schoenbach KH. Low temperature plasmas: fundamentals, technologies and techniques: Wiley-VCH. 2008.
47.
Zurück zum Zitat Moisan M, Barbeau J, Moreau S, Pelletier J, Tabrizian M, Yahia LH. Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms. Int J Pharm. 2001;226(1–2):1.CrossRefPubMed Moisan M, Barbeau J, Moreau S, Pelletier J, Tabrizian M, Yahia LH. Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms. Int J Pharm. 2001;226(1–2):1.CrossRefPubMed
48.
Zurück zum Zitat Moreau M, Orange N, Feuilloley M. Non-thermal plasma technologies: new tools for bio-decontamination. Biotechnol Adv. 2008;26(6):610.CrossRefPubMed Moreau M, Orange N, Feuilloley M. Non-thermal plasma technologies: new tools for bio-decontamination. Biotechnol Adv. 2008;26(6):610.CrossRefPubMed
49.
Zurück zum Zitat Laroussi M, Lu X, Keidar M. Perspective: the physics, diagnostics, and applications of atmospheric pressure low temperature plasma sources used in plasma medicine. J Appl Phys. 2017;122(2):020901.CrossRef Laroussi M, Lu X, Keidar M. Perspective: the physics, diagnostics, and applications of atmospheric pressure low temperature plasma sources used in plasma medicine. J Appl Phys. 2017;122(2):020901.CrossRef
50.
Zurück zum Zitat Ermolaeva SA, Varfolomeev AF, Chernukha MY, Yurov DS, Vasiliev MM, Kaminskaya AA, et al. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J Med Microbiol. 2011;60(Pt 1):75.CrossRefPubMed Ermolaeva SA, Varfolomeev AF, Chernukha MY, Yurov DS, Vasiliev MM, Kaminskaya AA, et al. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J Med Microbiol. 2011;60(Pt 1):75.CrossRefPubMed
51.
Zurück zum Zitat Taha M, Kalab M, Yi QL, Landry C, Greco-Stewart V, Brassinga AK, et al. Biofilm-forming skin microflora bacteria are resistant to the bactericidal action of disinfectants used during blood donation. Transfusion. 2014;54(11):2974.CrossRefPubMed Taha M, Kalab M, Yi QL, Landry C, Greco-Stewart V, Brassinga AK, et al. Biofilm-forming skin microflora bacteria are resistant to the bactericidal action of disinfectants used during blood donation. Transfusion. 2014;54(11):2974.CrossRefPubMed
52.
Zurück zum Zitat Horner C, Mawer D, Wilcox M. Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter? J Antimicrob Chemother. 2012;67(11):2547.CrossRefPubMed Horner C, Mawer D, Wilcox M. Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter? J Antimicrob Chemother. 2012;67(11):2547.CrossRefPubMed
53.
Zurück zum Zitat Gupta TT, Karki SB, Matson JS, Gehling DJ, Ayan H. Sterilization of biofilm on a titanium surface using a combination of nonthermal plasma and chlorhexidine digluconate. Biomed Res Int. 2017;2017:6085741.PubMedPubMedCentral Gupta TT, Karki SB, Matson JS, Gehling DJ, Ayan H. Sterilization of biofilm on a titanium surface using a combination of nonthermal plasma and chlorhexidine digluconate. Biomed Res Int. 2017;2017:6085741.PubMedPubMedCentral
54.
Zurück zum Zitat Brade KD, Rybak JM, Rybak MJ. Oritavancin: a new lipoglycopeptide antibiotic in the treatment of Gram-positive infections. Infect Dis Ther. 2016;5(1):1.CrossRefPubMedPubMedCentral Brade KD, Rybak JM, Rybak MJ. Oritavancin: a new lipoglycopeptide antibiotic in the treatment of Gram-positive infections. Infect Dis Ther. 2016;5(1):1.CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Zhanel GG, Schweizer F, Karlowsky JA. Oritavancin: mechanism of action. Clin Infect Dis. 2012;54(suppl_3):S214.CrossRefPubMed Zhanel GG, Schweizer F, Karlowsky JA. Oritavancin: mechanism of action. Clin Infect Dis. 2012;54(suppl_3):S214.CrossRefPubMed
56.
Zurück zum Zitat Lehoux D, Ostiguy V, Cadieux C, Malouin M, Belanger O, Far AR, et al. Oritavancin pharmacokinetics and bone penetration in rabbits. Antimicrob Agents Chemother. 2015;59(10):6501.CrossRefPubMedPubMedCentral Lehoux D, Ostiguy V, Cadieux C, Malouin M, Belanger O, Far AR, et al. Oritavancin pharmacokinetics and bone penetration in rabbits. Antimicrob Agents Chemother. 2015;59(10):6501.CrossRefPubMedPubMedCentral
57.
Zurück zum Zitat Crotty MP, Krekel T, Burnham C-AD, Ritchie DJ. New gram-positive agents: the next generation of oxazolidinones and lipoglycopeptides. J Clin Microbiol 54(9): 2225, 2016. Crotty MP, Krekel T, Burnham C-AD, Ritchie DJ. New gram-positive agents: the next generation of oxazolidinones and lipoglycopeptides. J Clin Microbiol 54(9): 2225, 2016.
58.
Zurück zum Zitat Dunne MW, Puttagunta S, Sprenger CR, Rubino C, Van Wart S, Baldassarre J. Extended-duration dosing and distribution of dalbavancin into bone and articular tissue. Antimicrob Agents Chemother 59(4): 1849, 2015. Dunne MW, Puttagunta S, Sprenger CR, Rubino C, Van Wart S, Baldassarre J. Extended-duration dosing and distribution of dalbavancin into bone and articular tissue. Antimicrob Agents Chemother 59(4): 1849, 2015.
59.
Zurück zum Zitat Fernández J, Greenwood-Quaintance KE, Patel R. In vitro activity of dalbavancin against biofilms of staphylococci isolated from prosthetic joint infections. Diagn Microbiol Infect Dis. 2016;85(4):449.CrossRefPubMed Fernández J, Greenwood-Quaintance KE, Patel R. In vitro activity of dalbavancin against biofilms of staphylococci isolated from prosthetic joint infections. Diagn Microbiol Infect Dis. 2016;85(4):449.CrossRefPubMed
60.
Zurück zum Zitat Barnea Y, Lerner A, Aizic A, Navon-Venezia S, Rachi E, Dunne MW, et al. Efficacy of dalbavancin in the treatment of MRSA rat sternal osteomyelitis with mediastinitis. J Antimicrob Chemother. 2015;71(2):460.CrossRefPubMed Barnea Y, Lerner A, Aizic A, Navon-Venezia S, Rachi E, Dunne MW, et al. Efficacy of dalbavancin in the treatment of MRSA rat sternal osteomyelitis with mediastinitis. J Antimicrob Chemother. 2015;71(2):460.CrossRefPubMed
61.
Zurück zum Zitat Yang Y, Qian M, Yi S, Liu S, Li B, Yu R, et al. Monoclonal antibody targeting staphylococcus aureus surface protein A (SasA) protect against staphylococcus aureus sepsis and peritonitis in mice. PLoS One. 2016;11(2):e0149460.CrossRefPubMedPubMedCentral Yang Y, Qian M, Yi S, Liu S, Li B, Yu R, et al. Monoclonal antibody targeting staphylococcus aureus surface protein A (SasA) protect against staphylococcus aureus sepsis and peritonitis in mice. PLoS One. 2016;11(2):e0149460.CrossRefPubMedPubMedCentral
62.
Zurück zum Zitat Varshney AK, Kuzmicheva GA, Lin J, Sunley KM, Bowling RA Jr, Kwan T-Y, et al. A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia. PLoS One. 2018;13(1):e0190537.CrossRefPubMedPubMedCentral Varshney AK, Kuzmicheva GA, Lin J, Sunley KM, Bowling RA Jr, Kwan T-Y, et al. A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia. PLoS One. 2018;13(1):e0190537.CrossRefPubMedPubMedCentral
63.
Zurück zum Zitat Li YJ, Harroun SG, Su YC, Huang CF, Unnikrishnan B, Lin HJ, et al. Synthesis of self-assembled spermidine-carbon quantum dots effective against multidrug-resistant bacteria. Adv Healthcare Mater. 2016;5(19):2545.CrossRef Li YJ, Harroun SG, Su YC, Huang CF, Unnikrishnan B, Lin HJ, et al. Synthesis of self-assembled spermidine-carbon quantum dots effective against multidrug-resistant bacteria. Adv Healthcare Mater. 2016;5(19):2545.CrossRef
64.
Zurück zum Zitat Qayyum S, Khan AU. Biofabrication of broad range antibacterial and antibiofilm silver nanoparticles. IET Nanobiotechnol. 2016;10(5):349.CrossRefPubMed Qayyum S, Khan AU. Biofabrication of broad range antibacterial and antibiofilm silver nanoparticles. IET Nanobiotechnol. 2016;10(5):349.CrossRefPubMed
65.
Zurück zum Zitat Kulshrestha S, Qayyum S, Khan AU. Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: a comparative study on inhibition of gram-positive and gram-negative biofilms. Microb Pathog. 2017;103:167.CrossRefPubMed Kulshrestha S, Qayyum S, Khan AU. Antibiofilm efficacy of green synthesized graphene oxide-silver nanocomposite using Lagerstroemia speciosa floral extract: a comparative study on inhibition of gram-positive and gram-negative biofilms. Microb Pathog. 2017;103:167.CrossRefPubMed
68.
Zurück zum Zitat Gao Y, Wu D, Wang L, Lin C, Ma C, Xi X, et al. Targeted modification of a novel amphibian antimicrobial peptide from Phyllomedusa tarsius to enhance its activity against MRSA and microbial biofilm. Front Microbiol. 2017;8:628.PubMedPubMedCentral Gao Y, Wu D, Wang L, Lin C, Ma C, Xi X, et al. Targeted modification of a novel amphibian antimicrobial peptide from Phyllomedusa tarsius to enhance its activity against MRSA and microbial biofilm. Front Microbiol. 2017;8:628.PubMedPubMedCentral
69.
Zurück zum Zitat Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, et al. Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. Front Microbiol. 2015;6:617.CrossRefPubMedPubMedCentral Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, et al. Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. Front Microbiol. 2015;6:617.CrossRefPubMedPubMedCentral
70.
Zurück zum Zitat Zapotoczna M, Forde É, Hogan S, Humphreys H, O’gara JP, Fitzgerald-Hughes D, Devocelle M, O’neill E. Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides. J Infect Dis 215(6): 975, 2017. Zapotoczna M, Forde É, Hogan S, Humphreys H, O’gara JP, Fitzgerald-Hughes D, Devocelle M, O’neill E. Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides. J Infect Dis 215(6): 975, 2017.
71.
Zurück zum Zitat de la Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, Hernández D, Brackman G, et al. D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections. Chem Biol. 2015;22(2):196.CrossRefPubMedPubMedCentral de la Fuente-Núñez C, Reffuveille F, Mansour SC, Reckseidler-Zenteno SL, Hernández D, Brackman G, et al. D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections. Chem Biol. 2015;22(2):196.CrossRefPubMedPubMedCentral
72.
Zurück zum Zitat Mansour SC, Pletzer D, de la Fuente-Nunez C, Kim P, GYC C, Joo HS, et al. Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically. EBioMedicine. 2016;12:219.CrossRefPubMedPubMedCentral Mansour SC, Pletzer D, de la Fuente-Nunez C, Kim P, GYC C, Joo HS, et al. Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically. EBioMedicine. 2016;12:219.CrossRefPubMedPubMedCentral
73.
Zurück zum Zitat de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, et al. The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci Transl Med. 2018;10(423):eaan4044.CrossRefPubMed de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, et al. The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci Transl Med. 2018;10(423):eaan4044.CrossRefPubMed
74.
Zurück zum Zitat Salmond GP, Fineran PC. A century of the phage: past, present and future. Nat Rev Microbiol. 2015;13(12):777.CrossRefPubMed Salmond GP, Fineran PC. A century of the phage: past, present and future. Nat Rev Microbiol. 2015;13(12):777.CrossRefPubMed
75.
Zurück zum Zitat •• Gutiérrez D, Rodríguez-Rubio L, Martínez B, Rodríguez A, García P. Bacteriophages as weapons against bacterial biofilms in the food industry. Front Microbiol. 2016;7:825. This paper demonstrates the capability of bacteriophages in clearing established biofilms on food surfaces. The described experiment performs successful against clinically relevant bacterial strains and has indirect application to periprosthetic joint infection research. CrossRefPubMedPubMedCentral •• Gutiérrez D, Rodríguez-Rubio L, Martínez B, Rodríguez A, García P. Bacteriophages as weapons against bacterial biofilms in the food industry. Front Microbiol. 2016;7:825. This paper demonstrates the capability of bacteriophages in clearing established biofilms on food surfaces. The described experiment performs successful against clinically relevant bacterial strains and has indirect application to periprosthetic joint infection research. CrossRefPubMedPubMedCentral
76.
Zurück zum Zitat Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, et al. Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection. Antimicrob Agents Chemother. 2017;61(10):e00954.CrossRefPubMedPubMedCentral Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, et al. Development and use of personalized bacteriophage-based therapeutic cocktails to treat a patient with a disseminated resistant Acinetobacter baumannii infection. Antimicrob Agents Chemother. 2017;61(10):e00954.CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Akanda ZZ, Taha M, Abdelbary H. Current review—the rise of bacteriophage as a unique therapeutic platform in treating peri-prosthetic joint infections. J Orthop Res, 2017. Akanda ZZ, Taha M, Abdelbary H. Current review—the rise of bacteriophage as a unique therapeutic platform in treating peri-prosthetic joint infections. J Orthop Res, 2017.
78.
Zurück zum Zitat Alves DR, Perez-Esteban P, Kot W, Bean J, Arnot T, Hansen LH, Enright MC, Jenkins ATA. A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions. Microb Biotechnol 9(1): 61, 2016. Alves DR, Perez-Esteban P, Kot W, Bean J, Arnot T, Hansen LH, Enright MC, Jenkins ATA. A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions. Microb Biotechnol 9(1): 61, 2016.
79.
Zurück zum Zitat Kumaran D, Taha M, Yi Q, Ramirez S, Diallo J-S, Carli A, et al. Does treatment order matter? Investigating the ability of bacteriophage to augment antibiotic activity against Staphylococcus aureus biofilms. Front Microbiol. 2018;9:127.CrossRefPubMedPubMedCentral Kumaran D, Taha M, Yi Q, Ramirez S, Diallo J-S, Carli A, et al. Does treatment order matter? Investigating the ability of bacteriophage to augment antibiotic activity against Staphylococcus aureus biofilms. Front Microbiol. 2018;9:127.CrossRefPubMedPubMedCentral
80.
Zurück zum Zitat Chaudhry WN, Concepción-Acevedo J, Park T, Andleeb S, Bull JJ, Levin BR. Synergy and order effects of antibiotics and phages in killing Pseudomonas aeruginosa biofilms. PLoS One. 2017;12(1):e0168615.CrossRefPubMedPubMedCentral Chaudhry WN, Concepción-Acevedo J, Park T, Andleeb S, Bull JJ, Levin BR. Synergy and order effects of antibiotics and phages in killing Pseudomonas aeruginosa biofilms. PLoS One. 2017;12(1):e0168615.CrossRefPubMedPubMedCentral
81.
Zurück zum Zitat Kishor C, Mishra RR, Saraf SK, Kumar M, Srivastav AK, Nath G. Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model. Indian J Med Res. 2016;143(1):87.CrossRefPubMedPubMedCentral Kishor C, Mishra RR, Saraf SK, Kumar M, Srivastav AK, Nath G. Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model. Indian J Med Res. 2016;143(1):87.CrossRefPubMedPubMedCentral
82.
Zurück zum Zitat Breyne K, Honaker RW, Hobbs Z, Richter M, Żaczek M, Spangler T, et al. Safety of a bovine-associated Staphylococcus aureus phage cocktail in a murine model of mastitis. Front Microbiol. 2017;8 Breyne K, Honaker RW, Hobbs Z, Richter M, Żaczek M, Spangler T, et al. Safety of a bovine-associated Staphylococcus aureus phage cocktail in a murine model of mastitis. Front Microbiol. 2017;8
83.
Zurück zum Zitat Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagn Photodyn Ther. 2005;2(1):1.CrossRef Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagn Photodyn Ther. 2005;2(1):1.CrossRef
84.
Zurück zum Zitat •• Briggs T, Blunn G, Hislop S, Ramalhete R, Bagley C, McKenna D, Coathup M. Antimicrobial photodynamic therapy—a promising treatment for prosthetic joint infections. Lasers Med Sci. 2017;1. This paper involved a thorough evaluation of the photodynamic therapy (PDT) on the biofilms of four distinct clinical isolates of bacteria found in clinical periprosthetic joint infection. The study found that staphylococcus bacteria could be effectively removed using PDT in tested conditions/. •• Briggs T, Blunn G, Hislop S, Ramalhete R, Bagley C, McKenna D, Coathup M. Antimicrobial photodynamic therapy—a promising treatment for prosthetic joint infections. Lasers Med Sci. 2017;1. This paper involved a thorough evaluation of the photodynamic therapy (PDT) on the biofilms of four distinct clinical isolates of bacteria found in clinical periprosthetic joint infection. The study found that staphylococcus bacteria could be effectively removed using PDT in tested conditions/.
85.
Zurück zum Zitat Giannelli M, Landini G, Materassi F, Chellini F, Antonelli A, Tani A, et al. Effects of photodynamic laser and violet-blue led irradiation on Staphylococcus aureus biofilm and Escherichia coli lipopolysaccharide attached to moderately rough titanium surface: in vitro study. Lasers Med Sci. 2017;32(4):857.CrossRefPubMed Giannelli M, Landini G, Materassi F, Chellini F, Antonelli A, Tani A, et al. Effects of photodynamic laser and violet-blue led irradiation on Staphylococcus aureus biofilm and Escherichia coli lipopolysaccharide attached to moderately rough titanium surface: in vitro study. Lasers Med Sci. 2017;32(4):857.CrossRefPubMed
86.
Zurück zum Zitat Ehrensberger MT, Tobias ME, Nodzo SR, Hansen LA, Luke-Marshall NR, Cole RF, et al. Cathodic voltage-controlled electrical stimulation of titanium implants as treatment for methicillin-resistant Staphylococcus aureus periprosthetic infections. Biomaterials. 2015;41:97.CrossRefPubMed Ehrensberger MT, Tobias ME, Nodzo SR, Hansen LA, Luke-Marshall NR, Cole RF, et al. Cathodic voltage-controlled electrical stimulation of titanium implants as treatment for methicillin-resistant Staphylococcus aureus periprosthetic infections. Biomaterials. 2015;41:97.CrossRefPubMed
87.
Zurück zum Zitat •• Nodzo SR, Tobias M, Ahn R, Hansen L, Luke-Marshall NR, Howard C, et al. Cathodic voltage-controlled electrical stimulation plus prolonged vancomycin reduce bacterial burden of a titanium implant-associated infection in a rodent model. Clin Orthop Relat Res. 2016;474(7):1668. This paper provides a clinically representative rodent model of shoulder periprosthetic joint infection, demonstrating the effectiveness of electrical stimulation combined with vancomycin in clearing infection on a shoulder implant with established biofilm. CrossRefPubMedPubMedCentral •• Nodzo SR, Tobias M, Ahn R, Hansen L, Luke-Marshall NR, Howard C, et al. Cathodic voltage-controlled electrical stimulation plus prolonged vancomycin reduce bacterial burden of a titanium implant-associated infection in a rodent model. Clin Orthop Relat Res. 2016;474(7):1668. This paper provides a clinically representative rodent model of shoulder periprosthetic joint infection, demonstrating the effectiveness of electrical stimulation combined with vancomycin in clearing infection on a shoulder implant with established biofilm. CrossRefPubMedPubMedCentral
Metadaten
Titel
New Innovations in the Treatment of PJI and Biofilms—Clinical and Preclinical Topics
verfasst von
Mariam Taha
Hesham Abdelbary
F. Patrick Ross
Alberto V. Carli
Publikationsdatum
20.06.2018
Verlag
Springer US
Erschienen in
Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2018
Elektronische ISSN: 1935-9748
DOI
https://doi.org/10.1007/s12178-018-9500-5

Weitere Artikel der Ausgabe 3/2018

Current Reviews in Musculoskeletal Medicine 3/2018 Zur Ausgabe

Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)

The Use of Antibiograms in Orthopedic Surgery

PCL Update (K Jones and M Alaia, section editors)

Graft Considerations in Posterior Cruciate Ligament Reconstruction

Foot and Ankle Trauma (G Moloney, section editor)

Current Concepts in Talar Neck Fracture Management

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.