Skip to main content
Erschienen in: Infection 1/2014

01.02.2014 | Guideline

New Italian guidelines for malaria prophylaxis in travellers to endemic areas

verfasst von: G. Calleri, F. Castelli, I. El Hamad, F. Gobbi, A. Matteelli, G. Napoletano, R. Romi, A. Rossanese

Erschienen in: Infection | Ausgabe 1/2014

Einloggen, um Zugang zu erhalten

Abstract

Background and Methods

As a consequence of the rapid evolution of malaria prophylaxis recommendations throughout the world, the Italian Society of Tropical Medicine (SIMET—Società Italiana di Medicina Tropicale) has set up a working group in charge of preparing a new national guideline. Other scientific societies interested in the topic were also involved in the project.

Results and Conclusions

The group stated that awareness about malaria risk and characteristics, as well as protection from mosquito bites, are recommended for all travellers visiting malaria-endemic countries. The risk and benefit of malaria chemoprophylaxis must be carefully balanced before prescribing drugs: the disease-related risk must outweigh the possibility of drugs’ side effects. As a general rule, malaria pills are the first choice for travellers to high-risk areas, such as sub-Saharan Africa, Eastern India, Myanmar, Eastern Indonesia, Papua New Guinea and, with some limitations, South-East Asia, and the Amazon part of Venezuela, Guyana and French Guyana. However, several other factors, such as itinerary, season, duration of trip, availability of insect bite protection, pre-existing conditions and compliance, must be taken into account. In low-risk areas, stand-by emergency treatment is the first option. In minimal-risk areas and in Plasmodium vivax areas, a prompt diagnosis only is advised (Central America, South America outside the Amazon basin, Middle East, China, Thailand, Nepal). Recommendations may be modified when particular groups of travellers are concerned, such as long-term residents, visiting friends and relatives, patients with pre-existing conditions, pregnant women and children.
Literatur
3.
Zurück zum Zitat Centers for Disease Control and Prevention (CDC). The yellow book 2012. Health information for international travel. Atlanta: CDC; 2012. Centers for Disease Control and Prevention (CDC). The yellow book 2012. Health information for international travel. Atlanta: CDC; 2012.
5.
Zurück zum Zitat Chiodini P, Hill D, Lalloo D, Lea G, Walker E, Whitty C, Bannister B. Guidelines for malaria prevention in travellers from the United Kingdom. London: Health Protection Agency; 2007. Chiodini P, Hill D, Lalloo D, Lea G, Walker E, Whitty C, Bannister B. Guidelines for malaria prevention in travellers from the United Kingdom. London: Health Protection Agency; 2007.
6.
Zurück zum Zitat Calleri G, Behrens RH, Bisoffi Z, Bjorkman A, Castelli F, Gascon J, Gobbi F, Grobusch MP, Jelinek T, Schmid ML, Niero M, Caramello P. Variability in malaria prophylaxis prescribing across Europe: a Delphi method analysis. J Travel Med. 2008;15:294–301. doi:10.1111/j.1708-8305.2008.00226.x.PubMedCrossRef Calleri G, Behrens RH, Bisoffi Z, Bjorkman A, Castelli F, Gascon J, Gobbi F, Grobusch MP, Jelinek T, Schmid ML, Niero M, Caramello P. Variability in malaria prophylaxis prescribing across Europe: a Delphi method analysis. J Travel Med. 2008;15:294–301. doi:10.​1111/​j.​1708-8305.​2008.​00226.​x.PubMedCrossRef
7.
Zurück zum Zitat Bisoffi Z, Napoletano G, Castelli F, Romi R. Linee guida per la profilassi antimalarica. Giorn Ital Med Trop. 2003;8:15–30. Bisoffi Z, Napoletano G, Castelli F, Romi R. Linee guida per la profilassi antimalarica. Giorn Ital Med Trop. 2003;8:15–30.
8.
Zurück zum Zitat Calleri G, Behrens RH, Schmid ML, Gobbi F, Grobusch MP, Castelli F, Gascon J, Bisoffi Z, Jelinek T, Caramello P; TropNetEurop. Malaria chemoprophylaxis recommendations for immigrants to Europe, visiting relatives and friends—a Delphi method study. Malar J. 2011;10;137. doi:10.1186/1475-2875-10-137.PubMedCentralPubMedCrossRef Calleri G, Behrens RH, Schmid ML, Gobbi F, Grobusch MP, Castelli F, Gascon J, Bisoffi Z, Jelinek T, Caramello P; TropNetEurop. Malaria chemoprophylaxis recommendations for immigrants to Europe, visiting relatives and friends—a Delphi method study. Malar J. 2011;10;137. doi:10.​1186/​1475-2875-10-137.PubMedCentralPubMedCrossRef
9.
Zurück zum Zitat Frickmann H, Schwarz NG, Holtherm HU, Maassen W, Vorderwülbecke F, Erkens K, Fischer M, Morwinsky T, Hagen RM. Compliance with antimalarial chemoprophylaxis in German soldiers: a 6-year survey. Infection. 2013;41:311–20. doi:10.1007/s15010-013-0411-5.PubMedCrossRef Frickmann H, Schwarz NG, Holtherm HU, Maassen W, Vorderwülbecke F, Erkens K, Fischer M, Morwinsky T, Hagen RM. Compliance with antimalarial chemoprophylaxis in German soldiers: a 6-year survey. Infection. 2013;41:311–20. doi:10.​1007/​s15010-013-0411-5.PubMedCrossRef
10.
Zurück zum Zitat Behrens RH, Carroll B, Hellgren U, Visser LG, Siikamäki H, Vestergaard LS, Calleri G, Jänisch T, Myrvang B, Gascon J, Hatz C. The incidence of malaria in travellers to South-East Asia: is local malaria transmission a useful risk indicator? Malar J. 2010;9:266. doi:10.1186/1475-2875-9-266.PubMedCentralPubMedCrossRef Behrens RH, Carroll B, Hellgren U, Visser LG, Siikamäki H, Vestergaard LS, Calleri G, Jänisch T, Myrvang B, Gascon J, Hatz C. The incidence of malaria in travellers to South-East Asia: is local malaria transmission a useful risk indicator? Malar J. 2010;9:266. doi:10.​1186/​1475-2875-9-266.PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat World Health Organization (WHO). World malaria report. Geneva: WHO; 2012. World Health Organization (WHO). World malaria report. Geneva: WHO; 2012.
13.
Zurück zum Zitat Rombo L. Who needs drug prophylaxis against malaria? My personal view. J Travel Med. 2005;12:217–21.PubMedCrossRef Rombo L. Who needs drug prophylaxis against malaria? My personal view. J Travel Med. 2005;12:217–21.PubMedCrossRef
14.
Zurück zum Zitat Petersen E. Malaria chemoprophylaxis: when should we use it and what are the options? Expert Rev Anti Infect Ther. 2004;2:119–32.PubMedCrossRef Petersen E. Malaria chemoprophylaxis: when should we use it and what are the options? Expert Rev Anti Infect Ther. 2004;2:119–32.PubMedCrossRef
17.
Zurück zum Zitat Franco-Paredes C, Santos-Preciado JI. Problem pathogens: prevention of malaria in travellers. Lancet Infect Dis. 2006;6:139–49.PubMedCrossRef Franco-Paredes C, Santos-Preciado JI. Problem pathogens: prevention of malaria in travellers. Lancet Infect Dis. 2006;6:139–49.PubMedCrossRef
19.
Zurück zum Zitat Jacquerioz FA, Croft AM. Drugs for preventing malaria in travellers. Cochrane Database Syst Rev. 2009;(4):CD006491. Jacquerioz FA, Croft AM. Drugs for preventing malaria in travellers. Cochrane Database Syst Rev. 2009;(4):CD006491.
21.
Zurück zum Zitat Askling HH, Bruneel F, Burchard G, Castelli F, Chiodini PL, Grobusch MP, Lopez-Vélez R, Paul M, Petersen E, Popescu C, Ramharter M, Schlagenhauf P; European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology. Management of imported malaria in Europe. Malar J. 2012;11:328. doi:10.1186/1475-2875-11-328.PubMedCentralPubMedCrossRef Askling HH, Bruneel F, Burchard G, Castelli F, Chiodini PL, Grobusch MP, Lopez-Vélez R, Paul M, Petersen E, Popescu C, Ramharter M, Schlagenhauf P; European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology. Management of imported malaria in Europe. Malar J. 2012;11:328. doi:10.​1186/​1475-2875-11-328.PubMedCentralPubMedCrossRef
22.
Zurück zum Zitat Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, Tatem AJ, Hay SI. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J. 2011;10:378.PubMedCentralPubMedCrossRef Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, Tatem AJ, Hay SI. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J. 2011;10:378.PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG. Clinical and parasitological characteristics of puerperal malaria. J Infect Dis. 2005;191:1005–9.PubMedCrossRef Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG. Clinical and parasitological characteristics of puerperal malaria. J Infect Dis. 2005;191:1005–9.PubMedCrossRef
24.
Zurück zum Zitat McGready R, Ashley EA, Nosten F. Malaria and the pregnant traveller. Travel Med Infect Dis. 2004;2:127–42.PubMedCrossRef McGready R, Ashley EA, Nosten F. Malaria and the pregnant traveller. Travel Med Infect Dis. 2004;2:127–42.PubMedCrossRef
26.
Zurück zum Zitat Schlagenhauf P, Blumentals WA, Suter P, Regep L, Vital-Durand G, Schaerer MT, Boutros MS, Rhein HG, Adamcova M. Pregnancy and fetal outcomes after exposure to mefloquine in the pre- and periconception period and during pregnancy. Clin Infect Dis. 2012;54:e124–31.PubMedCrossRef Schlagenhauf P, Blumentals WA, Suter P, Regep L, Vital-Durand G, Schaerer MT, Boutros MS, Rhein HG, Adamcova M. Pregnancy and fetal outcomes after exposure to mefloquine in the pre- and periconception period and during pregnancy. Clin Infect Dis. 2012;54:e124–31.PubMedCrossRef
28.
Zurück zum Zitat Matteelli A, Carvalho AC, Bigoni S. Visiting relatives and friends (VFR), pregnant, and other vulnerable travelers. Infect Dis Clin North Am. 2012;26:625–35.PubMedCrossRef Matteelli A, Carvalho AC, Bigoni S. Visiting relatives and friends (VFR), pregnant, and other vulnerable travelers. Infect Dis Clin North Am. 2012;26:625–35.PubMedCrossRef
29.
Zurück zum Zitat Steffen R, Heusser R, Mächler R, Bruppacher R, Naef U, Chen D, Hofmann AM, Somaini B. Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions, and efficacy. Bull World Health Organ. 1990;68:313–22.PubMedCentralPubMed Steffen R, Heusser R, Mächler R, Bruppacher R, Naef U, Chen D, Hofmann AM, Somaini B. Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions, and efficacy. Bull World Health Organ. 1990;68:313–22.PubMedCentralPubMed
31.
Zurück zum Zitat Mascarello M, Gobbi F, Angheben A, Concia E, Marocco S, Anselmi M, Monteiro G, Rossanese A, Bisoffi Z. Imported malaria in immigrants to Italy: a changing pattern observed in north eastern Italy. J Travel Med. 2009;16:317–21.PubMedCrossRef Mascarello M, Gobbi F, Angheben A, Concia E, Marocco S, Anselmi M, Monteiro G, Rossanese A, Bisoffi Z. Imported malaria in immigrants to Italy: a changing pattern observed in north eastern Italy. J Travel Med. 2009;16:317–21.PubMedCrossRef
32.
Zurück zum Zitat Scolari C, Tedoldi S, Casalini C, Scarcella C, Matteelli A, Casari S, El Hamad I, Castelli F. Knowledge, attitudes, and practices on malaria preventive measures of migrants attending a public health clinic in northern Italy. J Travel Med. 2002;9:160–2.PubMedCrossRef Scolari C, Tedoldi S, Casalini C, Scarcella C, Matteelli A, Casari S, El Hamad I, Castelli F. Knowledge, attitudes, and practices on malaria preventive measures of migrants attending a public health clinic in northern Italy. J Travel Med. 2002;9:160–2.PubMedCrossRef
33.
Zurück zum Zitat Joint Formulary Committee. British National Formulary. London: British Medical Association and Royal Pharmaceutical Society of Great Britain; 2006. Joint Formulary Committee. British National Formulary. London: British Medical Association and Royal Pharmaceutical Society of Great Britain; 2006.
34.
Zurück zum Zitat Castelli F, Patroni A. The human immunodeficiency virus-infected traveler. Clin Infect Dis. 2000;31:1403–8.PubMedCrossRef Castelli F, Patroni A. The human immunodeficiency virus-infected traveler. Clin Infect Dis. 2000;31:1403–8.PubMedCrossRef
35.
Zurück zum Zitat World Health Organization (WHO). Standards for maternal and neonatal care. Geneva: WHO; 2004. World Health Organization (WHO). Standards for maternal and neonatal care. Geneva: WHO; 2004.
36.
Zurück zum Zitat Abecasis J, Dores H, Arroja I, Santos JM, Silva A. Travelers on beta-blockers: is malaria chemoprophylaxis dangerous? Rev Port Cardiol. 2009;28:1153–9.PubMed Abecasis J, Dores H, Arroja I, Santos JM, Silva A. Travelers on beta-blockers: is malaria chemoprophylaxis dangerous? Rev Port Cardiol. 2009;28:1153–9.PubMed
37.
Zurück zum Zitat Steketee RW, Nahlen BL, Parise ME, Menendez C. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg. 2001;64:28–35.PubMed Steketee RW, Nahlen BL, Parise ME, Menendez C. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg. 2001;64:28–35.PubMed
38.
Zurück zum Zitat Descloux E, De Monbrison F, Basselin C, Vial T, Peyron F. Mefloquine adverse effects with atypical facial lesions in an overweight patient. Travel Med Infect Dis. 2010;8:318–21.PubMedCrossRef Descloux E, De Monbrison F, Basselin C, Vial T, Peyron F. Mefloquine adverse effects with atypical facial lesions in an overweight patient. Travel Med Infect Dis. 2010;8:318–21.PubMedCrossRef
Metadaten
Titel
New Italian guidelines for malaria prophylaxis in travellers to endemic areas
verfasst von
G. Calleri
F. Castelli
I. El Hamad
F. Gobbi
A. Matteelli
G. Napoletano
R. Romi
A. Rossanese
Publikationsdatum
01.02.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Infection / Ausgabe 1/2014
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-013-0563-3

Weitere Artikel der Ausgabe 1/2014

Infection 1/2014 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.