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01.04.2013 | Original Paper

New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis

verfasst von: Syed Mustafa Ghanadian, Abdul Majid Ayatollahi, Suleiman Afsharypuor, Shaghayegh Haghjooy Javanmard, Nasim Dana

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2013

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Abstract

Euphorbia microsciadia (Euphorbiaceae) is a perennial plant growing in Iran. Two new cyclomyrsinol esters, 3-O-propionyl-5, 10, 14-O-triacetyl-8-O-(2′-methyl-butanoyl)-cyclomyrsinol (1) and 3, 5, 10, 14, 15-O-pentaacetyl-8-O-isobutanoyl-cyclomyrsinol (2) were isolated from the methanolic extract of its dried aerial parts. The structures were elucidated based on ¹³C- and ¹H-NMR as well as 2D-NMR, IR and different MS spectra. Anti-angiogenic activity was also evaluated on vascular endothelium growth factor (VEGF)-induced angiogenesis in cultured human umbilical vein endothelial cells in vitro by assessing capillary-like tube network formation.

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Titel: New mirsinane-type diterpenes from Euphorbia microsciadia Boiss. with inhibitory effect on VEGF-induced angiogenesis
verfasst von: Syed Mustafa Ghanadian
Abdul Majid Ayatollahi
Suleiman Afsharypuor
Shaghayegh Haghjooy Javanmard
Nasim Dana
Publikationsdatum: 01.04.2013
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2013
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-012-0686-3

Springer Medizin

Abstract

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