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Current Cardiovascular Imaging Reports
Erschienen in: Current Cardiovascular Imaging Reports 6/2019

01.06.2019 | Molecular Imaging (J Wu and P Nguyen, Section Editors)

New Molecular Imaging Strategies to Detect Inflammation in the Vulnerable Plaque

verfasst von: Paolo Raggi

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 6/2019

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Abstract

Purpose of review

Inflammation is an essential component of atherosclerosis and is intimately linked with plaque destabilization. Recent trials showed that therapies directed at inhibiting the systemic inflammatory cascade reduce atherosclerotic cardiovascular events. Hence, accurate molecular imaging of inflammation may help us identify patients for whom targeted therapies could be maximally effective.

Recent findings

Numerous probes have been developed to detect different inflammatory components of atherosclerosis. Although 18F-deoxyglucose has been in use for a long time, new tracers such as 18F-sodium and 67Ga-dotatate have shown greater specificity for coronary artery lesions and have preferentially localized in unstable plaques.

Summary

Despite recent progress, clear evidence that imaging of inflammation within atherosclerotic lesions translates into optimization of treatment and reduction of events is still missing. Imaging research will continue to attempt to deliver precision care to patients in greater need.
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Metadaten
Titel
New Molecular Imaging Strategies to Detect Inflammation in the Vulnerable Plaque
verfasst von
Paolo Raggi
Publikationsdatum
01.06.2019
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 6/2019
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-019-9499-z

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