Improvements in oocyte cryopreservation techniques and establishment of cryopreserved donor oocyte banks have led to improved access to and lower cost of donor oocytes, upending the traditional practice of fresh oocyte donation. The objective of this study was to examine national trends in utilization and live birth rates with fresh versus cryopreserved donor oocytes.
A retrospective analysis of 2013 through 2015 aggregate U.S. national data reported by the Society for Assisted Reproductive Technology which included 30,160 IVF cycles with either fresh or cryopreserved donor oocytes was performed.
During the study period utilization of fresh oocyte donations rapidly declined by 32.9%, while cryopreserved oocyte donation increased by 44.4%. Fresh donor oocytes produced significantly higher live birth rates per recipient cycle start than cryopreserved donor oocytes (51.1% vs. 39.7%). Over the three-year study period fresh donor oocytes produced stable live birth rates per recipient cycle start while those with cryopreserved oocytes significantly declined year-by-year.
Despite rising popularity of cryopreserved donor oocytes, prospective patients should be counselled that fresh donor oocytes still represent standard of care due to higher live birth rates.
Practice Committees of American Society for Reproductive Medicine, Society for Assisted Reproductive Technology. Mature oocyte cryopreservation: a guideline. Fertil Steril. 2013;99(1):37–43. CrossRef
Society for Assisted Reproductive Technology, National Data Summary [Internet]. [cited 2017 May 10]. Available from: https://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx?reportingYear=2015
Kushnir VA, Darmon SK, Shapiro AJ, Albertini DF, Barad DH, Gleicher N. Utilization of third-party in vitro fertilization in the United States. Am J Obstet Gynecol. 2016;216(3):266–e1. PubMed
Dorfmann AD, Machovina JM, Geltinger ME, Iwaszko MA, Lincoln SR, Udoff LC. Frozen embryo transfers using embryos derived from vitrified donor oocytes from the fairfax eggbank. Fertil Steril. 2014;102(3):e124. CrossRef
- New national outcome data on fresh versus cryopreserved donor oocytes
Vitaly A. Kushnir
Sarah K. Darmon
David H. Barad
- BioMed Central
Neu im Fachgebiet Gynäkologie und Geburtshilfe
Meistgelesene Bücher aus dem Fachgebiet
e.Med Kampagnen-Visual, Mail Icon II