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Journal of Natural Medicines

Erschienen in:

01.01.2019 | Note

New neolignans from the seeds of Myristica fragrans and their cytotoxic activities

verfasst von: Parinuch Chumkaew, Theera Srisawat

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2019

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Abstract

Three new dihydrobenzofuran neolignans, myticaganal A–C (1–3), along with five known compounds (4–8), were isolated from the seeds of Myristica fragrans. Their structures were elucidated by extensive spectroscopic analysis. In vitro cytotoxic activities of the isolated compounds against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer) were evaluated. Neolignan 3 showed significant cytotoxicity against KB and NCI-H187 cell lines with IC₅₀ values of 5.9 and 6.3 μM, respectively.

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Titel: New neolignans from the seeds of Myristica fragrans and their cytotoxic activities
verfasst von: Parinuch Chumkaew
Theera Srisawat
Publikationsdatum: 01.01.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1246-2

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

New neolignans from the seeds of Myristica fragrans and their cytotoxic activities

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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