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Inflammopharmacology

Erschienen in:

22.02.2018 | Original Article

New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy

verfasst von: Neveen A. Salem, Marwa El-Shamarka, Yasser Khadrawy, Shaimaa El-Shebiney

Erschienen in: Inflammopharmacology | Ausgabe 4/2018

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Abstract

Temporal lobe epilepsy (TLE) is present in 30% of epileptic patients and does not respond to conventional treatments. Bone marrow derived mesenchymal stem cells (BMSCs) induce endogenous neural stem cells, inhibit neurodegeneration, and promote brain self-repair mechanisms. The present study addresses the feasibility of BMSCs transplantation against pilocarpine-induced TLE experimentally. BMSCs were injected either intravenously (IV) or in hippocampus bilaterally (IC). Increased cell count of BMSCs was achieved via IC route. BMSCs treatment ameliorated the pilocarpine-induced neurochemical and histological changes, retained amino acid neurotransmitters to the normal level, downregulated the immunoreactivity to insulin growth factor-1 receptor, synaptophysin, and caspase-3 and reduced oxidative insult and inflammatory markers detected in epileptic model. It is worth noting that BMSCs IC-administered showed more pronounced effects than those administered via IV route. BMSCs transplantation presents a promise for TLE treatment that has to be elucidated clinically.

Amengual-Cladera E, Nadal-Casellas A, Gómez-Pérez Y, Gomila I, Prieto RM, Proenza AM, Lladó I (2011) Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation. Exp Biol Med 236(10):1133–1138CrossRef

Arroyo S, de La MA (2001) Life-threatening adverse events of antiepileptic drugs. Epilepsy Res 47:155–174CrossRefPubMed

Bancroft JD, Stevens A, Turner DR (1996) Theory and practice of histological techniques. Churchill Livingstone, New York (the text: 766)

Brenneman M, Sharma S, Harting M, Strong R, Cox CS Jr, Aronowski J, Savitz SI (2010) Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J Cereb Blood Flow Metab 30(1):140–149CrossRefPubMed

Calió M, Darci S, Gui Mi K (2014) Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free Radical Biol Med 70:141–154CrossRef

Cavalheiro EA, Leite JP, Bortolotto ZA (1991) Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous I recurrent seizures. Epilepsia 32(6):778–782CrossRefPubMed

Cheng W, Qiantao Z, Shenyang Z (2015) Human umbilical cord mesenchymal stem cells protect against ischemic brain injury in mouse by regulating peripheral immunoinflammation. Brain Res 1594:293–304CrossRefPubMed

Costa F, Zaquer S, Affonso S, Michele F (2010) Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy. Seizure Eur J Epilepsy 19(2):84–92CrossRef

DaCosta J, Maria J, Danielle D (2011) Seizure frequency in patients with mesial temporal lobe epilepsy transplanted with autologous bone marrow mononuclear cells: preliminary results. In: Tissue engineering part A, New Rochelle, USA, pp. 544–544

Dal P, Felipe FK, Mônica MR (2000) Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats. Neurosci Lett 291(3):179–182CrossRef

Danzer C, Kristy RC, Donald C, James O (2002) Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. J Neurosci 22(22):9754–9763CrossRefPubMed

Dominici M, Le Blanc K, Mueller I (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy Position Statement. Cytotherapy 8(4):315–317CrossRefPubMed

Eastwood L, Paul J (2001) Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull 55(5):569–578CrossRefPubMed

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70–77CrossRefPubMed

Grdic R, Marija LR, Karmela B (2011) The paraoxonase 1, 2 and 3 in humans. Biochemia Medica 21(2):122–130CrossRef

Griffin W, Sue T, Robert E (2002) Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in alzheimer’s disease. J Leukoc Biol 72(2):233–238PubMedPubMedCentral

Gupta S (2003) Molecular signaling in death receptor and mitochondrial pathways of apoptosis (review). Int J Oncol 22(1):15–20PubMed

Hattiangady B, Rao MS, Zaman V, Shetty AK (2006) Incorporation of embryonic CA3 cell grafts into the adult hippocampus at 4-months after injury: effects of combined neurotrophic supplementation and caspase inhibition. Neuroscience 139(4):1369–1383CrossRefPubMed

Jiang G, Wang W, Cao Q, Gu J, Mi X, Wang K, Chen G, Wang X (2015) Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain. Clin Sci 129(12):1047–1060

Jiang L, Xiao L, Sugiura H, Huang X, Ali A, Kuro-o M, Deberardinis RJ, Boothman DA (2015) Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition. Oncogene 34(30):3908–3916CrossRefPubMed

Kim YH, Rhyu IJ, Park KW (2001) The induction of BDNF and c-Fos mRNA in the hippocampal formation after febrile seizures. NeuroReport 12(15):3243–3246CrossRefPubMed

Kim H, Jae-Ho L, Se-Hyuk K (2010) Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: secretion of neurotrophic factors and inhibition of apoptosis. J Neurotrauma 27(1):131–138CrossRefPubMed

Kitaur H, Mark S, Kunihiko A (2004) Marrow stromal cells and osteoclast precursors differentially contribute to TNF-α-induced osteoclastogenesis in vivo. J Immunol 173(8):4838–4846CrossRef

Koo J, Cheol H, Se H (2003) The postnatal environment can counteract prenatal effects on cognitive ability, cell proliferation, and synaptic protein expression. FASEB J 17(11):1556–1558CrossRefPubMed

Kwan P, Brodie MJ (2006) Combination therapy in epilepsy. Drugs 66(14):1817–1829CrossRefPubMed

Li Y, Jieli C, Chun L (2005) Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia 49(3):407–417CrossRefPubMed

Magistretti J, Li M, Mark H (2004) Spike patterning by Ca²⁺-dependent regulation of a muscarinic cation current in entorhinal cortex layer II neurons. J Neurophysiol 92(3):1644–1657CrossRefPubMed

Mert T, Akif H, Mahmut A (2015) Anti-inflammatory and anti-nociceptive actions of systemically or locally treated adipose-derived mesenchymal stem cells in experimental inflammatory model. Inflammation 38(3):1302–1310CrossRefPubMed

Nascimento V, Márcia S, Aline A (2005) Antioxidant effect of nimodipine in young rats after pilocarpine-induced seizures. Pharmacol Biochem Behav 82(1):11–16CrossRefPubMed

Paglioli NE, Palmini A, Portuguez M, Paglioli E, Azambuja N, daCosta JC (2006) Seizure and memory outcome following temporal lobe surgery: selective compared with nonselective approaches for hippocampal sclerosis. J Neurosurg 1:70–78CrossRef

Parr M, Charles H, Armand K (2007) Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 40(7):609–619CrossRefPubMed

Raedt R, Annelies V, Kristl V, Paul B (2007) Cell therapy in models for temporal lobe epilepsy. Seizure 16(7):565–578CrossRefPubMed

Ramey WL, Martirosyan NL, Lieu CM, Hasham HA, Lemole GM, Weinand ME (2013) Current management and surgical outcomes of medically intractable epilepsy. Clin Neurol Neurosurg 115(12):2411–2418CrossRefPubMed

Riazi K, Michael A, Quentin J (2010) Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsy Res 89(1):34–42CrossRefPubMed

Ruiz L, Ma B, Ana Ma L, Mariana L, Mercedes L, Herbert D (1994) Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes. Steroids 59(6):383–388CrossRef

Sashindranath M, Karen JM, Ian AT, Richard GC, Mark JC (2010) Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model. Epilepsy Res 90(3):285–294CrossRefPubMed

Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to ImageJ: 25 years of image analysis. Nat Methods 9(7):671–675CrossRefPubMedPubMedCentral

Schwartz R, Morayma R, Lisa K (2002) Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Investig 109(10):1291–1302CrossRefPubMed

Scorza F, Ricardo M, da Maria G, Naffah M (2009) The pilocarpine model of epilepsy: what have we learned? Anais Da Academia Brasileira de Ciencias 81(3):345–365CrossRefPubMed

Stafstrom CE, Carmant L (2015) Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harb Perspect Med 5(6):1–19CrossRef

Tabakman R, Shimon L, Stela S, Hadar A, Philip L (2004) Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury. Prog Brain Res 146:385–401CrossRef

Tamaoki J, Mitsuko K, Kazuhiro K (1999) Macrolide antibiotics protect against immune complex-induced lung injury in rats: role of nitric oxide from alveolar macrophages. J Immunol 163(5):2909–2915PubMed

Tang Y, Takao Y, Koichi H (2007) Transplantation of bone marrow-derived stem cells: a promising therapy for stroke. Cell Transplant 16(2):159–169PubMedCrossRef

Tarsa L, Yukiko G (2002) Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons. Proc Natl Acad Sci 99(2):1012–1016CrossRefPubMed

Turski W, Esper A, Michael S (1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9(3):315–335CrossRefPubMed

Vezzani A, Silvia B, Teresa R (2008) The role of cytokines in the pathophysiology of epilepsy. Brain Behav Immun 22(6):797–803CrossRefPubMed

Vu NB, Phi LT, Dao TT, Le HT, Van Pham P (2016) Adipose derived stem cell transplantation is better than bone marrow mesenchymal stem cell transplantation in treating hindlimb ischemia in mice. Biomed Res Ther 3(9):46CrossRef

Wang Q, Sue Y, Agnes S (2004) Resveratrol protects against neurotoxicity induced by kainic acid. Neurochem Res 29(11):2105–2112CrossRefPubMed

Watson AD, Berliner JA, Hama SY (1995) Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Investig 96(6):2882CrossRefPubMed

Williams NR, Okun MS (2013) Deep brain stimulation (DBS) at the interface of neurology and psychiatry. J Clin Invest 123(11):4546–4556CrossRefPubMedPubMedCentral

Xiao L , Saiki C, Ide R (2014) Stem cell therapy for central nerve system injuries: glial cells hold the key. Neural Regen Res 9(13):1253CrossRefPubMedPubMedCentral

Zappia E, Simona C, Enrico P (2005) Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106(5):1755–1761CrossRefPubMed

Titel: New prospects of mesenchymal stem cells for ameliorating temporal lobe epilepsy
verfasst von: Neveen A. Salem
Marwa El-Shamarka
Yasser Khadrawy
Shaimaa El-Shebiney
Publikationsdatum: 22.02.2018
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 4/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-018-0456-2

Springer Medizin

Abstract

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