Skip to main content
Erschienen in:

01.06.2019 | Dissociation and Addictive Behaviors (J Billieux and A Schimmenti, Section Editors)

New Psychoactive Substances (NPS), Psychedelic Experiences and Dissociation: Clinical and Clinical Pharmacological Issues

verfasst von: Fabrizio Schifano, Flavia Napoletano, Stefania Chiappini, Laura Orsolini, Amira Guirguis, John Martin Corkery, Stefania Bonaccorso, Angelo Ricciardi, Norbert Scherbaum, Alessandro Vento

Erschienen in: Current Addiction Reports | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of the Review

A significant increase in the number, type and availability of new psychoactive substances (NPS) with dissociative and psychedelic potential has occurred worldwide over the last few decades. Psychedelic substances have historically been used in order to achieve altered states of consciousness such as dissociative states. We aimed here at describing both a large number of novel ketamine-like dissociatives and tryptamine/lysergamide/phenethylamine psychedelics available, whilst describing the acute/long-term clinical scenarios most commonly associated with their intake.

Recent Findings

An updated overview of the clinical and clinical pharmacological issues related to some of the most popular NPS categories has been provided, describing both psychosis and remaining psychopathological issues related to them.

Conclusions

Although the complex link between NPS and psychiatric illnesses is yet to be fully understood, NPS misuse is now a significant clinical issue and an increasing challenge for clinicians working in both mental health and emergency departments.
Literatur
2.
Zurück zum Zitat Schifano F. Recent changes in drug abuse scenarios: the new/novel psychoactive substances (NPS) phenomenon. Brain Sci. 2018;8(12). Schifano F. Recent changes in drug abuse scenarios: the new/novel psychoactive substances (NPS) phenomenon. Brain Sci. 2018;8(12).
3.
Zurück zum Zitat Jaffe JH. Drug addiction and drug abuse. In: Goodman AG, Rall TW, Nies AS, Taylor P, editors. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 8th ed. New York: McGraw Hill; 1990. p. 522–73. Jaffe JH. Drug addiction and drug abuse. In: Goodman AG, Rall TW, Nies AS, Taylor P, editors. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 8th ed. New York: McGraw Hill; 1990. p. 522–73.
4.
Zurück zum Zitat • Martinotti G, Santacroce R, Pettorruso M, Montemitro C, Spano MC, Lorusso M, et al. Hallucinogen persisting perception disorder: etiology, clinical features, and therapeutic perspectives. Brain Sci. 2018;8(3). This review focused on the aetiology of Hallucinogen Persisting Perception Disorder induction, the possible hallucinogens involved, the clinical features, the possible psychiatric comorbidities, and the available potential therapeutic strategies. • Martinotti G, Santacroce R, Pettorruso M, Montemitro C, Spano MC, Lorusso M, et al. Hallucinogen persisting perception disorder: etiology, clinical features, and therapeutic perspectives. Brain Sci. 2018;8(3). This review focused on the aetiology of Hallucinogen Persisting Perception Disorder induction, the possible hallucinogens involved, the clinical features, the possible psychiatric comorbidities, and the available potential therapeutic strategies.
5.
Zurück zum Zitat Schifano F, Orsolini L, Duccio Papanti G, Corkery JM. Novel psychoactive substances of interest for psychiatry. World Psychiatry. 2015;14(1):15–26.CrossRefPubMedPubMedCentral Schifano F, Orsolini L, Duccio Papanti G, Corkery JM. Novel psychoactive substances of interest for psychiatry. World Psychiatry. 2015;14(1):15–26.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Barker SA. N, N-dimethyltryptamine (DMT), an endogenous hallucinogen: past, present, and future research to determine its role and function. Front Neurosci. 2018;12:536.CrossRefPubMedPubMedCentral Barker SA. N, N-dimethyltryptamine (DMT), an endogenous hallucinogen: past, present, and future research to determine its role and function. Front Neurosci. 2018;12:536.CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Strassman R. DMT: the spirit molecule: a doctor’s revolutionary research into the biology of near-death and mystical experiences. Vermont: Park Street Press Rochester; 2001. Strassman R. DMT: the spirit molecule: a doctor’s revolutionary research into the biology of near-death and mystical experiences. Vermont: Park Street Press Rochester; 2001.
8.
Zurück zum Zitat Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, et al. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A. 2012;109(6):2138–43.CrossRefPubMedPubMedCentral Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, et al. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A. 2012;109(6):2138–43.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Bleuler E. Dementia praecox or the group of schizophrenias. New York, NY: International Universities Press; 1950. Bleuler E. Dementia praecox or the group of schizophrenias. New York, NY: International Universities Press; 1950.
10.
Zurück zum Zitat Maatz A, Hoff P, Angst J. Eugen Bleuler’s schizophrenia—a modern perspective. Dialogues Clin Neurosci. 2015;17(1). Maatz A, Hoff P, Angst J. Eugen Bleuler’s schizophrenia—a modern perspective. Dialogues Clin Neurosci. 2015;17(1).
11.
Zurück zum Zitat Moskowitz A, Heim G. Eugen Bleuler’s dementia praecox or the group of schizophrenias (1911): a centenary appreciation and reconsideration. Schizophr Bull. 2011;37(3):471–9.CrossRefPubMedPubMedCentral Moskowitz A, Heim G. Eugen Bleuler’s dementia praecox or the group of schizophrenias (1911): a centenary appreciation and reconsideration. Schizophr Bull. 2011;37(3):471–9.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Dell PF, O’Neil JA. Dissociation and the dissociative disorders: DSM-V and beyond. New York, NY: Routledge; 2009. Dell PF, O’Neil JA. Dissociation and the dissociative disorders: DSM-V and beyond. New York, NY: Routledge; 2009.
13.
Zurück zum Zitat American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013.CrossRef American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013.CrossRef
14.
Zurück zum Zitat •• Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N. Dissociation in psychiatric disorders: a meta-analysis of studies using the Dissociative Experiences Scale. Am J Psychiatry. 2018;175:37–46. This meta-analysis provides information on the prevalence and distribution of dissociative symptoms within different categories of mental disorders.CrossRefPubMed •• Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N. Dissociation in psychiatric disorders: a meta-analysis of studies using the Dissociative Experiences Scale. Am J Psychiatry. 2018;175:37–46. This meta-analysis provides information on the prevalence and distribution of dissociative symptoms within different categories of mental disorders.CrossRefPubMed
15.
Zurück zum Zitat St John-Smith P, McQueen D, Edwards L, Schifano F. Classical and novel psychoactive substances: rethinking drug misuse from an evolutionary psychiatric perspective. Hum Psychopharmacol. 2013;28(4):394–401.CrossRefPubMed St John-Smith P, McQueen D, Edwards L, Schifano F. Classical and novel psychoactive substances: rethinking drug misuse from an evolutionary psychiatric perspective. Hum Psychopharmacol. 2013;28(4):394–401.CrossRefPubMed
16.
Zurück zum Zitat Orsolini L, St John-Smith P, McQueen D, Papanti D, Corkery J, Schifano F. Evolutionary considerations on the emerging subculture of the E-psychonauts and the novel psychoactive substances: a comeback to the shamanism? Curr Neuropharmacol. 2017;15(5):731–7.CrossRefPubMedPubMedCentral Orsolini L, St John-Smith P, McQueen D, Papanti D, Corkery J, Schifano F. Evolutionary considerations on the emerging subculture of the E-psychonauts and the novel psychoactive substances: a comeback to the shamanism? Curr Neuropharmacol. 2017;15(5):731–7.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Hofmann A. translated from the original German (LSD Ganz persönlich) by J. Ott. MAPS-Vol. 6, No. 69 (Summer 1969). Hofmann A. translated from the original German (LSD Ganz persönlich) by J. Ott. MAPS-Vol. 6, No. 69 (Summer 1969).
18.
Zurück zum Zitat Hofmann A. LSD – mein Sorgenkind. München, dtv, 1993. Hofmann A. LSD – mein Sorgenkind. München, dtv, 1993.
19.
Zurück zum Zitat Corazza O, Schifano F. Ketamine-induced ‘near-death experience’ states in a sample of 50 misusers. Subst Use Misuse. 2010;45:916–24.CrossRefPubMed Corazza O, Schifano F. Ketamine-induced ‘near-death experience’ states in a sample of 50 misusers. Subst Use Misuse. 2010;45:916–24.CrossRefPubMed
20.
Zurück zum Zitat Abdulrahim D, Bowden-Jones O, on behalf of the NEPTUNE Expert Group. Guidance on the management of acute and chronic harms of club drugs and novel psychoactive substances. London: Novel Psychoactive Treatment UK Network (NEPTUNE); 2015. Abdulrahim D, Bowden-Jones O, on behalf of the NEPTUNE Expert Group. Guidance on the management of acute and chronic harms of club drugs and novel psychoactive substances. London: Novel Psychoactive Treatment UK Network (NEPTUNE); 2015.
21.
Zurück zum Zitat Caloro M, Calabrò G, de Pisa E, Rosini E, Kotzalidis GD, Lonati D, et al. Combined NMDA inhibitor use in a patient with multisubstance-induced psychotic disorder. J Addict Med. 2018;12(3):247–51.CrossRefPubMed Caloro M, Calabrò G, de Pisa E, Rosini E, Kotzalidis GD, Lonati D, et al. Combined NMDA inhibitor use in a patient with multisubstance-induced psychotic disorder. J Addict Med. 2018;12(3):247–51.CrossRefPubMed
22.
Zurück zum Zitat Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol. 2012;27(2):145–9.CrossRefPubMed Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol. 2012;27(2):145–9.CrossRefPubMed
23.
Zurück zum Zitat Corazza O, Assi S, Schifano F. From ‘special K’ to ‘special M’: the evolution of the recreational use of ketamine and methoxetamine. CNS Neurosci Ther. 2013;19(6):454–60.CrossRefPubMedPubMedCentral Corazza O, Assi S, Schifano F. From ‘special K’ to ‘special M’: the evolution of the recreational use of ketamine and methoxetamine. CNS Neurosci Ther. 2013;19(6):454–60.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat • Hearne E, Van Hout MC. ‘Trip-Sitting’ in the black hole: a netnographic study of dissociation and indigenous harm reduction. J Psychoactive Drugs. 2016;48(4):233–42. This paper provides information relating to the use of dissociative novel psychoactive substances within the cyber drug user community.CrossRefPubMed • Hearne E, Van Hout MC. ‘Trip-Sitting’ in the black hole: a netnographic study of dissociation and indigenous harm reduction. J Psychoactive Drugs. 2016;48(4):233–42. This paper provides information relating to the use of dissociative novel psychoactive substances within the cyber drug user community.CrossRefPubMed
25.
Zurück zum Zitat Orsolini L, Ciccarese M, Papanti D, De Berardis D, Guirguis A, Corkery JM, et al. Psychedelic fauna for psychonaut hunters: a mini-review. Front Psychiatry. 2018;9:153.CrossRefPubMedPubMedCentral Orsolini L, Ciccarese M, Papanti D, De Berardis D, Guirguis A, Corkery JM, et al. Psychedelic fauna for psychonaut hunters: a mini-review. Front Psychiatry. 2018;9:153.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat • Orsolini L, Papanti GD, De Berardis D, Guirguis A, Corkery JM, Schifano F. The “Endless Trip” among the NPS users: psychopathology and psychopharmacology in the hallucinogen-persisting perception disorder. A systematic review. Front Psychiatry. 2017;8:240. This review focuses on the psychopathological background, the aetiological hypotheses, and psychopharmacological approaches towards the hallucinogen-persisting perception disorder, including its association with the intake of some novel psychoactive substances.CrossRefPubMedPubMedCentral • Orsolini L, Papanti GD, De Berardis D, Guirguis A, Corkery JM, Schifano F. The “Endless Trip” among the NPS users: psychopathology and psychopharmacology in the hallucinogen-persisting perception disorder. A systematic review. Front Psychiatry. 2017;8:240. This review focuses on the psychopathological background, the aetiological hypotheses, and psychopharmacological approaches towards the hallucinogen-persisting perception disorder, including its association with the intake of some novel psychoactive substances.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Baumeister D, Tojo LM, Tracy DK. Legal highs: staying on top of the flood of novel psychoactive substances. Ther Adv Psychopharmacol. 2015;5(2):97–132.CrossRefPubMedPubMedCentral Baumeister D, Tojo LM, Tracy DK. Legal highs: staying on top of the flood of novel psychoactive substances. Ther Adv Psychopharmacol. 2015;5(2):97–132.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat •• Schifano F, Papanti GD, Orsolini L, Corkery JM. Novel psychoactive substances: the pharmacology of stimulants and hallucinogens. Expert Rev Clin Pharmacol. 2016;9(7):943–54 This paper provides an overview of the clinical pharmacological issues related to some of the most popular NPS categories, e.g. stimulants and hallucinogens.CrossRefPubMed •• Schifano F, Papanti GD, Orsolini L, Corkery JM. Novel psychoactive substances: the pharmacology of stimulants and hallucinogens. Expert Rev Clin Pharmacol. 2016;9(7):943–54 This paper provides an overview of the clinical pharmacological issues related to some of the most popular NPS categories, e.g. stimulants and hallucinogens.CrossRefPubMed
29.
Zurück zum Zitat Miliano C, Serpelloni G, Rimondo C, Mereu M, Marti M, De Luca MA. Neuropharmacology of new psychoactive substances (NPS): focus on the rewarding and reinforcing properties of cannabimimetics and amphetamine-like stimulants. Front Neurosci. 2016;10:153.CrossRefPubMedPubMedCentral Miliano C, Serpelloni G, Rimondo C, Mereu M, Marti M, De Luca MA. Neuropharmacology of new psychoactive substances (NPS): focus on the rewarding and reinforcing properties of cannabimimetics and amphetamine-like stimulants. Front Neurosci. 2016;10:153.CrossRefPubMedPubMedCentral
30.
Zurück zum Zitat Ott J, Bigwood J. Teonanacatl hallucinogenic mushrooms of North America. Seattle, WA: Madrona Publishers; 1978. Ott J, Bigwood J. Teonanacatl hallucinogenic mushrooms of North America. Seattle, WA: Madrona Publishers; 1978.
31.
Zurück zum Zitat Schultes RE, Hofmann A. Plants of the gods: origins of hallucinogenic use. New York: Alfred van der Marck Editions; 1979. Schultes RE, Hofmann A. Plants of the gods: origins of hallucinogenic use. New York: Alfred van der Marck Editions; 1979.
32.
Zurück zum Zitat Pettigrew J. Iconography in Bradshaw rock art: breaking the circularity. Clin Exp Optom. 2011;94(5):403–17.CrossRefPubMed Pettigrew J. Iconography in Bradshaw rock art: breaking the circularity. Clin Exp Optom. 2011;94(5):403–17.CrossRefPubMed
33.
Zurück zum Zitat Turton S, Nutt DJ, Carhart-Harris RL. A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment. Curr Drug Abuse Rev. 2014;7(2):117–27.CrossRefPubMed Turton S, Nutt DJ, Carhart-Harris RL. A qualitative report on the subjective experience of intravenous psilocybin administered in an FMRI environment. Curr Drug Abuse Rev. 2014;7(2):117–27.CrossRefPubMed
34.
Zurück zum Zitat Kometer M, Schmidt A, Jäncke L, Vollenweider FX. Activation of serotonin 2A receptors underlies the psilocybin-induced effects on a oscillations, N170 visual-evoked potentials, and visual hallucinations. J Neurosci. 2013;33(25):10544–51.CrossRefPubMedPubMedCentral Kometer M, Schmidt A, Jäncke L, Vollenweider FX. Activation of serotonin 2A receptors underlies the psilocybin-induced effects on a oscillations, N170 visual-evoked potentials, and visual hallucinations. J Neurosci. 2013;33(25):10544–51.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Studerus E, Gamma A, Vollenweider FX. Psychometric evaluation of the altered states of consciousness rating scale (OAV). PLoS One. 2010;5(8):e12412.CrossRefPubMedPubMedCentral Studerus E, Gamma A, Vollenweider FX. Psychometric evaluation of the altered states of consciousness rating scale (OAV). PLoS One. 2010;5(8):e12412.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Johnson MW, Sewell RA, Griffiths RR. Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers. Drug Alcohol Depend. 2012;123(1–3):132–40.CrossRefPubMed Johnson MW, Sewell RA, Griffiths RR. Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers. Drug Alcohol Depend. 2012;123(1–3):132–40.CrossRefPubMed
37.
Zurück zum Zitat Bickel M, Ditting T, Watz H, Roesler A, Weidauer S, Jacobi V, et al. Severe rhabdomyolysis, acute renal failure and posterior encephalopathy after ‘magic mushroom’ abuse. Eur J Emerg Med. 2005;12(6):306–8.CrossRefPubMed Bickel M, Ditting T, Watz H, Roesler A, Weidauer S, Jacobi V, et al. Severe rhabdomyolysis, acute renal failure and posterior encephalopathy after ‘magic mushroom’ abuse. Eur J Emerg Med. 2005;12(6):306–8.CrossRefPubMed
38.
Zurück zum Zitat El-Seedi HR, De Smet PA, Beck O, Possnert G, Bruhn JG. Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas. J Ethnopharmacol. 2005;101(1–3):238–42.CrossRefPubMed El-Seedi HR, De Smet PA, Beck O, Possnert G, Bruhn JG. Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas. J Ethnopharmacol. 2005;101(1–3):238–42.CrossRefPubMed
39.
Zurück zum Zitat Bruhn JG, De Smet PA, El-Seedi HR, Beck O. Mescaline use for 5700 years. Lancet. 2002;359(9320):1866.CrossRefPubMed Bruhn JG, De Smet PA, El-Seedi HR, Beck O. Mescaline use for 5700 years. Lancet. 2002;359(9320):1866.CrossRefPubMed
40.
Zurück zum Zitat Halpern JH, Sherwood AR, Hudson JI, Yurgelun-Todd D, Pope HG Jr. Psychological and cognitive effects of long-term peyote use among Native Americans. Biol Psychiatry. 2005;58(8):624–31.CrossRefPubMed Halpern JH, Sherwood AR, Hudson JI, Yurgelun-Todd D, Pope HG Jr. Psychological and cognitive effects of long-term peyote use among Native Americans. Biol Psychiatry. 2005;58(8):624–31.CrossRefPubMed
41.
Zurück zum Zitat Lu BY, Woofter C, Escalona R. A case of prolonged peyote-induced psychosis resolved by sleep. J Clin Psychiatry. 2004;65(10):1433–4.CrossRefPubMed Lu BY, Woofter C, Escalona R. A case of prolonged peyote-induced psychosis resolved by sleep. J Clin Psychiatry. 2004;65(10):1433–4.CrossRefPubMed
42.
Zurück zum Zitat Dobkin de Rios M. Ayahuasca–the healing vine. Int J Soc Psychiatry. 1971 Winter;17(4):256–69.CrossRefPubMed Dobkin de Rios M. Ayahuasca–the healing vine. Int J Soc Psychiatry. 1971 Winter;17(4):256–69.CrossRefPubMed
43.
Zurück zum Zitat • Bouso JC, Palhano-Fontes F, Rodríguez-Fornells A, Ribeiro S, Sanches R, Crippa JA, et al. Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. Eur Neuropsychopharmacol. 2015;25(4):483–92. This paper suggests that regular use of psychedelic drugs could potentially lead to structural changes in brain areas supporting attentional processes, self-referential thought, and internal mentation.CrossRefPubMed • Bouso JC, Palhano-Fontes F, Rodríguez-Fornells A, Ribeiro S, Sanches R, Crippa JA, et al. Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. Eur Neuropsychopharmacol. 2015;25(4):483–92. This paper suggests that regular use of psychedelic drugs could potentially lead to structural changes in brain areas supporting attentional processes, self-referential thought, and internal mentation.CrossRefPubMed
44.
Zurück zum Zitat Grob CS, McKenna DJ, Callaway JC, Brito GS, Neves ES, Oberlaender G, et al. Human psychopharmacology of hoasca, a a plant hallucinogen used in ritual context in Brazil. J Nerv Ment Dis. 1996;184(2):86–94.CrossRefPubMed Grob CS, McKenna DJ, Callaway JC, Brito GS, Neves ES, Oberlaender G, et al. Human psychopharmacology of hoasca, a a plant hallucinogen used in ritual context in Brazil. J Nerv Ment Dis. 1996;184(2):86–94.CrossRefPubMed
45.
Zurück zum Zitat De Araujo DB, Ribeiro S, Cecchi GA, Carvalho FM, Sanchez TA, Pinto JP, et al. Seeing with the eyes shut: neural basis of enhanced imagery following Ayahuasca ingestion. Hum Brain Mapp. 2012;33(11):2550–60.CrossRefPubMed De Araujo DB, Ribeiro S, Cecchi GA, Carvalho FM, Sanchez TA, Pinto JP, et al. Seeing with the eyes shut: neural basis of enhanced imagery following Ayahuasca ingestion. Hum Brain Mapp. 2012;33(11):2550–60.CrossRefPubMed
46.
Zurück zum Zitat Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider FX, et al. Acute effects of lysergic acid diethylamide in healthy subjects. Biol Psychiatry. 2015;78(8):544–53.CrossRefPubMed Schmid Y, Enzler F, Gasser P, Grouzmann E, Preller KH, Vollenweider FX, et al. Acute effects of lysergic acid diethylamide in healthy subjects. Biol Psychiatry. 2015;78(8):544–53.CrossRefPubMed
47.
Zurück zum Zitat Sjobergand BM Jr, Hollister LE. The effects of psychotomimetic drugs on primary suggestibility. Psychopharmacology. 1965;8(4):251–62.CrossRef Sjobergand BM Jr, Hollister LE. The effects of psychotomimetic drugs on primary suggestibility. Psychopharmacology. 1965;8(4):251–62.CrossRef
48.
Zurück zum Zitat Middlefell R. The effects of LSD on body sway suggestibility in a group of hospital patients. Br J Psychiatry. 1967;113(496):277–80.CrossRefPubMed Middlefell R. The effects of LSD on body sway suggestibility in a group of hospital patients. Br J Psychiatry. 1967;113(496):277–80.CrossRefPubMed
50.
Zurück zum Zitat Carhart-Harris RL, Kaelen M, Whalley MG, Bolstridge M, Feilding A, Nutt DJ. LSD enhances suggestibility in healthy volunteers. Psychopharmacology. 2015;232(4):785–94.CrossRefPubMed Carhart-Harris RL, Kaelen M, Whalley MG, Bolstridge M, Feilding A, Nutt DJ. LSD enhances suggestibility in healthy volunteers. Psychopharmacology. 2015;232(4):785–94.CrossRefPubMed
51.
Zurück zum Zitat Zentner M, Grandjean D, Scherer KR. Emotions evoked by the sound of music: characterization, classification, and measurement. Emotion. 2008;8(4):494–521.CrossRefPubMed Zentner M, Grandjean D, Scherer KR. Emotions evoked by the sound of music: characterization, classification, and measurement. Emotion. 2008;8(4):494–521.CrossRefPubMed
52.
Zurück zum Zitat Krebs TS, Johansen PO. Psychedelics and mental health: a population study. PloS One. 8:e63972. Krebs TS, Johansen PO. Psychedelics and mental health: a population study. PloS One. 8:e63972.
53.
Zurück zum Zitat Berrens Z, Lammers J, White C. Rhabdomyolysis after LSD ingestion. Psychosomatics. 2010;51(4):356–356.e3.CrossRefPubMed Berrens Z, Lammers J, White C. Rhabdomyolysis after LSD ingestion. Psychosomatics. 2010;51(4):356–356.e3.CrossRefPubMed
54.
Zurück zum Zitat Raval MV, Gaba RC, Brown K, Sato KT, Eskandari MK. Percutaneous transluminal angioplasty in the treatment of extensive LSD-induced lower extremity vasospasm refractory to pharmacologic therapy. J Vasc Interv Radiol. 2008;19(8):1227–30.CrossRefPubMed Raval MV, Gaba RC, Brown K, Sato KT, Eskandari MK. Percutaneous transluminal angioplasty in the treatment of extensive LSD-induced lower extremity vasospasm refractory to pharmacologic therapy. J Vasc Interv Radiol. 2008;19(8):1227–30.CrossRefPubMed
55.
Zurück zum Zitat Bernhard MK, Ulrich K. Recurrent cortical blindness after LSD-intake. Fortschr Neurol Psychiatr. 2009;77(2):102–4.CrossRefPubMed Bernhard MK, Ulrich K. Recurrent cortical blindness after LSD-intake. Fortschr Neurol Psychiatr. 2009;77(2):102–4.CrossRefPubMed
56.
Zurück zum Zitat • Graziano S, Orsolini L, Rotolo MC, Tittarelli R, Schifano F, Pichini S. Herbal highs: review on psychoactive effects and neuropharmacology. Curr Neuropharmacol. 2017;15(5):750–61. This review focuses on the psychoactive effects and neuropharmacology of the most popular “herbal highs”, considering both the subjective and eventual secondary effects, including intoxications and fatalities as well.CrossRefPubMedPubMedCentral • Graziano S, Orsolini L, Rotolo MC, Tittarelli R, Schifano F, Pichini S. Herbal highs: review on psychoactive effects and neuropharmacology. Curr Neuropharmacol. 2017;15(5):750–61. This review focuses on the psychoactive effects and neuropharmacology of the most popular “herbal highs”, considering both the subjective and eventual secondary effects, including intoxications and fatalities as well.CrossRefPubMedPubMedCentral
58.
Zurück zum Zitat Suzuki J, Dekker MA, Valenti ES, Arbelo Cruz FA, Correa AM, Poklis JL, et al. Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literature. Psychosomatics. 2015;56(2):129–39.CrossRefPubMed Suzuki J, Dekker MA, Valenti ES, Arbelo Cruz FA, Correa AM, Poklis JL, et al. Toxicities associated with NBOMe ingestion-a novel class of potent hallucinogens: a review of the literature. Psychosomatics. 2015;56(2):129–39.CrossRefPubMed
59.
Zurück zum Zitat Andreasen MF, Telving R, Birkler RI, Schumacher B, Johannsen M. A fatal poisoning involving Bromo-dragonfly. Forensic Sci Int. 2009;183(1–3):91–6.CrossRefPubMed Andreasen MF, Telving R, Birkler RI, Schumacher B, Johannsen M. A fatal poisoning involving Bromo-dragonfly. Forensic Sci Int. 2009;183(1–3):91–6.CrossRefPubMed
60.
Zurück zum Zitat Balíková M. Nonfatal and fatal DOB (2,5-dimethoxy-4-bromoamphetamine) overdose. Forensic Sci Int. 2005;153(1):85–91.CrossRefPubMed Balíková M. Nonfatal and fatal DOB (2,5-dimethoxy-4-bromoamphetamine) overdose. Forensic Sci Int. 2005;153(1):85–91.CrossRefPubMed
61.
Zurück zum Zitat Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, et al. Pharmacological investigations of the dissociative ‘legal highs’ diphenidine, methoxphenidine and analogues. PLoS One. 2016;11(6):e0157021.CrossRefPubMedPubMedCentral Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, et al. Pharmacological investigations of the dissociative ‘legal highs’ diphenidine, methoxphenidine and analogues. PLoS One. 2016;11(6):e0157021.CrossRefPubMedPubMedCentral
62.
Zurück zum Zitat • Wallach J, Brandt SD. 1,2-Diarylethylamine- and ketamine-based new psychoactive substances. In: Handbook of experimental pharmacology. Berlin, Heidelberg: Springer; 2018. This chapter described some dissociative NPS having emerged on the market in recent years, considering their pharmacology and effects. • Wallach J, Brandt SD. 1,2-Diarylethylamine- and ketamine-based new psychoactive substances. In: Handbook of experimental pharmacology. Berlin, Heidelberg: Springer; 2018. This chapter described some dissociative NPS having emerged on the market in recent years, considering their pharmacology and effects.
63.
Zurück zum Zitat Morris H, Wallach J. From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. Drug Test Anal. 2014;6(7–8):614–32.CrossRefPubMed Morris H, Wallach J. From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs. Drug Test Anal. 2014;6(7–8):614–32.CrossRefPubMed
64.
Zurück zum Zitat Halberstadt AL, Slepak N, Hyun J, Buell MR, Powell SB. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents. Psychopharmacology. 2016;233(7):1215–25.CrossRefPubMedPubMedCentral Halberstadt AL, Slepak N, Hyun J, Buell MR, Powell SB. The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents. Psychopharmacology. 2016;233(7):1215–25.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR. High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. Psychopharmacol (Berl). 2012;223(1):1–15.CrossRef Reissig CJ, Carter LP, Johnson MW, Mintzer MZ, Klinedinst MA, Griffiths RR. High doses of dextromethorphan, an NMDA antagonist, produce effects similar to classic hallucinogens. Psychopharmacol (Berl). 2012;223(1):1–15.CrossRef
66.
Zurück zum Zitat Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, et al. The ketamine analogue methoxetamine and 3-and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PloS One. 2013;8(3):e59334.CrossRefPubMedPubMedCentral Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, et al. The ketamine analogue methoxetamine and 3-and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PloS One. 2013;8(3):e59334.CrossRefPubMedPubMedCentral
67.
Zurück zum Zitat Luby ED, Cohen BD, Rosenbaum G, Gottlieb JS, Kelley R. Study of a new schizophrenomimetic drug—sernyl. AMA Arch Neurol Psychiatry. 1959;81(3):363–9.CrossRefPubMed Luby ED, Cohen BD, Rosenbaum G, Gottlieb JS, Kelley R. Study of a new schizophrenomimetic drug—sernyl. AMA Arch Neurol Psychiatry. 1959;81(3):363–9.CrossRefPubMed
68.
Zurück zum Zitat Vollenweider FX, Leenders KL, Øye I, Hell D, Angst J. Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)-and I-ketamine in healthy volunteers using positron emission tomography (PET). Eur Neuropsychopharmacol. 1997;7(1):25–38.CrossRefPubMed Vollenweider FX, Leenders KL, Øye I, Hell D, Angst J. Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)-and I-ketamine in healthy volunteers using positron emission tomography (PET). Eur Neuropsychopharmacol. 1997;7(1):25–38.CrossRefPubMed
69.
Zurück zum Zitat Bonta IL. Schizophrenia, dissociative anaesthesia and near-death experience; three events meeting at the NMDA receptor. Med Hypotheses. 2004;62(1):23–8.CrossRefPubMed Bonta IL. Schizophrenia, dissociative anaesthesia and near-death experience; three events meeting at the NMDA receptor. Med Hypotheses. 2004;62(1):23–8.CrossRefPubMed
70.
Zurück zum Zitat • Tracy D, Wood DM, Baumeister D. Novel psychoactive substances: types, mechanisms of action, and effects. BMJ. 2017;356:i6848. This paper reviews the recent literature regarding NPS, classifying them into their major groupings and providing information on the desired effects of these compounds, their pharmacology, and the risks associated with their use.CrossRefPubMed • Tracy D, Wood DM, Baumeister D. Novel psychoactive substances: types, mechanisms of action, and effects. BMJ. 2017;356:i6848. This paper reviews the recent literature regarding NPS, classifying them into their major groupings and providing information on the desired effects of these compounds, their pharmacology, and the risks associated with their use.CrossRefPubMed
71.
Zurück zum Zitat Waelbers T, Polis I, Vermeire S, Dobbeleir A, Eersels J, De Spiegeleer B, et al. 5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT. J Nucl Med. 2013;54:1428–33.CrossRefPubMed Waelbers T, Polis I, Vermeire S, Dobbeleir A, Eersels J, De Spiegeleer B, et al. 5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT. J Nucl Med. 2013;54:1428–33.CrossRefPubMed
72.
Zurück zum Zitat Nishimura M, Sato K. Ketamine stereoselectively inhibits rat dopamine transporter. Neurosci Lett. 1999;274:131–4.CrossRefPubMed Nishimura M, Sato K. Ketamine stereoselectively inhibits rat dopamine transporter. Neurosci Lett. 1999;274:131–4.CrossRefPubMed
74.
Zurück zum Zitat Corazza O. Near-death experiences: exploring the mind-body connection. London/New York: Routledge; 2008.CrossRef Corazza O. Near-death experiences: exploring the mind-body connection. London/New York: Routledge; 2008.CrossRef
75.
Zurück zum Zitat Jansen KLR. Ketamine: dreams and realities. MAPS: Sarasota, FL; 2011. Jansen KLR. Ketamine: dreams and realities. MAPS: Sarasota, FL; 2011.
76.
Zurück zum Zitat Schifano F, Corkery J, Oyefeso A, Tonia T, Ghodse AH. Trapped in the ‘K-hole’; overview of deaths associated with ketamine misuse in the UK (1993-2006). J Clin Psychopharmacol. 2008;28:114–6.CrossRefPubMed Schifano F, Corkery J, Oyefeso A, Tonia T, Ghodse AH. Trapped in the ‘K-hole’; overview of deaths associated with ketamine misuse in the UK (1993-2006). J Clin Psychopharmacol. 2008;28:114–6.CrossRefPubMed
77.
Zurück zum Zitat Comer NL, Madow L, Dixon JL. Observation of sensory deprivation in a life-threatening situation. Am J Psychiat. 1967;124:164–9.CrossRefPubMed Comer NL, Madow L, Dixon JL. Observation of sensory deprivation in a life-threatening situation. Am J Psychiat. 1967;124:164–9.CrossRefPubMed
78.
Zurück zum Zitat Greyson B, Stevenson I. The phenomenology of near-death experiences. Am J Psychiat. 1980;137:1193–6.CrossRefPubMed Greyson B, Stevenson I. The phenomenology of near-death experiences. Am J Psychiat. 1980;137:1193–6.CrossRefPubMed
79.
Zurück zum Zitat Moody RA. Life after life. Atlanta, GA: Mockingbird Books; 1975. Moody RA. Life after life. Atlanta, GA: Mockingbird Books; 1975.
80.
Zurück zum Zitat Persinger M. Religious and mystical experiences as artefacts of temporal lobe function: a general hypothesis. Percept Motor Skills. 1983;57:1255–62.CrossRefPubMed Persinger M. Religious and mystical experiences as artefacts of temporal lobe function: a general hypothesis. Percept Motor Skills. 1983;57:1255–62.CrossRefPubMed
81.
Zurück zum Zitat Morgan CJ, Monaghan L, Curran HV. Beyond the K-hole: a 3-year longitudinal investigation of the cognitive and subjective effects of ketamine in recreational users who have substantially reduced their use of the drug. Addiction. 2004;99:1450–61.CrossRefPubMed Morgan CJ, Monaghan L, Curran HV. Beyond the K-hole: a 3-year longitudinal investigation of the cognitive and subjective effects of ketamine in recreational users who have substantially reduced their use of the drug. Addiction. 2004;99:1450–61.CrossRefPubMed
82.
Zurück zum Zitat Luciano RL, Perazella MA. Nephrotoxic effects of designer drugs: synthetic is not better! Nat Rev Nephrol. 2014;10:314–24.CrossRefPubMed Luciano RL, Perazella MA. Nephrotoxic effects of designer drugs: synthetic is not better! Nat Rev Nephrol. 2014;10:314–24.CrossRefPubMed
83.
Zurück zum Zitat Corkery J, Claridge H, Loi B, Goodair C, Schifano F. Drug related deaths in the UK. NPSAD Annual Report 2013. London: International Centre for Drug Policy, St. George’s University of London; 2014. Corkery J, Claridge H, Loi B, Goodair C, Schifano F. Drug related deaths in the UK. NPSAD Annual Report 2013. London: International Centre for Drug Policy, St. George’s University of London; 2014.
87.
Zurück zum Zitat Hofer KE, Grager B, Müller DM, Rauber-Lüthy C, Kupferschmidt H, Rentsch KM, et al. Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med. 2012;60(1):97–9.CrossRefPubMed Hofer KE, Grager B, Müller DM, Rauber-Lüthy C, Kupferschmidt H, Rentsch KM, et al. Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med. 2012;60(1):97–9.CrossRefPubMed
88.
Zurück zum Zitat Dargan PI, Tang HC, Liang W, Wood DM, Yew DT. Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice. Clin Toxicol. 2014;52:176–80.CrossRef Dargan PI, Tang HC, Liang W, Wood DM, Yew DT. Three months of methoxetamine administration is associated with significant bladder and renal toxicity in mice. Clin Toxicol. 2014;52:176–80.CrossRef
89.
Zurück zum Zitat EMCDDA. Risk assessments. Methoxetamine. Report on the risk assessment of 2-(3-methoxyphenyl)-2-(ethylamino) cyclohexanone (methoxetamine) in the framework of the council decision on new psychoactive substances. European Monitoring Centre for Drugs and Drug Addiction: Lisbon; 2014. EMCDDA. Risk assessments. Methoxetamine. Report on the risk assessment of 2-(3-methoxyphenyl)-2-(ethylamino) cyclohexanone (methoxetamine) in the framework of the council decision on new psychoactive substances. European Monitoring Centre for Drugs and Drug Addiction: Lisbon; 2014.
90.
Zurück zum Zitat Chiappini S, Claridge H, Corkery J, Goodair C, Loi B, Schifano F. Special M related fatalities in the UK. Res Adv Psychiatry. 2014;1(Suppl. 1):38. Chiappini S, Claridge H, Corkery J, Goodair C, Loi B, Schifano F. Special M related fatalities in the UK. Res Adv Psychiatry. 2014;1(Suppl. 1):38.
91.
Zurück zum Zitat Chiappini S, Claridge H, Corkery JM, Goodair C, Loi B, Schifano F. Methoxetamine-related deaths in the UK: an overview. Hum Psychopharmacol. 2015;30(4):244–8.CrossRefPubMed Chiappini S, Claridge H, Corkery JM, Goodair C, Loi B, Schifano F. Methoxetamine-related deaths in the UK: an overview. Hum Psychopharmacol. 2015;30(4):244–8.CrossRefPubMed
92.
Zurück zum Zitat Greifenstein FE, Yoshitake J, DeVault M, Gajewski JE. A study of 1-aryl cyclo hexyl amine for anaesthesia. Anasth Analog. 1958;5:283. Greifenstein FE, Yoshitake J, DeVault M, Gajewski JE. A study of 1-aryl cyclo hexyl amine for anaesthesia. Anasth Analog. 1958;5:283.
93.
Zurück zum Zitat Lear E. Intravenous anaesthesia: a survey of newer agents. Anaesth Analog. 1968;47:154. Lear E. Intravenous anaesthesia: a survey of newer agents. Anaesth Analog. 1968;47:154.
94.
Zurück zum Zitat Domino EF. Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists. J Psychopharmacol. 1992;6:418–24.CrossRefPubMed Domino EF. Chemical dissociation of human awareness: focus on non-competitive NMDA receptor antagonists. J Psychopharmacol. 1992;6:418–24.CrossRefPubMed
96.
Zurück zum Zitat Burns RS, Lerner SE. Causes of phencyclidine-related deaths. Clin Toxicol. 1978b;12(4):463–81.CrossRefPubMed Burns RS, Lerner SE. Causes of phencyclidine-related deaths. Clin Toxicol. 1978b;12(4):463–81.CrossRefPubMed
97.
Zurück zum Zitat Burns RS, Lerner SE, Corrado R, James SH, Schnoll SH. Phencyclidine–states of acute intoxication and fatalities. West J Med. 1975;123(5):345–9.PubMedPubMedCentral Burns RS, Lerner SE, Corrado R, James SH, Schnoll SH. Phencyclidine–states of acute intoxication and fatalities. West J Med. 1975;123(5):345–9.PubMedPubMedCentral
98.
Zurück zum Zitat DeRoux SJ, Sgarlato A, Marker E. Phencyclidine: a 5-year retrospective review from the New York City Medical Examiner’s Office. J Forensic Sci. 2011;56(3):656–9.CrossRefPubMed DeRoux SJ, Sgarlato A, Marker E. Phencyclidine: a 5-year retrospective review from the New York City Medical Examiner’s Office. J Forensic Sci. 2011;56(3):656–9.CrossRefPubMed
99.
Zurück zum Zitat Eastman JW, Cohen SN. Hypertensive crisis and death associated with phencyclidine poisoning. JAMA. 1975;231(12):1270–1.CrossRefPubMed Eastman JW, Cohen SN. Hypertensive crisis and death associated with phencyclidine poisoning. JAMA. 1975;231(12):1270–1.CrossRefPubMed
100.
Zurück zum Zitat Noguchi TT, Nakamura GR. Phencyclidine-related deaths in Los Angeles County, 1976. J Forensic Sci. 1978;23(3):503–7.PubMed Noguchi TT, Nakamura GR. Phencyclidine-related deaths in Los Angeles County, 1976. J Forensic Sci. 1978;23(3):503–7.PubMed
101.
Zurück zum Zitat Pestaner JP, Southall PE. Sudden death during arrest and phencyclidine intoxication. Am J Forensic Med Pathol. 2003;24(2):119–22.PubMed Pestaner JP, Southall PE. Sudden death during arrest and phencyclidine intoxication. Am J Forensic Med Pathol. 2003;24(2):119–22.PubMed
102.
Zurück zum Zitat Poklis A, Graham M, Maginn D, Branch CA, Gantner GE. Phencyclidine and violent deaths in St. Louis, Missouri: a survey of medical examiners’ cases from 1977 through 1986. Am J Drug Alcohol Abuse. 1990;16(3–4):265–74.CrossRefPubMed Poklis A, Graham M, Maginn D, Branch CA, Gantner GE. Phencyclidine and violent deaths in St. Louis, Missouri: a survey of medical examiners’ cases from 1977 through 1986. Am J Drug Alcohol Abuse. 1990;16(3–4):265–74.CrossRefPubMed
103.
Zurück zum Zitat Miller SC. Dextromethorphan psychosis, dependence and physical withdrawal. Addict Biol. 2005;10(4):325–7.CrossRefPubMed Miller SC. Dextromethorphan psychosis, dependence and physical withdrawal. Addict Biol. 2005;10(4):325–7.CrossRefPubMed
104.
Zurück zum Zitat Spangler DC, Loyd CM, Skor EE. Dextromethorphan: a case study on addressing abuse of a safe and effective drug. Subst Abuse Treat Prev Policy. 2016;11:22.CrossRefPubMedPubMedCentral Spangler DC, Loyd CM, Skor EE. Dextromethorphan: a case study on addressing abuse of a safe and effective drug. Subst Abuse Treat Prev Policy. 2016;11:22.CrossRefPubMedPubMedCentral
105.
Zurück zum Zitat Sheridan DC, Hendrickson RG, Beauchamp G, Laurie A, Fu R, Horowitz BZ. Adolescent intentional abuse ingestions. Overall 10-year trends and regional variation. Pediatr Emer Care. 2016;00:00–0. Sheridan DC, Hendrickson RG, Beauchamp G, Laurie A, Fu R, Horowitz BZ. Adolescent intentional abuse ingestions. Overall 10-year trends and regional variation. Pediatr Emer Care. 2016;00:00–0.
106.
Zurück zum Zitat Karami S, Major JM, Calderon S, McAninch JK. Trends in dextromethorphan cough and cold products: 2000–2015 National Poison Data System intentional abuse exposure calls. Clin Toxicol (Phila). 2018;56(7):656–63.CrossRef Karami S, Major JM, Calderon S, McAninch JK. Trends in dextromethorphan cough and cold products: 2000–2015 National Poison Data System intentional abuse exposure calls. Clin Toxicol (Phila). 2018;56(7):656–63.CrossRef
107.
Zurück zum Zitat Storck M, Black L, Liddell M. Inhalant abuse and dextromethorphan. Child Adolesc Psychiatric Clin N Am. 2016;25(3):497–508.CrossRef Storck M, Black L, Liddell M. Inhalant abuse and dextromethorphan. Child Adolesc Psychiatric Clin N Am. 2016;25(3):497–508.CrossRef
108.
Zurück zum Zitat Romanelli F, Smith K. Dextromethorphan abuse: clinical effects and management. J Am Pharm Assoc. 2009;49(2):e20–7.CrossRef Romanelli F, Smith K. Dextromethorphan abuse: clinical effects and management. J Am Pharm Assoc. 2009;49(2):e20–7.CrossRef
109.
Zurück zum Zitat Martinak B, Bolis RA, Ryne J, Fargason RE, Birur B. Dextromethorphan in cough syrup: the poor man’s psychosis. Psychopharmacol Bull. 2017;47(4):59–63.PubMedPubMedCentral Martinak B, Bolis RA, Ryne J, Fargason RE, Birur B. Dextromethorphan in cough syrup: the poor man’s psychosis. Psychopharmacol Bull. 2017;47(4):59–63.PubMedPubMedCentral
110.
Zurück zum Zitat Roy AK, Hsieh C, Crapanzano K. Dextromethorphan addiction mediated through the NMDA system: common pathways with alcohol? J Addict Med. 2015;9:499–501.CrossRefPubMed Roy AK, Hsieh C, Crapanzano K. Dextromethorphan addiction mediated through the NMDA system: common pathways with alcohol? J Addict Med. 2015;9:499–501.CrossRefPubMed
111.
Zurück zum Zitat Levine DA. ‘Pharming’: the abuse of prescription and over-the-counter drugs in teens. Curr Opin Pediatr. 2007;19(3):270–4.CrossRefPubMed Levine DA. ‘Pharming’: the abuse of prescription and over-the-counter drugs in teens. Curr Opin Pediatr. 2007;19(3):270–4.CrossRefPubMed
112.
Zurück zum Zitat Ahmed G, Saleem MD, Naim H. How many deaths before we put cough syrups behind the counter? Perspect Public Health. 2014;134(6):309.CrossRefPubMed Ahmed G, Saleem MD, Naim H. How many deaths before we put cough syrups behind the counter? Perspect Public Health. 2014;134(6):309.CrossRefPubMed
113.
Zurück zum Zitat Carhart-Harris RL, Leech R, Williams TM, Erritzoe D, Abbasi N, Bargiotas T, et al. Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin. Brit J Psychiatry. 2012;200(3):238–44.CrossRef Carhart-Harris RL, Leech R, Williams TM, Erritzoe D, Abbasi N, Bargiotas T, et al. Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin. Brit J Psychiatry. 2012;200(3):238–44.CrossRef
114.
Zurück zum Zitat Pahnke WN, Kurland AA, Goodman LE, Richards WA. LSD-assisted psychotherapy with terminal cancer patients. Curr Psychiatr Ther. 1969;9:144–52.PubMed Pahnke WN, Kurland AA, Goodman LE, Richards WA. LSD-assisted psychotherapy with terminal cancer patients. Curr Psychiatr Ther. 1969;9:144–52.PubMed
115.
Zurück zum Zitat Pahnke WN, Kurland AA, Unger S, Savage C, Grof S. The experimental use of psychedelic (LSD) psychotherapy. JAMA. 1970;212(11):1856–63.CrossRefPubMed Pahnke WN, Kurland AA, Unger S, Savage C, Grof S. The experimental use of psychedelic (LSD) psychotherapy. JAMA. 1970;212(11):1856–63.CrossRefPubMed
116.
Zurück zum Zitat Pahnke WN, Kurland AA, Unger S, Savage C, Wolff MC, Goodman LE. Psychedelic therapy (utilizing LSD) with cancer patients. J Psychedelic Drugs. 1970;3:63–75.CrossRef Pahnke WN, Kurland AA, Unger S, Savage C, Wolff MC, Goodman LE. Psychedelic therapy (utilizing LSD) with cancer patients. J Psychedelic Drugs. 1970;3:63–75.CrossRef
117.
Zurück zum Zitat Grof S, Goodman LE, Richards WA, Kurland AA. LSD-assisted psychotherapy in patients with terminal cancer. Int Pharmacopsychiatry. 1973;8(3):129–44.CrossRefPubMed Grof S, Goodman LE, Richards WA, Kurland AA. LSD-assisted psychotherapy in patients with terminal cancer. Int Pharmacopsychiatry. 1973;8(3):129–44.CrossRefPubMed
118.
Zurück zum Zitat Griffiths R. Psilocybin, mystical-type experiences, and the treatment of symptoms of anxiety and depression in patients with a life-threatening cancer diagnosis. Presentation at the 168th Annual Meeting of the American Psychiatric Association, Abstract 1162. Griffiths R. Psilocybin, mystical-type experiences, and the treatment of symptoms of anxiety and depression in patients with a life-threatening cancer diagnosis. Presentation at the 168th Annual Meeting of the American Psychiatric Association, Abstract 1162.
119.
Zurück zum Zitat Kometer M, Schmidt A, Bachmann R, Studerus E, Seifritz E, Vollenweider FX. Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic sub- receptors. Biol Psychiatry. 2012;72(11):898–906.CrossRefPubMed Kometer M, Schmidt A, Bachmann R, Studerus E, Seifritz E, Vollenweider FX. Psilocybin biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic sub- receptors. Biol Psychiatry. 2012;72(11):898–906.CrossRefPubMed
120.
Zurück zum Zitat Moreno FA, Wiegand CB, Taitano EK, Delgado PL. Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. J Clin Psychiatry. 2006;67(11):1735–40.CrossRefPubMed Moreno FA, Wiegand CB, Taitano EK, Delgado PL. Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder. J Clin Psychiatry. 2006;67(11):1735–40.CrossRefPubMed
121.
Zurück zum Zitat Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PCR, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept trial. J Psychopharmacol. 2015;29(3):289–99.CrossRefPubMed Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PCR, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept trial. J Psychopharmacol. 2015;29(3):289–99.CrossRefPubMed
122.
Zurück zum Zitat Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR. Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol. 2014;28(11):983–92.CrossRefPubMedPubMedCentral Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR. Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol. 2014;28(11):983–92.CrossRefPubMedPubMedCentral
123.
Zurück zum Zitat Sewell RA, Halpern JH, Pope HG Jr. Response of cluster headache to psilocybin and LSD. Neurology. 2006;66:1920–2.CrossRefPubMed Sewell RA, Halpern JH, Pope HG Jr. Response of cluster headache to psilocybin and LSD. Neurology. 2006;66:1920–2.CrossRefPubMed
124.
Zurück zum Zitat Savage C. Lysergic acid diethylamide; a clinical-psychological study. Am J Psychiatry. 1952;108(12):896–900.CrossRefPubMed Savage C. Lysergic acid diethylamide; a clinical-psychological study. Am J Psychiatry. 1952;108(12):896–900.CrossRefPubMed
125.
Zurück zum Zitat Mendelson SD. The current status of the platelet 5-HT(2A) receptor in depression. J Affect Disord. 2000;57(1–3):13–24.CrossRefPubMed Mendelson SD. The current status of the platelet 5-HT(2A) receptor in depression. J Affect Disord. 2000;57(1–3):13–24.CrossRefPubMed
126.
Zurück zum Zitat Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Pandey SC, Pesold C, et al. Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. Am J Psychiatry. 2002;159(3):419–29.CrossRefPubMed Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Pandey SC, Pesold C, et al. Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. Am J Psychiatry. 2002;159(3):419–29.CrossRefPubMed
127.
Zurück zum Zitat Shelton RC, Sanders-Bush E, Manier DH, Lewis DA. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience. 2009;158(4):1406–15.CrossRefPubMed Shelton RC, Sanders-Bush E, Manier DH, Lewis DA. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience. 2009;158(4):1406–15.CrossRefPubMed
128.
Zurück zum Zitat Sheline YI, Mintun MA, Barch DM, Wilkins C, Snyder AZ, Moerlein SM. Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F] altanserin positron emission tomography. Neuropsychopharmacology. 2004;29(12):2235–41.CrossRefPubMed Sheline YI, Mintun MA, Barch DM, Wilkins C, Snyder AZ, Moerlein SM. Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F] altanserin positron emission tomography. Neuropsychopharmacology. 2004;29(12):2235–41.CrossRefPubMed
129.
Zurück zum Zitat Meyer JH, McMain S, Kennedy SH, Korman L, Brown GM, DaSilva JN, et al. Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. Am J Psychiatry. 2003;160(1):90–9.CrossRefPubMed Meyer JH, McMain S, Kennedy SH, Korman L, Brown GM, DaSilva JN, et al. Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. Am J Psychiatry. 2003;160(1):90–9.CrossRefPubMed
130.
Zurück zum Zitat Bhagwagar Z, Hinz R, Taylor M, Fancy S, Cowen P, Grasby P. Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C] MDL 100,907. Am J Psychiatry. 2006;163(9):1580–7.CrossRefPubMed Bhagwagar Z, Hinz R, Taylor M, Fancy S, Cowen P, Grasby P. Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C] MDL 100,907. Am J Psychiatry. 2006;163(9):1580–7.CrossRefPubMed
131.
Zurück zum Zitat Meyer JH. Neuroimaging markers of cellular function in major depressive disorder: implications for therapeutics, personalized medicine, and prevention. Clin Pharmacol Ther. 2012;91(2):201–14.CrossRefPubMed Meyer JH. Neuroimaging markers of cellular function in major depressive disorder: implications for therapeutics, personalized medicine, and prevention. Clin Pharmacol Ther. 2012;91(2):201–14.CrossRefPubMed
132.
Zurück zum Zitat Brandrup E, Vanggaard T. LSD treatment in a severe case of compulsive neurosis. Acta Psychiatr Scand. 1977;55(2):127–41.CrossRefPubMed Brandrup E, Vanggaard T. LSD treatment in a severe case of compulsive neurosis. Acta Psychiatr Scand. 1977;55(2):127–41.CrossRefPubMed
133.
Zurück zum Zitat Karst M, Halpern JH, Bernateck M, Passie T. The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: an open, non-randomized case series. Cephalalgia. 2010;30(9):1140–4.CrossRefPubMed Karst M, Halpern JH, Bernateck M, Passie T. The non-hallucinogen 2-bromo-lysergic acid diethylamide as preventative treatment for cluster headache: an open, non-randomized case series. Cephalalgia. 2010;30(9):1140–4.CrossRefPubMed
134.
Zurück zum Zitat Nic Dhonnchadha BA, Hascoët M, Jolliet P, Bourin M. Evidence for a 5- HT2A receptor mode of action in the anxiolytic-like properties of DOI in mice. Behav Brain Res. 2003;147(1–2):175–84.CrossRefPubMed Nic Dhonnchadha BA, Hascoët M, Jolliet P, Bourin M. Evidence for a 5- HT2A receptor mode of action in the anxiolytic-like properties of DOI in mice. Behav Brain Res. 2003;147(1–2):175–84.CrossRefPubMed
135.
Zurück zum Zitat Ripoll N, Nic Dhonnchadha BA, Sébille V, Bourin M, Hascoët M. The four- plates test-retest paradigm to discriminate anxiolytic effects. Psychopharmacology. 2005;180(1):73–83.CrossRefPubMed Ripoll N, Nic Dhonnchadha BA, Sébille V, Bourin M, Hascoët M. The four- plates test-retest paradigm to discriminate anxiolytic effects. Psychopharmacology. 2005;180(1):73–83.CrossRefPubMed
136.
Zurück zum Zitat Massé F, Hascoët M, Bourin M. Effect of GABAergic ligands on the anxiolytic-like activity of DOI (a 5-HT(2A/2C) agonist) in the four-plate test in mice. Eur Neuropsychopharmacol. 2007;17(6–7):483–91.CrossRefPubMed Massé F, Hascoët M, Bourin M. Effect of GABAergic ligands on the anxiolytic-like activity of DOI (a 5-HT(2A/2C) agonist) in the four-plate test in mice. Eur Neuropsychopharmacol. 2007;17(6–7):483–91.CrossRefPubMed
137.
138.
Zurück zum Zitat Botanas CJ, de la Peña JB, Kim HJ, Lee YS, Cheong JH. Methoxetamine: a foe or friend? Neurochem Int. 2019;122:1–7.CrossRefPubMed Botanas CJ, de la Peña JB, Kim HJ, Lee YS, Cheong JH. Methoxetamine: a foe or friend? Neurochem Int. 2019;122:1–7.CrossRefPubMed
141.
Zurück zum Zitat •• Calvey T, Howells FM. An introduction to psychedelic neuroscience. Prog Brain Res. 2018;242:1–23. This paper gives an overview of the neurobiological mechanisms of psychedelic drugs and the eventual resulting changes in brain activity.CrossRefPubMed •• Calvey T, Howells FM. An introduction to psychedelic neuroscience. Prog Brain Res. 2018;242:1–23. This paper gives an overview of the neurobiological mechanisms of psychedelic drugs and the eventual resulting changes in brain activity.CrossRefPubMed
142.
Zurück zum Zitat Mason O, Morgan CJA, Dhiman SK, Patel A, Parti N, Curran HV. Acute cannabis use causes increased psychotomimetic experiences in individuals prone to psychosis. Psychol Med. 2009;39(6):951–6.CrossRefPubMed Mason O, Morgan CJA, Dhiman SK, Patel A, Parti N, Curran HV. Acute cannabis use causes increased psychotomimetic experiences in individuals prone to psychosis. Psychol Med. 2009;39(6):951–6.CrossRefPubMed
143.
144.
Zurück zum Zitat Dong H, Yang C, Shen Y, Liu L, Liu M, Hao W. Effects of ketamine use on psy4hotic disorders and symptoms in male, methamphetamine-dependent subjects. Am J Drug Alcohol Abuse. 2019;14:1–9. Dong H, Yang C, Shen Y, Liu L, Liu M, Hao W. Effects of ketamine use on psy4hotic disorders and symptoms in male, methamphetamine-dependent subjects. Am J Drug Alcohol Abuse. 2019;14:1–9.
146.
Zurück zum Zitat •• De Gregorio D, Enns JP, Nuñez NA, Posa L, Gobbi G. d-Lysergic acid diethylamide, psilocybin, and other classic hallucinogens: Mechanism of action and potential therapeutic applications in mood disorders. Prog Brain Res. 2018;242:69–96. This paper reviewed the pharmacology of psychedelic drugs, reporting the clinical evidence of their therapeutic potentials in mood disorders.CrossRefPubMed •• De Gregorio D, Enns JP, Nuñez NA, Posa L, Gobbi G. d-Lysergic acid diethylamide, psilocybin, and other classic hallucinogens: Mechanism of action and potential therapeutic applications in mood disorders. Prog Brain Res. 2018;242:69–96. This paper reviewed the pharmacology of psychedelic drugs, reporting the clinical evidence of their therapeutic potentials in mood disorders.CrossRefPubMed
147.
Zurück zum Zitat Bonhoeffer K. Klinische und anatomische Beitrage zur Kennt- nis der Alkoholdelirien. Mschr Psychiat Neurol. 1897:6–41. Bonhoeffer K. Klinische und anatomische Beitrage zur Kennt- nis der Alkoholdelirien. Mschr Psychiat Neurol. 1897:6–41.
148.
Zurück zum Zitat Martinotti G, Di Nicola M, Quattrone D, Santacroce R, Schifano F, Murray R, et al. Novel psychoactive substances and induced phenomena in psychopathology: the lysergic psychoma. J Psychopathol. 2015;21:400–5. Martinotti G, Di Nicola M, Quattrone D, Santacroce R, Schifano F, Murray R, et al. Novel psychoactive substances and induced phenomena in psychopathology: the lysergic psychoma. J Psychopathol. 2015;21:400–5.
149.
Zurück zum Zitat Halpern JH, Lerner AG, Passie T. A review of hallucinogen persisting perception disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD. Curr Top Behav Neurosci. 2018;36:333–60.CrossRefPubMed Halpern JH, Lerner AG, Passie T. A review of hallucinogen persisting perception disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD. Curr Top Behav Neurosci. 2018;36:333–60.CrossRefPubMed
150.
Zurück zum Zitat • Murnane KS. The renaissance in psychedelic research: what do preclinical models have to offer. Prog Brain Res. 2018;242:25–67. This chapter documents the current status of psychedelic research, with the thematic argument that new preclinical studies would benefit this field.CrossRefPubMed • Murnane KS. The renaissance in psychedelic research: what do preclinical models have to offer. Prog Brain Res. 2018;242:25–67. This chapter documents the current status of psychedelic research, with the thematic argument that new preclinical studies would benefit this field.CrossRefPubMed
151.
Zurück zum Zitat Davidson C, Schifano F. The potential utility of some legal highs in CNS disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2016;64:267–74.CrossRef Davidson C, Schifano F. The potential utility of some legal highs in CNS disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2016;64:267–74.CrossRef
152.
Zurück zum Zitat •• Schifano F, Orsolini L, Papanti D, Corkery J. NPS: medical consequences associated with their intake. Curr Top Behav Neurosci. 2017;32:351–80. https://doi.org/10.1007/7854_2016_15 This paper provides an overview of the clinical and pharmacological issues relating to some NPS categories, considering their effects/toxicity and the management of their adverse events.CrossRefPubMed •• Schifano F, Orsolini L, Papanti D, Corkery J. NPS: medical consequences associated with their intake. Curr Top Behav Neurosci. 2017;32:351–80. https://​doi.​org/​10.​1007/​7854_​2016_​15 This paper provides an overview of the clinical and pharmacological issues relating to some NPS categories, considering their effects/toxicity and the management of their adverse events.CrossRefPubMed
153.
Zurück zum Zitat Van Buskirk J, Griffiths P, Farrell M, Degenhardt L. Trends in new psychoactive substances from surface and “dark” net monitoring. Lancet Psychiatry. 2017;4(1):16–8.CrossRefPubMed Van Buskirk J, Griffiths P, Farrell M, Degenhardt L. Trends in new psychoactive substances from surface and “dark” net monitoring. Lancet Psychiatry. 2017;4(1):16–8.CrossRefPubMed
154.
Zurück zum Zitat Simonato P, Corazza O, Santonastaso P, Corkery J, Deluca P, Davey Z, et al. Novel psychoactive substances as a novel challenge for health professionals: results from an Italian survey. Hum Psychopharmacol. 2013;28(4):324–31.CrossRefPubMed Simonato P, Corazza O, Santonastaso P, Corkery J, Deluca P, Davey Z, et al. Novel psychoactive substances as a novel challenge for health professionals: results from an Italian survey. Hum Psychopharmacol. 2013;28(4):324–31.CrossRefPubMed
Metadaten
Titel
New Psychoactive Substances (NPS), Psychedelic Experiences and Dissociation: Clinical and Clinical Pharmacological Issues
verfasst von
Fabrizio Schifano
Flavia Napoletano
Stefania Chiappini
Laura Orsolini
Amira Guirguis
John Martin Corkery
Stefania Bonaccorso
Angelo Ricciardi
Norbert Scherbaum
Alessandro Vento
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
Current Addiction Reports / Ausgabe 2/2019
Elektronische ISSN: 2196-2952
DOI
https://doi.org/10.1007/s40429-019-00249-z

Neu im Fachgebiet Psychiatrie

Einer von sieben Frauen macht die Menopause sehr zu schaffen

Von mäßigen bis schweren vasomotorischen Beschwerden sind 14,7% der Frauen in der Postmenopause betroffen. Das haben kanadische Forscherinnen in einer Subgruppenanalyse der WARM-Studie herausgefunden.

Depressive Senioren fahren besonders riskant

Beim Autofahren machen ältere Depressive häufiger eine Vollbremsung, gehen öfter zu schnell in Kurven und halten sich seltener an Tempolimits als Senioren ohne Depression. Offenbar scheint eine Depression eine riskante Fahrweise im Alter zu verstärken.

Verhaltenstherapie plus Stimulanz reduziert Binge Eating

Die Kombination von kognitiver Verhaltenstherapie plus Lisdexamfetamin bringt Personen mit Binge-Eating-Störung deutlich häufiger in Remission als die jeweiligen Einzeltherapien. Zudem nimmt das Gewicht der Betroffenen spürbar ab.

Die elektronische Patientenakte kommt: Das sollten Sie jetzt wissen

Am 15. Januar geht die „ePA für alle“ zunächst in den Modellregionen an den Start. Doch schon bald soll sie in allen Praxen zum Einsatz kommen. Was ist jetzt zu tun? Was müssen Sie wissen? Wir geben in einem FAQ Antworten auf 21 Fragen.

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.