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Arthritis Research & Therapy

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01.04.2010 | Review

New role for Agrin in T cells and its potential importance in immune system regulation

verfasst von: Elizabeth C Jury, Panagiotis S Kabouridis

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2010

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Abstract

Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system.

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Titel: New role for Agrin in T cells and its potential importance in immune system regulation
verfasst von: Elizabeth C Jury
Panagiotis S Kabouridis
Publikationsdatum: 01.04.2010
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2010
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2957

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