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Erschienen in: Heart and Vessels 4/2021

13.10.2020 | Original Article

New transluminal attenuation gradient derived from dynamic coronary CT angiography: diagnostic ability of ischemia detected by 13N-ammonia PET

verfasst von: Tsukasa Kojima, Michinobu Nagao, Hidetake Yabuuchi, Yuzo Yamasaki, Takashi Shirasaka, Masateru Kawakubo, Kenji Fukushima, Toyoyuki Kato, Atsushi Yamamoto, Risako Nakao, Akiko Sakai, Eri Watanabe, Shuji Sakai

Erschienen in: Heart and Vessels | Ausgabe 4/2021

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Abstract

Coronary computed tomography angiography (CCTA) has low specificity for detecting significant functional coronary stenosis. We developed a new transluminal attenuation gradient (TAG)-derived dynamic CCTA with dose modulation, and we investigated its diagnostic performance for myocardial ischemia depicted by 13N-ammonia positron emission tomography (PET). Data from 48 consecutive patients who had undergone both dynamic CCTA and 13N-ammonia PET were retrospectively analyzed. Dynamic CCTA was continuously performed in mid-diastole for five cardiac cycles with prospective electrocardiography gating after a 10-s contrast medium injection. One scan of the dynamic CCTA was performed as a boost scan for conventional CCTA at the peak phase of the ascending aorta. Absolute TAG values at five phases around the boost scan were calculated. The dynamic TAG index (DTI) was defined as the ratio of the maximum absolute TAG to the standard deviation of five TAG values. We categorized the coronary territories as non-ischemia or ischemia based on the 13N-ammonia PET results. A receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff of the DTI for identifying ischemia. The DTI was significantly higher for ischemia compared to non-ischemia (8.8 ± 3.9 vs. 4.6 ± 2.0, p < 0.01). The ROC analysis revealed 5.60 as the optimal DTI cutoff to detect ischemia, with an area under the curve of 0.87, 85.7% sensitivity, and 76.2% specificity. TAG provided no additional diagnostic value for the detection of ischemia. We propose the DTI derived from dynamic CCTA as a novel coronary flow index. The DTI is a valid technique for detecting functional coronary stenosis.
Literatur
1.
Zurück zum Zitat Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, Scherer M, Bellinger R, Martin A, Benton R, Delago A, Min JK (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 52(21):1724–1732CrossRef Budoff MJ, Dowe D, Jollis JG, Gitter M, Sutherland J, Halamert E, Scherer M, Bellinger R, Martin A, Benton R, Delago A, Min JK (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 52(21):1724–1732CrossRef
2.
Zurück zum Zitat Kern MJ, Lerman A, Bech JW, De Bruyne B, Eeckhout E, Fearon WF, Higano ST, Lim MJ, Meuwissen M, Piek JJ, Pijls NH, Siebes M, Spaan JA, American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology (2006) Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization Council on Clinical Cardiology. Circulation 114(12):1321–1341CrossRef Kern MJ, Lerman A, Bech JW, De Bruyne B, Eeckhout E, Fearon WF, Higano ST, Lim MJ, Meuwissen M, Piek JJ, Pijls NH, Siebes M, Spaan JA, American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology (2006) Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization Council on Clinical Cardiology. Circulation 114(12):1321–1341CrossRef
3.
Zurück zum Zitat Tobis J, Azarbal B, Slavin L (2007) Assessment of intermediate severity coronary lesions in the catheterization laboratory. J Am Coll Cardiol 49(8):839–848CrossRef Tobis J, Azarbal B, Slavin L (2007) Assessment of intermediate severity coronary lesions in the catheterization laboratory. J Am Coll Cardiol 49(8):839–848CrossRef
4.
Zurück zum Zitat Wong DT, Ko BS, Cameron JD, Leong DP, Leung MC, Malaiapan Y, Nerlekar N, Crossett M, Troupis J, Meredith IT, Seneviratne SK (2014) Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve. J Am Coll Cardiol 63(18):1904–1912CrossRef Wong DT, Ko BS, Cameron JD, Leong DP, Leung MC, Malaiapan Y, Nerlekar N, Crossett M, Troupis J, Meredith IT, Seneviratne SK (2014) Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve. J Am Coll Cardiol 63(18):1904–1912CrossRef
5.
Zurück zum Zitat Wong DT, Ko BS, Cameron JD, Nerlekar N, Leung MC, Malaiapan Y, Crossett M, Leong DP, Worthley SG, Troupis J, Meredith IT, Seneviratne SK (2013) Transluminal attenuation gradient in coronary computed tomography angiography is a novel noninvasive approach to the identification of functionally significant coronary artery stenosis: a comparison with fractional flow reserve. J Am Coll Cardiol 61(12):1271–1279CrossRef Wong DT, Ko BS, Cameron JD, Nerlekar N, Leung MC, Malaiapan Y, Crossett M, Leong DP, Worthley SG, Troupis J, Meredith IT, Seneviratne SK (2013) Transluminal attenuation gradient in coronary computed tomography angiography is a novel noninvasive approach to the identification of functionally significant coronary artery stenosis: a comparison with fractional flow reserve. J Am Coll Cardiol 61(12):1271–1279CrossRef
6.
Zurück zum Zitat Steigner ML, Mitsouras D, Whitmore AG, Otero HJ, Wang C, Buckley O, Levit NA, Hussain AZ, Cai T, Mather RT, Smedby O, DiCarli MF, Rybicki FJ (2010) Iodinated contrast opacification gradients in normal coronary arteries imaged with prospectively ECG-gated single heart beat 320-detector row computed tomography. Circ Cardiovasc Imaging 3(2):179–186CrossRef Steigner ML, Mitsouras D, Whitmore AG, Otero HJ, Wang C, Buckley O, Levit NA, Hussain AZ, Cai T, Mather RT, Smedby O, DiCarli MF, Rybicki FJ (2010) Iodinated contrast opacification gradients in normal coronary arteries imaged with prospectively ECG-gated single heart beat 320-detector row computed tomography. Circ Cardiovasc Imaging 3(2):179–186CrossRef
7.
Zurück zum Zitat Zheng M, Wei M, Wen D, Zhao H, Liu Y, Li J, Li J (2015) Transluminal attenuation gradient in coronary computed tomography angiography for determining stenosis severity of calcified coronary artery: a primary study with dual-source CT. Eur Radiol 25(5):1219–1228CrossRef Zheng M, Wei M, Wen D, Zhao H, Liu Y, Li J, Li J (2015) Transluminal attenuation gradient in coronary computed tomography angiography for determining stenosis severity of calcified coronary artery: a primary study with dual-source CT. Eur Radiol 25(5):1219–1228CrossRef
8.
Zurück zum Zitat Takx RA, Blomberg BA, El Aidi H, Habets J, de Jong PA, Nagel E, Hoffmann U, Leiner T (2015) Diagnostic accuracy of stress myocardial perfusion imaging compared to invasive coronary angiography with fractional flow reserve meta-analysis. Circ Cardiovasc Imaging 8(1):e002666CrossRef Takx RA, Blomberg BA, El Aidi H, Habets J, de Jong PA, Nagel E, Hoffmann U, Leiner T (2015) Diagnostic accuracy of stress myocardial perfusion imaging compared to invasive coronary angiography with fractional flow reserve meta-analysis. Circ Cardiovasc Imaging 8(1):e002666CrossRef
9.
Zurück zum Zitat Rochitte CE, George RT, Chen MY, Arbab-Zadeh A, Dewey M, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Nakamori S, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, de Roos A, Laule M, Tan SY, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Cox C, Clouse ME, Di Carli MF, Lima JAC (2014) Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur Heart J 35(17):1120–1130CrossRef Rochitte CE, George RT, Chen MY, Arbab-Zadeh A, Dewey M, Miller JM, Niinuma H, Yoshioka K, Kitagawa K, Nakamori S, Laham R, Vavere AL, Cerci RJ, Mehra VC, Nomura C, Kofoed KF, Jinzaki M, Kuribayashi S, de Roos A, Laule M, Tan SY, Hoe J, Paul N, Rybicki FJ, Brinker JA, Arai AE, Cox C, Clouse ME, Di Carli MF, Lima JAC (2014) Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur Heart J 35(17):1120–1130CrossRef
10.
Zurück zum Zitat Tanabe Y, Kido T, Uetani T, Kurata A, Kono T, Ogimoto A, Miyagawa M, Soma T, Murase K, Iwaki H, Mochizuki T (2016) Differentiation of myocardial ischemia and infarction assessed by dynamic computed tomography perfusion imaging and comparison with cardiac magnetic resonance and single-photon emission computed tomography. Eur Radiol 26(11):3790–3801CrossRef Tanabe Y, Kido T, Uetani T, Kurata A, Kono T, Ogimoto A, Miyagawa M, Soma T, Murase K, Iwaki H, Mochizuki T (2016) Differentiation of myocardial ischemia and infarction assessed by dynamic computed tomography perfusion imaging and comparison with cardiac magnetic resonance and single-photon emission computed tomography. Eur Radiol 26(11):3790–3801CrossRef
11.
Zurück zum Zitat Norgaard BL, Leipsic J, Gaur S, Seneviratne S, Ko BS, Ito H, Jensen JM, Mauri L, De Bruyne B, Bezerra H, Osawa K, Marwan M, Naber C, Erglis A, Park SJ, Christiansen EH, Kaltoft A, Lassen JF, Botker HE, Achenbach S (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 63(12):1145–1155CrossRef Norgaard BL, Leipsic J, Gaur S, Seneviratne S, Ko BS, Ito H, Jensen JM, Mauri L, De Bruyne B, Bezerra H, Osawa K, Marwan M, Naber C, Erglis A, Park SJ, Christiansen EH, Kaltoft A, Lassen JF, Botker HE, Achenbach S (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 63(12):1145–1155CrossRef
12.
Zurück zum Zitat Nakazato R, Park HB, Berman DS, Gransar H, Koo BK, Erglis A, Lin FY, Dunning AM, Budoff MJ, Malpeso J, Leipsic J, Min JK (2013) Noninvasive fractional flow reserve derived from computed tomography angiography for coronary lesions of intermediate stenosis severity results from the DeFACTO Study. Circ Cardiovasc Imaging 6(6):881–889CrossRef Nakazato R, Park HB, Berman DS, Gransar H, Koo BK, Erglis A, Lin FY, Dunning AM, Budoff MJ, Malpeso J, Leipsic J, Min JK (2013) Noninvasive fractional flow reserve derived from computed tomography angiography for coronary lesions of intermediate stenosis severity results from the DeFACTO Study. Circ Cardiovasc Imaging 6(6):881–889CrossRef
13.
Zurück zum Zitat Miyajima K, Motoyama S, Sarai M, Kawai H, Nagahara Y, Matsumoto R, Fujiwara W, Muramatsu T, Takahashi H, Naruse H, Ishii J, Kondo T, Narula J, Izawa H, Ozaki Y (2020) On-site assessment of computed tomography-derived fractional flow reserve in comparison with myocardial perfusion imaging and invasive fractional flow reserve. Heart Vessels 35(10):1331–1340. https://doi.org/10.1007/s00380-00020-01606-zCrossRefPubMed Miyajima K, Motoyama S, Sarai M, Kawai H, Nagahara Y, Matsumoto R, Fujiwara W, Muramatsu T, Takahashi H, Naruse H, Ishii J, Kondo T, Narula J, Izawa H, Ozaki Y (2020) On-site assessment of computed tomography-derived fractional flow reserve in comparison with myocardial perfusion imaging and invasive fractional flow reserve. Heart Vessels 35(10):1331–1340. https://​doi.​org/​10.​1007/​s00380-00020-01606-zCrossRefPubMed
14.
Zurück zum Zitat Nagata K, Tanaka R, Takagi H, Fusazaki T, Morino Y, Yoshioka K (2018) Improved diagnostic performance of transluminal attenuation gradient in combination with morphological evaluation of coronary artery stenosis using 320-row computed tomography. Jpn J Radiol 36(1):51–58CrossRef Nagata K, Tanaka R, Takagi H, Fusazaki T, Morino Y, Yoshioka K (2018) Improved diagnostic performance of transluminal attenuation gradient in combination with morphological evaluation of coronary artery stenosis using 320-row computed tomography. Jpn J Radiol 36(1):51–58CrossRef
15.
Zurück zum Zitat Choi JH, Kim EK, Kim SM, Song YB, Hahn JY, Choi SH, Gwon HC, Lee SH, Choe YH, Oh JK (2014) Noninvasive evaluation of coronary collateral arterial flow by coronary computed tomographic angiography. Circ Cardiovasc Imaging 7(3):482–490CrossRef Choi JH, Kim EK, Kim SM, Song YB, Hahn JY, Choi SH, Gwon HC, Lee SH, Choe YH, Oh JK (2014) Noninvasive evaluation of coronary collateral arterial flow by coronary computed tomographic angiography. Circ Cardiovasc Imaging 7(3):482–490CrossRef
16.
Zurück zum Zitat Choi JH, Min JK, Labounty TM, Lin FY, Mendoza DD, Shin DH, Ariaratnam NS, Koduru S, Granada JF, Gerber TC, Oh JK, Gwon HC, Choe YH (2011) Intracoronary transluminal attenuation gradient in coronary CT angiography for determining coronary artery stenosis. JACC Cardiovasc Imaging 4(11):1149–1157CrossRef Choi JH, Min JK, Labounty TM, Lin FY, Mendoza DD, Shin DH, Ariaratnam NS, Koduru S, Granada JF, Gerber TC, Oh JK, Gwon HC, Choe YH (2011) Intracoronary transluminal attenuation gradient in coronary CT angiography for determining coronary artery stenosis. JACC Cardiovasc Imaging 4(11):1149–1157CrossRef
17.
Zurück zum Zitat Wang R, Renker M, Schoepf UJ, Wichmann JL, Fuller SR, Rier JD, Bayer RR, Steinberg DH, De Cecco CN, Baumann S (2015) Diagnostic value of quantitative stenosis predictors with coronary CT angiography compared to invasive fractional flow reserve. Eur J Radiol 84(8):1509–1515CrossRef Wang R, Renker M, Schoepf UJ, Wichmann JL, Fuller SR, Rier JD, Bayer RR, Steinberg DH, De Cecco CN, Baumann S (2015) Diagnostic value of quantitative stenosis predictors with coronary CT angiography compared to invasive fractional flow reserve. Eur J Radiol 84(8):1509–1515CrossRef
18.
Zurück zum Zitat Stuijfzand WJ, Danad I, Raijmakers PG, Marcu CB, Heymans MW, van Kuijk CC, van Rossum AC, Nieman K, Min JK, Leipsic J, van Royen N, Knaapen P (2014) Additional value of transluminal attenuation gradient in CT angiography to predict hemodynamic significance of coronary artery stenosis. JACC Cardiovasc Imaging 7(4):374–386CrossRef Stuijfzand WJ, Danad I, Raijmakers PG, Marcu CB, Heymans MW, van Kuijk CC, van Rossum AC, Nieman K, Min JK, Leipsic J, van Royen N, Knaapen P (2014) Additional value of transluminal attenuation gradient in CT angiography to predict hemodynamic significance of coronary artery stenosis. JACC Cardiovasc Imaging 7(4):374–386CrossRef
19.
Zurück zum Zitat Funama Y, Utsunomiya D, Oda S, Shimonobo T, Nakaura T, Mukunoki T, Kidoh M, Yuki H, Yamashita Y (2016) Transluminal attenuation-gradient coronary CT angiography on a 320-MDCT volume scanner: Effect of scan timing, coronary artery stenosis, and cardiac output using a contrast medium flow phantom. Phys Med 32(11):1415–1421CrossRef Funama Y, Utsunomiya D, Oda S, Shimonobo T, Nakaura T, Mukunoki T, Kidoh M, Yuki H, Yamashita Y (2016) Transluminal attenuation-gradient coronary CT angiography on a 320-MDCT volume scanner: Effect of scan timing, coronary artery stenosis, and cardiac output using a contrast medium flow phantom. Phys Med 32(11):1415–1421CrossRef
20.
Zurück zum Zitat Tamaki N, Yonekura Y, Konishi J, Senda M, Yamashita K, Koide H, Saji H, Hashimoto T, Fudo T, Kambara H, Kawai C (1988) Value and limitation of stress thallium-201 single photon emission computed tomography: comparison with nitrogen-13 ammonia positron tomography. J Nucl Med 29(7):1181–1188PubMed Tamaki N, Yonekura Y, Konishi J, Senda M, Yamashita K, Koide H, Saji H, Hashimoto T, Fudo T, Kambara H, Kawai C (1988) Value and limitation of stress thallium-201 single photon emission computed tomography: comparison with nitrogen-13 ammonia positron tomography. J Nucl Med 29(7):1181–1188PubMed
21.
Zurück zum Zitat Husmann L, Wiegand M, Valenta I, Gaemperli O, Schepis T, Siegrist PT, Namdar M, Wyss CA, Alkadhi H, Kaufmann PA (2008) Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography. Int J Cardiovasc Imaging 24(5):511–551CrossRef Husmann L, Wiegand M, Valenta I, Gaemperli O, Schepis T, Siegrist PT, Namdar M, Wyss CA, Alkadhi H, Kaufmann PA (2008) Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography. Int J Cardiovasc Imaging 24(5):511–551CrossRef
22.
Zurück zum Zitat Di Carli MF, Hachamovitch R (2007) New technology for noninvasive evaluation of coronary artery disease. Circulation 115(11):1464–1480CrossRef Di Carli MF, Hachamovitch R (2007) New technology for noninvasive evaluation of coronary artery disease. Circulation 115(11):1464–1480CrossRef
23.
Zurück zum Zitat Fathala A, Aboulkheir M, Shoukri MM, Alsergani H (2019) Diagnostic accuracy of (13)N-ammonia myocardial perfusion imaging with PET-CT in the detection of coronary artery disease. Cardiovasc Diagn Ther 9(1):35–42CrossRef Fathala A, Aboulkheir M, Shoukri MM, Alsergani H (2019) Diagnostic accuracy of (13)N-ammonia myocardial perfusion imaging with PET-CT in the detection of coronary artery disease. Cardiovasc Diagn Ther 9(1):35–42CrossRef
24.
Zurück zum Zitat Jaarsma C, Leiner T, Bekkers SC, Crijns HJ, Wildberger JE, Nagel E, Nelemans PJ, Schalla S (2012) Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis. J Am Coll Cardiol 59(19):1719–1728CrossRef Jaarsma C, Leiner T, Bekkers SC, Crijns HJ, Wildberger JE, Nagel E, Nelemans PJ, Schalla S (2012) Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis. J Am Coll Cardiol 59(19):1719–1728CrossRef
25.
Zurück zum Zitat Driessen RS, Raijmakers PG, Stuijfzand WJ, Knaapen P (2017) Myocardial perfusion imaging with PET. Int J Cardiovasc Imaging 33(7):1021–1031CrossRef Driessen RS, Raijmakers PG, Stuijfzand WJ, Knaapen P (2017) Myocardial perfusion imaging with PET. Int J Cardiovasc Imaging 33(7):1021–1031CrossRef
26.
Zurück zum Zitat Bateman TM, Dilsizian V, Beanlands RS, DePuey EG, Heller GV, Wolinsky DA (2016) American Society of Nuclear Cardiology and Society of Nuclear Medicine and molecular imaging joint position statement on the clinical indications for myocardial perfusion PET. J Nucl Cardiol 23(5):1227–1231CrossRef Bateman TM, Dilsizian V, Beanlands RS, DePuey EG, Heller GV, Wolinsky DA (2016) American Society of Nuclear Cardiology and Society of Nuclear Medicine and molecular imaging joint position statement on the clinical indications for myocardial perfusion PET. J Nucl Cardiol 23(5):1227–1231CrossRef
27.
Zurück zum Zitat Shirasaka T, Nagao M, Yamasaki Y, Kojima T, Kondo M, Shimomiya Y, Kamitani T, Honda H (2019) Feasible scan timing for 320-row coronary CT angiography generated by the time to peak in the ascending aorta. Clin Imaging 54:153–158CrossRef Shirasaka T, Nagao M, Yamasaki Y, Kojima T, Kondo M, Shimomiya Y, Kamitani T, Honda H (2019) Feasible scan timing for 320-row coronary CT angiography generated by the time to peak in the ascending aorta. Clin Imaging 54:153–158CrossRef
28.
Zurück zum Zitat Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, McGoon DC, Murphy ML, Roe BB (1975) A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery American Heart Association. Circulation 51(4 Suppl):5–40CrossRef Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, McGoon DC, Murphy ML, Roe BB (1975) A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery American Heart Association. Circulation 51(4 Suppl):5–40CrossRef
29.
Zurück zum Zitat Ko BS, Wong DT, Norgaard BL, Leong DP, Cameron JD, Gaur S, Marwan M, Achenbach S, Kuribayashi S, Kimura T, Meredith IT, Seneviratne SK (2016) Diagnostic performance of transluminal attenuation gradient and noninvasive fractional flow reserve derived from 320-detector row CT angiography to diagnose hemodynamically significant coronary stenosis: an NXT substudy. Radiology 279(1):75–83CrossRef Ko BS, Wong DT, Norgaard BL, Leong DP, Cameron JD, Gaur S, Marwan M, Achenbach S, Kuribayashi S, Kimura T, Meredith IT, Seneviratne SK (2016) Diagnostic performance of transluminal attenuation gradient and noninvasive fractional flow reserve derived from 320-detector row CT angiography to diagnose hemodynamically significant coronary stenosis: an NXT substudy. Radiology 279(1):75–83CrossRef
30.
Zurück zum Zitat Kato E, Fujimoto S, Takamura K, Kawaguchi Y, Aoshima C, Hiki M, Kumamaru KK, Daida H (2018) Clinical significance of transluminal attenuation gradient in 320-row area detector coronary CT angiography. Heart Vessels 33(5):462–469CrossRef Kato E, Fujimoto S, Takamura K, Kawaguchi Y, Aoshima C, Hiki M, Kumamaru KK, Daida H (2018) Clinical significance of transluminal attenuation gradient in 320-row area detector coronary CT angiography. Heart Vessels 33(5):462–469CrossRef
31.
Zurück zum Zitat Trattner S, Halliburton S, Thompson CM, Xu Y, Chelliah A, Jambawalikar SR, Peng B, Peters MR, Jacobs JE, Ghesani M, Jang JJ, Al-Khalidi H, Einstein AJ (2018) Cardiac-Specific conversion factors to estimate radiation effective dose from dose-length product in computed tomography. JACC Cardiovasc Imaging 11(1):64–74CrossRef Trattner S, Halliburton S, Thompson CM, Xu Y, Chelliah A, Jambawalikar SR, Peng B, Peters MR, Jacobs JE, Ghesani M, Jang JJ, Al-Khalidi H, Einstein AJ (2018) Cardiac-Specific conversion factors to estimate radiation effective dose from dose-length product in computed tomography. JACC Cardiovasc Imaging 11(1):64–74CrossRef
32.
Zurück zum Zitat Metz CE (2008) ROC analysis in medical imaging: a tutorial review of the literature. Radiol Phys Technol 1(1):2–12CrossRef Metz CE (2008) ROC analysis in medical imaging: a tutorial review of the literature. Radiol Phys Technol 1(1):2–12CrossRef
33.
Zurück zum Zitat DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44(3):837–845CrossRef DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44(3):837–845CrossRef
34.
Zurück zum Zitat Bom MJ, Driessen RS, Stuijfzand WJ, Raijmakers PG, Van Kuijk CC, Lammertsma AA, van Rossum AC, van Royen N, Knuuti J, Mäki M, Nieman K, Min JK, Leipsic JA, Danad I, Knaapen P (2019) Diagnostic value of transluminal attenuation gradient for the presence of ischemia as defined by fractional flow reserve and quantitative positron emission tomography. JACC Cardiovasc Imaging 12(2):323–333CrossRef Bom MJ, Driessen RS, Stuijfzand WJ, Raijmakers PG, Van Kuijk CC, Lammertsma AA, van Rossum AC, van Royen N, Knuuti J, Mäki M, Nieman K, Min JK, Leipsic JA, Danad I, Knaapen P (2019) Diagnostic value of transluminal attenuation gradient for the presence of ischemia as defined by fractional flow reserve and quantitative positron emission tomography. JACC Cardiovasc Imaging 12(2):323–333CrossRef
35.
Zurück zum Zitat Park EA, Lee W, Park SJ, Kim YK, Hwang HY (2016) Influence of coronary artery diameter on intracoronary transluminal attenuation gradient during CT angiography. JACC Cardiovasc Imaging 9(9):1074–1083CrossRef Park EA, Lee W, Park SJ, Kim YK, Hwang HY (2016) Influence of coronary artery diameter on intracoronary transluminal attenuation gradient during CT angiography. JACC Cardiovasc Imaging 9(9):1074–1083CrossRef
36.
Zurück zum Zitat Xu L, Sun Z, Fan Z (2015) Noninvasive physiologic assessment of coronary stenoses using cardiac CT. Biomed Res Int 2015:435737PubMedPubMedCentral Xu L, Sun Z, Fan Z (2015) Noninvasive physiologic assessment of coronary stenoses using cardiac CT. Biomed Res Int 2015:435737PubMedPubMedCentral
37.
Zurück zum Zitat Nagao M, Yamasaki Y, Kamitani T, Kawanami S, Sagiyama K, Yamanouchi T, Shimomiya Y, Matoba T, Mukai Y, Odashiro K, Baba S, Maruoka Y, Kitamura Y, Nishie A, Honda H (2016) Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis. Eur J Radiol 85(5):996–1003CrossRef Nagao M, Yamasaki Y, Kamitani T, Kawanami S, Sagiyama K, Yamanouchi T, Shimomiya Y, Matoba T, Mukai Y, Odashiro K, Baba S, Maruoka Y, Kitamura Y, Nishie A, Honda H (2016) Quantification of coronary flow using dynamic angiography with 320-detector row CT and motion coherence image processing: Detection of ischemia for intermediate coronary stenosis. Eur J Radiol 85(5):996–1003CrossRef
38.
Zurück zum Zitat Maeda E, Tomizawa N, Kanno S, Yasaka K, Kubo T, Ino K, Torigoe R, Ohtomo K (2017) The feasibility of Forward-projected model-based Iterative Reconstruction SoluTion (FIRST) for coronary 320-row computed tomography angiography: a pilot study. J Cardiovasc Comput Tomogr 11(1):40–45CrossRef Maeda E, Tomizawa N, Kanno S, Yasaka K, Kubo T, Ino K, Torigoe R, Ohtomo K (2017) The feasibility of Forward-projected model-based Iterative Reconstruction SoluTion (FIRST) for coronary 320-row computed tomography angiography: a pilot study. J Cardiovasc Comput Tomogr 11(1):40–45CrossRef
39.
Zurück zum Zitat Tatsugami F, Higaki T, Nakamura Y, Yu Z, Zhou J, Lu Y, Fujioka C, Kitagawa T, Kihara Y, Iida M, Awai K (2019) Deep learning-based image restoration algorithm for coronary CT angiography. Eur Radiol 29(10):5322–5329CrossRef Tatsugami F, Higaki T, Nakamura Y, Yu Z, Zhou J, Lu Y, Fujioka C, Kitagawa T, Kihara Y, Iida M, Awai K (2019) Deep learning-based image restoration algorithm for coronary CT angiography. Eur Radiol 29(10):5322–5329CrossRef
Metadaten
Titel
New transluminal attenuation gradient derived from dynamic coronary CT angiography: diagnostic ability of ischemia detected by 13N-ammonia PET
verfasst von
Tsukasa Kojima
Michinobu Nagao
Hidetake Yabuuchi
Yuzo Yamasaki
Takashi Shirasaka
Masateru Kawakubo
Kenji Fukushima
Toyoyuki Kato
Atsushi Yamamoto
Risako Nakao
Akiko Sakai
Eri Watanabe
Shuji Sakai
Publikationsdatum
13.10.2020
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 4/2021
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-020-01712-y

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