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Metabolic Brain Disease

Erschienen in:

06.04.2018 | Review Article

New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease

verfasst von: Kai Long Zhong, Fang Chen, Hao Hong, Xuan Ke, Yang Ge Lv, Su Su Tang, Yu Bing Zhu

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2018

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Abstract

Mounting evidence suggests that diabetes mellitus (DM) is associated with mild cognitive impairment (MCI), vascular dementia and Alzheimer’s disease (AD). Biological, clinical and epidemiological data support a close link between DM and AD. Increasingly, studies have found that several antidiabetic agents can promote neurogenesis, and clinically ameliorate cognitive and memory impairments in different clinical settings. Data has shown that these antidiabetic drugs positively affect mitochondrial and synaptic function, neuroinflammation, and brain metabolism. Evidence to date strongly suggests that these antidiabetic drugs could be developed as disease-modifying therapies for MCI and AD in patients with and without diabetes.

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Titel: New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease
verfasst von: Kai Long Zhong
Fang Chen
Hao Hong
Xuan Ke
Yang Ge Lv
Su Su Tang
Yu Bing Zhu
Publikationsdatum: 06.04.2018
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0227-1

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