Background
Methods
Patients
Cytogenetics and fusion genes analysis
Next-generation sequencing
Statistical analysis
Results
Clinical characteristics
Total (n = 179) | Younger patients (n = 111) | Older patients (n = 68) | p value | |
---|---|---|---|---|
Age, years (median, range) | 53 (18–88) | 44 (18–59) | 67 (60–88) | |
Male (n, %) | 116 (64.8) | 71 (64.0) | 45 (66.2) | 0.872 |
WBC (× 109/L) (median, range) | 7.82 (0.4–362.6) | 8.48 (0.4–362.6) | 7.42 (0.6–271.4) | 0.380 |
Blast cells in BM (%, range) | 53 (10–95) | 57 (10–94.5) | 53 (21–95) | 0.824 |
Complex karyotype | 16/130 (12.3) | 9/81 (11.1) | 7/49 (14.3) | 0.784 |
RUNX1–RUNX1T1 | 18 (10.1) | 16 (14.4) | 2 (2.9) | 0.019 |
CBFβ–MYH11 | 10 (5.6) | 8 (7.2) | 2 (2.9) | 0.322 |
Molecular gene mutations of patients
Total (n = 179) | Younger patients (n = 111) | Older patients (n = 68) | p value | |
---|---|---|---|---|
Mutation number (mean) | 2.08 | 1.83 | 2.50 | 0.003 |
CEBPA
| 32 (17.9) | 22 (19.8) | 10 (14.7) | 0.428 |
TET2
| 30 (16.8) | 15 (13.5) | 15 (22.1) | 0.153 |
ASXL1
| 25 (14.0) | 10 (9.0) | 15 (22.1) | 0.025 |
NRAS
| 21 (11.7) | 17 (15.3) | 4 (5.9) | 0.092 |
NPM1
| 20 (11.2) | 12 (10.8) | 8 (11.8) | 1 |
IDH2
| 18 (10.1) | 10 (9.0) | 8 (11.8) | 0.768 |
FLT3–ITD | 18 (10.1) | 12 (10.8) | 6 (8.8) | 0.800 |
DNMT3A
| 16 (8.9) | 6 (5.4) | 10 (14.7) | 0.056 |
KIT
| 14 (7.8) | 12 (10.8) | 2 (2.9) | 0.083 |
TP53
| 13 (7.3) | 4 (3.6) | 9 (13.2) | 0.034 |
RUNX1
| 13 (7.3) | 5 (4.5) | 8 (11.8) | 0.081 |
IDH1
| 12 (6.7) | 5 (4.5) | 7 (10.3) | 0.216 |
WT1
| 9 (5.0) | 7 (6.3) | 2 (2.9) | 0.486 |
GATA2
| 5 (2.8) | 2 (1.8) | 3 (4.4) | 0.370 |
FLT3–TKD | 5 (2.8) | 3 (2.7) | 2 (2.9) | 1 |
KRAS
| 4 (2.2) | 3 (2.7) | 1 (1.5) | 1 |
DNA methylation | 63 (35.2) | 30 (27.0) | 33 (48.5) | 0.004 |
RNA splicing | 37 (20.7) | 16 (14.4) | 21 (30.9) | 0.013 |
Chromatin architecture | 32 (17.9) | 12 (10.8) | 20 (29.4) | 0.002 |
Transcriptional deregulation | 50 (27.9) | 31 (27.9) | 19 (27.9) | 1 |
Activated signaling | 55 (30.7) | 42 (37.8) | 13 (19.1) | 0.012 |
CEBPA
Mut
|
CEBPA
WT
| p value | |
---|---|---|---|
GATA2
Mut
| 5 | 0 | |
GATA2
WT
| 27 | 147 | < 0.001 |
ASXL1
Mut
|
ASXL1
WT
| p value | |
---|---|---|---|
TET2
Mut
| 8 | 22 | |
TET2
WT
| 17 | 132 | 0.041 |
IDH2
mut
| 6 | 12 | |
IDH2
WT
| 19 | 142 | 0.023 |
SETBP1
mut
| 4 | 3 | |
SETBP`
WT
| 21 | 151 | 0.008 |
NPM1
Mut
|
NPM1
WT
| p value | |
---|---|---|---|
DNMT3A
Mut
| 6 | 10 | |
DNMT3A
WT
| 14 | 149 | 0.004 |
IDH2
mut
| 5 | 13 | |
IDH2
WT
| 15 | 146 | 0.034 |
TET2
Mut
|
TET2
WT
| p value | |
---|---|---|---|
IDH2
Mut
| 0 | 18 | |
IDH2
WT
| 30 | 131 | 0.046 |