Skip to main content
main-content

01.08.2011 | Review | Ausgabe 4/2011

Breast Cancer Research 4/2011

NF-κB, stem cells and breast cancer: the links get stronger

Zeitschrift:
Breast Cancer Research > Ausgabe 4/2011
Autoren:
Kateryna Shostak, Alain Chariot
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​bcr2886) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Abstract

Self-renewing breast cancer stem cells are key actors in perpetuating tumour existence and in treatment resistance and relapse. The molecular pathways required for their maintenance are starting to be elucidated. Among them is the transcription factor NF-κB, which is known to play critical roles in cell survival, inflammation and immunity. Recent studies indicate that mammary epithelial NF-κB regulates the self-renewal of breast cancer stem cells in a model of Her2-dependent tumourigenesis. We will describe here the NF-κB-activating pathways that are involved in this process and in which progenitor cells this transcription factor is actually activated.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Zusatzmaterial
Authors’ original file for figure 1
13058_2011_2706_MOESM1_ESM.tiff
Authors’ original file for figure 2
13058_2011_2706_MOESM2_ESM.tiff
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2011

Breast Cancer Research 4/2011 Zur Ausgabe

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise