nach oben

Journal of Cancer Survivorship

Erschienen in:

23.07.2019

Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study

verfasst von: Jennifer N. Vega, Kimberly M. Albert, Ingrid A. Mayer, Warren D. Taylor, Paul A. Newhouse

Erschienen in: Journal of Cancer Survivorship | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Persistent chemotherapy-related cognitive impairment (pCRCI) is commonly reported following cancer treatment and negatively affects quality of life; however, there is currently no pharmacological treatment indicated for pCRCI. This pilot study obtained preliminary data regarding the use of transdermal nicotine patches as a therapeutic strategy for women with pCRCI to (1) reduce subjective cognitive complaints and (2) enhance objective cognitive performance in breast, colon, lymphoma, or ovarian cancer survivors with pCRCI.

Methods

Participants were randomized to either placebo (n = 11) or transdermal nicotine (n = 11) for 6 weeks, followed by 2 weeks of treatment withdrawal for a total of 8 weeks. Participants were assessed using both subjective and objective measures of cognitive functioning at five visits before, during, and after treatment.

Results

Over the course of the study, women in both groups improved substantially in severity of self-reported cognitive complaints measured by Functional Assessment of Cancer Therapy-Cognitive Function Perceived Cognitive Impairments regardless of treatment arm. Additionally, objective cognitive performance measures improved in both groups; however, there was no significant difference in improvement between groups.

Conclusions

Due to a large placebo response, we were unable to determine if a drug effect was present. However, we did observe substantial improvement in self-reported cognitive symptoms, likely resulting from factors related to participation in the trial rather than specific drug treatment effects.

Trial registration

The study was registered with clinicaltrials.gov (trial registration: NCT02312943).

Implications for Cancer Survivors

These results suggest that women with pCRCI can exhibit improvement in subjective cognition, with attention paid to symptoms and close follow-up over a short period of time.

Nur mit Berechtigung zugänglich

Janelsins MC, Kohli S, Mohile SG, Usuki K, Ahles TA, Morrow GR. An update on cancer- and chemotherapy-related cognitive dysfunction: current status. Semin Oncol. 2011 [cited 2014 Jan 22];38:431–8. Available from: http://www.sciencedirect.com/science/article/pii/S0093775411000844.

Silberfarb PM. Chemotherapy and cognitive defects in cancer patients. Annu Rev Med. 1983 [cited 2014 Feb 26];34:35–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6344764.

Ahles TA. Brain vulnerability to chemotherapy toxicities. Psychooncology. 2012 [cited 2014 Feb 24];21:1141–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3788849&tool=pmcentrez&rendertype=abstract.

Ahles TA, Saykin AJ, Furstenberg CT, Cole B, Mott LA, Skalla K, et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol. 2002 [cited 2014 Feb 18];20:485–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11786578.

Craig CD, Monk BJ, Farley JH, Chase DM. Cognitive impairment in gynecologic cancers: a systematic review of current approaches to diagnosis and treatment. Support Care Cancer. 2014 [cited 2014 Apr 4];22:279–87. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24212261.

Mandelblatt JS, Hurria A, McDonald BC, Saykin AJ, Stern RA, VanMeter JW, et al. Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? Semin Oncol. 2013 [cited 2015 Jun 17];40:709–25. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3880205&tool=pmcentrez&rendertype=abstract

Vega JN, Newhouse PA. Mild cognitive impairment: diagnosis, longitudinal course, and emerging treatments. Curr Psychiatry Rep. 2014 [cited 2014 Aug 30];16:490. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25160795.

Wefel JS, Kesler SR, Noll KR, Schagen SB. Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA Cancer J Clin. 2015 [cited 2016 Jun 3];65:123–38. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4355212&tool=pmcentrez&rendertype=abstract.

Wefel JS, Schagen SB. Chemotherapy-related cognitive dysfunction. Curr Neurol Neurosci Rep. 2012 [cited 2014 Feb 21];12:267–75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22453825.

10.

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016 [cited 2016 Jun 7]; Available from: http://doi.wiley.com/10.3322/caac.21349

11.

Pedersen AD, Rossen P, Mehlsen MY, Pedersen CG, Zachariae R, von der Maase H. Long-term cognitive function following chemotherapy in patients with testicular cancer. J Int Neuropsychol Soc. 2009 [cited 2016 May 5];15:296–301. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19203434.

12.

Wefel JS, Vidrine DJ, Marani SK, Swartz RJ, Veramonti TL, Meyers CA, et al. A prospective study of cognitive function in men with non-seminomatous germ cell tumors. Psychooncology. 2014 [cited 2016 Jun 3];23:626–33. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4066616&tool=pmcentrez&rendertype=abstract

13.

Jones D, Vichaya EG, Wang XS, Sailors MH, Cleeland CS, Wefel JS. Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant. Cancer. 2013 [cited 2016 Jun 3];119:4188–95. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3834212&tool=pmcentrez&rendertype=abstract.

14.

Vardy J, Tannock I. Cognitive function after chemotherapy in adults with solid tumours. Crit Rev Oncol Hematol.2007 [cited 2014 Mar 7];63:183–202. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17678745.

15.

Correa DD, Zhou Q, Thaler HT, Maziarz M, Hurley K, Hensley ML. Cognitive functions in long-term survivors of ovarian cancer. Gynecol Oncol. 2010 [cited 2014 Mar 10];119:366–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20630576.

16.

Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, et al. Effects of androgen deprivation on brain function in prostate cancer patients - a prospective observational cohort analysis. BMC Cancer. 2012 [cited 2016 Jun 3];12:371. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3502584&tool=pmcentrez&rendertype=abstract.

17.

Ahles TA, Saykin AJ. Breast cancer chemotherapy-related cognitive dysfunction. Clin Breast Cancer. 2002 [cited 2014 Feb 27];3 Suppl 3:S84–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12533268.

18.

Scheibel RS, Valentine AD, O’Brien S, Meyers CA. Cognitive dysfunction and depression during treatment with interferon-alpha and chemotherapy. J Neuropsychiatry Clin Neurosci. 2004 [cited 2019 Jun 7];16:185–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15260370.

19.

Hodgson KD, Hutchinson AD, Wilson CJ, Nettelbeck T. A meta-analysis of the effects of chemotherapy on cognition in patients with cancer. Cancer Treat Rev. 2013 [cited 2014 Feb 27];39:297–304. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23219452.

20.

Vega JN, Dumas J, Newhouse P. Cognitive effects of chemotherapy and cancer-related treatments in older adults. Am J Geriatr Psychiatry. 2017 [cited 2017 Apr 13];25:1415–26. Available from: http://www.sciencedirect.com/science/article/pii/S1064748117302786.

21.

Lower EE, Fleishman S, Cooper A, Zeldis J, Faleck H, Yu Z, et al. Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial. J Pain Symptom Manage. 2009 [cited 2014 Mar 10];38:650–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19896571.

22.

Mar Fan HG, Clemons M, Xu W, Chemerynsky I, Breunis H, Braganza S, et al. A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer. Support Care Cancer. 2008 [cited 2014 Mar 10];16:577–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17972110.

23.

Kohli S, Fisher SG, Tra Y, Adams MJ, Mapstone ME, Wesnes KA, et al. The effect of modafinil on cognitive function in breast cancer survivors. Cancer. 2009 [cited 2014 Mar 10];115:2605–16. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2796482&tool=pmcentrez&rendertype=abstract.

24.

Lundorff LE, Jønsson BH, Sjøgren P. Modafinil for attentional and psychomotor dysfunction in advanced cancer: a double-blind, randomised, cross-over trial. Palliat Med. 2009 [cited 2014 Mar 10];23:731–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19648224.

25.

O’Shaughnessy JA. Effects of epoetin alfa on cognitive function, mood, asthenia, and quality of life in women with breast cancer undergoing adjuvant chemotherapy. Clin Breast Cancer. 2002 [cited 2014 Mar 10];3 Suppl 3:S116–20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12533272.

26.

Fan HGM, Park A, Xu W, Yi Q-L, Braganza S, Chang J, et al. The influence of erythropoietin on cognitive function in women following chemotherapy for breast cancer. Psychooncology. 2009 [cited 2014 Feb 16];18:156–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18561284.

27.

Shaw EG, Rosdhal R, D’Agostino RB, Lovato J, Naughton MJ, Robbins ME, et al. Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. J Clin Oncol. 2006 [cited 2016 Dec 5];24:1415–20. Available from: http://www.jco.org/cgi/doi/10.1200/JCO.2005.03.3001

28.

Castellino SM, Tooze JA, Flowers L, Hill DF, McMullen KP, Shaw EG, et al. Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Pediatr Blood Cancer. 2012 [cited 2016 Dec 5];59:540–7. Available from: http://doi.wiley.com/10.1002/pbc.24078

29.

Lawrence JA, Griffin L, Balcueva EP, Groteluschen DL, Samuel TA, Lesser GJ, et al. A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy. J Cancer Surviv [Internet]. 2016 [cited 2016 Jul 20];10:176–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26130292.

30.

Dumas JA, Newhouse PA. The cholinergic hypothesis of cognitive aging revisited again: cholinergic functional compensation. Pharmacol Biochem Behav [Internet]. 2011 [cited 2014 Jan 30];99:254–61. Available from: http://www.sciencedirect.com/science/article/pii/S0091305711000682

31.

Ellis JR, Ellis KA, Bartholomeusz CF, Harrison BJ, Wesnes KA, Erskine FF, et al. Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans. Int J Neuropsychopharmacol [Internet]. 2006 [cited 2014 Feb 20];9:175–89. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15877932.

32.

Newhouse PA, Potter A, Corwin J, Lenox R. Age-related effects of the nicotinic antagonist mecamylamine on cognition and behavior. Neuropsychopharmacology [Internet]. 1994 [cited 2014 Feb 20];10:93–107. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8024677.

33.

Vitiello B, Martin A, Hill J, Mack C, Molchan S, Martinez R, et al. Cognitive and behavioral effects of cholinergic, dopaminergic, and serotonergic blockade in humans. Neuropsychopharmacology [Internet]. 1997 [cited 2014 Feb 20];16:15–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8981385.

34.

Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (Berl) [Internet]. 2010 [cited 2014 Feb 25];210:453–69. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3151730&tool=pmcentrez&rendertype=abstract

35.

Dawkins L, Powell JH, West R, Powell J, Pickering A. A double-blind placebo-controlled experimental study of nicotine: II--effects on response inhibition and executive functioning. Psychopharmacology (Berl) [Internet]. 2007 [cited 2014 Apr 9];190:457–67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17205318.

36.

Engeland C, Mahoney C, Mohr E, Ilivitsky V, Knott V. Nicotine and sensory memory in Alzheimer’s disease: an event-related potential study. Brain Cogn [Internet]. 2002 [cited 2014 Apr 9];49:232–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15259398.

37.

Howe MN, Price IR. Effects of transdermal nicotine on learning, memory, verbal fluency, concentration, and general health in a healthy sample at risk for dementia. Int Psychogeriatr [Internet]. 2001 [cited 2014 Apr 9];13:465–75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12003253.

38.

Newhouse PA, Sunderland T, Tariot PN, Blumhardt CL, Weingartner H, Mellow A, et al. Intravenous nicotine in Alzheimer’s disease: a pilot study. Psychopharmacology (Berl) [Internet]. 1988 [cited 2014 Apr 9];95:171–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3137593.

39.

Wilson AL, Langley LK, Monley J, Bauer T, Rottunda S, McFalls E, et al. Nicotine patches in Alzheimer’s disease: pilot study on learning, memory, and safety. Pharmacol Biochem Behav [Internet]. 1995 [cited 2014 Apr 9];51:509–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7667377.

40.

Newhouse P, Kellar K, Aisen P, White H, Wesnes K, Coderre E, et al. Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. Neurology [Internet]. 2012 [cited 2014 Feb 5];78:91–101. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3466669&tool=pmcentrez&rendertype=abstract

41.

Potter AS, Bucci DJ, Newhouse PA. Manipulation of nicotinic acetylcholine receptors differentially affects behavioral inhibition in human subjects with and without disordered baseline impulsivity. Psychopharmacology (Berl) [Internet]. 2012 [cited 2014 25];220:331–40. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3288699&tool=pmcentrez&rendertype=abstract

42.

Mandelblatt JS, Hurria A, McDonald BC, Saykin AJ, Stern RA, VanMeter JW, et al. Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? Semin Oncol [Internet]. 2013 [cited 2014 Mar 17];40:709–25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24331192.

43.

Ahles TA, Li Y, McDonald BC, Schwartz GN, Kaufman PA, Tsongalis GJ, Moore JH SA. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: the impact of APOE and smoking. Psychooncology [Internet]. 2014 [cited 2014 Jul 23]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24789331.

44.

Rezvani AH, Levin ED. Cognitive effects of nicotine. Biol Psychiatry [Internet]. Elsevier; 2001 [cited 2019 31];49:258–67. Available from: https://www.sciencedirect.com/science/article/pii/S0006322300010945?via%3Dihub

45.

Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA, West JD, et al. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology [Internet]. 2006 [cited 2014 May 6];67:834–42. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3488276&tool=pmcentrez&rendertype=abstract

46.

Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA, West JD, et al. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology [Internet]. 2006 [cited 2016 May 9];67:834–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16966547.

47.

Dumas JA, Kutz AM, Naylor MR, Johnson J V, Newhouse PA. Estradiol treatment altered anticholinergic-related brain activation during working memory in postmenopausal women. Neuroimage [Internet]. 2012 [cited 2015 Jun 17];60:1394–403. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3303937&tool=pmcentrez&rendertype=abstract

48.

Gilewski MJ, Zelinski EM, Schaie KW. The Memory Functioning Questionnaire for assessment of memory complaints in adulthood and old age. Psychol Aging [Internet]. 1990 [cited 2014 May 6];5:482–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2278670.

49.

Squire LR, Wetzel CD, Slater PC. Memory complaint after electroconvulsive therapy: assessment with a new self-rating instrument. Biol Psychiatry [Internet]. 1979 [cited 2014 May 6];14:791–801. Available from: http://www.ncbi.nlm.nih.gov/pubmed/497304.

50.

Saykin AJ. Neurobehavioral function and activities of daily living rating scale (NBFADL-63 item version). Hanover, NH: Dartmouth Medical School.

51.

Jorm AF, Christensen H, Henderson AS, Korten AE, Mackinnon AJ, Scott R. Complaints of cognitive decline in the elderly: a comparison of reports by subjects and informants in a community survey. Psychol Med [Internet]. 1994 [cited 2014 May 6];24:365–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/8084932.

52.

Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res [Internet]. [cited 2014 May 6];17:37–49. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7183759.

53.

Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol [Internet]. 1982 [cited 2014 May 6];37:323–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7069156.

54.

Jacobs SR, Jacobsen PB, Booth-Jones M, Wagner LI, Anasetti C. Evaluation of the Functional Assessment of Cancer Therapy Cognitive Scale with hematopoietic stem cell transplant patients. J Pain Symptom Manage [Internet]. 2007 [cited 2014 May 6];33:13–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17196903.

55.

Lai J-S, Butt Z, Wagner L, Sweet JJ, Beaumont JL, Vardy J, et al. Evaluating the dimensionality of perceived cognitive function. J Pain Symptom Manage [Internet]. NIH Public Access; 2009 [cited 2017 Dec 19];37:982–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19500722.

56.

Sanford SD, Beaumont JL, Butt Z, Sweet JJ, Cella D, Wagner LI. Prospective longitudinal evaluation of a symptom cluster in breast cancer. J Pain Symptom Manage [Internet]. 2014 [cited 2014 May 20];47:721–30. Available from: http://www.sciencedirect.com/science/article/pii/S0885392413003254

57.

Wagner LI, Sweet J, Butt Z, Lai J-S, Cella D. Measuring patient self-reported cognitive function: development of the Functional Assessment of Cancer Therapy-Cognitive Function instrument. J Support Oncol. 2009;7:W32–9.

58.

The Conners continuous performance test. Toronto, Canada: multi-health systems; 1994.

59.

The continuous performance test. Toronto, Canada: multi-health systems; 1995.

60.

Kupke T, Lewis R. Relative influence of subject variables and neurological parameters on neuropsychological performance of adult seizure patients. Arch Clin Neuropsychol [Internet]. 1989 [cited 2014 May 21];4:351–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14591131.

61.

Hindmarch I. Psychological performance models as indicators of the effects of hypnotic drugs on sleep. Psychopharmacology Suppl [Internet]. 1984 [cited 2014 May 21];1:58–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6382255.

62.

Buschke H, Fuld PA. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology [Internet]. 1974 [cited 2014 Oct 2];24:1019–25. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4473151.

63.

Maruff P, Thomas E, Cysique L, Brew B, Collie A, Snyder P, et al. Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Arch Clin Neuropsychol [Internet]. 2009 [cited 2014 Apr 1];24:165–78. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19395350.

64.

Darby D, Maruff P, Collie A, Mc Stephen M. Mild cognitive impairment can be detected by multiple assessments in a single day. Neurology [Internet]. 2002 [cited 2014 May 21];59:1042–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12370459.

65.

Tannock IF, Ahles TA, Ganz PA, Van Dam FS. Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol [Internet]. 2004 [cited 2014 Feb 18];22:2233–9. Available from: http://jco.ascopubs.org/content/22/11/2233.full

66.

Bell ML, Dhillon HM, Bray VJ, Vardy JL. Important differences and meaningful changes for the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). J Patient-Reported Outcomes [Internet]. Springer; 2018 [cited 2019 23];2:48. Available from: https://jpro.springeropen.com/articles/10.1186/s41687-018-0071-4

67.

Peciña M, Bohnert ASB, Sikora M, Avery ET, Langenecker SA, Mickey BJ, et al. Association between placebo-activated neural systems and antidepressant responses: neurochemistry of placebo effects in major depression. JAMA psychiatry [Internet]. NIH Public Access; 2015 [cited 2018 Feb 27];72:1087–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26421634.

68.

Agid O, Siu CO, Potkin SG, Kapur S, Watsky E, Vanderburg D, et al. Meta-regression analysis of placebo response in antipsychotic trials, 1970–2010. Am J Psychiatry [Internet]. 2013 [cited 2018 Feb 27];170:1335–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23896810.

69.

Colagiuri B, Schenk LA, Kessler MD, Dorsey SG, Colloca L. The placebo effect: from concepts to genes. Neuroscience [Internet]. NIH Public Access; 2015 [cited 2018 Feb 27];307:171–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26272535.

70.

Mestre TA, Shah P, Marras C, Tomlinson G, Lang AE. Another face of placebo: the lessebo effect in Parkinson disease: meta-analyses. Neurology [Internet]. American Academy of Neurology; 2014 [cited 2018 Feb 27];82:1402–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24658930.

71.

Rutherford BR, Roose SP. A model of placebo response in antidepressant clinical trials. Am J Psychiatry [Internet]. NIH Public Access; 2013 [cited 2018 Mar 2];170:723–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23318413.

72.

Posternak MA, Zimmerman M. Therapeutic effect of follow-up assessments on antidepressant and placebo response rates in antidepressant efficacy trials. Br J Psychiatry [Internet]. 2007 [cited 2018 Feb 28];190:287–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17401033.

73.

Oken BS. Placebo effects: clinical aspects and neurobiology. Brain [Internet]. Oxford University Press; 2008 [cited 2018 Feb 28];131:2812–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18567924.

74.

Khan A, Kolts RL, Thase ME, Krishnan KRR, Brown W. Research design features and patient characteristics associated with the outcome of antidepressant clinical trials. Am J Psychiatry [Internet]. 2004 [cited 2018 Mar 2];161:2045–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15514405.

75.

Benedetti F. Mechanisms of placebo and placebo-related effects across diseases and treatments. Annu Rev Pharmacol Toxicol [Internet]. 2008 [cited 2018 Mar 2];48:33–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17666008.

76.

Brody H. The placebo response. Recent research and implications for family medicine. J Fam Pract [Internet]. 2000 [cited 2018 Feb 28];49:649–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10923577.

77.

Di Blasi Z, Harkness E, Ernst E, Georgiou A, Kleijnen J. Influence of context effects on health outcomes: a systematic review. Lancet (London, England) [Internet]. 2001 [cited 2018 Feb 28];357:757–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11253970.

78.

Armey MF, Schatten HT, Haradhvala N, Miller IW. Ecological momentary assessment (EMA) of depression-related phenomena. Curr Opin Psychol [Internet]. Elsevier; 2015 [cited 2018 Apr 24];4:21–5. Available from: https://www.sciencedirect.com/science/article/pii/S2352250X15000494

79.

Shiffman S, Stone AA, Hufford MR. Ecological momentary assessment. Annu Rev Clin Psychol [Internet]. 2008 [cited 2018 Apr 20];4:1–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18509902.

80.

Kesler SR, Blayney DW. Neurotoxic effects of anthracycline- vs nonanthracycline-based chemotherapy on cognition in breast cancer survivors. JAMA Oncol [Internet]. 2016 [cited 2016 Jul 20];2:185–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26633037.

81.

Cerulla N, Arcusa À, Navarro J-B, Garolera M, Enero C, Chico G, et al. Role of taxanes in chemotherapy-related cognitive impairment: a prospective longitudinal study. Breast Cancer Res Treat [Internet]. 2017 [cited 2018 Jun 5];164:179–87. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28421379.

82.

Collins B, MacKenzie J, Tasca GA, Scherling C, Smith A. Cognitive effects of chemotherapy in breast cancer patients: a dose-response study. Psychooncology [Internet]. 2013 [cited 2016 Oct 14];22:1517–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22936651.

83.

American Cancer Society. Cancer facts & figures. Atlanta; 2013.

84.

Janelsins MC, Kesler SR, Ahles TA, Morrow GR. Prevalence, mechanisms, and management of cancer-related cognitive impairment. Int Rev Psychiatry [Internet]. Informa Healthcare USA; 2014 [cited 2014 6];26:102–13. Available from: http://informahealthcare.com/doi/abs/10.3109/09540261.2013.864260

85.

Joly F, Giffard B, Rigal O, De Ruiter MB, Small BJ, Dubois M, et al. Impact of cancer and its treatments on cognitive function: advances in research from the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012. J Pain Symptom Manage [Internet]. 2015 [cited 2016 Dec 3];50:830–41. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26344551.

86.

Ferguson RJ, McDonald BC, Rocque MA, Furstenberg CT, Horrigan S, Ahles TA, et al. Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial. Psychooncology [Internet]. 2012 [cited 2016 5];21:176–86. Available from: http://doi.wiley.com/10.1002/pon.1878

87.

Ferguson RJ, Ahles TA, Saykin AJ, McDonald BC, Furstenberg CT, Cole BF, et al. Cognitive-behavioral management of chemotherapy-related cognitive change. Psychooncology [Internet]. 2007 [cited 2016 Dec 5];16:772–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17152119.

88.

Kesler S, Hadi Hosseini SM, Heckler C, Janelsins M, Palesh O, Mustian K, et al. Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors. Clin Breast Cancer [Internet]. 2013 [cited 2016 Dec 5];13:299–306. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1526820913000499

89.

Janelsins MC, Peppone LJ, Heckler CE, Kesler SR, Sprod LK, Atkins J, et al. YOCAS©® yoga reduces self-reported memory difficulty in cancer survivors in a nationwide randomized clinical trial: investigating relationships between memory and sleep. Integr Cancer Ther [Internet]. 2015 [cited 2016 Jun 1]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26621521.

Titel: Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study
verfasst von: Jennifer N. Vega
Kimberly M. Albert
Ingrid A. Mayer
Warren D. Taylor
Paul A. Newhouse
Publikationsdatum: 23.07.2019
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 5/2019
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-019-00786-6

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study

Abstract

Purpose

Methods

Results

Conclusions

Trial registration

Implications for Cancer Survivors

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Trial registration

Implications for Cancer Survivors

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2019

The relationship between diet and cognitive function in adult cancer survivors: a systematic review

Evidence-based recommendations for the organization of long-term follow-up care for childhood and adolescent cancer survivors: a report from the PanCareSurFup Guidelines Working Group

Implications for patient-provider communication and health self-efficacy among cancer survivors with multiple chronic conditions: results from the Health Information National Trends Survey

Interventions to improve adherence to surveillance guidelines in survivors of childhood cancer: a systematic review

Unmet needs of family cancer caregivers predict quality of life in long-term cancer survivorship

Continued smoking after a cancer diagnosis: a longitudinal study of intentions and attempts to quit

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie