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Journal of Natural Medicines

Erschienen in:

20.06.2017 | Note

Nine pairs of megastigmane enantiomers from the leaves of Eucommia ulmoides Oliver

verfasst von: Jiankun Yan, Xuliu Shi, Paul Owusu Donkor, Huajie Zhu, Xiumei Gao, Liqin Ding, Feng Qiu

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2017

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Abstract

Nine pairs of megastigmane enantiomers (1a/1b–9a/9b), comprising two new compounds (6S,9R)-blumenol C (7b), (6S,9S)-blumenol C (8b), two pairs of enantiomers (+)-(6R)-eucomegastigmane A (1a), (−)-(6S)-eucomegastigmane A (1b), (+)-(3S,4S)-eucomegastigmane B (5a), (−)-(3R,4R)-eucomegastigmane B (5b) isolated by chiral resolution firstly, and twelve known compounds, were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis. Absolute configurations of the megastigmane enantiomers were assigned by comparing experimental ECD and OR with calculated ECD and OR. Docking-based virtual screening of all compounds showed that megastigmane enantiomers have weak intermolecular interactions with the binding site residues of angiotensin-converting enzyme (ACE) and angiotensin II type 1 receptor (AT₁R).

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Titel: Nine pairs of megastigmane enantiomers from the leaves of Eucommia ulmoides Oliver
verfasst von: Jiankun Yan
Xuliu Shi
Paul Owusu Donkor
Huajie Zhu
Xiumei Gao
Liqin Ding
Feng Qiu
Publikationsdatum: 20.06.2017
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1102-9

Springer Medizin

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